JP2018536856A - 混沌波センサを利用した試料特性探知装置 - Google Patents
混沌波センサを利用した試料特性探知装置 Download PDFInfo
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Abstract
Description
本発明の他の実施形態は、試料を収容する試料配置部、前記試料配置部と隣接するように配置され、基準試料を収容する基準試料配置部、前記試料配置部内の前記試料、及び前記基準試料配置部内の前記基準試料に向けて波動を照射する波動源、前記照射された波動が、前記試料及び前記基準試料それぞれによって多重散乱(multiple scattering)されて発生した第1レーザスペックル(laser speckle)及び基準レーザスペックルを検出するが、事前に設定された同一時点ごとに検出する検出部、並びに前記検出された第1レーザスペックルを利用し、前記検出された第1レーザスペックルの経時的変化である時間相関関係(temporal correlation)を獲得し、前記獲得された時間相関関係に基づいて、前記試料の特性をリアルタイム(real−time)で探知し、前記検出部は、前記試料と前記検出部との間、または前記検出部内部の一領域において、前記レーザスペックルを検出する試料特性探知装置を提供する。
本発明の一実施形態において、前記試料配置部内の前記試料に、所定抗生物質を投与する抗生物質適用部をさらに含み、前記制御部は、前記レーザスペックルの時間相関関係に基づいて、前記試料に前記抗生物質が投与される前またはその後の前記試料内の微生物の存在いかん、または微生物の濃度を推定し、前記推定された微生物存在いかん、または前記微生物の濃度変化により、前記抗生物質の適合性をリアルタイムで判断することができる。
本発明の一実施形態において、前記第1映像情報及び前記第2映像情報は、レーザスペックルのパターン情報、及び波動の強度情報のうち少なくともいずれか一つを含んでもよい。
図1は、本発明の一実施形態による混沌波センサの原理について説明するための図面である。
とすれば、制御部140は、特定遅延時間を
について、各地点で時間相関係数を前述のように演算することができる。制御部140において、微生物の存在いかん、または微生物の濃度変化を推定する方法については、後述する。
は、時間相関関係係数、
は、標準化された光強度、(x,y)は、カメラのピクセル座標、tは、測定された時間、Tは、総測定時間、
は、タイムラグ(time lag)を示す。
とすれば、検出部130は、特定遅延時間を
について、各地点で時間相関関係係数を、前述の数式3に基づいて計算することができる。そして、検出部130は、計算された時間相関関係係数の変化度に基づいて、特定身体部位の中またはその表面に、微生物が存在するか否かということを測定することができ、測定された試験結果は、図42のようなものがある。ここで、数式3に基づいて、時間相関関係係数を計算する構成、及び計算された時間相関関係係数に基づいて、特定身体部位に微生物が存在するか否かということを測定することは、すでに数式3で説明したので、重複説明は省略する。
Claims (20)
- 試料に向けて波動を照射する波動源と、
前記照射された波動が、前記試料によって多重散乱されて発生したレーザスペックルを検出するが、前記レーザスペックルを、事前に設定された時点ごとに検出する検出部と、
前記検出されたレーザスペックルの経時的変化である時間相関関係を獲得し、前記獲得された時間相関関係に基づいて、前記試料の特性をリアルタイムで探知する制御部と、を含み、
前記検出部は、前記試料と前記検出部との間、または前記検出部内部の一領域において、前記レーザスペックルを検出する試料特性探知装置。 - 前記制御部は、前記試料内部で動きがある細菌や微生物またはウイルスから生成されるスペックルの変化により、前記細菌や微生物またはウイルスの存在いかん、またはその濃度をリアルタイムで推定することを特徴とする請求項1に記載の試料特性探知装置。
- 前記検出部は、前記試料の表面から一定距離離隔された前記第1領域において、前記レーザスペックルを検出することを特徴とする請求項1に記載の試料特性探知装置。
- 前記第1領域は、前記試料の表面から第1距離離隔された第1地点を含む第1面と、前記試料の表面から前記第1距離より遠い第2距離離隔された第2地点を含む第2面との間に配置されることを特徴とする請求項3に記載の試料特性探知装置。
- 前記時間相関関係は、第1時点で検出された前記レーザスペックルの第1映像情報と、前記第1時点と異なる第2時点で検出された前記レーザスペックルの第2映像情報との差を含むことを特徴とする請求項1に記載の試料特性探知装置。
- 前記第1映像情報及び前記第2映像情報は、前記レーザスペックルのパターン情報、及び前記波動の強度情報のうち少なくともいずれか一つを含むことを特徴とする請求項5に記載の試料特性探知装置。
- 前記試料を収容する試料配置部をさらに含むことを特徴とする請求項1に記載の試料特性探知装置。
- 前記試料配置部内の前記試料に、所定抗生物質を投与する抗生物質適用部をさらに含み、
前記制御部は、前記レーザスペックルの時間相関関係に基づいて、前記試料に前記抗生物質が投与される前またはその後の前記試料内の微生物の存在いかん、または微生物の濃度を推定し、前記推定された微生物存在いかん、または前記微生物の濃度変化により、前記抗生物質の適合性をリアルタイムで判断することを特徴とする請求項7に記載の試料特性探知装置。 - 前記試料が外部環境に露出されないように、少なくとも前記試料配置部をカバーするカバー部材と、
