CN106237547A - A kind of manufacture method of individuation closely single tube apparatus for wave-energy source - Google Patents
A kind of manufacture method of individuation closely single tube apparatus for wave-energy source Download PDFInfo
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- CN106237547A CN106237547A CN201610749392.0A CN201610749392A CN106237547A CN 106237547 A CN106237547 A CN 106237547A CN 201610749392 A CN201610749392 A CN 201610749392A CN 106237547 A CN106237547 A CN 106237547A
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- wave
- energy source
- single tube
- tube apparatus
- dose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1007—Arrangements or means for the introduction of sources into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/103—Treatment planning systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
Abstract
The present invention relates to the manufacture method of a kind of individuation closely single tube apparatus for wave-energy source, belong to the preparation method of radiological unit in medical field, its method is: first obtain patient's faultage image when secondary plesioradiotherapy；Then described faultage image is sent in treatment planning systems, sketch out patient target area outline and jeopardize extraorgan's profile, by the target area of individual patients and surrounding are jeopardized organ dose and are carried out reverse optimization, target area is made to reach prescribed dose, around jeopardize the radioactive dose of organ less than limiting dosage, obtain the optimum three-dimensional single tube apparatus for wave-energy source model with the barrier material thickness of different parts, different directions, then printed the individuation single tube apparatus for wave-energy source of this individual patients applicable by 3D printer.The single tube apparatus for wave-energy source using the method to make is suitable for the practical situation of individual patients, is conducive to improving precision and the accuracy for the treatment of, simple to operate.
Description
Technical field
The present invention relates to the preparation method of radiological unit in medical field, be specifically related to a kind of individuation closely single tube and execute
The manufacture method of source device.
Background technology
Three-dimensional intracavitary brachytherapy is radiocurable a kind of form, can be positioned over by emission source pernicious swollen accurately
Within tumor or near, utilize high-energy ray that tumor cell is killed, have that direct killing tumor, therapeutic effect be good, recurrence
The advantage that rate is low, is widely used in the treatment of clinical tumor.Owing to the size of its tumor of difference, the position of patient also have with shape
Difference, current apparatus for wave-energy source can only form the prescribed dose curve of the rich tumor of bag by optimizing dwell point position and time, but
For tumour 3 D changes in spatial distribution bigger time dosage line can be caused to hold full tumor area, if or dosage line hold complete swollen
Tumor district then can cause normal surrounding tissue to exceed restriction dosage, causes radioactivity complication.
Summary of the invention
The technical problem to be solved is to provide the manufacture method of a kind of individuation closely single tube apparatus for wave-energy source, and one
Plant and there is tune powerful individuation closely single tube apparatus for wave-energy source, in treatment planning systems, by the target area to individual patients
And around jeopardizing organ dose carries out reverse optimization so that target area reaches prescribed dose, the radioactive dose around jeopardizing organ is low
In limiting dosage, obtain the optimum three-dimensional single tube apparatus for wave-energy source model with the barrier material thickness of different parts, different directions, then
The individuation single tube apparatus for wave-energy source of this individual patients applicable is printed by 3D printer.
The technical scheme is that
The manufacture method of a kind of individuation closely single tube apparatus for wave-energy source, it comprises the steps:
(1) patient's faultage image when secondary plesioradiotherapy is obtained；
(2) by described faultage image transmission to radiotherapy planning system, sketch out patient target area outline and jeopardize organ
Outline, and generate target area and jeopardize the 3-D view of organ；
(3) outline of described target area and the 3-D view jeopardizing organ is carried out spatial sampling, and obtain spatial sampling
The position coordinates of point；
(4) equal with prescribed dose based on radiological dose at the outline of target volume and jeopardize and put at extraorgan's profile
Penetrate dosage less than limit dosage principle, respectively the position coordinates at described target area spatial sampling point arrange prescribed dose parameter and
At the described position coordinates jeopardizing organ spatial sampling point, restriction dosimetry parameter is set；
(5) according to Optimum Theory to the position coordinates of described target area spatial sampling point and prescribed dose parameter and described danger
And the position coordinates of organ spatial sampling point and limit dosimetry parameter simulation and rebuild three-dimensional single tube apparatus for wave-energy source model, obtain having not
Same position, the optimum three-dimensional single tube apparatus for wave-energy source model of barrier material thickness of different directions；
(6) according to described optimum three-dimensional single tube apparatus for wave-energy source model, use 3D printer to print, obtain single tube apparatus for wave-energy source.
