CN105833434A - Manufacture method of brachytherapy source applicator template - Google Patents
Manufacture method of brachytherapy source applicator template Download PDFInfo
- Publication number
- CN105833434A CN105833434A CN201610403621.3A CN201610403621A CN105833434A CN 105833434 A CN105833434 A CN 105833434A CN 201610403621 A CN201610403621 A CN 201610403621A CN 105833434 A CN105833434 A CN 105833434A
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- wave
- energy source
- template
- dose
- vaginal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1002—Intraluminal radiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1016—Gynaecological radiation therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1049—Monitoring, verifying, controlling systems and methods for verifying the position of the patient with respect to the radiation beam
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Abstract
The invention relates to a manufacture method of a brachytherapy source applicator template. The method includes the following steps that: vaginal packing is carried out; three-dimensional simulation positioning is carried out; a target area, normal organs requiring protection and a contour which is formed after the vaginal packing are delineated in a treatment planning system; a plan is formulated in a simulation manner, source applicators are reconstructed, sources are distributed, dwell time is adjusted, and dosage distribution is formed; the plan is evaluated, if a user is not satisfied with the dosage distribution, the positions and/or number of the source applicators is adjusted, so that a plan is formulated again in a simulation manner; and the positions and channels of the reconstructed source applicators in the vaginal contour are marked; and the vaginal contour with the channels is subjected to 3D printing, so that a vaginal template can be formed. According to the method, an individualized template can be designed according to the relative positions of a tumor and adjacent normal organs of a patient in brachytherapy and required dosage distribution; and based on the guidance of the template, the source applicators can be placed to desired positions; and therefore, the dosage distribution in brachytherapy can achieve a desired effect.
Description
Technical field
The present invention relates to the manufacture method of a kind of close-range treatment apparatus for wave-energy source template.
Background technology
Radiotherapy is one of main treatment means of cervical cancer, and the cervical cancer patient more than 2/3rds need to accept radiotherapy.The most optional for early cervical carcinoma, radiotherapy and operation, the two therapeutic equivalence；For stage middle-advanced cervical carcinoma, radiotherapy is the only treatment means that may arrive radical cure effect.
Close-range treatment is the important component part of irradiation for cervical cancer, close-range treatment relies on and adjusts radioactive source position resident in apparatus for wave-energy source and the dose distribution of residence time acquisition needs, and satisfied dose distribution requires that the normal organ dosage that target dose is the highest and neighbouring is the lowest.Close-range treatment has topical high-dose but the little feature of coverage, and the area for treatment of cervical cancer patient is neighbouring with the normal organ such as intestinal, bladder, and therefore the accuracy of apparatus for wave-energy source position is of great significance obtaining satisfied dose distribution tool.
The usual step of close-range treatment is: places apparatus for wave-energy source, position, plan, treat.Unpredictable apparatus for wave-energy source and target area and the position relationship of neighbouring normal organ placing apparatus for wave-energy source when, cause being likely to because of the reason of apparatus for wave-energy source position when designing radiotherapy planning, in any case the dwell point of adjustment radioactive source and residence time all can not reach satisfied dose distribution, even if utilizing ultrasonic or other images to assist when placing apparatus for wave-energy source, enable apparatus for wave-energy source to arrive certain point, but not can determine that path that apparatus for wave-energy source arrives is the most optimum and still cannot predict the dose distribution ultimately formed.Additionally, due to the form of every patient tumors, position, tumor all differ with the relation of neighbouring normal organ, and the reason such as the change of tumor in therapeutic process, it is impossible to it is applicable to all patients or the treatment of same patient's different times with same apparatus for wave-energy source.
Summary of the invention
It is an object of the invention to overcome the defect of prior art, a kind of close-range treatment apparatus for wave-energy source template construct method is provided, by this template-directed so that apparatus for wave-energy source can be placed into intended position by the path of design, and makes dose distribution during treatment produce a desired effect.
