CN107041998A - A kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy - Google Patents
A kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy Download PDFInfo
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- CN107041998A CN107041998A CN201710084320.3A CN201710084320A CN107041998A CN 107041998 A CN107041998 A CN 107041998A CN 201710084320 A CN201710084320 A CN 201710084320A CN 107041998 A CN107041998 A CN 107041998A
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- barrier material
- source
- cervical carcinoma
- radioactive source
- single tube
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1016—Gynaecological radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
Abstract
The invention discloses a kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy, comprise the following steps：1）Subject device of the source applicator as cervical carcinoma Afterloading radiotherapy plan using after the single tube with barrier material；2）Faultage image when selecting suitable radioactive source and barrier material, and obtaining patient's plesioradiotherapy；3）According to common afterloading radiotherapy plan, dwell point, time of launch are determined；4）Dosage distributed model is built, overall Patients During Radiotherapy dose contribution distributed model is simulated；5）Object authentication；6）Dosage distributed model is imported in after-loading treatment planning system, plan is filled after formulation.The present invention is modified by the rear dress plan to radiotherapy for uterocervical cancer, the distributed model that source applicator after the single tube with barrier material builds corresponding 3-dimensional dose can be directed to by drawing, the precise degrees that plan is filled after cervical carcinoma are substantially increased, the Gospel brought for the patient using source applicator treatment after single tube.
Description
Technical field
The present invention relates to intraluminal radiotherapy treatment technology field, specifically referring to one kind is used to improve to put to penetrate after cervical carcinoma to control
Treat the formulating method of the plan degree of accuracy.
Background technology
The applicating device that mainly uses for the treatment of cervical carcinoma is for three pipe applicating devices at present, after three pipe applicating devices are the cervical carcinoma of classics
Treatment applicating device is filled, isodose curve can be obtained in just flat pears type distribution, front and back dose ratio both sides are low, thus effectively protect
The bladder and the rectum at rear protected in front of uterus, the rectal bladder damage of patient is reduced after treatment.But due to three pipe applicating devices
It is that the constitution to American-European women is relatively agreed with, for the constitution of Asia women from America and Europe's introduction, the three of three pipe applicating devices
Root is using and operate and all bringing larger difficulty for three pipe applicating devices, especially applied in three pipes mutually in the supply radiator duct at 90 ° of angles
During the device use of source, the pain of patient is than larger.
Afterwards it has been observed that the mode of radioactive ray can be blocked by using barrier material, single tube applicating device is set also to realize
The effect of three pipe applicating devices, can equally obtain isodose curve in just flat pears type distribution, the effectively bladder in front of protection uterus
With the rectum at rear, the rectovesical damage of patient after treatment, and single tube applicating device only one of which root supply radiator duct are reduced, is made
With and be all relatively easy to during operation, patient is over the course for the treatment of, basic without pain.
Applicant is based on this principle, in September in 2007 22 days, has applied for Patent No.：ZL200710050108.1, specially
Profit is entitled：Available for the cervical carcinoma single tube after-loading source applicator of CT scan, patent of invention, and authorized.The patent is
It is that the treatment end of applicating device is arranged to the oval inner tube being made by function of shielding material, the radioactive ray of radioactive source is carried out
Selectivity is blocked, so as to realize the radiation effect of three pipe applicating devices.
In traditional after-loading therapy system, the 3-dimensional dose distributed model of structure is directed to without putting for blocking
Source is penetrated, because the radioactive source of the single tube applicating device being blocked by barrier material, ray can be blocked material absorption, and occur to dissipate
Penetrate, reuse original 3-dimensional dose distributed model, then larger error occurs in after-loading therapy system, so as to cause whole
Individual afterloading radiotherapy plan it is inaccurate, it is therefore desirable to original rear dress plan is modified, and can be used to be directed to applicant
The single tube applicating device treatment of invention.
The content of the invention
It is an object of the invention to provide a kind of more accurate, for improving the cervical carcinoma Afterloading radiotherapy plan degree of accuracy
Formulating method.