前記試料の一定培養環境を維持するように環境条件を調節する培養環境調節部と、をさらに含むことを特徴とする請求項7に記載の試料特性探知装置。 - 前記検出部を2以上含む場合、前記複数の検出部から検出された複数の前記レーザスペックルを利用し、三次元スペックルイメージを生成する三次元イメージ生成部をさらに含み、
前記制御部は、前記三次元スペックルイメージを利用し、前記試料の特性を探知することを特徴とする請求項1に記載の試料特性探知装置。 - 前記試料から多重散乱されて出射される前記波動の少なくとも一部を、前記試料に反射させ、前記試料での多重散乱回数を増幅させる多重散乱増幅部をさらに含むことを特徴とする請求項1に記載の試料特性探知装置。
- 前記多重散乱増幅部は、
前記試料の中心を通る延長線上に配置され、前記試料から多重散乱されて出射される前記波動の少なくとも一部を、前記試料に反射させる第1多重散乱増幅部と、
前記試料を基準に、前記第1多重散乱増幅部と対向するように配置され、前記試料から多重散乱されて出射される前記波動の少なくとも一部を、前記試料に反射させる第2多重散乱増幅部と、を含むことを特徴とする請求項11に記載の試料特性探知装置。 - 試料を収容する試料配置部と、
前記試料配置部と隣接するように配置され、基準試料を収容する基準試料配置部と、
前記試料配置部内の前記試料、及び前記基準試料配置部内の前記基準試料に向けて波動を照射する波動源と、
前記照射された波動が、前記試料及び前記基準試料それぞれによって多重散乱されて発生した第1レーザスペックル及び基準レーザスペックルを検出するが、事前に設定された同一時点ごとに検出する検出部と、
前記検出された第1レーザスペックルを利用し、前記検出された第1レーザスペックルの経時的変化である時間相関関係を獲得し、前記獲得された時間相関関係に基づいて、前記試料の特性をリアルタイムで探知し、
前記検出部は、前記試料と前記検出部との間、または前記検出部内部の一領域において、前記レーザスペックルを検出する試料特性探知装置。 - 前記制御部は、前記試料内部で動きがある細菌や微生物またはウイルスから生成されるスペックルの変化により、前記細菌や微生物またはウイルスの存在いかん、またはその濃度をリアルタイムで推定することを特徴とする請求項13に記載の試料特性探知装置。
- 前記試料配置部内の前記試料に、所定抗生物質を投与する抗生物質適用部をさらに含み、
前記制御部は、前記レーザスペックルの時間相関関係に基づいて、前記試料に前記抗生物質が投与される前またはその後の前記試料内の微生物の存在いかん、または微生物の濃度を推定し、前記推定された微生物存在いかん、または前記微生物の濃度変化により、前記抗生物質の適合性をリアルタイムで判断することを特徴とする請求項13に記載の試料特性探知装置。 - 前記時間相関関係は、第1時点で検出された前記第1レーザスペックルの第1映像情報と、前記第1時点と異なる第2時点で検出された前記第1レーザスペックルの第2映像情報との差を含むことを特徴とする請求項13に記載の試料特性探知装置。
- 前記第1映像情報及び前記第2映像情報は、レーザスペックルのパターン情報、及び波動の強度情報のうち少なくともいずれか一つを含むことを特徴とする請求項16に記載の試料特性探知装置。
- 前記制御部は、前記検出された基準レーザスペックルを利用し、前記検出された基準レーザスペックルの基準情報を獲得し、前記基準情報を利用し、前記第1レーザスペックルの時間相関関係に係わるノイズを除去することを特徴とする請求項17に記載の試料特性探知装置。
- 前記波動源から入射された波動を分割させ、複数の波動経路に提供する多重ビームリフレクタと、
前記多重ビームリフレクタから提供される前記波動経路上に配置され、前記試料及び前記基準試料で反射されて出射される前記波動の経路を変更し、前記検出部に提供するビームスプリッタと、をさらに含むことを特徴とする請求項13に記載の試料特性探知装置。 - 試料に向けて波動を照射する波動源と、
前記照射された波動が、前記試料によって多重散乱されて発生したレーザスペックルを検出するが、前記レーザスペックルが拡散する経路上の一領域において、前記レーザスペックルを、事前に設定された時点ごとに検出する検出部と、
前記検出されたレーザスペックルの時間相関関係を獲得し、前記獲得された時間相関関係に基づいて、前記試料の特性をリアルタイムで探知する制御部と、を含む試料特性探知装置。
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WO2022059829A1 (ko) * | 2020-09-18 | 2022-03-24 | (주)더웨이브톡 | 수질 검사기 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111417411A (zh) * | 2017-10-30 | 2020-07-14 | 豪倍公司 | 抗菌背光设备 |
EP3803293A4 (en) * | 2018-05-30 | 2022-06-15 | Pendar Technologies, LLC | METHODS AND DEVICES FOR GAP DIFFERENTIAL RAMAN SPECTROSCOPY WITH INCREASED OCULAR SAFETY AND REDUCED RISK OF EXPLOSION |
US11353390B2 (en) * | 2018-12-27 | 2022-06-07 | Apple Inc. | Methods to reduce power consumption of an optical particle sensor via an ASIC design |
