HK1258091A1 - 用於发现预测对检查点抑制剂敏感的 msi 和新表位的系统、组合物和方法 - Google Patents

用於发现预测对检查点抑制剂敏感的 msi 和新表位的系统、组合物和方法 Download PDF

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Publication number
HK1258091A1
HK1258091A1 HK19100475.3A HK19100475A HK1258091A1 HK 1258091 A1 HK1258091 A1 HK 1258091A1 HK 19100475 A HK19100475 A HK 19100475A HK 1258091 A1 HK1258091 A1 HK 1258091A1
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Hong Kong
Prior art keywords
neoepitopes
systems
methods
msi
discovery
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HK19100475.3A
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English (en)
Chinese (zh)
Inventor
Andrew Nguyen
Kayvan Niazi
Patrick Soon-Shiong
Stephen Charles BENZ
Shahrooz Rabizadeh
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Nantomics, Llc
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Publication of HK1258091A1 publication Critical patent/HK1258091A1/zh

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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

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HK19100475.3A 2015-10-12 2016-10-12 用於发现预测对检查点抑制剂敏感的 msi 和新表位的系统、组合物和方法 HK1258091A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562240494P 2015-10-12 2015-10-12
US62/240,494 2015-10-12
PCT/US2016/056692 WO2017066357A1 (en) 2015-10-12 2016-10-12 Systems, compositions, and methods for discovery of msi and neoepitopes that predict sensitivity to checkpoint inhibitors

Publications (1)

Publication Number Publication Date
HK1258091A1 true HK1258091A1 (zh) 2019-11-01

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US (2) US11626187B2 (cg-RX-API-DMAC10.html)
EP (1) EP3362930A4 (cg-RX-API-DMAC10.html)
JP (1) JP2018532736A (cg-RX-API-DMAC10.html)
KR (1) KR20180087244A (cg-RX-API-DMAC10.html)
CN (1) CN108701173A (cg-RX-API-DMAC10.html)
AU (1) AU2016339035A1 (cg-RX-API-DMAC10.html)
CA (1) CA3003251A1 (cg-RX-API-DMAC10.html)
HK (1) HK1258091A1 (cg-RX-API-DMAC10.html)
IL (1) IL258679A (cg-RX-API-DMAC10.html)
WO (1) WO2017066357A1 (cg-RX-API-DMAC10.html)

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AU2016339035A1 (en) 2015-10-12 2018-05-10 Nantomics, Llc Systems, compositions, and methods for discovery of MSI and neoepitopes that predict sensitivity to checkpoint inhibitors
CN108701172A (zh) 2016-02-12 2018-10-23 南托米克斯有限责任公司 高通量识别患者特异性新表位作为癌症免疫疗法的治疗靶点
AU2017315468B2 (en) 2016-08-25 2020-02-13 Nantomics, Llc Immunotherapy markers and uses therefor
BR112019018307A2 (pt) * 2017-03-03 2020-03-31 Treos Bio Zrt Plataforma para identificação de peptídeos imunogênicos baseada em população
CN111373050A (zh) 2017-06-20 2020-07-03 生物辐射实验室股份有限公司 用于遗传不稳定性的数字扩增试验
WO2019031938A2 (ko) * 2017-08-10 2019-02-14 주식회사 굳티셀 암 치료를 위한 t 세포의 활성화 방법
US11773449B2 (en) 2017-09-01 2023-10-03 The Hospital For Sick Children Profiling and treatment of hypermutant cancer
US20200385815A1 (en) * 2017-12-20 2020-12-10 Nantomics, Llc Using cfRNA for Diagnosing Minimal Residual Disease
JP2021521812A (ja) * 2018-04-25 2021-08-30 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． 免疫療法反応の改善予測バイオマーカーとしての腫瘍機能変異及びエピトープ負荷
WO2020022897A1 (en) 2018-07-26 2020-01-30 Frame Pharmaceuticals B.V. Method of preparing subject-specific immunogenic compositions based on a neo open-reading-frame peptide database
EP3827262A1 (en) 2018-07-26 2021-06-02 Frame Pharmaceuticals B.V. Cancer vaccines for breast cancer
WO2020041561A1 (en) * 2018-08-23 2020-02-27 Nantcell, Inc. Assessing microsatellite instability by liquid biopsy
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WO2020091944A1 (en) * 2018-10-31 2020-05-07 Nantomics, Llc Genomic and immune infiltration differences between msi and mss gi tumors
CN110556164B (zh) * 2019-09-09 2023-02-07 深圳裕策生物科技有限公司 用于目标区域捕获测序检测msi的方法、装置和存储介质
CN110910957B (zh) * 2019-12-31 2023-06-27 求臻医学科技(浙江)有限公司 一种基于单肿瘤样本高通量测序微卫星不稳定性探测位点筛选方法
CN111785324B (zh) * 2020-07-02 2021-02-02 深圳市海普洛斯生物科技有限公司 一种微卫星不稳定分析方法及装置
CN112183557A (zh) * 2020-09-29 2021-01-05 山西医科大学 基于胃癌组织病理图像纹理特征的msi预测模型构建方法
CN114974420A (zh) * 2021-10-29 2022-08-30 无锡臻和生物科技有限公司 预测胃肠肿瘤免疫检查点抑制剂疗效的标志物及其应用

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US11626187B2 (en) 2023-04-11
JP2018532736A (ja) 2018-11-08
US20230307090A1 (en) 2023-09-28
IL258679A (en) 2018-06-28
US20170032082A1 (en) 2017-02-02
EP3362930A1 (en) 2018-08-22
AU2016339035A1 (en) 2018-05-10
CN108701173A (zh) 2018-10-23
WO2017066357A1 (en) 2017-04-20
EP3362930A4 (en) 2019-06-19
KR20180087244A (ko) 2018-08-01
CA3003251A1 (en) 2017-04-20

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