JP2018535214A5 - - Google Patents

Info

Publication number

JP2018535214A5

JP2018535214A5 JP2018522909A JP2018522909A JP2018535214A5 JP 2018535214 A5 JP2018535214 A5 JP 2018535214A5 JP 2018522909 A JP2018522909 A JP 2018522909A JP 2018522909 A JP2018522909 A JP 2018522909A JP 2018535214 A5 JP2018535214 A5 JP 2018535214A5

Authority

JP

Japan

Prior art keywords

ligand

target

group

complex

iii

Prior art date

2016-11-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000003446 ligand Substances 0.000 claims 13
• 150000001875 compounds Chemical class 0.000 claims 7
• 239000011159 matrix material Substances 0.000 claims 7
• 125000002947 alkylene group Chemical group 0.000 claims 6
• 102000003886 Glycoproteins Human genes 0.000 claims 5
• 108090000288 Glycoproteins Proteins 0.000 claims 5
• DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 claims 4
• 238000000034 method Methods 0.000 claims 4
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
• 102000002068 Glycopeptides Human genes 0.000 claims 3
• 108010015899 Glycopeptides Proteins 0.000 claims 3
• 210000004027 cell Anatomy 0.000 claims 3
• 239000003153 chemical reaction reagent Substances 0.000 claims 3
• 125000001072 heteroaryl group Chemical group 0.000 claims 3
• 230000003993 interaction Effects 0.000 claims 3
• 125000001424 substituent group Chemical group 0.000 claims 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• 150000001720 carbohydrates Chemical group 0.000 claims 2
• 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
• 125000005597 hydrazone group Chemical group 0.000 claims 2
• 239000012528 membrane Substances 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims 1
• 102000018697 Membrane Proteins Human genes 0.000 claims 1
• 108010052285 Membrane Proteins Proteins 0.000 claims 1
• UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims 1
• DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 1
• 241000700605 Viruses Species 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 150000001412 amines Chemical group 0.000 claims 1
• 229960004050 aminobenzoic acid Drugs 0.000 claims 1
• 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims 1
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
• 239000000872 buffer Substances 0.000 claims 1
• 239000004202 carbamide Substances 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 239000003054 catalyst Substances 0.000 claims 1
• 239000003431 cross linking reagent Substances 0.000 claims 1
• 230000009089 cytolysis Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 125000000524 functional group Chemical group 0.000 claims 1
• 125000002541 furyl group Chemical group 0.000 claims 1
• 125000005842 heteroatom Chemical group 0.000 claims 1
• 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• -1 hydroxysuccinimide ester Chemical class 0.000 claims 1
• 125000002883 imidazolyl group Chemical group 0.000 claims 1
• 125000001041 indolyl group Chemical group 0.000 claims 1
• 125000000468 ketone group Chemical group 0.000 claims 1
• 238000004949 mass spectrometry Methods 0.000 claims 1
• 125000001624 naphthyl group Chemical group 0.000 claims 1
• 230000001590 oxidative effect Effects 0.000 claims 1
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 125000004076 pyridyl group Chemical group 0.000 claims 1
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
• 150000003384 small molecules Chemical class 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 125000006850 spacer group Chemical group 0.000 claims 1
• 125000003107 substituted aryl group Chemical group 0.000 claims 1
• 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
• 125000000335 thiazolyl group Chemical group 0.000 claims 1
• 125000001544 thienyl group Chemical group 0.000 claims 1
• 150000003573 thiols Chemical group 0.000 claims 1