WO2020153649A1 (ko) * | 2019-01-25 | 2020-07-30 | 주식회사 더웨이브톡 | 인체 주입물 이송 장치와 방법 및 튜브 장치 |
CN113518827B (zh) * | 2019-03-01 | 2024-09-06 | 安格瑞卡姆有限公司 | 用于检测微生物的方法、装置和系统 |
KR102191007B1 (ko) * | 2019-04-19 | 2020-12-14 | 한국과학기술원 | 3 차원 이미지 생성 방법 및 장치 |
CN110501311B (zh) * | 2019-07-29 | 2021-08-20 | 宁波方太厨具有限公司 | 一种油烟浓度检测装置及该装置的检测方法 |
KR102285089B1 (ko) * | 2020-03-02 | 2021-08-04 | 주식회사 더웨이브톡 | 미생물 검출 장비 |
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WO2023145208A1 (ja) | 2022-01-31 | 2023-08-03 | 株式会社エンプラス | 流体取扱装置、その製造方法、および流体取扱装置への流動性媒体の導入方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006058009A (ja) * | 2004-08-17 | 2006-03-02 | Shimadzu Corp | レーザ式多重反射セル式ガス分析計 |
JP4241038B2 (ja) * | 2000-10-30 | 2009-03-18 | ザ ジェネラル ホスピタル コーポレーション | 組織分析のための光学的な方法及びシステム |
JP2013083482A (ja) * | 2011-10-06 | 2013-05-09 | Azbil Corp | 状態検出装置 |
WO2015056197A1 (en) * | 2013-10-16 | 2015-04-23 | Koninklijke Philips N.V. | Device for dental plaque detection |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4676951A (en) * | 1985-07-01 | 1987-06-30 | American Hospital Supply Corp. | Automatic specimen analyzing system |
JPS63188766A (ja) * | 1987-02-02 | 1988-08-04 | Nippon Telegr & Teleph Corp <Ntt> | レ−ザ磁気免疫測定法および測定装置 |
JP2502546B2 (ja) * | 1986-10-25 | 1996-05-29 | 日本電信電話株式会社 | レ−ザ磁気免疫測定方法 |
DE3844104A1 (de) * | 1988-12-28 | 1990-07-05 | Boehringer Mannheim Gmbh | Testtraeger-analysesystem |
JPH05264545A (ja) * | 1992-03-17 | 1993-10-12 | Fujikura Ltd | レーザ磁気免疫測定における干渉縞の観察方法およびレーザ磁気免疫測定装置 |
US6076010A (en) * | 1996-06-20 | 2000-06-13 | Trustees Of The University Of Pennsylvania | Imaging spatially varying dynamic media with diffusing correlation waves |
US5956139A (en) * | 1997-08-04 | 1999-09-21 | Ohio Aerospace Institute | Cross-correlation method and apparatus for suppressing the effects of multiple scattering |
GB2369182B (en) | 2000-11-15 | 2004-12-08 | Rusteck Ltd | Optical detection of particles in a liquid medium |
KR100848988B1 (ko) | 2002-03-28 | 2008-07-30 | 타카이 토후 앤 소이 밀크 이큅먼트 컴퍼니 리미티드 | 식품의 겔 상태 또는 졸-겔 상태 변화의 평가 방법 |
US7122384B2 (en) | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
FR2859531B1 (fr) * | 2003-09-08 | 2006-02-10 | Univ Nantes | Procede et dispositif de mesure en ligne des caracteristiques d'un systeme disperse liquide-liquide ou liquide-solide contenu dans une installation principale |
FR2860300B1 (fr) * | 2003-09-25 | 2006-01-27 | Formulaction | Procede et dispositif d'analyse du mouvement dans un milieu diffusant. |
