JP2018532736A - チェックポイント阻害物質への感受性を予測するｍｓｉおよびネオエピトープの探索のための系、組成物、および方法 - Google Patents

チェックポイント阻害物質への感受性を予測するｍｓｉおよびネオエピトープの探索のための系、組成物、および方法 Download PDF

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JP2018532736A
JP2018532736A JP2018519039A JP2018519039A JP2018532736A JP 2018532736 A JP2018532736 A JP 2018532736A JP 2018519039 A JP2018519039 A JP 2018519039A JP 2018519039 A JP2018519039 A JP 2018519039A JP 2018532736 A JP2018532736 A JP 2018532736A
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neoepitope
hla
patient
matched
tumor
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ニュギュエン，アンドリュー
ニアジ，カイバン
スン−シオン，パトリック
チャールズ ベンズ，ステファン
チャールズ ベンズ，ステファン
ラビザド，シャールーズ
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ナントミクス，エルエルシー
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JP2018519039A 2015-10-12 2016-10-12 チェックポイント阻害物質への感受性を予測するｍｓｉおよびネオエピトープの探索のための系、組成物、および方法 Pending JP2018532736A (ja)

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US201562240494P 2015-10-12 2015-10-12
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PCT/US2016/056692 WO2017066357A1 (en) 2015-10-12 2016-10-12 Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors

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AU (1) AU2016339035A1 (cg-RX-API-DMAC10.html)
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US11626187B2 (en) 2015-10-12 2023-04-11 Nantomics Llc Systems, compositions, and methods for discovery of MSI and neoepitopes that predict sensitivity to checkpoint inhibitors

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CN108701172A (zh) 2016-02-12 2018-10-23 南托米克斯有限责任公司 高通量识别患者特异性新表位作为癌症免疫疗法的治疗靶点
AU2017315468B2 (en) 2016-08-25 2020-02-13 Nantomics, Llc Immunotherapy markers and uses therefor
BR112019018307A2 (pt) * 2017-03-03 2020-03-31 Treos Bio Zrt Plataforma para identificação de peptídeos imunogênicos baseada em população
CN111373050A (zh) 2017-06-20 2020-07-03 生物辐射实验室股份有限公司 用于遗传不稳定性的数字扩增试验
WO2019031938A2 (ko) * 2017-08-10 2019-02-14 주식회사 굳티셀 암 치료를 위한 t 세포의 활성화 방법
US11773449B2 (en) 2017-09-01 2023-10-03 The Hospital For Sick Children Profiling and treatment of hypermutant cancer
US20200385815A1 (en) * 2017-12-20 2020-12-10 Nantomics, Llc Using cfRNA for Diagnosing Minimal Residual Disease
JP2021521812A (ja) * 2018-04-25 2021-08-30 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 免疫療法反応の改善予測バイオマーカーとしての腫瘍機能変異及びエピトープ負荷
WO2020022897A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
EP3827262A1 (en) 2018-07-26 2021-06-02 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
WO2020041561A1 (en) * 2018-08-23 2020-02-27 Nantcell, Inc. Assessing microsatellite instability by liquid biopsy
CN113329761A (zh) 2018-09-04 2021-08-31 特雷斯生物有限公司 肽疫苗
WO2020091944A1 (en) * 2018-10-31 2020-05-07 Nantomics, Llc Genomic and immune infiltration differences between msi and mss gi tumors
CN110556164B (zh) * 2019-09-09 2023-02-07 深圳裕策生物科技有限公司 用于目标区域捕获测序检测msi的方法、装置和存储介质
CN110910957B (zh) * 2019-12-31 2023-06-27 求臻医学科技(浙江)有限公司 一种基于单肿瘤样本高通量测序微卫星不稳定性探测位点筛选方法
CN111785324B (zh) * 2020-07-02 2021-02-02 深圳市海普洛斯生物科技有限公司 一种微卫星不稳定分析方法及装置
CN112183557A (zh) * 2020-09-29 2021-01-05 山西医科大学 基于胃癌组织病理图像纹理特征的msi预测模型构建方法
CN114974420A (zh) * 2021-10-29 2022-08-30 无锡臻和生物科技有限公司 预测胃肠肿瘤免疫检查点抑制剂疗效的标志物及其应用

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US11626187B2 (en) 2015-10-12 2023-04-11 Nantomics Llc Systems, compositions, and methods for discovery of MSI and neoepitopes that predict sensitivity to checkpoint inhibitors

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US11626187B2 (en) 2023-04-11
US20230307090A1 (en) 2023-09-28
IL258679A (en) 2018-06-28
US20170032082A1 (en) 2017-02-02
EP3362930A1 (en) 2018-08-22
AU2016339035A1 (en) 2018-05-10
CN108701173A (zh) 2018-10-23
WO2017066357A1 (en) 2017-04-20
EP3362930A4 (en) 2019-06-19
HK1258091A1 (zh) 2019-11-01
KR20180087244A (ko) 2018-08-01
CA3003251A1 (en) 2017-04-20

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