JP2018538511A - 高スループット定量的プロテオミクス及びペプチドミクスのための質量欠損ベースの多重化ジメチルピリミジニルオルニチン（ｄｉｐｙｒｏ）タグ - Google Patents

高スループット定量的プロテオミクス及びペプチドミクスのための質量欠損ベースの多重化ジメチルピリミジニルオルニチン（ｄｉｐｙｒｏ）タグ Download PDF

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JP2018538511A
JP2018538511A JP2018513641A JP2018513641A JP2018538511A JP 2018538511 A JP2018538511 A JP 2018538511A JP 2018513641 A JP2018513641 A JP 2018513641A JP 2018513641 A JP2018513641 A JP 2018513641A JP 2018538511 A JP2018538511 A JP 2018538511A
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isotope
isotopes
enriched
compound
formula
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JP2018538511A5 (enExample
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リンジュン リー，
リンジュン リー，
ダスティン フロスト，
ダスティン フロスト，
アマンダ ブーフベルガー，
アマンダ ブーフベルガー，
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
JP2018513641A 2015-10-14 2016-10-14 高スループット定量的プロテオミクス及びペプチドミクスのための質量欠損ベースの多重化ジメチルピリミジニルオルニチン（ｄｉｐｙｒｏ）タグ Pending JP2018538511A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562241590P 2015-10-14 2015-10-14
US62/241,590 2015-10-14
PCT/US2016/057156 WO2017066650A1 (en) 2015-10-14 2016-10-14 Mass defect-based multiplex dimethyl pyrimidinyl ornithine (dipyro) tags for high-throughput quantitative proteomics and peptidomics

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JP2018538511A true JP2018538511A (ja) 2018-12-27
JP2018538511A5 JP2018538511A5 (enExample) 2019-11-21

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JP2018513641A Pending JP2018538511A (ja) 2015-10-14 2016-10-14 高スループット定量的プロテオミクス及びペプチドミクスのための質量欠損ベースの多重化ジメチルピリミジニルオルニチン（ｄｉｐｙｒｏ）タグ

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Country Link
US (1) US11408897B2 (enExample)
EP (1) EP3362438A4 (enExample)
JP (1) JP2018538511A (enExample)
AU (1) AU2016338691A1 (enExample)
CA (1) CA2999331A1 (enExample)
WO (1) WO2017066650A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022548913A (ja) * 2019-09-19 2022-11-22 ヤンセン バイオテツク，インコーポレーテツド 分子コンジュゲート及び共役の示差的特徴付けのための材料及び方法

Families Citing this family (4)

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CA3013020A1 (en) 2017-08-01 2019-02-01 Carlos Moreno Method and apparatus for non-intrusive program tracing with bandwidth reduction for embedded computing systems
US11355330B2 (en) * 2017-11-14 2022-06-07 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaf 1 En E.V. Uses of isobaric tags in mass spectrometry
CN112146967A (zh) * 2019-06-28 2020-12-29 Fei 公司 用于制备和递送用于带电粒子分析的生物样品的系统和方法
US12111322B2 (en) 2019-12-13 2024-10-08 Wisconsin Alumni Research Foundation Mass spectrometry-based method for simultaneous qualitative and quantitative protein citrullination analysis of complex biological samples

Citations (3)

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JP2005514404A (ja) * 2001-11-05 2005-05-19 アイアールエム エルエルシー 標識試薬とその使用方法
JP2009503485A (ja) * 2005-07-26 2009-01-29 エレクトロフォレティクス リミテッド 質量標識体
JP2009526998A (ja) * 2006-02-15 2009-07-23 アプライド バイオシステムズ インコーポレイテッド 定量分析のための質量標識

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Publication number Priority date Publication date Assignee Title
DK71801C (da) 1949-03-09 1950-12-04 Landmand Aage Pallesen Fasterh Kartoffeloptagemaskine.
EP1776588A1 (en) 2004-07-12 2007-04-25 Applera Corporation Mass tags for quantitative analyses
US9388132B2 (en) * 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
US9366678B2 (en) * 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005514404A (ja) * 2001-11-05 2005-05-19 アイアールエム エルエルシー 標識試薬とその使用方法
JP2009503485A (ja) * 2005-07-26 2009-01-29 エレクトロフォレティクス リミテッド 質量標識体
JP2009526998A (ja) * 2006-02-15 2009-07-23 アプライド バイオシステムズ インコーポレイテッド 定量分析のための質量標識

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BURLET, O. AND GASKELL, S. J.: "Decompositions of Cationized Heterodimers of Amino Acids in Relation to Charge Location in Peptide I", J. AM. SOC. MASS. SPECTROM., vol. 4, JPN6020035989, June 1993 (1993-06-01), pages 461 - 469, ISSN: 0004496562 *
HENERT, A. S. ET AL.: "Amine-reactive Neutron-encoded Labels for Highly Plexed Proteomic Quantitation", MOLECULAR & CELLULAR PROTEOMICS, JPN6020035985, 23 July 2013 (2013-07-23), pages 3360 - 3369, ISSN: 0004496560 *
SHEK, P. Y. I. ET AL.: "Fragmentations of Protonated Arginine, Lysine and Their Methylated Derivatives: Concomitant Losses o", J. PHYS. CHEM. A, vol. 110, JPN6020035991, 21 December 2005 (2005-12-21), pages 8282 - 8296, ISSN: 0004496563 *
SULLIVANA, A. G. ET AL.: "The exploitation of selective cleavage of singly protonatedpeptide ions adjacent to aspartic acid re", INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, vol. Vol.210/211, JPN6020035995, 14 September 2001 (2001-09-14), pages 665 - 676, ISSN: 0004496561 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022548913A (ja) * 2019-09-19 2022-11-22 ヤンセン バイオテツク，インコーポレーテツド 分子コンジュゲート及び共役の示差的特徴付けのための材料及び方法
JP7728250B2 (ja) 2019-09-19 2025-08-22 ヤンセン バイオテツク，インコーポレーテツド 分子コンジュゲート及び共役の示差的特徴付けのための材料及び方法

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EP3362438A4 (en) 2019-06-12
EP3362438A1 (en) 2018-08-22
AU2016338691A1 (en) 2018-04-12
US20180299464A1 (en) 2018-10-18
CA2999331A1 (en) 2017-04-20
US11408897B2 (en) 2022-08-09
WO2017066650A1 (en) 2017-04-20

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