The present invention is achieved through the following technical solutions：It is a kind of to be used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy
Formulating method, comprises the following steps：
(1) source applicator after the single tube with barrier material is used to be controlled as the main body of cervical carcinoma Afterloading radiotherapy plan
Treat device；
(2) faultage image when selecting suitable radioactive source and barrier material, and obtaining patient's plesioradiotherapy；
(3) common afterloading radiotherapy plan is made by after-loading treatment planning system, according to common afterloading radiotherapy plan, it is determined that
Time of launch of the dwell point and radioactive source of radioactive source in dwell point；
(4) by the 3-dimensional dose distributed model of source applicator after business mathematics software building single tube, business mathematics is passed through
The circumstance of occlusion of the dwell point of software combination radioactive source, time of launch and radioactive source, is simulated three-dimensional in overall Patients During Radiotherapy
Dose contribution distributed model；
(5) object authentication is carried out to simulating source applicator 3-dimensional dose distributed model after single tube；
(6) source applicator 3-dimensional dose distributed model after single tube is imported in after-loading treatment planning system, controlled by rear dress
Treat the formulation that planning system aids in cervical carcinoma Afterloading radiotherapy plan.
Method in order to which the present invention is better achieved, further, in the step (4), passes through business mathematics software structure
The 3-dimensional dose distributed model of source applicator is after the single tube built：
Wherein, radioactive source j coordinates areTarget point i is relative to radioactive source j coordinateThere is m target point i in three dimensions where radioactive source j, then m-th of target point i coordinate isSkFor air kerma intensity, ∧ is dose rate constant, and G (r, θ) is geometrical factor G (r, θ),
g(rim, θim) it is radial dose function, F (rim, θim) it is directivity function, the above can be by the radiation of crack radioactive source
Therapeutic dose formula (TG43) is drawn；Mean attenuation coefficient of the barrier material for radioactive sourceAccording to barrier material and radiation
Source property is drawn；Barrier material thickness Lim, according to the mathematical modulo of barrier material thickness in source applicator after single tube in claim 1
Type is drawn；The independent variable that time of launch t is contributed as radiological dose, dimIt is then radiation of the radioactive source j at m-th of target point i
Dose contribution, that is, the 3-dimensional dose contribution distributed model that there is barrier material；
Total radiological dose contribution D of all target pointsiFor：
Method in order to which the present invention is better achieved, further, barrier material is horizontal stroke in source applicator after the single tube
Section is the cylinder of ellipse, and radius of the middle part provided with placement radioactive source of the cylinder is r0Circular hole, then barrier material thickness
LimComputational methods be：
Wherein, it is ellipse that plane where m-th of target point i on barrier material, which intercepts barrier material, if the transverse
Length is a, and minor axis length is that b, a and b value can be drawn according to point i coordinate.
Method in order to which the present invention is better achieved, further, in the step (2), the faultage image of patient is used
The scanning of CT machines is obtained.
Method in order to which the present invention is better achieved, further, in the step (2), the barrier material of selection is lead
Or tungsten alloy.
Method in order to which the present invention is better achieved, further, in the step (2), the radioactive source of selection is
Ir192。
Method in order to which the present invention is better achieved, further, business mathematics software is Matlab in the step (4)
Software.
Method in order to which the present invention is better achieved, further, in the step (5), to 3-dimensional dose distributed model
Verification process be that source applicator after single tube is placed in simulated person's vivo environment, according to actual radiotherapy demand, use business
Mathematical software draws the actual radiation dosage in the model of show dose distribution, detection zone space, then will be actually measured
Radiological dose is compared with the dosage that model is shown.
The present invention compared with prior art, with advantages below and beneficial effect：
The present invention to cervical carcinoma Afterloading radiotherapy plan by being modified, and drawing can be directed to barrier material
Source applicator builds the distributed model of corresponding 3-dimensional dose after single tube, substantially increases and the accurate of plan is filled after cervical carcinoma
Degree, the Gospel brought for the patient using source applicator treatment after single tube.