To achieve these goals, the technical scheme that the present invention takes is as follows:
A kind of close-range treatment apparatus for wave-energy source template construct method, its key technology is, it comprises the steps:
Vaginal plugging, the profile formed after the vaginal plugging obtaining patient；
Three-dimensional simulation positions；
The profile formed after drawing target outline, need normal organ to be protected and vaginal plugging in treatment planning systems；
Simulation is made a plan, and apparatus for wave-energy source is rebuild in the position and the dose requirements simulation that according to target area, need normal organ to be protected, and cloth source also adjusts residence time, forms dose distribution；
Evaluate plan, if dose distribution is unsatisfied with, then adjust the position of the apparatus for wave-energy source of reconstruction and/or quantity till reaching satisfied dose distribution；
Apparatus for wave-energy source position on vagina profile that labelling is rebuild and passage thereof；
3D prints the vagina profile of tape channel and forms vagina template.
Further improving as the present invention, described vaginal plugging is to use the rapid prototyping material to human non-toxic, compatible CT to carry out vaginal plugging.
Further improving as the present invention, described dose requirements refers to that this plans the dose distribution requirement that reach, or the dose requirements that each academic organisations is recommended, also or for the Individuated dose requirement of concrete patient.
A kind of method utilizing above-mentioned template-directed apparatus for wave-energy source to place: design the position of apparatus for wave-energy source according to required dose distribution, guides apparatus for wave-energy source to arrive intended position by vagina template.Owing to template is that individuation makes, meets the vagina feature of individuation, therefore can repeat position during simulator locating when actual therapeutic, so that it is guaranteed that apparatus for wave-energy source can be by template position expected from the path of design arrives.
Compared with prior art, having the beneficial effect that acquired by the present invention:
Apparatus for wave-energy source template made by the inventive method adapts to form and the distribution of individual's tumor, the position of reversal design apparatus for wave-energy source is come according to required dose distribution, guided by the passage in vaginal stent, apparatus for wave-energy source can be placed into anticipated position, so that Radiotherapy dosimetry meets intended dose distribution by the path of design exactly.
Accompanying drawing explanation
Accompanying drawing 1 is the flow chart of the inventive method.
Detailed description of the invention
Below in conjunction with accompanying drawing 1 and specific embodiment, the present invention is carried out further details of narration.
As shown in Figure 1, close-range treatment apparatus for wave-energy source template construct method is specific as follows:
Vaginal plugging.The rapid prototyping material to human non-toxic, compatible CT is used to carry out vaginal plugging, it is therefore an objective to obtaining vagina profile, this profile can embody the vagina form after patient's vaginal plugging and the form of tumor, position.
Three-dimensional simulation positions and by image transmitting to treatment planning systems.
The profile formed after drawing target outline, need normal organ to be protected and vaginal plugging in treatment planning systems, and carry out three-dimensional reconstruction.
Simulation game in treatment planning systems.According to target area, needing the position of normal organ to be protected to simulate reconstruction apparatus for wave-energy source, apparatus for wave-energy source is intended the part in cloth source and is positioned at target area and as far as possible away from the normal organ that target area is neighbouring, and apparatus for wave-energy source enters the vitals that the path organized is avoided protecting.
To the apparatus for wave-energy source cloth source rebuild in treatment planning systems, adjust the residence time of each radioactive source dwell point according to the dose requirements to target area and the dose requirements to normal organ, form dose distribution.Dose requirements to target area and the dose requirements to normal organ refer to that this plans the dose distribution requirement that reach, and can be the dose requirements of each academic organisations recommendation, it is also possible to be the Individuated dose requirement for concrete patient.
According to the requirement of dose distribution being evaluated the plan of this simulation, if dose distribution is unsatisfied with, then adjusting the position of the apparatus for wave-energy source of reconstruction and/or adjusting apparatus for wave-energy source quantity, again forming dose distribution, till being so repeated up to reach satisfied dose distribution.
Position and the required passage of apparatus for wave-energy source simulation rebuild are marked at the vagina profile of three-dimensional reconstruction, form the vagina contoured three-dimensional model of band apparatus for wave-energy source passage.
The vagina contoured three-dimensional model of band apparatus for wave-energy source passage is modified, the sharp-pointed place of polishing, it is to avoid patient is damaged, uses the material 3D to human non-toxic to print the vagina profile of this band apparatus for wave-energy source passage, it is thus achieved that template in software.
