JP2018534288A - 悪性腫瘍の治療のための併用療法 - Google Patents

悪性腫瘍の治療のための併用療法 Download PDF

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JP2018534288A
JP2018534288A JP2018519487A JP2018519487A JP2018534288A JP 2018534288 A JP2018534288 A JP 2018534288A JP 2018519487 A JP2018519487 A JP 2018519487A JP 2018519487 A JP2018519487 A JP 2018519487A JP 2018534288 A JP2018534288 A JP 2018534288A
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compound
cytarabine
day
aml
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JP2018534288A5 (cg-RX-API-DMAC7.html
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ブイ． アグレスタ サムエル
ブイ． アグレスタ サムエル
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アジオス ファーマシューティカルズ， インコーポレイテッド
アジオス ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2018534288A publication Critical patent/JP2018534288A/ja
Publication of JP2018534288A5 publication Critical patent/JP2018534288A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2018519487A 2015-10-15 2016-10-14 悪性腫瘍の治療のための併用療法 Withdrawn JP2018534288A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021087311A JP2021130682A (ja) 2015-10-15 2021-05-25 悪性腫瘍の治療のための併用療法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562242256P 2015-10-15 2015-10-15
US62/242,256 2015-10-15
US201562255194P 2015-11-13 2015-11-13
US62/255,194 2015-11-13
PCT/US2016/057083 WO2017066599A1 (en) 2015-10-15 2016-10-14 Combination therapy for treating malignancies

Related Child Applications (1)

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JP2021087311A Division JP2021130682A (ja) 2015-10-15 2021-05-25 悪性腫瘍の治療のための併用療法

Publications (2)

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JP2018534288A true JP2018534288A (ja) 2018-11-22
JP2018534288A5 JP2018534288A5 (cg-RX-API-DMAC7.html) 2019-11-28

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JP2018519487A Withdrawn JP2018534288A (ja) 2015-10-15 2016-10-14 悪性腫瘍の治療のための併用療法
JP2021087311A Pending JP2021130682A (ja) 2015-10-15 2021-05-25 悪性腫瘍の治療のための併用療法

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US (2) US10905692B2 (cg-RX-API-DMAC7.html)
EP (2) EP4147692A1 (cg-RX-API-DMAC7.html)
JP (2) JP2018534288A (cg-RX-API-DMAC7.html)
KR (2) KR20250065944A (cg-RX-API-DMAC7.html)
CN (1) CN108366980A (cg-RX-API-DMAC7.html)
AU (1) AU2016340087C1 (cg-RX-API-DMAC7.html)
BR (1) BR112018007304A2 (cg-RX-API-DMAC7.html)
CA (1) CA3001599A1 (cg-RX-API-DMAC7.html)
CL (1) CL2018000927A1 (cg-RX-API-DMAC7.html)
EA (1) EA201890968A1 (cg-RX-API-DMAC7.html)
IL (2) IL311873A (cg-RX-API-DMAC7.html)
MX (2) MX394796B (cg-RX-API-DMAC7.html)
SG (1) SG10201912886XA (cg-RX-API-DMAC7.html)
WO (1) WO2017066599A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201802088B (cg-RX-API-DMAC7.html)

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CA2962943A1 (en) 2014-09-29 2016-04-07 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
CA2975506A1 (en) 2015-02-04 2016-08-11 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
KR102701893B1 (ko) 2015-10-15 2024-09-03 셀진 코포레이션 악성종양을 치료하기 위한 조합 요법
US12064445B2 (en) 2015-12-03 2024-08-20 Biosight Ltd. Cytarabine conjugates for cancer therapy
BR112019004356A2 (pt) 2016-09-07 2019-05-28 Celgene Corporation composições de comprimido
WO2018204787A1 (en) 2017-05-05 2018-11-08 Memorial Sloan Kettering Cancer Center Methods of treatment of myeloproliferative neoplasm
CN110869029A (zh) * 2017-07-09 2020-03-06 拜欧赛特有限公司 组合癌症治疗
US10980788B2 (en) * 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
WO2020092894A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid forms of 2-methyl-1-[(4-[6-(trifluoromethyl) pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl) amino]propan-2-ol
WO2020092906A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Co-crystals of 2-methyl-1 -[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl) pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol, compositions and methods of use thereof
WO2020092915A1 (en) 2018-11-02 2020-05-07 Celgene Corporation Solid dispersions for treatment of cancer
EP4058028B1 (en) 2019-11-14 2025-03-05 Celgene Corporation Pediatric formulations for treatment of cancer
CN111087408B (zh) * 2020-01-03 2021-04-02 浙江大学 一种大环结构的idh2突变体抑制剂及其医药用途

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WO2015017821A2 (en) * 2013-08-02 2015-02-05 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use

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US6635280B2 (en) 1997-06-06 2003-10-21 Depomed, Inc. Extending the duration of drug release within the stomach during the fed mode
AU767812B2 (en) 2000-02-04 2003-11-27 Depomed, Inc. Shell-and-core dosage form approaching zero-order drug release
US6723340B2 (en) 2001-10-25 2004-04-20 Depomed, Inc. Optimal polymer mixtures for gastric retentive tablets
JP6067226B2 (ja) 2009-03-13 2017-01-25 アジオス ファーマシューティカルズ， インコーポレイテッド 細胞増殖関連疾患のための方法および組成物
CA2793836C (en) * 2009-10-21 2020-03-24 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
EP4647076A2 (en) 2012-01-06 2025-11-12 Les Laboratoires Servier Therapeutically active compounds and their methods of use
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CA2962943A1 (en) 2014-09-29 2016-04-07 Agios Pharmaceuticals, Inc. Therapeutically active compounds and their methods of use
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KR102701893B1 (ko) 2015-10-15 2024-09-03 셀진 코포레이션 악성종양을 치료하기 위한 조합 요법
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Also Published As

Publication number Publication date
BR112018007304A2 (pt) 2018-10-23
KR20180063125A (ko) 2018-06-11
AU2016340087A1 (en) 2018-04-12
JP2021130682A (ja) 2021-09-09
EP4147692A1 (en) 2023-03-15
CA3001599A1 (en) 2017-04-20
MX2022006701A (es) 2022-07-12
MX2018004595A (es) 2019-07-04
EA201890968A1 (ru) 2018-09-28
IL258269A (en) 2018-05-31
KR20250065944A (ko) 2025-05-13
EP3362057A1 (en) 2018-08-22
IL311873A (en) 2024-06-01
US20210386749A1 (en) 2021-12-16
US20180311249A1 (en) 2018-11-01
ZA201802088B (en) 2021-07-28
WO2017066599A1 (en) 2017-04-20
SG10201912886XA (en) 2020-02-27
AU2016340087C1 (en) 2022-08-18
AU2016340087B2 (en) 2022-05-12
US10905692B2 (en) 2021-02-02
CN108366980A (zh) 2018-08-03
CL2018000927A1 (es) 2018-09-14
MX394796B (es) 2025-03-24
NZ740792A (en) 2024-05-31

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