JP2008507269A (ja) | 2004-07-20 | 2008-03-13 | シージーケー カンパニー リミテッド | 物質の相互作用探索システム |
US20060066850A1 (en) * | 2004-09-29 | 2006-03-30 | Fuji Photo Film Co., Ltd. | Light measuring device, biochemical analyzer, biochemical analysis method, and spectrophotometer |
KR101453554B1 (ko) | 2005-07-20 | 2014-10-23 | 한국과학기술원 | 물질의 상호작용을 탐색하는 방법 및 키트 |
US20080106737A1 (en) | 2005-08-16 | 2008-05-08 | Amnon Weichselbaum | Detecting and counting bacteria suspended in biological fluids |
EP1934945A4 (en) * | 2005-10-11 | 2016-01-20 | Apple Inc | METHOD AND SYSTEM FOR RECONSTRUCTING AN OBJECT |
JP2009537024A (ja) * | 2006-02-01 | 2009-10-22 | ザ ジェネラル ホスピタル コーポレイション | 少なくとも一つのファイバの少なくとも二つの部位の少なくとも一つを制御する装置 |
JP2010512534A (ja) | 2006-12-12 | 2010-04-22 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | ラベル粒子を検出するマイクロエレクトロニクスセンサデバイス |
JP2008232887A (ja) * | 2007-03-22 | 2008-10-02 | Omron Corp | 物体検知装置、および照射軸調整方法 |
JP5132982B2 (ja) | 2007-05-02 | 2013-01-30 | 株式会社日立ハイテクノロジーズ | パターン欠陥検査装置および方法 |
WO2009008745A2 (en) * | 2007-07-06 | 2009-01-15 | Industrial Research Limited | Laser speckle imaging systems and methods |
US8445217B2 (en) * | 2007-09-20 | 2013-05-21 | Vanderbilt University | Free solution measurement of molecular interactions by backscattering interferometry |
CN101408555A (zh) * | 2007-10-08 | 2009-04-15 | 南京理工大学 | 激光散斑测试系统 |
US8509879B2 (en) * | 2007-11-06 | 2013-08-13 | The Regents Of The University Of California | Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging |
WO2009061377A2 (en) * | 2007-11-06 | 2009-05-14 | Claro Scientific Llc | Detecting microorganisms in blood utilizing physical and chemical changes in blood |
US7772556B2 (en) * | 2007-11-14 | 2010-08-10 | University Of Maine System Board Of Trustees | Detection system for detecting an analyte in a fluid medium |
US8628976B2 (en) * | 2007-12-03 | 2014-01-14 | Azbil BioVigilant, Inc. | Method for the detection of biologic particle contamination |
WO2009111609A2 (en) * | 2008-03-05 | 2009-09-11 | Purdue Research Foundation | Method and apparatus for motility contrast imaging |
WO2010105197A2 (en) | 2009-03-12 | 2010-09-16 | The General Hospital Corporation | Non-contact optical system, computer-accessible medium and method for measuring at least one mechanical property of tissue using coherent speckle techniques(s) |
