JP2018532689A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018532689A5 JP2018532689A5 JP2018502118A JP2018502118A JP2018532689A5 JP 2018532689 A5 JP2018532689 A5 JP 2018532689A5 JP 2018502118 A JP2018502118 A JP 2018502118A JP 2018502118 A JP2018502118 A JP 2018502118A JP 2018532689 A5 JP2018532689 A5 JP 2018532689A5
- Authority
- JP
- Japan
- Prior art keywords
- functional fragment
- radiolabeled
- seq
- composition according
- vhh
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562193700P | 2015-07-17 | 2015-07-17 | |
| US62/193,700 | 2015-07-17 | ||
| EP16153372 | 2016-01-29 | ||
| EP16153372.4 | 2016-01-29 | ||
| PCT/EP2016/066934 WO2017013026A1 (en) | 2015-07-17 | 2016-07-15 | Radiolabelled antibody fragments for use in treating cancer |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532689A JP2018532689A (ja) | 2018-11-08 |
| JP2018532689A5 true JP2018532689A5 (enExample) | 2019-05-16 |
| JP6917357B2 JP6917357B2 (ja) | 2021-08-11 |
Family
ID=57833837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018502118A Active JP6917357B2 (ja) | 2015-07-17 | 2016-07-15 | 癌治療に使用する放射標識抗体断片 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11298433B2 (enExample) |
| EP (1) | EP3325020B1 (enExample) |
| JP (1) | JP6917357B2 (enExample) |
| KR (2) | KR20180042226A (enExample) |
| CN (1) | CN108025093B (enExample) |
| AU (1) | AU2016294858B2 (enExample) |
| CA (1) | CA2991398A1 (enExample) |
| MX (1) | MX390949B (enExample) |
| WO (1) | WO2017013026A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11517632B2 (en) * | 2017-06-20 | 2022-12-06 | Nanomab Technology Limited | Anti-Her2 single chain antibody and coding sequence and use thereof |
| EP3967674A1 (en) * | 2020-09-11 | 2022-03-16 | Precirix N.V. | Reactions of radioactive compounds facilitated by a solid phase |
| CN112561871B (zh) * | 2020-12-08 | 2021-09-03 | 中国医学科学院北京协和医院 | 一种基于平扫ct图像的主动脉夹层分割方法和装置 |
| KR20230159831A (ko) * | 2021-02-22 | 2023-11-22 | 압데라 테라퓨틱스 인크. | 표적화된 방사성 동위원소 요법을 위한 면역접합체 |
| CN119604536A (zh) * | 2022-05-23 | 2025-03-11 | 塞雷乌斯股份有限公司 | Her2结合剂及其用途 |
| CN121293357A (zh) | 2022-08-22 | 2026-01-09 | 雅博得乐医疗公司 | Dll3结合分子及其用途 |
| CN116719074B (zh) * | 2023-05-29 | 2026-04-07 | 中国核电工程有限公司 | 一种两栖生物辐射剂量率的获取方法及装置 |
| WO2025034806A1 (en) | 2023-08-08 | 2025-02-13 | Wisconsin Alumni Research Foundation | Single-domain antibodies and variants thereof against fibroblast activation protein |
| WO2025195495A1 (zh) * | 2024-03-21 | 2025-09-25 | 启德医药科技（苏州）有限公司 | 一种放射性核素偶联物及其制备方法和用途 |
| WO2026008881A1 (en) | 2024-07-05 | 2026-01-08 | Synaffix B.V. | Extracellular vesicles comprising biomolecule-conjugates |
| US12600794B2 (en) | 2024-07-23 | 2026-04-14 | Abdera Therapeutics Inc. | 5T4 binding polypeptides and uses thereof |
| WO2026030445A1 (en) | 2024-07-30 | 2026-02-05 | Wisconsin Alumni Research Foundation | Degradation targeting agents and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| ATE370235T1 (de) | 1994-09-16 | 2007-09-15 | Cancer Res Fund Of Contra Cost | Rekombinantpeptide hergeleitet vom mc3 antikörper gegen ba46, verfahren zu deren verwendung und verfahren zur humanisierung von antikörperpeptiden |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| JP2000515002A (ja) | 1996-06-27 | 2000-11-14 | フラームス・インテルウニフェルジテール・インスティテュート・フォール・ビオテヒノロジー・ヴェーゼットウェー | 標的分子の活性部位またはクレフトと特異的に相互作用する認識分子 |
