JP2019014137A - Barrier laminate and outer packaging bag for infusion bag - Google Patents

Abstract

To provide a barrier laminate which is excellent in transparency and laminate strength and has suitable water vapor barrier property, and can prevent dew condensation even when used as an outer packaging bag for infusion bag.SOLUTION: A barrier laminate has an outer resin layer, a barrier film and an inner sealant layer in this order, where the barrier film has a resin base material, a transparent vapor-deposited layer and a barrier coat layer in order from the outside, and water vapor permeability of the barrier film as measured according to JIS K 7129 is 10 g/mday or more, and water vapor permeability of the barrier laminate as measured according to JIS K 7129 is 1.0 g/mday or more and 3.5 g/mday or less.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a barrier laminate, and more particularly to a barrier laminate comprising an outer resin layer, a barrier film, and an inner sealant layer in this order. The present invention also relates to an outer bag for an infusion bag provided with the barrier laminate.

  In recent years, as a gas barrier material against oxygen, water vapor, or the like, a barrier film in which an inorganic substance is formed on a film substrate by a vacuum deposition method, a sputtering method, an ion plating method, a chemical vapor deposition method or the like has attracted attention. In particular, in a medical packaging bag, in order to avoid an accident due to misidentification of contents for pharmaceuticals or the like, a barrier film having a transparent vapor deposition layer excellent in contents visibility is used.

When the contents contain amino acids, vitamins, etc. like medical infusion bags, in order to prevent the deterioration of those components, the infusion bag is covered with a barrier film having a low gas barrier property. Yes. However, when the water vapor barrier property of the outer bag for the infusion bag is too high, water that has permeated from the main body of the infusion bag has condensed in the outer bag, and there is a possibility that water droplets may be generated inside. In such a state, bag breakage and liquid leakage were suspected, and there was a problem that the infusion bag package could not be used. In response to such a technical problem, a water vapor permeability of 2.5 g measured at a temperature of 40 ° C. and a humidity of 90% RH is provided with a polyethylene terephthalate film as a base material layer and a specific metal oxide layer. It has been proposed to use a laminated film of / m ² · day or more for an outer bag for an infusion bag (see Patent Document 1). Moreover, when the exterior bag for infusion bags is equipped with a transparent vapor deposition layer, it is also requested | required that it is excellent in the lamination strength with another layer.

International Publication No. 2016/052456

  The present invention has been made in view of the above-mentioned background art, and its purpose is excellent in transparency and laminate strength, has a suitable water vapor barrier property, and is used as an outer bag for an infusion bag. It is providing the barriering laminated body which can prevent dew condensation.

  As a result of intensive studies to solve the above problems, the present inventors have found that in a barrier laminate comprising an outer resin layer, a barrier film, and an inner sealant layer in this order, the barrier film and the barrier laminate. It has been found that by adjusting the water vapor permeability of each body within an appropriate range, condensation can be prevented when used as an outer bag for an infusion bag. The present invention has been completed based on such findings.

That is, according to one aspect of the present invention,
A barrier laminate comprising an outer resin layer, a barrier film, and an inner sealant layer in this order,
The barrier film comprises, in order from the outside, a resin base material, a transparent vapor deposition layer, and a barrier coat layer.
The water vapor permeability measured according to JIS K7129 of the barrier film is 10 g / m ² · day or more,
A barrier laminate is provided in which the water vapor permeability of the barrier laminate measured according to JIS K7129 is 1.0 g / m ² · day to 3.5 g / m ² · day.

  In the aspect of the present invention, the transparent vapor deposition layer is preferably an inorganic oxide vapor deposition film mainly composed of aluminum oxide.

  In the aspect of this invention, it is preferable that the said resin base material contains a polyamide resin.

  In the aspect of the present invention, the barrier coat layer is preferably a cured film of a hydrolysis product of a metal alkoxide and a water-soluble polymer.

  In the aspect of this invention, it is preferable that the said outer side resin layer contains polyolefin resin.

  In the aspect of this invention, it is preferable that the said inner side sealant layer contains polyolefin resin.

  In the aspect of the present invention, it is preferable that an adhesive resin layer is further provided between the barrier coat layer and the inner sealant layer.

  In the aspect of the present invention, the barrier laminate is preferably used for an outer bag for an infusion bag.

  According to the other aspect of this invention, the exterior bag for infusion bags provided with the said barriering laminated body is provided.

  In another aspect of the present invention, an infusion bag package including an infusion bag main body and the outer bag for an infusion bag is provided.