BR112012013362A2 (pt) | 2009-12-04 | 2016-03-01 | Unisensor As | sistema para a determinação de um valor para pelo menos um parâmetro que descreve a atividade microbiana de organismos biológicos individuais em uma amostra de líquido, e, método para a determinação da atividade microbiana em uma amostra de líquido |
WO2011073866A1 (en) * | 2009-12-18 | 2011-06-23 | Koninklijke Philips Electronics N.V. | Substance determining apparatus |
DE102011001091C5 (de) * | 2010-10-19 | 2022-07-14 | Leica Microsystems Cms Gmbh | Verfahren und Einrichtung zur mikroskopischen Bildaufnahme einer Probenstruktur |
CN102565002A (zh) * | 2011-04-08 | 2012-07-11 | 曾春雨 | 一种激光散斑管道气体颗粒测量设备及方法 |
EP2713878B1 (en) * | 2011-05-26 | 2021-07-07 | The General Hospital Corporation | Optical thromboelastography system and method for evaluation of blood coagulation metrics |
CA2843445C (en) | 2011-08-02 | 2019-09-24 | The Regents Of The University Of California | Rapid, massively parallel single-cell drug response measurements via live cell interferometry |
CN202394176U (zh) * | 2011-10-28 | 2012-08-22 | 沈阳联动天下科技有限公司 | 基于智能图像采集和运动识别技术的3d互动系统 |
WO2014043609A1 (en) * | 2012-09-17 | 2014-03-20 | The General Hospital Corporation | Compensation for causes of temporal fluctuations of backscattered speckle patterns in laser speckle rheology of biological fluids |
CN103063145B (zh) * | 2013-01-11 | 2015-06-10 | 沈阳师范大学 | 多功能智能型激光散斑干涉测量装置及方法 |
KR102117261B1 (ko) | 2013-03-05 | 2020-06-01 | 삼성전자주식회사 | 거리 검출 및 생체 인증 방법, 저장 매체 및 단말 |
CN103234921B (zh) * | 2013-03-27 | 2015-01-28 | 中国科学院安徽光学精密机械研究所 | 水体细菌微生物快速在线检测装置及检测方法 |
KR101516176B1 (ko) | 2013-06-24 | 2015-05-04 | 에스엘 주식회사 | 변속 레버의 솔레노이드 장치 |
US10539772B2 (en) * | 2013-10-09 | 2020-01-21 | Howard Hughes Medical Institute | Multiview light-sheet microscopy |
KR20150050265A (ko) | 2013-10-31 | 2015-05-08 | 서울바이오시스 주식회사 | 미생물 탐지 장치 및 이를 이용하는 미생물 탐지 방법 |
CN103759651B (zh) * | 2014-01-21 | 2016-05-25 | 沈阳师范大学 | 一种实时监控变温变压型激光散斑测量系统 |
CN103983340B (zh) * | 2014-05-20 | 2017-06-13 | 厦门大学 | 基于远距离脉冲激光散斑的微振动测量系统及测量方法 |
KR20160109901A (ko) | 2015-03-13 | 2016-09-21 | 주식회사 올인원바이오 | 휴대 기기용 미생물 활성 발견 장치 및 그 장치를 이용한 미생물 활성 발견 방법 |
WO2016161022A2 (en) * | 2015-03-30 | 2016-10-06 | Accerlate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
US10253355B2 (en) * | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
US20170000375A1 (en) * | 2015-07-01 | 2017-01-05 | Verily Life Sciences Llc | Magnetic Nanoparticle Detection and Separation by Magnetic Relaxation Time |
GB201507021D0 (en) * | 2015-04-24 | 2015-06-10 | Isis Innovation | Compact microscope |