The invention has the beneficial effects as follows: by the target area of individual patients and surrounding are jeopardized organ dose and carried out the most excellent
Change so that target area reaches prescribed dose, around jeopardize the radioactive dose of organ less than limiting dosage, obtain having different parts,
The optimum three-dimensional single tube apparatus for wave-energy source model of the barrier material thickness of different directions, then print this patient applicable by 3D printer
Individual individuation single tube apparatus for wave-energy source, the single tube apparatus for wave-energy source using the method to make is suitable for the practical situation of individual patients, favorably
In improving the precision and accuracy treated, simple to operate.
On the basis of technique scheme, the present invention can also do following improvement.
Further, described faultage image uses CT machine or the scanning of other image collecting devices to obtain.
Further, the prescribed dose in described step (4) and restriction dosage are all that dosage that this plan should reach divides
Cloth requirement；Or the dose requirements that each academic organisations is recommended；Or the Individuated dose requirement according to patient.
Above-mentioned further scheme is used to provide the benefit that the dose distribution that can form applicable individual.
Further, in described step (5) barrier material be lead.
Above-mentioned further scheme is used to provide the benefit that lead can block ray.
Accompanying drawing explanation
Fig. 1 is the manufacture method flow chart of the present invention.
Detailed description of the invention
Being described principle and the feature of the present invention below in conjunction with accompanying drawing, example is served only for explaining the present invention, and
Non-for limiting the scope of the present invention.
As it is shown in figure 1, the invention provides the manufacture method of a kind of individuation closely single tube apparatus for wave-energy source, one has tune
Powerful individuation closely single tube apparatus for wave-energy source, in treatment planning systems, by the target area of individual patients and around endangering
And organ dose carries out reverse optimization so that target area reaches prescribed dose, the radioactive dose around jeopardizing organ is the lowest, obtains
There is the optimum three-dimensional single tube apparatus for wave-energy source model of the barrier material thickness of different parts, different directions, then beaten by 3D printer
Printing off the individuation single tube apparatus for wave-energy source of this individual patients applicable, it specifically includes following steps:
(1) patient's faultage image when secondary plesioradiotherapy is obtained；Herein, preferably select the scanning of CT machine to obtain to suffer from
Faultage image at person's tumor locus, it would however also be possible to employ the harvester of other acquisition human body images selected clinically；
(2) transmission of described faultage image is sketched out patient target area outline and jeopardizes extraorgan to radiotherapy planning system
Profile, and generate target area and jeopardize the 3-D view of organ；The described organ that jeopardizes is the normal organ adjacent with tumor；
(3) outline of described target area and the 3-D view jeopardizing organ is carried out spatial sampling, and obtain spatial sampling
The position coordinates of point；Specific practice be radiotherapy planning system automatically by target area, jeopardize the outline of organ be divided into 0.3cm ×
The calculating grid (size can take 0.2cm～0.4cm) of 0.3cm × 0.3cm, takes the position that grid element center coordinate is sampled point and sits
Mark；
(4) equal with prescribed dose based on radiological dose at the outline of target volume and jeopardize and put at extraorgan's profile
Penetrating dosage less than the principle limiting dosage, the position coordinates at described target area outline sampled point arranges prescribed dose parameter respectively
Restriction dosimetry parameter is set with the position coordinates at the described extraorgan's of jeopardizing configuration sampling point；Described prescribed dose and restriction dosage
It it is all this dose distribution requirement planning reach；Or the dose requirements that each academic organisations is recommended；Or according to patient
Individuated dose requirement；
(5) according to Optimum Theory to the position coordinates of described target area spatial sampling point and prescribed dose parameter and described danger
And the position coordinates of organ spatial sampling point and limit dosimetry parameter simulation and rebuild three-dimensional single tube apparatus for wave-energy source model, obtain having not
Same position, the optimum three-dimensional single tube apparatus for wave-energy source model of barrier material thickness of different directions；
(6) according to described optimum three-dimensional single tube apparatus for wave-energy source model, use 3D printer to print, obtain single tube apparatus for wave-energy source.
In the present invention, described barrier material can be selected for the preferable metal of alpha ray shield effect, such as lead.
Described three-dimensional single tube apparatus for wave-energy source model different parts, difference is determined according to Optimum Theory below in step (5)
The barrier material thickness in direction illustrates, and barrier material selects lead here, referred to as keeps off lead.