  According to the present invention, it is possible to provide a barrier laminate that is excellent in transparency and laminate strength, has a suitable water vapor barrier property, and can prevent condensation when used as an outer bag for an infusion bag. . Furthermore, by using such a barrier laminate, an outer bag for an infusion bag that can prevent dew condensation can be provided.

It is the schematic sectional drawing which showed one Embodiment of the barriering laminated body of this invention. It is the schematic sectional drawing which showed one Embodiment of the barriering laminated body of this invention.

<Barrier laminate>
The barrier laminate obtained by the present invention comprises at least an outer resin layer, a barrier film, and an inner sealant layer in this order, and is excellent in transparency and laminate strength and has a suitable water vapor barrier property. Condensation can be prevented when used as an outer bag for an infusion bag. In addition, the barrier laminate can be provided with other resin layers, print layers, and other films between the outer resin layer and the barrier film within the range where the effects of the present invention are exhibited. Other resin layers, printing layers, and other films can also be provided on the inner sealant layer.

The barrier laminate has a water vapor permeability measured in accordance with JIS K7129 of 1.0 g / m ² · day to 3.5 g / m ² · day, preferably 1.1 g / m ² · day. It is 3.0 g / m ² · day or less, more preferably 1.2 g / m ² · day or more and 2.5 g / m ² · day or less, and further preferably 1.3 g / m ² · day or more and 2 or more. 0.0 g / m ² · day or less. If the water vapor permeability of the barrier laminate satisfies the above numerical range, it has suitable water vapor barrier properties, so that when it is used as an outer bag for an infusion bag, the moisture that has permeated outside from the infusion bag body is appropriately It can permeate outside (not staying in the exterior bag) and prevent condensation. The water vapor permeability can be measured using a water vapor permeability meter (manufactured by MOCON: PERMATRAN) in an environment of a temperature of 40 ° C. and a humidity of 90 RH%.

The barrier laminate has a water vapor permeability measured in accordance with JIS K7129 after being stored for 500 hours in an environment of a temperature of 60 ° C. and a humidity of 90 RH%, preferably 1.0 g / m ² · day to 4.0 g / m m ² · day or less, more preferably 1.1 g / m ² · day or more and 3.5 g / m ² · day or less, and still more preferably 1.2 g / m ² · day or more and 3.0 g / m ^2. · Day or less, and even more preferably 1.3 g / m ² · day or more and 2.5 g / m ² · day or less. If the water vapor permeability after the storage test of the barrier laminate satisfies the above numerical range, it retains suitable water vapor barrier properties even after long-term use, so when used as an outer bag for an infusion bag In addition, moisture that has permeated out of the infusion bag body permeates appropriately to the outside of the outer bag (not staying in the outer bag), thereby preventing condensation.

  The water vapor permeability of the barrier laminate can be adjusted by adjusting the water vapor permeability of the following barrier film by changing the type and film thickness of the transparent deposition layer and the film quality and film thickness of the barrier coat layer. . In addition, the water vapor permeability of the barrier laminate can be adjusted by changing the layer thickness or resin type of the outer resin layer or inner sealant layer. Furthermore, these changes may be combined.

Barrier laminate, the oxygen permeability was measured under the environment of temperature 23 ° C. and humidity 60 RH% is preferably located at 0.01cc ^/ m 2 · day · atm or more 2.0cc ^/ m 2 · day · atm or less , more preferably 0.05cc ^/ m 2 · day · atm or more 1.0cc ^/ m 2 · day · atm or less. If the oxygen permeability of the barrier laminate satisfies the above numerical range, it has suitable oxygen barrier properties, and therefore, when used as an outer bag for an infusion bag, it suppresses adverse effects on the contents of the infusion bag. Can do.

  The barrier laminate is excellent in light transmittance and has a total light transmittance of preferably 70% or more, more preferably 80% or more, and further preferably 90% or more. When the total light transmittance satisfies the above numerical range, the contents are excellent in visibility when used as an outer bag for an infusion bag. The total light transmittance can be measured according to JIS K7361 using HAZE METER HM-150 manufactured by Murakami Color Research Co., Ltd.

  The barrier laminate is excellent in permeability and has a haze of preferably 10% or less, more preferably 5% or less, and further preferably 3% or less. When the haze satisfies the above numerical range, the contents are highly visible when used as an outer bag for an infusion bag. Haze can be measured in accordance with JIS K7136 using HAZE METER HM-150 manufactured by Murakami Color Research Co., Ltd.

