|
CA2853829C
(en)
|
2011-07-22 |
2023-09-26 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9228207B2
(en)
|
2013-09-06 |
2016-01-05 |
President And Fellows Of Harvard College |
Switchable gRNAs comprising aptamers
|
|
US9388430B2
(en)
|
2013-09-06 |
2016-07-12 |
President And Fellows Of Harvard College |
Cas9-recombinase fusion proteins and uses thereof
|
|
US20150166982A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting pi3k point mutations
|
|
EP3177718B1
(en)
|
2014-07-30 |
2022-03-16 |
President and Fellows of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
EP3025719B1
(en)
|
2014-11-26 |
2018-09-26 |
Miltenyi Biotec GmbH |
Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
|
|
CN108290939B
(zh)
|
2015-10-16 |
2023-01-13 |
纽约市哥伦比亚大学理事会 |
用于抑制谱系特异性抗原的组合物和方法
|
|
SG11201803173VA
(en)
|
2015-10-23 |
2018-05-30 |
Harvard College |
Nucleobase editors and uses thereof
|
|
KR20180073679A
(ko)
*
|
2015-11-04 |
2018-07-02 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
조혈 줄기 세포에서의 유전자 편집을 위한 방법 및 조성물
|
|
AU2017221456B2
(en)
*
|
2016-02-19 |
2024-04-04 |
The Regents Of The University Of California |
Short hairpin RNA (shRNA734) and use of same to positively select and eliminate genetically modified cells
|
|
JP7231935B2
(ja)
|
2016-08-03 |
2023-03-08 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
アデノシン核酸塩基編集因子およびそれらの使用
|
|
CA3033327A1
(en)
|
2016-08-09 |
2018-02-15 |
President And Fellows Of Harvard College |
Programmable cas9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
WO2018071868A1
(en)
|
2016-10-14 |
2018-04-19 |
President And Fellows Of Harvard College |
Aav delivery of nucleobase editors
|
|
HRP20240842T1
(hr)
*
|
2016-11-02 |
2024-10-11 |
Universität Basel |
Imunološki uočljive varijante stanične površine za upotrebu u staničnoj terapiji
|
|
US10745677B2
(en)
|
2016-12-23 |
2020-08-18 |
President And Fellows Of Harvard College |
Editing of CCR5 receptor gene to protect against HIV infection
|
|
US11975029B2
(en)
*
|
2017-02-28 |
2024-05-07 |
Vor Biopharma Inc. |
Compositions and methods for inhibition of lineage specific proteins
|
|
EP3592853A1
(en)
|
2017-03-09 |
2020-01-15 |
President and Fellows of Harvard College |
Suppression of pain by gene editing
|
|
US12390514B2
(en)
|
2017-03-09 |
2025-08-19 |
President And Fellows Of Harvard College |
Cancer vaccine
|
|
JP2020510439A
(ja)
|
2017-03-10 |
2020-04-09 |
プレジデント アンド フェローズ オブ ハーバード カレッジ |
シトシンからグアニンへの塩基編集因子
|
|
KR20240116572A
(ko)
|
2017-03-23 |
2024-07-29 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
WO2019139645A2
(en)
|
2017-08-30 |
2019-07-18 |
President And Fellows Of Harvard College |
High efficiency base editors comprising gam
|
|
AU2018352592C1
(en)
|
2017-10-16 |
2025-09-25 |
Beam Therapeutics, Inc. |
Uses of adenosine base editors
|
|
EP3724214A4
(en)
|
2017-12-15 |
2021-09-01 |
The Broad Institute Inc. |
SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING
|
|
WO2019222545A1
(en)
|
2018-05-16 |
2019-11-21 |
Synthego Corporation |
Methods and systems for guide rna design and use
|
|
US12157760B2
(en)
|
2018-05-23 |
2024-12-03 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
IL260445B
(en)
*
|
2018-07-05 |
2019-08-29 |
Lempo Therapeutics Ltd |
Methods and compositions for modulating myeloperoxidase (mpo) expression
|
|
CN113423725A
(zh)
|
2018-08-28 |
2021-09-21 |
Vor生物制药股份有限公司 |