| WO1999037681A2 (en) | 1998-01-26 | 1999-07-29 | Unilever Plc | Method for producing antibody fragments |
| WO2000040968A1 (en) | 1999-01-05 | 2000-07-13 | Unilever Plc | Binding of antibody fragments to solid supports |
| AU2291700A (en) | 1999-01-19 | 2000-08-07 | Unilever Plc | Method for producing antibody fragments |
| CN1252264C (zh) | 1999-04-22 | 2006-04-19 | 荷兰联合利华有限公司 | 利用单价抗原－结合蛋白抑制病毒感染 |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| EP1242460B1 (en) | 1999-11-29 | 2006-10-18 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
| WO2001044301A1 (en) | 1999-11-29 | 2001-06-21 | Unilever Plc | Immobilized single domain antigen-binding molecules |
| EP1134231B1 (en) | 2000-03-14 | 2009-04-15 | Unilever N.V. | Antibody heavy chain variable domains against human dietary lipases, and their uses |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| ATE513854T1 (de) | 2000-12-13 | 2011-07-15 | Bac Ip B V | Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen |
| US7371849B2 (en) | 2001-09-13 | 2008-05-13 | Institute For Antibodies Co., Ltd. | Methods of constructing camel antibody libraries |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20050214857A1 (en) | 2001-12-11 | 2005-09-29 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| JP4323317B2 (ja) | 2001-12-21 | 2009-09-02 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 可変領域配列のクローニング方法 |
| WO2003055527A2 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| US20090304590A1 (en) | 2007-05-29 | 2009-12-10 | Wyeth | Therapeutic compositions and methods |
| WO2009068631A1 (en) * | 2007-11-27 | 2009-06-04 | Ablynx N.V. | Method for obtaining polypeptide constructs comprising two or more single domain antibodies |
| EP2143735A1 (en) | 2008-07-10 | 2010-01-13 | Institut Pasteur | Variable domains of camelid heavy-chain antibodies directed against glial fibrillary acidic proteins |
| US20110200525A1 (en) | 2008-10-09 | 2011-08-18 | Patz Jr Edward F | Vhh antibody fragments for use in the detection and treatment of cancer |
| EP3495000A1 (en) * | 2009-02-17 | 2019-06-12 | Cornell Research Foundation, Inc. | Methods and kits for diagnosis of cancer and prediction of therapeutic value |
| WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
| AU2013201422B2 (en) | 2012-01-23 | 2015-04-09 | Ablynx Nv | Sequences directed against hepatocyte growth factor (HFG) and polypeptides comprising the same for the treatment of cancers and/or tumors |
| WO2014140376A1 (en) | 2013-03-15 | 2014-09-18 | Vib Vzw | Anti-macrophage mannose receptor single variable domains for use in cardiovascular diseases |
| WO2014198748A1 (en) * | 2013-06-11 | 2014-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Anti-her2 single domain antibodies, polypeptides comprising thereof and their use for treating cancer |
| WO2015073746A2 (en) | 2013-11-13 | 2015-05-21 | Whitehead Institute For Biomedical Research | 18f labeling of proteins using sortases |
| JP6289733B2 (ja) | 2014-07-29 | 2018-03-07 | フレイエ ユニヴェルシテイト ブリュッセルＶｒｉｊｅ Ｕｎｉｖｅｒｓｉｔｅｉｔ Ｂｒｕｓｓｅｌ | 癌の予防及び／又は治療に用いるための放射標識抗体断片 |
| US20180036442A1 (en) * | 2014-07-29 | 2018-02-08 | Vrije Universiteit Brussel | Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response |
-
2016
- 2016-07-15 WO PCT/EP2016/066934 patent/WO2017013026A1/en not_active Ceased
- 2016-07-15 MX MX2018000598A patent/MX390949B/es unknown