The layer structure of the barrier laminate will be described with reference to the drawings.
A barrier laminate 10 shown in FIG. 1 includes an outer resin layer 11, a barrier film 12, and an inner sealant layer 13 in this order. The transparent vapor deposition layer 15 and the barrier coat layer 16 are provided.
The barrier laminate 20 shown in FIG. 2 includes an outer resin layer 21, an adhesive layer 27, a barrier film 22, an adhesive resin layer 28, and an inner sealant layer 23 in this order. The film 22 includes a resin base material 24, a transparent vapor deposition layer 25, and a barrier coat layer 26 in order from the outside.
Hereinafter, each layer constituting the barrier laminate of the present invention will be described.

(Barrier film)
The barrier film constituting the barrier laminate includes a resin substrate, a transparent vapor deposition layer, and a barrier coat layer in order from the outside.

The barrier film has a water vapor permeability measured according to JIS K7129 of 10 g / m ² · day or more, preferably 10 g / m ² · day or more and 50 g / m ² · day or less, more preferably It is 12 g / m ² · day or more and 40 g / m ² · day or less. Although the barrier film itself is apt to transmit water vapor and cannot be said to have sufficient barrier properties, the water vapor permeability of the entire barrier laminate having an outer resin layer and an inner sealant in addition to the barrier film is suitable. Can be adjusted within range. As a result, since it has a water vapor barrier property suitable for the entire barrier laminate, when it is used as an infusion bag exterior bag, moisture that has permeated out of the infusion bag body appropriately permeates out of the exterior bag ( Condensation can be prevented without staying in the outer bag. The water vapor permeability can be measured using a water vapor permeability meter (manufactured by MOCON: PERMATRAN) in an environment of a temperature of 40 ° C. and a humidity of 90 RH%.

(Resin base material)
The resin substrate is not particularly limited as long as it can carry the following transparent vapor deposition layer, and various known resin substrates can be used. For example, a thermosetting resin or a thermoplastic resin film can be used.

  Examples of the thermosetting resin include epoxy resins, unsaturated polyester resins, phenol resins, urea / melamine resins, polyurethane resins, silicone resins, and polyimides. Examples of the thermoplastic resin include polyolefins such as polyethylene, polypropylene, poly-4-methyl / 1-pentene, and polybutene, polyesters such as polyethylene terephthalate, polybutylene terephthalate, and polyethylene naphthalate, nylon-6, nylon-66, And polyamide such as polymetaxylene adipamide, polyvinyl chloride, polyimide, ethylene / vinyl acetate copolymer or saponified product thereof, polyvinyl alcohol, polyacrylonitrile, polycarbonate, polystyrene, ionomer, fluororesin, or a mixture thereof. It is done. In particular, thermoplastic resins having good stretchability and transparency, such as polypropylene, polyethylene terephthalate, and polyamide, are preferable, and polyamide resins are preferably used from the viewpoint of piercing durability and the like. The resin base material may have a single-layer structure or a multilayer structure composed of two or more thermoplastic resins.

  The thickness of the resin substrate is not particularly limited, but is preferably 5 μm or more and 100 μm or less, more preferably 10 μm or more and 50 μm or less.

(Transparent deposition layer)
A transparent vapor deposition layer is a layer which consists of a vapor deposition film of an inorganic oxide. The vapor deposition film can be formed by a conventionally known method, and the composition and formation method of the inorganic oxide are not particularly limited. By providing the transparent vapor-deposited layer, the laminated body is transparent, so that it is possible to impart or improve gas barrier properties that prevent permeation of oxygen gas, water vapor, and the like while maintaining the permeability of the contents. In addition, a laminated body may be provided with two or more transparent vapor deposition layers. When two or more transparent vapor deposition layers are provided, each may have the same composition or a different composition.

  Examples of the deposited film include silicon (Si), aluminum (Al), magnesium (Mg), calcium (Ca), potassium (K), tin (Sn), sodium (Na), boron (B), and titanium (Ti). ), Lead (Pb), zirconium (Zr), yttrium (Y), and the like. In particular, it is preferable to provide a vapor deposition film of aluminum oxide or silicon oxide for packaging bags, and a vapor deposition film of aluminum oxide is more preferable as an exterior bag for infusion bags.