Brief description of the drawings
By reading the detailed description made with reference to the following drawings to non-limiting example, other features of the invention,
Objects and advantages will become apparent：
Fig. 1 is isodose curve three-dimensional panorama figure；
Fig. 2 is the three-dimensional sagittal view of isodose curve；
Fig. 3 is the three-dimensional coronal-plane figure of isodose curve.
Embodiment
The present invention is described in further detail with reference to embodiment, but the implementation of the present invention is not limited to this,
Without departing from the idea case in the present invention described above, according to ordinary skill knowledge and customary means, various replace is made
Change and change, all should be included within the scope of the invention.To make the purpose of the present invention, process conditions and advantage effect clearer
Understand, with reference to following embodiment, the present invention is described in further detail.Specific implementation example described herein is only used to
The present invention is explained, is not intended to limit the present invention.
Embodiment 1：
The present embodiment discloses according to being used to improving the formulating method of the cervical carcinoma Afterloading radiotherapy plan degree of accuracy that there is provided one
Specific formulation example is planted, it is as follows：
Source applicator and selects lead to make as the subject device of cervical carcinoma Afterloading radiotherapy plan using after single tube
For the barrier material of source applicator after single tube, Ir192 simulates dress after single tube using Matlab softwares and applies source as radioactive source
Device 3-dimensional dose distributed model.
By common afterloading radiotherapy plan, 12 dwell points are drawn, are respectively：
X=-8:0.25:8；Y=x；Z=x；
[x, y, z]=meshgrid (x)；
xlr1=0, ylr1=0, zlr1=0.5；
xlr2=0, ylr2=0, zlr2=1；
xlr3=0, ylr3=0, zlr3=1.5；
xlr4=0, ylr4=0, zlr4=2；
xlr5=0, ylr5=0, zlr5=2.5；
xlr6=0, ylr6=0, zlr6=3；
xlr7=0, ylr7=0, zlr7=3.5；
xlr8=0, ylr8=0, zlr8=4；
xlr9=0, ylr9=0, zlr9=4.5；
xlr10=0, ylr10=0, zlr10=5；
xlr11=0, ylr11=0, zlr11=5.5；
xlr12=0, ylr12=0, zlr12=6；
And residence time tn, i.e.,
t1=60.93s,
t2=53.25s,
t3=36.20,
t4=42.02,
t5=21.45,
t6=9.64,
t7=11.84,
t8=34.84,
t9=76.68,
t10=126.17,
t11=165.05,
t12=194.51；
Then by the circumstance of occlusion of the dwell point of Matlab software combination radioactive sources, time of launch and radioactive source, i.e.,
Q=Heng_withblockzlg (x, y, z, xlr1, ylr1, zlr1, t1)+Heng_withblockzlg (x, y, z,
xlr2, ylr2, zlr2, t2)+Heng_withblockzlg (x, y, z, xlr3, ylr3, zlr3, t3)+Heng_withblockzlg (x,
Y, z, xlr4, ylr4, zlr4, t4)+Heng_withblockzlg (x, y, z, xlr5, ylr5, zlr5, t5)+Heng_withblockzlg
(x, y, z, xlr6, ylr6, zlr6, t6) and+Heng_withblockzlg (x, y, z, xlr7, ylr7, zlr7, t7)+Heng_
Withblockzlg (x, y, z, xlr8, ylr8, zlr8, t8)+Heng_withblockzlg (x, y, z, xlr9, ylr9, zlr9, t9)+
Heng_withblockzlg (x, y, z, xlr10, ylr10, zlr10, t10)+Heng_withblockzlg (x, y, z, xlr11, ylr11,
zlr11, t11)+Heng_withblockzlg (x, y, z, xlr12, ylr12, zlr12, t12)；
[p, v]=isosurface (x, y, z, q, 600)；% obtains point and the face of function f=0 figures with isosurface
Patch (' faces', p, ' vertices', v, ' facevertexcdata', jet (size (v, 1)), ' facecolor', '
W', ' edgecolor', ' flat')；% draws triangulation network trrellis diagram with patch and sets color view (3)；grid on； axis
equal。
Simulate 3-dimensional dose in overall Patients During Radiotherapy and contribute distributed model, image such as Fig. 1, Fig. 2, Fig. 3 institutes after simulation
Show.
