JP2019038797A5 - - Google Patents
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- JP2019038797A5 JP2019038797A5 JP2018021069A JP2018021069A JP2019038797A5 JP 2019038797 A5 JP2019038797 A5 JP 2019038797A5 JP 2018021069 A JP2018021069 A JP 2018021069A JP 2018021069 A JP2018021069 A JP 2018021069A JP 2019038797 A5 JP2019038797 A5 JP 2019038797A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- pharmaceutical composition
- solid tumor
- day
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 23
- 239000008194 pharmaceutical composition Substances 0.000 claims 15
- QYNUQALWYRSVHF-OLZOCXBDSA-N (6R)-5,10-methylenetetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1C1)N)N1C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QYNUQALWYRSVHF-OLZOCXBDSA-N 0.000 claims 10
- 206010009944 Colon cancer Diseases 0.000 claims 8
- 241000282412 Homo Species 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 229960002949 fluorouracil Drugs 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 235000006708 antioxidants Nutrition 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229940120638 avastin Drugs 0.000 claims 1
- 229960000397 bevacizumab Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- ZWAOHEXOSAUJHY-ZIYNGMLESA-N doxifluridine Chemical compound O[C@@H]1[C@H](O)[C@@H](C)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ZWAOHEXOSAUJHY-ZIYNGMLESA-N 0.000 claims 1
- 201000010175 gallbladder cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
- 229960004768 irinotecan Drugs 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000023707 liver extraskeletal osteosarcoma Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical group O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 229960001756 oxaliplatin Drugs 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187684.0A EP3446704A1 (en) | 2017-08-24 | 2017-08-24 | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| EP17187684.0 | 2017-08-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019038797A JP2019038797A (ja) | 2019-03-14 |
| JP2019038797A5 true JP2019038797A5 (https=) | 2019-08-08 |
Family
ID=59702573
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510518A Active JP7356411B2 (ja) | 2017-08-24 | 2018-01-05 | ５－フルオロウラシルに基づく化学療法における［６ｒ］－ｍｔｈｆ、有効な葉酸代替物 |
| JP2018021069A Pending JP2019038797A (ja) | 2017-08-24 | 2018-02-08 | ５−フルオロウラシルに基づく化学療法における［６ｒ］−ｍｔｈｆ、有効な葉酸代替物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020510518A Active JP7356411B2 (ja) | 2017-08-24 | 2018-01-05 | ５－フルオロウラシルに基づく化学療法における［６ｒ］－ｍｔｈｆ、有効な葉酸代替物 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US11013744B2 (https=) |
| EP (3) | EP3446704A1 (https=) |
| JP (2) | JP7356411B2 (https=) |
| KR (1) | KR102216031B1 (https=) |
| CN (1) | CN110290802A (https=) |
| AU (1) | AU2018320069B2 (https=) |
| BR (1) | BR112020003585A2 (https=) |
| CA (2) | CA3073555C (https=) |
| DK (1) | DK3446705T3 (https=) |
| ES (1) | ES2901621T3 (https=) |
| HU (1) | HUE057332T2 (https=) |
| IL (1) | IL272874B2 (https=) |
| MX (1) | MX2020002053A (https=) |
| PL (1) | PL3446705T3 (https=) |
| PT (1) | PT3446705T (https=) |
| RU (1) | RU2763934C2 (https=) |
| SG (2) | SG11202001372TA (https=) |
| TW (1) | TWI752147B (https=) |