Representation of the inorganic oxide, for _example, SiO X, as such AlO _X MO _X (In the formula, M represents an inorganic element, the value of X, varies each of an inorganic element range.) In expressed. As a range of the value of X, silicon (Si) is 0 to 2, aluminum (Al) is 0 to 1.5, magnesium (Mg) is 0 to 1, calcium (Ca) is 0 to 1, 0 to 0.5 for potassium (K), 0 to 2 for tin (Sn), 0 to 0.5 for sodium (Na), 0 to 1.5 for boron (B), titanium (Ti) Can take values ranging from 0 to 2, lead (Pb) from 0 to 2, zirconium (Zr) from 0 to 2, and yttrium (Y) from 0 to 1.5. In the above, when X = 0, it is a complete inorganic simple substance (pure substance) and is not transparent, and the upper limit of the range of X is a completely oxidized value. Silicon (Si) and aluminum (Al) are suitably used for the packaging material, silicon (Si) is in the range of 1.0 to 2.0, and aluminum (Al) is in the range of 0.5 to 1.5. Can be used.

  The film thickness of the inorganic oxide vapor-deposited film varies depending on the type of inorganic oxide to be used, desired barrier performance, and the like. For example, in the case of an aluminum oxide vapor-deposited film, it is preferably 1 nm to 50 nm, more preferably 2 nm. It is desirable to select and form arbitrarily within the range of 20 nm or less and more preferably 5 nm or more and 15 nm or less.

  A vapor deposition film can be formed in the base material layer etc. using the following formation methods. As a method for forming a vapor deposition film, for example, a physical vapor deposition method (Physical Vapor Deposition method, PVD method) such as a vacuum vapor deposition method, a sputtering method, and an ion plating method, or a plasma chemical vapor deposition method, a thermochemical method, or the like. Examples thereof include a chemical vapor deposition method (chemical vapor deposition method, CVD method) such as a vapor phase growth method and a photochemical vapor deposition method.

(Plasma pretreatment)
The resin base material is preferably subjected to plasma pretreatment in advance on the surface on which the transparent vapor deposition layer is formed. By performing plasma pretreatment in advance, a strong covalent bond can be generated between the resin substrate and the transparent vapor-deposited layer, and the adhesion (laminate strength) between the barrier film and the inner sealant layer can be improved. For example, when the transparent vapor-deposited layer is an aluminum oxide vapor-deposited film containing aluminum oxide as a main component, strong Al-OH bonding by special oxygen plasma treatment can improve adhesion with a nylon film, which has been difficult in the past. Can do.

(Barrier coat layer)
The barrier coat layer is a layer having gas barrier properties and is preferably a coating film. Furthermore, the barrier coat layer is preferably a cured film of a hydrolysis product of metal alkoxide and a water-soluble polymer. The barrier coat layer can be formed by, for example, the following gas barrier coating film. The coating film is a coating film that retains gas barrier properties in a high-temperature and high-humidity environment, and has a general formula R ¹ _n M (OR ² ) _m (where R ¹ and R ² have 1 to 8 carbon atoms) M represents a metal atom, n represents an integer of 0 or more, m represents an integer of 1 or more, and n + m represents the valence of M. It comprises one or more metal alkoxides and a water-soluble polymer, and further comprises a gas barrier composition obtained by polycondensation by a sol-gel method in the presence of a sol-gel method catalyst, an acid, water, and an organic solvent. It is a coating film. The composition is coated on the vapor deposition film to provide a coating film, and is heat-dried for 10 seconds to 10 minutes at a temperature of 20 ° C. to 200 ° C. and below the melting point of the resin substrate of the vapor deposition film. Can be formed.

  Further, the gas barrier composition is applied onto the vapor deposition film on the resin base material, and two or more coating films are stacked, and at a temperature of 20 ° C. to 200 ° C. and below the melting point of the resin base material. You may heat-dry for 10 seconds-10 minutes, and you may form the composite polymer layer which laminated | stacked two or more gas barrier coating films.

In the metal alkoxide, examples of the metal atom represented by M in the general formula R ¹ _n M (OR ² ) _m include silicon, zirconium, titanium, aluminum, and the like. In the present invention, two or more of the alkoxides may be used in combination. For example, when alkoxysilane and zirconium alkoxide are mixed and used, the toughness, heat resistance and the like of the resulting gas barrier laminate can be improved, and a decrease in the retort resistance of the film during stretching can be avoided. Moreover, when alkoxysilane and titanium alkoxide are mixed and used, the heat conductivity of the gas barrier coating film obtained will become low, and heat resistance will improve remarkably.