CN104819769B (zh) * | 2015-04-30 | 2019-05-14 | 杭州电子科技大学 | 一种基于偏振奇点光束激光散斑的振动测量装置 |
CN104776907A (zh) * | 2015-04-30 | 2015-07-15 | 杭州电子科技大学 | 一种基于多点激光散斑极值跟踪的振动检测方法 |
CN105043525A (zh) * | 2015-04-30 | 2015-11-11 | 杭州电子科技大学 | 一种基于激光散斑行为的振动信息检测方法 |
CN105043524B (zh) * | 2015-04-30 | 2018-11-02 | 杭州电子科技大学 | 一种基于激光散斑离焦成像的振动检测方法 |
CN104887216A (zh) * | 2015-06-10 | 2015-09-09 | 上海大学 | 多光束相干人体皮肤灌注成像系统和方法 |
US10770860B2 (en) * | 2016-10-31 | 2020-09-08 | Innoven Energy Llc | Lookthrough compression arrangement |
EP3795981A4 (en) * | 2018-05-18 | 2021-08-04 | The Wave Talk, Inc. | OPTICAL DETECTION SYSTEM |
GB2590883B (en) * | 2018-08-17 | 2021-10-06 | F Miller John | Measuring electrophoretic mobility |
-
2016
- 2016-11-17 CN CN202110183709.XA patent/CN113063755A/zh active Pending
- 2016-11-17 JP JP2018526645A patent/JP7058837B2/ja active Active
- 2016-11-17 CN CN201680079041.1A patent/CN108474740B/zh active Active
- 2016-11-17 US US15/776,584 patent/US10551293B2/en active Active
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- 2019-11-27 US US16/697,373 patent/US10914665B2/en active Active
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- 2021-01-06 US US17/142,529 patent/US11262287B2/en active Active
-
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- 2022-03-31 JP JP2022060460A patent/JP7377475B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4241038B2 (ja) * | 2000-10-30 | 2009-03-18 | ザ ジェネラル ホスピタル コーポレーション | 組織分析のための光学的な方法及びシステム |
JP2006058009A (ja) * | 2004-08-17 | 2006-03-02 | Shimadzu Corp | レーザ式多重反射セル式ガス分析計 |
JP2013083482A (ja) * | 2011-10-06 | 2013-05-09 | Azbil Corp | 状態検出装置 |
WO2015056197A1 (en) * | 2013-10-16 | 2015-04-23 | Koninklijke Philips N.V. | Device for dental plaque detection |
Non-Patent Citations (1)
Title |
---|
BIN ZHENG: "Feature information extraction from dynamic biospeckle", APPLED OPTICS, vol. 33, no. 3, JPN6020043937, 10 January 1994 (1994-01-10), pages 231 - 237, ISSN: 0004552650 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022059829A1 (ko) * | 2020-09-18 | 2022-03-24 | (주)더웨이브톡 | 수질 검사기 |
KR20220037795A (ko) * | 2020-09-18 | 2022-03-25 | 주식회사 더웨이브톡 | 수질 검사기 |
KR102407130B1 (ko) * | 2020-09-18 | 2022-06-10 | 주식회사 더웨이브톡 | 수질 검사기 |
US12000818B2 (en) | 2020-09-18 | 2024-06-04 | The Wave Talk, Inc. | Device for water examination |
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US10551293B2 (en) | 2020-02-04 |
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