| WO (1) | WO2019037898A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3446704A1 (en) | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| EP4450071A1 (en) | 2023-04-20 | 2024-10-23 | Isofol Medical AB | [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer |
| US20240350495A1 (en) * | 2023-04-20 | 2024-10-24 | Isofol Medical Ab | [6r]-mthf in b6 enhanced 5-fu based chemotherapy of carcinoma |
| US20240350467A1 (en) * | 2023-04-20 | 2024-10-24 | Isofol Medical Ab | [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer |
| EP4534088A1 (en) | 2023-10-04 | 2025-04-09 | Isofol Medical AB | Arfolitixorin for use in vitamin b6-enhanced, 5-fluorouracil-based chemotherapy of carcinomas |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5376658A (en) | 1990-05-11 | 1994-12-27 | University Of Southern California | 5,10-methylene-tetrahydrofolate as a modulator of a chemotherapeutic agent |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| WO2005097086A2 (en) * | 2004-04-02 | 2005-10-20 | Adventrx Pharmaceuticals, Inc. | Use of 5,10-methylene tetrahydrofolate for the treatment of cancer |
| CN1942189A (zh) * | 2004-04-02 | 2007-04-04 | 阿德文特克斯药物有限公司 | 5,10－亚甲基四氢叶酸在癌症治疗中的用途 |
| KR20070019725A (ko) | 2004-04-02 | 2007-02-15 | 어드벤트륵스 파마슈티칼스, 인크. | 암치료에 사용되는 5,10-메틸렌 테트라하이드로폴레이트의용도 |
| EP1750706B1 (en) | 2004-06-01 | 2016-10-05 | University Of Virginia Patent Foundation | Dual small molecule inhibitors of cancer and angiogenesis |
| EP1968551A2 (en) * | 2005-12-02 | 2008-09-17 | Adventrx Pharmaceuticals, Inc. | Stable pharmaceutical compositions of 5,10 methylenetetrahydrofolate |
| AU2007299080B2 (en) | 2006-09-18 | 2013-04-18 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring EGFR mutations |
| WO2008109349A1 (en) | 2007-03-06 | 2008-09-12 | Adventrx Pharmaceuticals, Inc. | Improved regimen for treating cancer with 5-fluorouracil, 5,10-methylenetetrahydrofolate and capecitabine |
| US20100239546A1 (en) | 2007-06-15 | 2010-09-23 | Beth Israel Deaconess Medical Center | Bacterial mediated tnf alpha gene silencing |
| WO2010035075A1 (en) | 2008-09-26 | 2010-04-01 | Centre Regional De Lutte Contre Le Cancer D'angers | Individual 5-fluorouracile dose optimization in folfox treatment |
| EP2558122A4 (en) | 2010-04-15 | 2014-03-05 | Vegenics Pty Ltd | COMBINATION TREATMENT WITH VEGF-C ANTAGONISTS |
| EP2617422A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Anti-tumor activity of reduced folates like methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate |
| EP2617421A1 (en) | 2012-01-20 | 2013-07-24 | Isofol Medical AB | Tetrahydrofolates in combination with EGFR-inhibitors in the use of treating cancer |
| EP2837631A1 (en) * | 2013-08-14 | 2015-02-18 | Merck & Cie | New stable salt of 5,10-methylene-(6R)-tetrahydrofolic acid |
| SG10201912553QA (en) | 2015-07-27 | 2020-02-27 | Innocimab Pte Ltd | Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using monoclonal antibodies against the epidermal growth factor receptor (egfr) |
| EP3305318A1 (en) | 2016-10-05 | 2018-04-11 | Isofol Medical AB | [6r]-5,10-methylenetetrahydrofolate in 5-fluorouracil based chemotherapy |
| EP3446703A1 (en) | 2017-08-24 | 2019-02-27 | Isofol Medical AB | 6r]-mthf multiple bolus administration in 5-fluorouracil based chemotherapy |
| EP3446704A1 (en) | 2017-08-24 | 2019-02-27 | Isofol Medical AB | [6r]-mthf - an efficient folate alternative in 5-fluorouracil based chemotherapy |