  As the water-soluble polymer used in the present invention, a polyvinyl alcohol resin or an ethylene / vinyl alcohol copolymer can be used alone, respectively, or a polyvinyl alcohol resin and an ethylene / vinyl alcohol copolymer can be used. It can be used in combination with coalescence. In the present invention, physical properties such as gas barrier properties, water resistance, weather resistance, and the like can be remarkably improved by using a polyvinyl alcohol resin and / or an ethylene / vinyl alcohol copolymer.

  As the polyvinyl alcohol resin, those obtained by saponifying polyvinyl acetate can be generally used. Polyvinyl alcohol resins include partially saponified polyvinyl alcohol resins in which several tens of percent of acetate groups remain, completely saponified polyvinyl alcohols in which no acetate groups remain, and modified polyvinyl alcohol resins in which OH groups have been modified. Well, not particularly limited.

  As the ethylene / vinyl alcohol copolymer, a saponified product of a copolymer of ethylene and vinyl acetate, that is, a product obtained by saponifying an ethylene-vinyl acetate random copolymer can be used. For example, it is not particularly limited, and includes a partially saponified product in which several tens mol% of acetic acid groups remain to a complete saponified product in which only several mol% of acetic acid groups remain or no acetic acid groups remain. However, it is preferable to use a saponification degree that is preferably 80 mol% or more, more preferably 90 mol% or more, and still more preferably 95 mol% or more from the viewpoint of gas barrier properties. In addition, the content of the repeating unit derived from ethylene in the ethylene / vinyl alcohol copolymer (hereinafter also referred to as “ethylene content”) is usually 0 to 50 mol%, preferably 20 to 45 mol%. It is preferable.

  In the present invention, a silane coupling material may be added to the barrier coat layer. For example, a silane coupling material having a reactive group such as an alkoxy group such as a methoxy group or an ethoxy group, an acetoxy group, an amino group, or an epoxy group can be used.

  The barrier coat layer can be produced by the following method. First, the above-described metal alkoxide, if necessary, a silane coupling agent, a water-soluble polymer, a sol-gel method catalyst, an acid, water, an organic solvent, and the like are mixed to prepare a gas barrier composition (barrier coating solution).

  Next, the gas barrier composition is applied onto the inorganic oxide vapor-deposited film. As a method of applying the gas barrier composition, for example, it may be applied once or a plurality of times by an application means such as a roll coat such as a gravure roll coater, spray coat, spin coat, dipping, brush, barcode, applicator or the like. A coating film having a dry film thickness of 0.01 to 30 μm, preferably about 0.1 to 10 μm can be formed.

  Subsequently, the vapor deposition film coated with the gas barrier composition is 20 ° C. to 200 ° C. and a temperature not higher than the melting point of the resin base material of the vapor deposition film, preferably at a temperature in the range of 50 ° C. to 180 ° C. for 10 seconds to 10 seconds. Heat and dry for minutes. Thereby, polycondensation is performed and a barrier coat layer can be formed.

  As described above, a barrier film having a barrier coat layer in which one or more barrier coat layers of the gas barrier composition are formed on the inorganic oxide vapor-deposited film can be produced.

(Outside resin layer)
The outer resin layer is a layer that becomes the innermost layer (outside side) in the outer bag for an infusion bag using the barrier laminate. For example, a thermosetting resin or a thermoplastic resin film can be used.

  Examples of the thermosetting resin include epoxy resins, unsaturated polyester resins, phenol resins, urea / melamine resins, polyurethane resins, silicone resins, and polyimides. Examples of the thermoplastic resin include polyolefins such as polyethylene, polypropylene, poly-4-methyl / 1-pentene, and polybutene, polyesters such as polyethylene terephthalate, polybutylene terephthalate, and polyethylene naphthalate, nylon-6, nylon-66, And polyamide such as polymetaxylene adipamide, polyvinyl chloride, polyimide, ethylene / vinyl acetate copolymer or saponified product thereof, polyvinyl alcohol, polyacrylonitrile, polycarbonate, polystyrene, ionomer, fluororesin, or a mixture thereof. It is done. In particular, it is preferable to use a thermoplastic resin having good stretchability and transparency, such as polypropylene, polyethylene terephthalate, and polyamide. In order to adjust the water vapor permeability of the barrier laminate, the outer resin layer made of these thermoplastic resins may have a single layer structure or a multilayer structure made of two or more kinds of thermoplastic resins.

  The thickness of the outer resin layer is not particularly limited, but is preferably 10 μm or more and 200 μm or less, more preferably 20 μm or more and 100 μm or less. The thickness of the outer resin layer can be adjusted as appropriate in order to adjust the water vapor permeability of the barrier laminate.