遗传工程化造血干细胞及其用途
|
|
JP7716976B2
(ja)
*
|
2018-09-19 |
2025-08-01 |
フジフィルム セルラー ダイナミクス,インコーポレイテッド |
キメラ抗原受容体改変免疫細胞の活性化及び拡大培養のためのプロテインl
|
|
US12331320B2
(en)
|
2018-10-10 |
2025-06-17 |
The Research Foundation For The State University Of New York |
Genome edited cancer cell vaccines
|
|
US12281338B2
(en)
|
2018-10-29 |
2025-04-22 |
The Broad Institute, Inc. |
Nucleobase editors comprising GeoCas9 and uses thereof
|
|
EP3873205A4
(en)
*
|
2018-10-31 |
2022-05-11 |
Humanigen, Inc. |
MATERIALS AND METHODS FOR TREATMENT OF CANCER
|
|
CN109852627B
(zh)
*
|
2018-12-26 |
2022-07-05 |
中国人民解放军军事科学院军事医学研究院 |
用于CRISPRi系统的质粒、其构建方法及其在使鼠疫菌目的基因定向沉默中的应用
|
|
EP3911371A4
(en)
*
|
2019-01-18 |
2023-04-26 |
University of Southern California |
METHODS AND COMPOSITIONS FOR IMPROVING THE SAFETY AND EFFICACY OF CELL THERAPY
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US20220202900A1
(en)
*
|
2019-02-22 |
2022-06-30 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for crispr/cas9 knock-out of cd33 in human hematopoietic stem / progenitor cells for allogenic transplantation in patients with relapsed - refractory acute myeloid leukemia
|
|
WO2020181101A1
(en)
|
2019-03-07 |
2020-09-10 |
The Regents Of The University Of California |
Crispr-cas effector polypeptides and methods of use thereof
|
|
GB2601617B
(en)
|
2019-03-19 |
2024-02-21 |
Broad Inst Inc |
Methods and compositions for editing nucleotide sequences
|
|
US12473543B2
(en)
|
2019-04-17 |
2025-11-18 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
CN114729367A
(zh)
*
|
2019-08-28 |
2022-07-08 |
Vor生物制药股份有限公司 |
用于cll1修饰的组合物和方法
|
|
CN114787352A
(zh)
*
|
2019-08-28 |
2022-07-22 |
Vor生物制药股份有限公司 |
用于cd123修饰的组合物和方法
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
AU2020361683A1
(en)
|
2019-10-11 |
2022-05-19 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeting CD13 and TIM-3 with CAR T cells to treat acute myeloid leukemia
|
|
KR20210109971A
(ko)
|
2020-02-28 |
2021-09-07 |
현대자동차주식회사 |
리튬이온 전지 음극 제조방법 및 이에 의해 제조된 리튬이온 전지 음극을 포함하는 리튬이온 전지
|
|
DE112021002672T5
(de)
|
2020-05-08 |
2023-04-13 |
President And Fellows Of Harvard College |
Vefahren und zusammensetzungen zum gleichzeitigen editieren beider stränge einer doppelsträngigen nukleotid-zielsequenz
|
|
KR20230126707A
(ko)
*
|
2020-12-31 |
2023-08-30 |
보르 바이오파마 인크. |
Cd34 유전자 변형을 위한 조성물 및 방법
|
|
CN115443333B
(zh)
*
|
2021-04-27 |
2025-04-25 |
上海驯鹿生物技术有限公司 |
一种基因编辑的造血干细胞及其与car-t细胞的联合应用
|
|
KR20240004702A
(ko)
*
|
2021-04-28 |
2024-01-11 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
안티센스 올리고뉴클레오티드 및 신경퇴행성 장애의 치료를 위한 이들의 용도
|
|
EP4430186A1
(en)
*
|
2021-11-09 |
2024-09-18 |
Vor Biopharma Inc. |
Compositions and methods for erm2 modification
|
|
WO2023091954A2
(en)
|
2021-11-19 |
2023-05-25 |
The Trustees Of The University Of Pennsylvania |
Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy
|
|
CA3247767A1
(en)
*
|
2022-01-11 |
2023-07-20 |
Actinium Pharmaceuticals, Inc. |
METHODS FOR THE TREATMENT OF CD33 POSITIVE MALIGNANT HEMATIC DISEASE
|
|
WO2025030010A1
(en)
|
2023-08-01 |
2025-02-06 |
Vor Biopharma Inc. |
Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof
|
|
WO2025059062A1
(en)
*
|
2023-09-11 |
2025-03-20 |
The Trustees Of The University Of Pennsylvania |
Genetic engineering of human hematopoietic stem/progenitor cells (hspcs) for locus-specific expression of therapeutic proteins
|