JP2018537486A - キノロン類似体及びその塩の結晶形 - Google Patents

キノロン類似体及びその塩の結晶形 Download PDF

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Publication number
JP2018537486A
JP2018537486A JP2018530880A JP2018530880A JP2018537486A JP 2018537486 A JP2018537486 A JP 2018537486A JP 2018530880 A JP2018530880 A JP 2018530880A JP 2018530880 A JP2018530880 A JP 2018530880A JP 2018537486 A JP2018537486 A JP 2018537486A
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crystalline form
cancer
compound
ray powder
diffraction pattern
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JP2018537486A5 (https=
Inventor
デイビッド エム． ライクマン，
デイビッド エム． ライクマン，
イーチン， グレース ユー，
イーチン， グレース ユー，
シオウ−ティン リウ，
シオウ−ティン リウ，
Original Assignee
センワ バイオサイエンシズ インコーポレイテッド
センワ バイオサイエンシズ インコーポレイテッド
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Publication of JP2018537486A publication Critical patent/JP2018537486A/ja
Publication of JP2018537486A5 publication Critical patent/JP2018537486A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2018530880A 2015-12-14 2015-12-14 キノロン類似体及びその塩の結晶形 Withdrawn JP2018537486A (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2015/065443 WO2017105382A1 (en) 2015-12-14 2015-12-14 Crystalline forms of quinolone analogs and their salts

Related Child Applications (1)

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JP2020144658A Division JP2020189888A (ja) 2020-08-28 2020-08-28 キノロン類似体及びその塩の結晶形

Publications (2)

Publication Number Publication Date
JP2018537486A true JP2018537486A (ja) 2018-12-20
JP2018537486A5 JP2018537486A5 (https=) 2019-02-07

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JP2018530880A Withdrawn JP2018537486A (ja) 2015-12-14 2015-12-14 キノロン類似体及びその塩の結晶形

Country Status (10)

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EP (2) EP4249072A3 (https=)
JP (1) JP2018537486A (https=)
KR (1) KR20180111797A (https=)
CN (1) CN108699083A (https=)
AU (2) AU2015417382A1 (https=)
CA (2) CA3006502A1 (https=)
ES (1) ES2959536T3 (https=)
IL (1) IL260004A (https=)
RU (1) RU2018124599A (https=)
WO (1) WO2017105382A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020189888A (ja) * 2020-08-28 2020-11-26 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体及びその塩の結晶形
JP2022544559A (ja) * 2019-08-14 2022-10-19 センワ バイオサイエンシズ インコーポレイテッド 四環式化合物及びそれらの塩、組成物、ならびにそれらの使用方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112334133A (zh) * 2018-02-15 2021-02-05 生华生物科技股份有限公司 喹诺酮类似物及其盐、组合物及其使用方法
CA3129722A1 (en) * 2019-02-11 2020-08-20 Phoenix Molecular Designs Crystalline forms of an rsk inhibitor
CA3151116A1 (en) * 2019-08-14 2021-02-18 Hshiou-Ting Liu Crystalline forms of quinoline analogs and salts thereof, compositions, and their methods for use
CN118005653B (zh) * 2023-04-23 2024-12-10 信义核新(北京)生物科技有限公司 喹诺酮类似物及其用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008513485A (ja) * 2004-09-17 2008-05-01 サイリーン ファーマシューティカルズ インコーポレーティッド キノロンアナログ
JP2010540663A (ja) * 2007-10-05 2010-12-24 サイリーン ファーマシューティカルズ インコーポレーティッド キノロン類似体およびそれに関連する方法
WO2012123938A1 (en) * 2011-03-17 2012-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
WO2015079411A1 (en) * 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009504192A (ja) * 2005-08-19 2009-02-05 サイリーン ファーマシューティカルズ インコーポレーティッド ヒトリボソームＤＮＡ（ｒＤＮＡ）およびリボソームＲＮＡ（ｒＲＮＡ）核酸ならびにそれらの使用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008513485A (ja) * 2004-09-17 2008-05-01 サイリーン ファーマシューティカルズ インコーポレーティッド キノロンアナログ
JP2010540663A (ja) * 2007-10-05 2010-12-24 サイリーン ファーマシューティカルズ インコーポレーティッド キノロン類似体およびそれに関連する方法
WO2012123938A1 (en) * 2011-03-17 2012-09-20 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
WO2015079411A1 (en) * 2013-11-28 2015-06-04 Tel Hashomer Medical Research Infrastructure And Services Ltd. Rna polymerase i inhibitors and uses thereof

Non-Patent Citations (9)

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BIOCHIMICA ET BIOPHYSICA ACTA, MOLECULAR BASIS OF DISEASE, vol. 1842(6), JPN6019041986, 2014, pages 802 - 816, ISSN: 0004143863 *
DRUG DISCOVERY TODAY, vol. 19(3), JPN6019041990, 2014, pages 259 - 265, ISSN: 0004143864 *
IYAKUHIN KENKYU, vol. 28(1), JPN6019041993, 1997, pages 1 - 11, ISSN: 0004143865 *
JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 66, no. 1, JPN6014023656, 1977, pages 1 - 19, ISSN: 0004404000 *
PHARM TECH JAPAN, vol. 18, no. 10, JPN7014002019, 2002, pages 81 - 96, ISSN: 0004404002 *
小嶌隆史: "医薬品開発における結晶性選択の効率化を目指して", 薬剤学, vol. 68, no. 5, JPN6009053757, 1 September 2008 (2008-09-01), pages 344 - 349, ISSN: 0004404003 *
平山令明編, 有機化合物結晶作製ハンドブック −原理とノウハウ−, JPN6011053065, 25 July 2008 (2008-07-25), pages 57 - 84, ISSN: 0004404004 *
長瀬博監訳, 最新 創薬化学 下巻, JPN6008054607, 25 September 1999 (1999-09-25), JP, pages 347 - 365, ISSN: 0004404001 *
高田則幸: "創薬段階における原薬Formスクリーニングと選択", PHARM STAGE, vol. 6, no. 10, JPN6009053755, 15 January 2007 (2007-01-15), pages 20 - 25, ISSN: 0004404005 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022544559A (ja) * 2019-08-14 2022-10-19 センワ バイオサイエンシズ インコーポレイテッド 四環式化合物及びそれらの塩、組成物、ならびにそれらの使用方法
JP7566010B2 (ja) 2019-08-14 2024-10-11 センワ バイオサイエンシズ インコーポレイテッド 四環式化合物及びそれらの塩、組成物、ならびにそれらの使用方法
JP2020189888A (ja) * 2020-08-28 2020-11-26 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体及びその塩の結晶形

Also Published As

Publication number Publication date
EP3394070A1 (en) 2018-10-31
CN108699083A (zh) 2018-10-23
AU2021203085A1 (en) 2021-06-10
EP3394070B1 (en) 2023-08-02
EP4249072A2 (en) 2023-09-27
IL260004A (en) 2018-07-31
EP3394070A4 (en) 2019-05-08
AU2015417382A1 (en) 2018-06-14
ES2959536T3 (es) 2024-02-26
AU2021203085B2 (en) 2023-06-08
EP4249072A3 (en) 2023-10-25
CA3255938A1 (en) 2025-11-28
RU2018124599A (ru) 2020-01-16
KR20180111797A (ko) 2018-10-11
CA3006502A1 (en) 2017-06-22
EP3394070C0 (en) 2023-08-02
WO2017105382A1 (en) 2017-06-22
RU2018124599A3 (https=) 2020-01-16

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