(Inner sealant layer)
As the inner sealant layer, a conventionally known sealant layer for packaging bags can be used, and can be formed using a thermoplastic resin. The sealant layer is a layer that becomes the innermost layer (content side) in the outer bag for an infusion bag using the barrier laminate.

  Examples of the thermoplastic resin include low density polyethylene, linear low density polyethylene, medium density polyethylene, high density polyethylene, polypropylene, propylene-ethylene copolymer, ethylene-vinyl acetate copolymer, ethylene-acrylic acid copolymer. Examples thereof include a copolymer, an ethylene-methacrylic acid copolymer, an ethylene-methyl acrylate copolymer, an ethylene-ethyl acrylate copolymer, an ethylene-methyl methacrylate copolymer, and an ionomer. In order to adjust the water vapor permeability of the barrier laminate, the inner sealant layer made of these thermoplastic resins may have a single layer structure or a multilayer structure made of two or more kinds of thermoplastic resins.

  The thickness of the inner sealant layer is not particularly limited, but is preferably 10 μm or more and 300 μm or less, more preferably 20 μm or more and 200 μm or less, and further preferably 30 μm or more and 100 μm or less. The thickness of the inner sealant layer can be appropriately adjusted in order to adjust the water vapor permeability of the barrier laminate.

(Adhesive resin layer)
The barrier laminate preferably includes an adhesive resin layer instead of an adhesive layer between the barrier film and the inner sealant. By providing the adhesive laminate with the adhesive laminate, the laminate strength at the interface between the barrier film (barrier coat layer) and the inner sealant can be improved. Furthermore, it can prevent that an adhesive agent elutes to the content by not using an adhesive agent inside the barrier film of a barriering laminated body.

  Examples of the thermoplastic resin that can be used for the adhesive resin layer include a polyethylene resin, a polypropylene resin, or a cyclic polyolefin resin, or a copolymer resin, a modified resin, or a mixture (based on an alloy). Can be used. Examples of polyolefin resins include low density polyethylene (LDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), linear (linear) low density polyethylene (LLDPE), polypropylene (PP), and metallocene catalysts. Ethylene-α / olefin copolymer, ethylene / polypropylene random or block copolymer, ethylene-vinyl acetate copolymer (EVA), ethylene-acrylic acid copolymer (EAA), ethylene Ethyl acrylate copolymer (EEA), ethylene-methacrylic acid copolymer (EMAA), ethylene-methyl methacrylate copolymer (EMMA), ethylene / maleic acid copolymer, ionomer resin, and interlayer adhesion In order to improve the , It can be used acrylic acid, methacrylic acid, maleic acid, maleic anhydride, fumaric acid, and an acid-modified polyolefin resin modified with an unsaturated carboxylic acid such as itaconic acid. Further, a resin obtained by graft polymerization or copolymerization of an unsaturated carboxylic acid, an unsaturated carboxylic acid anhydride, or an ester monomer can be used as the polyolefin resin. These materials can be used alone or in combination of two or more. As the cyclic polyolefin-based resin, for example, cyclic polyolefins such as ethylene-propylene copolymer, polymethylpentene, polybutene, and polynorbornene can be used. These resins can be used alone or in combination.

(Adhesive layer)
The barrier laminate is preferably provided with an adhesive layer between the outer resin layer and the barrier film. By providing the barrier laminate with an adhesive layer, the adhesion between the outer resin layer and the barrier film can be improved.

Examples of the adhesive include one-part or two-part cured or non-cured vinyl, (meth) acrylic, polyamide, polyester, polyether, polyurethane, epoxy, rubber, etc. An adhesive such as a solvent type, an aqueous type, or an emulsion type can be used. Examples of the coating method for the laminating adhesive include a direct gravure roll coating method, a gravure roll coating method, a kiss coating method, a reverse roll coating method, a fountain method, a transfer roll coating method, and other methods to form a laminate. It can apply | coat to the application surface of a layer. The coating amount is preferably 0.1 g / m ² or more and 10 g / m ² or less (dry state), and more preferably 1 g / m ² or more and 5 g / m ² or less (dry state).

(Print layer)
The barrier laminate may further include a printed layer on the surface of the resin substrate opposite to the transparent vapor deposition layer. The print layer is a layer that forms a desired arbitrary print pattern such as letters, numbers, pictures, figures, symbols, and patterns. A printing layer can be formed using a conventionally well-known pigment and dye, The formation method is not specifically limited.