M dwell point is set in assuming single tube apparatus for wave-energy source, in order to prevent the outer barrier material of adjacent dwell point from influencing each other,
Adjacent dwell point spacing distance should be bigger；Space ith sample point is (r relative to the spherical coordinates of jth dwell pointij, θij,
Фij), then the dose contribution of ith sample point is determined by jth dwell point by below equation:
Wherein, SkFor air kerma intensity, directly can be read by radiotherapy planning system；∧ is dose rate constant；F
(rij,θij) it is directivity function, it is known that rijWith θijThen can obtain；g(rij,θij) it is directivity function, it is known that rijWith θijThen may be used
Obtain；tjFor the time that jth dwell point is resident.
Assume that jth dwell point is at (θij, Фij) gear lead thickness on direction is Lij, then after adding gear lead, jth is resident
The dose contribution of ith sample point is determined by point by below equation:
Wherein, HVL is the barrier material half value layer for radioactive source, and barrier material determines that rear HVL is it is known that for list
M the dwell point set in pipe apparatus for wave-energy source, after adding gear lead to the contribution that the dosage of space ith sample point is total be:
It is that m the dwell point dose contribution to it is equal to D for target area outline sampled point dosage principlePrescription, suppose there is N
Individual jeopardizing organ, wherein jeopardizing organ 1 outline sampled point dosage principle is that m the dwell point dose contribution to it is less than D1、
Jeopardizing organ 2 outline sampled point dosage principle is that m the dwell point dose contribution to it is less than D2, jeopardize organ by that analogy
N outline sampled point dosage principle is that m the dwell point dose contribution to it is less than Dn。
By regulating the value of t Yu L, to meet above-mentioned condition, therefore pass through optimization method, build following object function:
Wherein, ωTWeight, ω is optimized for target area1For jeopardizing the optimization weight of organ 1, ω2Weigh for jeopardizing the optimization of organ 2
Weight, the like, ωnFor jeopardizing the optimization weight of organ N, nT is that target area outline sampled point number, n1 are for jeopardizing outside organ 1
Configuration sampling point number, n2 are for jeopardizing organ 2 outline sampled point number, by that analogy nN for jeopardizing the sampling of organ N outline
Point number.Solve above-mentioned object function minima, the methods such as descent method, Newton method, conjugate gradient method can be used, can obtain
tj, Lij, eventually through calculated applicable patient as the L of time after-loading therapyijBe converted to the barrier material thickness outside dwell point,
Input 3D printer, prints individuation closely single tube apparatus for wave-energy source.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all spirit in the present invention and
Within principle, any modification, equivalent substitution and improvement etc. made, should be included within the scope of the present invention.
Claims (4)
1. the manufacture method of an individuation closely single tube apparatus for wave-energy source, it is characterised in that it comprises the steps:
(1) patient's faultage image when secondary plesioradiotherapy is obtained；
(2) by described faultage image transmission to radiotherapy planning system, sketch out patient target area outline and jeopardize organ foreign steamer
Exterior feature, and generate target area and jeopardize the 3-D view of organ；
(3) outline to described target area and the 3-D view jeopardizing organ carries out spatial sampling, and obtains spatial sampling point
Position coordinates；
(4) equal with prescribed dose based on radiological dose at the outline of target volume and jeopardize radiological agent at extraorgan's profile
Amount is less than the principle of restriction dosage, and the position coordinates at described target area spatial sampling point arranges prescribed dose parameter and in institute respectively
State and jeopardize the position coordinates of organ spatial sampling point restriction dosimetry parameter is set；
(5) to the position coordinates of described target area spatial sampling point and prescribed dose parameter and described device is jeopardized according to Optimum Theory
Three-dimensional single tube apparatus for wave-energy source model is rebuild in position coordinates and the restriction dosimetry parameter simulation of official's spatial sampling point, obtains having difference portion
Position, the optimum three-dimensional single tube apparatus for wave-energy source model of barrier material thickness of different directions；
(6) according to described optimum three-dimensional single tube apparatus for wave-energy source model, use 3D printer to print, obtain single tube apparatus for wave-energy source.
The manufacture method of individuation the most according to claim 1 closely single tube apparatus for wave-energy source, it is characterised in that described tomography
Image uses CT machine or the scanning of other image collecting devices to obtain.
The manufacture method of individuation the most according to claim 1 closely single tube apparatus for wave-energy source, it is characterised in that described step
(4) prescribed dose and restriction dosage in are all this dose distribution requirements planning reach；Or each academic organisations pushes away
The dose requirements recommended；Or the Individuated dose requirement according to patient.
The manufacture method of individuation the most according to claim 1 closely single tube apparatus for wave-energy source, it is characterised in that described step
(5) in barrier material be lead.