The vagina template of individuation is made by this method, the position of vagina profile during simulation game can be repeated when reality places vagina template well, thus ensure that apparatus for wave-energy source can arrive the ideal position in simulation game by the passage in vagina template by the path of design.By being then based on 3-dimensional dose distribution reversal design template, therefore the radiotherapy planning when actual therapeutic and simulation game have good repeatability, so that it is guaranteed that obtain preferable dose distribution.In actual applications, repeating dwell point and the residence time of radioactive source during simulation game, form dose distribution, the error of target dose about 5%, bladder D2cc(accepts the 2cm of maximum dose level3Volume) dose error about 6%, rectum D2cc(accepts the 2cm of maximum dose level3Volume) dose error about 8%.
Simulation described in the inventive method is made a plan and evaluation plan all can use the conventional Calculation Method of dose requirements of the prior art and distribution to calculate, and here is omitted, and it is all applicable to the present processes, belongs to spirit herein territory.
The above embodiment is only the preferred embodiments of the present invention, and and the feasible enforcement of non-invention exhaustive.For persons skilled in the art, any obvious change done to it on the premise of without departing substantially from the principle of the invention and spirit, within all should being contemplated as falling with the claims of the present invention.
Claims (4)
1. a close-range treatment apparatus for wave-energy source template construct method, it is characterised in that it comprises the steps:
Vaginal plugging, the profile formed after obtaining the vaginal plugging of patient；
Three-dimensional simulation positions；
The profile formed after drawing target outline, need normal organ to be protected and vaginal plugging in treatment planning systems；
Simulation is made a plan, and apparatus for wave-energy source is rebuild in the position and the dose requirements simulation that according to target area, need normal organ to be protected, and cloth source also adjusts residence time, forms dose distribution；
Evaluate plan, if dose distribution is unsatisfied with, then adjust the position of the apparatus for wave-energy source of reconstruction and/or quantity till reaching satisfied dose distribution；
Apparatus for wave-energy source position on vagina profile that labelling is rebuild and passage thereof；
3D prints the vagina profile of tape channel and forms vagina template.
A kind of described close-range treatment apparatus for wave-energy source template construct method the most according to claim 1, it is characterised in that vaginal plugging is to use the rapid prototyping material to human non-toxic, compatible CT to carry out vaginal plugging.
A kind of described close-range treatment apparatus for wave-energy source template construct method the most according to claim 1, it is characterized in that, described dose requirements refers to that this plans the dose distribution requirement that reach, or the dose requirements that each academic organisations is recommended, also or for the Individuated dose requirement of concrete patient.
4. the method that the template-directed apparatus for wave-energy source utilizing the manufacture method as described in any one of claim 1-3 to prepare is placed: it is characterized in that, design the position of apparatus for wave-energy source according to required dose distribution and implant path, guiding apparatus for wave-energy source to arrive intended position by vagina template.
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| CN201610403621.3A CN105833434A (en) | 2016-06-08 | 2016-06-08 | Manufacture method of brachytherapy source applicator template |
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| CN201610403621.3A CN105833434A (en) | 2016-06-08 | 2016-06-08 | Manufacture method of brachytherapy source applicator template |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215334A (en) * | 2016-08-23 | 2016-12-14 | 广州医科大学附属肿瘤医院 | The reverse of a kind of afterloading radiotherapy dosage adjusts strong optimized calculation method and system |
| CN106237547A (en) * | 2016-08-29 | 2016-12-21 | 西南医科大学附属医院 | A kind of manufacture method of individuation closely single tube apparatus for wave-energy source |