  The printed layer preferably has a thickness of 0.1 μm to 10 μm, more preferably 1 μm to 5 μm, and still more preferably 1 μm to 3 μm.

(Other layers)
The barrier laminate may further include other resin layers and other films. For example, other resin layers and other films include polyesters such as polyethylene terephthalate and polybutylene terephthalate, polyolefins such as polyethylene and polypropylene, polyamides such as nylon and nylon 6 / metaxylylenediamine nylon 6, or polypropylene / ethylene- Examples thereof include vinyl alcohol copolymers, films of these resins, and composite films obtained by laminating two or more of these films.

<Infusion bag package>
The infusion bag package of the present invention comprises an infusion bag main body and an outer bag for an infusion bag using the barrier laminate. The outer bag for an infusion bag using the barrier laminate described above may prevent moisture from permeating from the main body of the infusion bag to the outside of the outer bag (not staying in the outer bag) and preventing condensation. it can.

  As the infusion bag body, a conventionally known product can be used, and is not particularly limited. For example, the infusion bag body is a plastic container, and includes a medical plastic container. Examples of the contents of the infusion bag body include chemical solutions that are easily altered by oxygen such as amino acids, vitamins, and fatty lactic acid, Ringer's solution, blood transfusions, and the like.

  The outer bag for infusion bags can be produced by bag-making the barrier laminate by a known method. For example, it can manufacture by leaving the opening part for inserting an infusion bag main body, and bag-making the other periphery by heat fusion.

<Manufacture of barrier laminate>
[Example 1]
Nylon film (thickness 15 μm) is prepared as a resin base material, and a continuous vapor deposition film forming apparatus in which a pretreatment section in which a plasma pretreatment apparatus is disposed and a film forming section are separated on the surface on which the vapor deposition layer of the nylon film is formed In the pretreatment section, plasma is introduced from a plasma supply nozzle under the following plasma conditions, plasma pretreatment is performed at a transfer speed of 600 m / min, and then on the plasma processing surface in the continuously transported film formation section. Under the following conditions, an aluminum oxide vapor deposition film having a thickness of 8 nm was formed by a reactive resistance heating method as a heating means of a vacuum vapor deposition method.
(Plasma pretreatment conditions)
・ Plasma intensity: 150 W · sec / m ²
Plasma forming gas: Argon 1200 (sccm), oxygen 3000 (sccm)
Magnetic forming means: 1000 gauss permanent magnet Applied voltage between pretreatment drum and plasma supply nozzle: 340V
-Vacuum degree of pretreatment section: 3.8 Pa
(Conditions for aluminum oxide film formation)
・ Degree of vacuum: 8.1 × 10 ⁻² Pa
-Light transmittance at wavelength 366 nm: 88%

Moreover, according to the composition shown in Table 1, the preliminarily prepared hydrolyzate of composition B was added to the prepared mixture of mixture A and stirred to obtain a colorless and transparent barrier coat solution.

  Next, the barrier coating solution prepared above was coated on the aluminum oxide vapor-deposited film of the resin substrate by a spin coating method. Then, it heat-processed in 180 degreeC for 60 second (s), the barrier coating layer about 400 nm thick was formed, and the barrier property film was obtained.

  Subsequently, while extruding low density polyethylene onto the barrier coat layer of the barrier film, a linear low density polyethylene film (LLDPE, thickness 60 μm) was bonded as an inner sealant layer by a sand lamination method. In addition, after applying an adhesive on the resin base of the barrier film, the ink surface of a biaxially stretched polypropylene film (OPP, thickness 20 μm) coated with UV cut ink is bonded by a dry laminating method, A conductive laminate was obtained.

[Example 2]
A barrier film was obtained in the same manner as in Example 1 except that the thickness of the aluminum oxide vapor deposition film was changed to 6 nm. Subsequently, a barrier laminate was obtained in the same manner as in Example 1.

[Example 3]
A barrier film was obtained in the same manner as in Example 1 except that the thickness of the aluminum oxide vapor deposition film was changed to 10 nm. Subsequently, a barrier laminate was obtained in the same manner as in Example 1.

[Comparative Example 1]
A barrier film was obtained in the same manner as in Example 1 except that a 10 nm thick aluminum oxide deposited film was formed directly on the nylon film without subjecting the nylon film to plasma pretreatment. Subsequently, a barrier laminate was obtained in the same manner as in Example 1.