| JP7122256B2 (ja) | 2017-02-14 | 2022-08-19 | アイソフォル・メディカル・エービー | 血漿２’－デオキシウリジン（ｄＵｒｄ）の増加およびチミジル酸合成酵素阻害のための方法 |
| US20230116137A1 (en) * | 2017-08-24 | 2023-04-13 | Isofol Medical Ab | Methods for treating colorectal and metastatic colorectal cancers |
| HUE061217T2 (hu) | 2018-01-05 | 2023-05-28 | Isofol Medical Ab | [6R]-MTHF több bólusának beadása 5-fluoruracil alapú kemoterápiában |
| CA3101694A1 (en) | 2018-05-30 | 2019-12-05 | David MACHOVER | Methods and pharmaceutical compositions for treating cancer |
| WO2023046305A1 (en) * | 2021-09-27 | 2023-03-30 | Isofol Medical Ab | [6r]-mthf in 5-fu based chemotherapy of left-sided colorectal cancer |
| WO2023046307A1 (en) | 2021-09-27 | 2023-03-30 | Isofol Medical Ab | [6r]-mthf in 5-fu based chemotherapy of right-sided colorectal cancer |
| WO2023046304A1 (en) | 2021-09-27 | 2023-03-30 | Isofol Medical Ab | [6r]-mthf in 5-fu based chemotherapy of braf- or kras-mutated colorectal cancer |
| US20230097085A1 (en) | 2021-09-28 | 2023-03-30 | Isofol Medical Ab | [6r]-mthf in 5-fu based chemotherapy of right-sided colorectal cancer |
| US20230095428A1 (en) * | 2021-09-28 | 2023-03-30 | Isofol Medical Ab | [6r]-mthf in 5-fu based chemotherapy of braf- or kras-mutated colorectal cancer |
| US20240350467A1 (en) | 2023-04-20 | 2024-10-24 | Isofol Medical Ab | [6r]-mthf in b6 enhanced 5-fu based chemotherapy of pancreatic cancer |
| US20240350495A1 (en) | 2023-04-20 | 2024-10-24 | Isofol Medical Ab | [6r]-mthf in b6 enhanced 5-fu based chemotherapy of carcinoma |
-
2017
- 2017-08-24 EP EP17187684.0A patent/EP3446704A1/en not_active Withdrawn
-
2018
- 2018-01-05 ES ES18150455T patent/ES2901621T3/es active Active
- 2018-01-05 EP EP18700857.8A patent/EP3672623A1/en not_active Withdrawn
- 2018-01-05 DK DK18150455.6T patent/DK3446705T3/da active
- 2018-01-05 PT PT181504556T patent/PT3446705T/pt unknown
- 2018-01-05 AU AU2018320069A patent/AU2018320069B2/en active Active
- 2018-01-05 CN CN201880008885.6A patent/CN110290802A/zh active Pending
- 2018-01-05 EP EP18150455.6A patent/EP3446705B1/en active Active
- 2018-01-05 SG SG11202001372TA patent/SG11202001372TA/en unknown
- 2018-01-05 IL IL272874A patent/IL272874B2/en unknown
- 2018-01-05 CA CA3073555A patent/CA3073555C/en active Active
- 2018-01-05 RU RU2020109130A patent/RU2763934C2/ru active
- 2018-01-05 WO PCT/EP2018/050273 patent/WO2019037898A1/en not_active Ceased
- 2018-01-05 PL PL18150455T patent/PL3446705T3/pl unknown
- 2018-01-05 BR BR112020003585-8A patent/BR112020003585A2/pt not_active IP Right Cessation
- 2018-01-05 MX MX2020002053A patent/MX2020002053A/es unknown
- 2018-01-05 JP JP2020510518A patent/JP7356411B2/ja active Active
- 2018-01-05 HU HUE18150455A patent/HUE057332T2/hu unknown
- 2018-01-09 US US15/865,870 patent/US11013744B2/en active Active
- 2018-01-09 CA CA2991357A patent/CA2991357A1/en not_active Abandoned
- 2018-01-09 KR KR1020180002962A patent/KR102216031B1/ko not_active Expired - Fee Related
- 2018-01-09 SG SG10201800195XA patent/SG10201800195XA/en unknown
- 2018-01-09 TW TW107100834A patent/TWI752147B/zh not_active IP Right Cessation
- 2018-02-08 JP JP2018021069A patent/JP2019038797A/ja active Pending
-
2021
- 2021-05-24 US US17/329,075 patent/US12527796B2/en active Active
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