| CN106362309A (en) * | 2016-09-29 | 2017-02-01 | 陕西东望科贸有限公司 | Method for customizing tumor radiotherapy baffle |
| CN107998518A (en) * | 2017-12-08 | 2018-05-08 | 广州医科大学附属肿瘤医院 | The production method of the individuation auxiliary device of transplanting treatment by cervical carcinoma chamber joint palace |
| CN109499014A (en) * | 2018-12-29 | 2019-03-22 | 王世广 | The production method of dress operation auxiliary device after a kind of gynecological tumor |
| CN109908494A (en) * | 2019-03-25 | 2019-06-21 | 天津大学 | The minimally invasive radiotherapy three-dimensional surgical guide designing system of close-range particle |
| CN112023281A (en) * | 2020-09-30 | 2020-12-04 | 重庆大学附属肿瘤医院 | Manufacturing method of applicator for treating cervical cancer |
| CN112516471A (en) * | 2020-12-01 | 2021-03-19 | 北京航空航天大学 | Radiotherapy plan simulation design method and system based on expansion and contraction theory |
| CN113018674A (en) * | 2021-03-18 | 2021-06-25 | 广西医科大学附属肿瘤医院 | Method for manufacturing guide plate for tissue insertion and guide plate for tissue insertion |
| CN113069680A (en) * | 2021-03-17 | 2021-07-06 | 江苏省肿瘤防治研究所（江苏省肿瘤医院） | Applicator brachytherapy device with balloon fixation device and method of use |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895732A (en) * | 2012-10-19 | 2013-01-30 | 张建国 | Radioactive particle implanting template and fabrication method thereof |
| CN105120950A (en) * | 2012-11-05 | 2015-12-02 | 核通业务有限公司 | A medical applicator and methods of making |
| CN105148390A (en) * | 2015-07-30 | 2015-12-16 | 泸州医学院附属医院 | Source applicator design method |
-
2016
- 2016-06-08 CN CN201610403621.3A patent/CN105833434A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895732A (en) * | 2012-10-19 | 2013-01-30 | 张建国 | Radioactive particle implanting template and fabrication method thereof |
| CN105120950A (en) * | 2012-11-05 | 2015-12-02 | 核通业务有限公司 | A medical applicator and methods of making |
| CN105148390A (en) * | 2015-07-30 | 2015-12-16 | 泸州医学院附属医院 | Source applicator design method |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106215334A (en) * | 2016-08-23 | 2016-12-14 | 广州医科大学附属肿瘤医院 | The reverse of a kind of afterloading radiotherapy dosage adjusts strong optimized calculation method and system |
| CN106237547A (en) * | 2016-08-29 | 2016-12-21 | 西南医科大学附属医院 | A kind of manufacture method of individuation closely single tube apparatus for wave-energy source |
| CN106237547B (en) * | 2016-08-29 | 2019-03-08 | 西南医科大学附属医院 | A kind of production method of individuation short distance single tube applicating device |
| CN106362309B (en) * | 2016-09-29 | 2019-03-22 | 陕西东望科技有限公司 | A method of customization tumour radiotherapy baffle |
| CN106362309A (en) * | 2016-09-29 | 2017-02-01 | 陕西东望科贸有限公司 | Method for customizing tumor radiotherapy baffle |
| CN107998518A (en) * | 2017-12-08 | 2018-05-08 | 广州医科大学附属肿瘤医院 | The production method of the individuation auxiliary device of transplanting treatment by cervical carcinoma chamber joint palace |
| CN107998518B (en) * | 2017-12-08 | 2020-07-28 | 广州医科大学附属肿瘤医院 | Manufacturing method of individualized auxiliary device for cervical cancer cavity combined parauterine implantation treatment |
| CN109499014A (en) * | 2018-12-29 | 2019-03-22 | 王世广 | The production method of dress operation auxiliary device after a kind of gynecological tumor |
| CN109908494A (en) * | 2019-03-25 | 2019-06-21 | 天津大学 | The minimally invasive radiotherapy three-dimensional surgical guide designing system of close-range particle |
| CN112023281A (en) * | 2020-09-30 | 2020-12-04 | 重庆大学附属肿瘤医院 | Manufacturing method of applicator for treating cervical cancer |
| CN112516471A (en) * | 2020-12-01 | 2021-03-19 | 北京航空航天大学 | Radiotherapy plan simulation design method and system based on expansion and contraction theory |
| CN113069680A (en) * | 2021-03-17 | 2021-07-06 | 江苏省肿瘤防治研究所（江苏省肿瘤医院） | Applicator brachytherapy device with balloon fixation device and method of use |
| CN113069680B (en) * | 2021-03-17 | 2021-10-26 | 江苏省肿瘤防治研究所（江苏省肿瘤医院） | Applicator brachytherapy device with balloon fixation device and method of use |
| CN113018674A (en) * | 2021-03-18 | 2021-06-25 | 广西医科大学附属肿瘤医院 | Method for manufacturing guide plate for tissue insertion and guide plate for tissue insertion |
| CN113018674B (en) * | 2021-03-18 | 2022-08-19 | 广西医科大学附属肿瘤医院 | Method for manufacturing guide plate for tissue insertion and guide plate for tissue insertion |
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