- 2016-07-15 KR KR1020187001952A patent/KR20180042226A/ko not_active Ceased
- 2016-07-15 US US15/742,161 patent/US11298433B2/en active Active
- 2016-07-15 EP EP16745643.3A patent/EP3325020B1/en active Active
- 2016-07-15 JP JP2018502118A patent/JP6917357B2/ja active Active
- 2016-07-15 CA CA2991398A patent/CA2991398A1/en active Pending
- 2016-07-15 KR KR1020257039216A patent/KR20250174696A/ko active Pending
- 2016-07-15 AU AU2016294858A patent/AU2016294858B2/en active Active
- 2016-07-15 CN CN201680053382.1A patent/CN108025093B/zh active Active
-
2022
- 2022-03-11 US US17/692,315 patent/US12440586B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Tolmachev | Imaging of HER-2 overexpression in tumors for guiding therapy | |
| US20250345466A1 (en) | Dota-hapten compositions for anti-dota/anti-tumor antigen bispecific antibody pretargeted radioimmunotherapy | |
| Tolmachev et al. | Affibody molecules: potential for in vivo imaging of molecular targets for cancer therapy | |
| Sugiura et al. | Radiolabeling strategies for tumor-targeting proteinaceous drugs | |
| Engfeldt et al. | Imaging of HER2-expressing tumours using a synthetic Affibody molecule containing the 99mTc-chelating mercaptoacetyl-glycyl-glycyl-glycyl (MAG3) sequence | |
| Rinne et al. | PET and SPECT imaging of the EGFR family (RTK class I) in oncology | |
| JP6917357B2 (ja) | 癌治療に使用する放射標識抗体断片 | |
| JP2020512281A5 (enExample) | ||
| JP2021525805A5 (enExample) | ||
| Mitran et al. | Radionuclide imaging of VEGFR2 in glioma vasculature using biparatopic affibody conjugate: proof-of-principle in a murine model | |
| Reddy et al. | Immuno-positron emission tomography in cancer models | |
| Tolmachev et al. | Optimal specific radioactivity of anti-HER2 Affibody molecules enables discrimination between xenografts with high and low HER2 expression levels | |
| Lindegren et al. | Binding affinity, specificity and comparative biodistribution of the parental murine monoclonal antibody MX35 (Anti-NaPi2b) and its humanized version Rebmab200 | |
| Walther et al. | Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT | |
| JP2016528299A5 (enExample) | ||
| Wållberg et al. | Design and evaluation of radiolabeled tracers for tumor imaging | |
| Sarcan et al. | Monoclonal antibodies and immuno-PET imaging: An overview | |
| Salsano et al. | PET imaging using radiolabelled antibodies: future direction in tumor diagnosis and correlate applications | |
| Wållberg et al. | Evaluation of the radiocobalt-labeled [MMA-DOTA-Cys61]-ZHER2: 2395-Cys affibody molecule for targeting of HER2-expressing tumors | |
| Niu et al. | Molecular imaging of human epidermal growth factor receptor 2 (HER-2) expression | |
| Kong et al. | Managing Lymphoma with Non‐FDG Radiotracers: Current Clinical and Preclinical Applications | |
| Suman et al. | Synthesis and preliminary evaluation of 99mTc-Hynic-fragments [F (ab') 2 and F (ab')] of Rituximab as radioimmunoscintigraphic agents for patients with Non-Hodgkin's lymphoma | |
| JP2009292815A (ja) | 腫瘍診断に使用するための抗−Ｍｅｔモノクローナル抗体、そのフラグメントおよび誘導体、対応する組成物およびキット | |
| CA3163311A1 (en) | Multimodal fluorine-cy3/5/7-dota-hapten compositions, diagnostics, fluorescence guided surgery and radioimmunotherapy | |
| Goldsmith et al. | An overview of the diagnostic and therapeutic use of monoclonal antibodies in medicine |