Then object authentication is carried out to simulating source applicator 3-dimensional dose distributed model after single tube；Dress after single tube is applied again
Source device 3-dimensional dose distributed model is imported in after-loading treatment planning system, passes through after-loading treatment planning system adjuvant radiation therapies palace
The formulation of plan is filled after neck cancer.
Embodiment 2：
The present embodiment is limited on the basis of above-described embodiment, further in the step (4), soft by business mathematics
The 3-dimensional dose distributed model of source applicator is after the single tube that part is built：
Wherein, radioactive source j coordinates areTarget point i is relative to radioactive source j coordinateThere is m target point i in three dimensions where radioactive source j, then m-th of target point i coordinate isSkFor air kerma intensity, ∧ is dose rate constant, and G (r, θ) is geometrical factor G (r, θ),
g(rim, θim) it is radial dose function, F (rim, θim) it is directivity function, the above can be by the radiation of crack radioactive source
Therapeutic dose formula (TG43) is drawn；Mean attenuation coefficient of the barrier material for radioactive sourceAccording to barrier material and radiation
Source property is drawn；Barrier material thickness Lim, according to the mathematical modulo of barrier material thickness in source applicator after single tube in claim 1
Type is drawn；The independent variable that time of launch t is contributed as radiological dose, dimIt is then radiation of the radioactive source j at m-th of target point i
Dose contribution, that is, the 3-dimensional dose contribution distributed model that there is barrier material；
Total radiological dose contribution D of all target pointsiFor：The other parts of the present embodiment with it is above-mentioned
Embodiment is identical, repeats no more.
Embodiment 3：
The present embodiment limits after the single tube barrier material in source applicator on the basis of above-described embodiment, further
For the cylinder that cross section is ellipse, radius of the middle part provided with placement radioactive source of the cylinder is r0Circular hole, then barrier material
Thickness LimComputational methods be：
Wherein, it is ellipse that plane where m-th of target point i on barrier material, which intercepts barrier material, if the transverse
Length is a, and minor axis length is that b, a and b value can be drawn according to point i coordinate.The other parts of the present embodiment and above-mentioned reality
Apply example identical, repeat no more.
Embodiment 4：
The present embodiment is limited on the basis of above-described embodiment, further in the step (2), the faultage image of patient
Scanned and obtained using CT machines.The other parts of the present embodiment are same as the previously described embodiments, repeat no more.
Embodiment 5：
The present embodiment is limited on the basis of above-described embodiment, further in the step (5), and 3-dimensional dose is distributed
The verification process of model is that source applicator after single tube is placed in simulated person's vivo environment, according to actual radiotherapy demand, is used
Business mathematics software draws the actual radiation dosage in the model of show dose distribution, detection zone space, is then surveyed actual
The radiological dose obtained is compared with the dosage that model is shown.The other parts of the present embodiment are same as the previously described embodiments, no longer
Repeat.
Although an embodiment of the present invention has been shown and described, it will be understood by those skilled in the art that：Not
A variety of change, modification, replacement and modification can be carried out to these embodiments by departing under the principle and objective of the present invention, of the invention
Scope is limited by claim and its equivalent.
Claims (8)
1. a kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy, it is characterised in that including following
Step：
(1) source applicator after the single tube with barrier material is used to be filled as the subject of cervical carcinoma Afterloading radiotherapy plan
Put；
(2) faultage image when selecting suitable radioactive source and barrier material, and obtaining patient's plesioradiotherapy；
(3) generic schema is made by after-loading treatment planning system, according to generic schema, determine radioactive source dwell point and
Time of launch of the radioactive source in dwell point；
(4) by the 3-dimensional dose distributed model of source applicator after business mathematics software building single tube, business mathematics software is passed through
With reference to the circumstance of occlusion of the dwell point of radioactive source, time of launch and radioactive source, 3-dimensional dose in overall Patients During Radiotherapy is simulated
Contribute distributed model；
(5) object authentication is carried out to simulating source applicator 3-dimensional dose distributed model after single tube；
(6) source applicator 3-dimensional dose distributed model after single tube is imported in after-loading treatment planning system, passes through after-loading therapy meter
Draw the formulation that plan is filled after system supplymentary radiotherapy for uterocervical cancer.
