AU2016338691A1 - Mass defect-based multiplex dimethyl pyrimidinyl ornithine (DiPyrO) tags for high-throughput quantitative proteomics and peptidomics - Google Patents

Mass defect-based multiplex dimethyl pyrimidinyl ornithine (DiPyrO) tags for high-throughput quantitative proteomics and peptidomics Download PDF

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Publication number
AU2016338691A1
AU2016338691A1 AU2016338691A AU2016338691A AU2016338691A1 AU 2016338691 A1 AU2016338691 A1 AU 2016338691A1 AU 2016338691 A AU2016338691 A AU 2016338691A AU 2016338691 A AU2016338691 A AU 2016338691A AU 2016338691 A1 AU2016338691 A1 AU 2016338691A1
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AU
Australia
Prior art keywords
isotopes
isotope
pct
isotopically enriched
formula
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Abandoned
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AU2016338691A
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English (en)
Inventor
Amanda Buchberger JONES
Dustin Frost
Lingjun Li
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Wisconsin Alumni Research Foundation
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Wisconsin Alumni Research Foundation
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Publication date
Application filed by Wisconsin Alumni Research Foundation filed Critical Wisconsin Alumni Research Foundation
Publication of AU2016338691A1 publication Critical patent/AU2016338691A1/en
Abandoned legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6806—Determination of free amino acids
    • G01N33/6812—Assays for specific amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
AU2016338691A 2015-10-14 2016-10-14 Mass defect-based multiplex dimethyl pyrimidinyl ornithine (DiPyrO) tags for high-throughput quantitative proteomics and peptidomics Abandoned AU2016338691A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562241590P 2015-10-14 2015-10-14
US62/241,590 2015-10-14
PCT/US2016/057156 WO2017066650A1 (en) 2015-10-14 2016-10-14 Mass defect-based multiplex dimethyl pyrimidinyl ornithine (dipyro) tags for high-throughput quantitative proteomics and peptidomics

Publications (1)

Publication Number Publication Date
AU2016338691A1 true AU2016338691A1 (en) 2018-04-12

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AU2016338691A Abandoned AU2016338691A1 (en) 2015-10-14 2016-10-14 Mass defect-based multiplex dimethyl pyrimidinyl ornithine (DiPyrO) tags for high-throughput quantitative proteomics and peptidomics

Country Status (6)

Country Link
US (1) US11408897B2 (enExample)
EP (1) EP3362438A4 (enExample)
JP (1) JP2018538511A (enExample)
AU (1) AU2016338691A1 (enExample)
CA (1) CA2999331A1 (enExample)
WO (1) WO2017066650A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3013020A1 (en) 2017-08-01 2019-02-01 Carlos Moreno Method and apparatus for non-intrusive program tracing with bandwidth reduction for embedded computing systems
US11355330B2 (en) * 2017-11-14 2022-06-07 Max-Planck-Gesellschaft Zur Förderung Der Wissenschaf 1 En E.V. Uses of isobaric tags in mass spectrometry
CN112146967A (zh) * 2019-06-28 2020-12-29 Fei 公司 用于制备和递送用于带电粒子分析的生物样品的系统和方法
WO2021055894A1 (en) * 2019-09-19 2021-03-25 Janssen Biotech, Inc. Materials and methods for differential characterization of molecular conjugates and conjugation
US12111322B2 (en) 2019-12-13 2024-10-08 Wisconsin Alumni Research Foundation Mass spectrometry-based method for simultaneous qualitative and quantitative protein citrullination analysis of complex biological samples

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK71801C (da) 1949-03-09 1950-12-04 Landmand Aage Pallesen Fasterh Kartoffeloptagemaskine.
DE60233520D1 (de) * 2001-11-05 2009-10-08 Irm Llc Markierungsreagens und anwendungsverfahren
US20070048752A1 (en) * 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
EP1776588A1 (en) 2004-07-12 2007-04-25 Applera Corporation Mass tags for quantitative analyses
GB0515323D0 (en) 2005-07-26 2005-08-31 Electrophoretics Ltd Mass labels
US9388132B2 (en) * 2011-09-15 2016-07-12 Wisconsin Alumni Research Foundation Isobaric tandem mass tags for quantitative proteomics and peptidomics
US9366678B2 (en) * 2012-10-25 2016-06-14 Wisconsin Alumni Research Foundation Neutron encoded mass tags for analyte quantification

Also Published As

Publication number Publication date
EP3362438A4 (en) 2019-06-12
EP3362438A1 (en) 2018-08-22
JP2018538511A (ja) 2018-12-27
US20180299464A1 (en) 2018-10-18
CA2999331A1 (en) 2017-04-20
US11408897B2 (en) 2022-08-09
WO2017066650A1 (en) 2017-04-20

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Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE NAME OF THE INVENTOR TO READ LI, LINGJUN; FROST, DUSTIN AND BUCHBERGER JONES, AMANDA

MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period