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| CN201610749392.0A CN106237547B (en) | 2016-08-29 | 2016-08-29 | A kind of production method of individuation short distance single tube applicating device |
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| CN201610749392.0A CN106237547B (en) | 2016-08-29 | 2016-08-29 | A kind of production method of individuation short distance single tube applicating device |
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| CN106237547A true CN106237547A (en) | 2016-12-21 |
| CN106237547B CN106237547B (en) | 2019-03-08 |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107041999A (en) * | 2017-02-16 | 2017-08-15 | 西南医科大学附属医院 | There is 3-dimensional dose contribution distributed model construction method and its application of barrier material |
| CN107041998A (en) * | 2017-02-16 | 2017-08-15 | 西南医科大学附属医院 | A kind of formulating method for being used to improve the cervical carcinoma Afterloading radiotherapy plan degree of accuracy |
| CN107335153A (en) * | 2017-08-05 | 2017-11-10 | 吴大可 | Robot lower energy photon plesioradiotherapy system |
| CN108452444A (en) * | 2018-03-12 | 2018-08-28 | 汤轶强 | The method and its application method of source applicator after nasopharyngeal carcinoma are printed using 3D printer |
| CN109499014A (en) * | 2018-12-29 | 2019-03-22 | 王世广 | The production method of dress operation auxiliary device after a kind of gynecological tumor |
| CN109529204A (en) * | 2018-10-25 | 2019-03-29 | 北京启麟科技有限公司 | Superficial tumor close-range treatment applicating device manufacturing method and applicating device |
| CN110141778A (en) * | 2019-04-02 | 2019-08-20 | 成都真实维度科技有限公司 | The acquisition of radioactive particle source total quantity, radioactive particle source cloth source and needle track paths planning method in knurl |
| CN110290833A (en) * | 2017-02-09 | 2019-09-27 | 肿瘤贝塔股份有限公司 | For applying the model radiated, the method for making the model and the purposes of the model |
| CN112023281A (en) * | 2020-09-30 | 2020-12-04 | 重庆大学附属肿瘤医院 | Manufacturing method of applicator for treating cervical cancer |
| CN112245815A (en) * | 2020-10-26 | 2021-01-22 | 北京航空航天大学 | Afterloading radiotherapy plan and 3D printing template integrated simulation design method and system |
| CN112933428A (en) * | 2021-01-28 | 2021-06-11 | 苏州普能医疗科技有限公司 | Insertion guide plate design method and insertion guide plate |
| CN112957620A (en) * | 2021-01-28 | 2021-06-15 | 苏州普能医疗科技有限公司 | Brachytherapy plan design system and method |
| CN116258735A (en) * | 2023-05-16 | 2023-06-13 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
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Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110290833A (en) * | 2017-02-09 | 2019-09-27 | 肿瘤贝塔股份有限公司 | For applying the model radiated, the method for making the model and the purposes of the model |
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| CN109499014A (en) * | 2018-12-29 | 2019-03-22 | 王世广 | The production method of dress operation auxiliary device after a kind of gynecological tumor |
| CN110141778A (en) * | 2019-04-02 | 2019-08-20 | 成都真实维度科技有限公司 | The acquisition of radioactive particle source total quantity, radioactive particle source cloth source and needle track paths planning method in knurl |
| CN112023281A (en) * | 2020-09-30 | 2020-12-04 | 重庆大学附属肿瘤医院 | Manufacturing method of applicator for treating cervical cancer |
| CN112245815B (en) * | 2020-10-26 | 2021-08-27 | 北京航空航天大学 | Afterloading radiotherapy plan and 3D printing template integrated simulation design method and system |
| CN112245815A (en) * | 2020-10-26 | 2021-01-22 | 北京航空航天大学 | Afterloading radiotherapy plan and 3D printing template integrated simulation design method and system |
| CN112933428A (en) * | 2021-01-28 | 2021-06-11 | 苏州普能医疗科技有限公司 | Insertion guide plate design method and insertion guide plate |
| CN112957620A (en) * | 2021-01-28 | 2021-06-15 | 苏州普能医疗科技有限公司 | Brachytherapy plan design system and method |
| CN112933428B (en) * | 2021-01-28 | 2022-09-27 | 苏州普能医疗科技有限公司 | Insertion guide plate design method and insertion guide plate |
| CN116258735A (en) * | 2023-05-16 | 2023-06-13 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
| CN116258735B (en) * | 2023-05-16 | 2023-07-21 | 四川省肿瘤医院 | Cervical cancer inter-tissue insertion needle reconstruction system |
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