2. a kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to claim 1,
Characterized in that, in the step (4), passing through the 3-dimensional dose distributed mode of source applicator after the single tube of business mathematics software building
Type is：
Wherein, radioactive source j coordinates areTarget point i is relative to radioactive source j coordinate
There is m target point i in three dimensions where radioactive source j, then m-th of target point i coordinate is
SkFor air kerma intensity, ∧ is dose rate constant, and G (r, θ) is geometrical factor G (r, θ), g (rim, θim) it is Radial Dose
Function, F (rim, θim) it is directivity function, the above can be obtained by the radiotherapy dosage formula (TG43) of crack radioactive source
Go out；Mean attenuation coefficient of the barrier material for radioactive sourceDrawn according to barrier material and radioactive source property；Barrier material is thick
Spend Lim, drawn according to the mathematical modeling of barrier material thickness in source applicator after single tube in claim 1；Time of launch t conducts
The independent variable of radiological dose contribution, dimIt is then radiological dose contributions of the radioactive source j at m-th of target point i, that is, exists and block material
The 3-dimensional dose contribution distributed model of material；
Total radiological dose contribution D of all target pointsiFor：
3. a kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to claim 2,
Characterized in that, barrier material is to be set in the middle part of the cylinder that cross section is ellipse, the cylinder in source applicator after the single tube
The radius for having placement radioactive source is r0Circular hole, then barrier material thickness LimComputational methods be：
Wherein, it is ellipse that plane where m-th of target point i on barrier material, which intercepts barrier material, if the transverse length
For a, minor axis length is that b, a and b value can be drawn according to point i coordinate.
4. it is a kind of for improving the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to any one of claims 1 to 3
Formulating method, it is characterised in that in the step (2), the faultage image of patient is scanned using CT machines to be obtained.
5. it is a kind of for improving the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to any one of claims 1 to 3
Formulating method, it is characterised in that in the step (2), the barrier material of selection is lead or tungsten alloy.
6. it is a kind of for improving the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to any one of claims 1 to 3
Formulating method, it is characterised in that in the step (2), the radioactive source of selection is Ir192.
7. it is a kind of for improving the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to any one of claims 1 to 3
Formulating method, it is characterised in that business mathematics software is Matlab softwares in the step (4).
8. it is a kind of for improving the cervical carcinoma Afterloading radiotherapy plan degree of accuracy according to any one of claims 1 to 3
Formulating method, it is characterised in that in the step (5), be to the verification process of 3-dimensional dose distributed model, dress after single tube is applied
Source device is placed in simulated person's vivo environment, according to actual radiotherapy demand, show that show dose is distributed using business mathematics software
Model, the actual radiation dosage in detection zone space, the dosage for then showing actually measured radiological dose and model
It is compared.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112245815A (en) * | 2020-10-26 | 2021-01-22 | 北京航空航天大学 | Afterloading radiotherapy plan and 3D printing template integrated simulation design method and system |
| CN116258735A (en) * | 2023-05-16 | 2023-06-13 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
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| CN112245815A (en) * | 2020-10-26 | 2021-01-22 | 北京航空航天大学 | Afterloading radiotherapy plan and 3D printing template integrated simulation design method and system |
| CN112245815B (en) * | 2020-10-26 | 2021-08-27 | 北京航空航天大学 | Afterloading radiotherapy plan and 3D printing template integrated simulation design method and system |
| CN116258735A (en) * | 2023-05-16 | 2023-06-13 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
| CN116258735B (en) * | 2023-05-16 | 2023-07-21 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
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