[Comparative Example 2]
A barrier film was obtained in the same manner as in Example 1 except that the thickness of the aluminum oxide vapor deposition film was changed to 14 nm. Subsequently, a barrier laminate was obtained in the same manner as in Example 1.

[Comparative Example 3]
Instead of the barrier film, a biaxially stretched polypropylene film (OPP) in which a polyvinyl alcohol film (PVA 15 μm) was bonded by a dry laminating method was prepared. Subsequently, while extruding low density polyethylene onto the PVA film surface of the OPP film, a linear low density polyethylene film (LLDPE, thickness 60 μm) was bonded by a sand laminating method to obtain a barrier laminate.

<Performance evaluation of barrier film and barrier laminate>
The following measurements were performed on the barrier films and barrier laminates produced in the examples and comparative examples.

(Measurement of water vapor permeability 1)
The water vapor permeability of the barrier films and barrier laminates produced in Examples and Comparative Examples was measured using a water vapor permeability measuring device (manufactured by MOCON: PERMATRAN) at a temperature of 40 ° C. and a humidity of 90 RH in accordance with JIS K7129. % In an environment. The measurement results were as shown in Table 2 below.

(Measurement of water vapor permeability 2)
The water vapor permeability of the barrier laminates produced in the examples and comparative examples was stored for 500 hours in an environment of a temperature of 60 ° C. and a humidity of 90 RH%, and then used with a water vapor permeability meter (manufactured by MOCON: PERMATRAN). It was measured. The measurement results were as shown in Table 2 below.

(Measurement of laminate strength)
Barrier properties of the barrier laminates produced in Examples and Comparative Examples using a tensile testing machine (Orientec Co., Ltd. [model name: Tensilon Universal Material Testing Machine]) according to JIS K6854-2 The adhesive strength at the adhesive interface between the film and the LLDPE film was measured using 180 ° peeling (T-shaped peeling method) at a peeling speed of 50 mm / min. The measurement results were as shown in Table 2 below.

(Appearance evaluation)
First, a plastic infusion bag body in which an aqueous solution containing amino acids, vitamins, and the like was enclosed was prepared. Next, using the barrier laminates produced in Examples and Comparative Examples as the outer bag for an infusion bag, the infusion bag body was packaged to produce an infusion bag package. The manufactured infusion bag package was stored in a 40 ° C. oven and cooled, and then the appearance of the package was visually evaluated according to the following criteria. The evaluation results were as shown in Table 2 below. However, in Comparative Example 2, no condensation occurred, but it was unsuitable because the weight of the infusion bag package increased.
-○: Condensation did not occur.
-X: Condensation had occurred.

DESCRIPTION OF SYMBOLS 10, 20 Barrier laminated body 11, 21 Outer resin layer 12, 22 Barrier film 13, 23 Inner sealant layer 14, 24 Resin base material 15, 25 Transparent vapor deposition layer 16, 26 Barrier coat layer 27 Adhesive layer 28 Adhesiveness Resin layer

Claims (10)

A barrier laminate comprising an outer resin layer, a barrier film, and an inner sealant layer in this order,
The barrier film comprises, in order from the outside, a resin base material, a transparent vapor deposition layer, and a barrier coat layer.
The water vapor permeability measured according to JIS K7129 of the barrier film is 10 g / m ² · day or more,
The barrier laminate having a water vapor permeability measured in accordance with JIS K7129 of the barrier laminate of 1.0 g / m ² · day to 3.5 g / m ² · day.   The barrier laminate according to claim 1, wherein the transparent vapor deposition layer is an inorganic oxide vapor deposition film containing aluminum oxide as a main component.   The barrier laminate according to claim 1 or 2, wherein the resin base material includes a polyamide resin.   The barrier laminate according to any one of claims 1 to 3, wherein the barrier coat layer is a cured film of a hydrolysis product of a metal alkoxide and a water-soluble polymer.   The barrier laminate according to any one of claims 1 to 4, wherein the outer resin layer contains a polyolefin resin.   The barrier laminate according to any one of claims 1 to 5, wherein the inner sealant layer contains a polyolefin resin.   The barrier laminate according to any one of claims 1 to 6, further comprising an adhesive resin layer between the barrier coat layer and the inner sealant layer.   The barrier laminate according to any one of claims 1 to 7, which is used for an outer bag for an infusion bag.   An outer bag for an infusion bag comprising the barrier laminate according to any one of claims 1 to 8.   An infusion bag package comprising an infusion bag main body and the outer bag for an infusion bag according to claim 9.

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