JP2018532403A5 - - Google Patents
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- Publication number
- JP2018532403A5 JP2018532403A5 JP2018516030A JP2018516030A JP2018532403A5 JP 2018532403 A5 JP2018532403 A5 JP 2018532403A5 JP 2018516030 A JP2018516030 A JP 2018516030A JP 2018516030 A JP2018516030 A JP 2018516030A JP 2018532403 A5 JP2018532403 A5 JP 2018532403A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- item
- tissue
- guide rna
- genome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234340P | 2015-09-29 | 2015-09-29 | |
| US62/234,340 | 2015-09-29 | ||
| PCT/US2016/053960 WO2017058793A1 (en) | 2015-09-29 | 2016-09-27 | Delivery methods and compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018532403A JP2018532403A (ja) | 2018-11-08 |
| JP2018532403A5 true JP2018532403A5 (https=) | 2019-10-31 |
Family
ID=58408949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516030A Pending JP2018532403A (ja) | 2015-09-29 | 2016-09-27 | 送達方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20170087224A1 (https=) |
| EP (1) | EP3355954A4 (https=) |
| JP (1) | JP2018532403A (https=) |
| CN (1) | CN108601883A (https=) |
| AU (1) | AU2016332704A1 (https=) |
| CA (1) | CA2999922A1 (https=) |
| HK (1) | HK1258900A1 (https=) |
| WO (1) | WO2017058793A1 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| EP3474760B1 (en) | 2016-06-27 | 2023-01-11 | Galvanize Therapeutics, Inc. | Generator and a catheter with an electrode for treating a lung passageway |
| US12403305B2 (en) | 2016-06-27 | 2025-09-02 | Galvanize Therapeutics, Inc. | Immunostimulation in the treatment of viral infection |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR102622411B1 (ko) | 2016-10-14 | 2024-01-10 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
| KR20240116572A (ko) | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| KR20250107288A (ko) | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| DK3731771T3 (da) | 2017-12-26 | 2023-08-28 | Galvanize Therapeutics Inc | V462033dk00 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020015279A1 (zh) * | 2018-07-17 | 2020-01-23 | 杭州观梓健康科技有限公司 | 一种在干细胞中进行基因定向敲入的方法 |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020102532A1 (en) * | 2018-11-15 | 2020-05-22 | President And Fellows Of Harvard College | Genetically engineered skin cells for the systemic in vivo treatment of deficient enzymes, factors or proteins |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12098429B2 (en) * | 2019-03-25 | 2024-09-24 | The Chinese University Of Hong Kong | Determining linear and circular forms of circulating nucleic acids |
| CN113556970B (zh) * | 2019-04-08 | 2025-07-15 | 维兰尼迪科技有限责任公司 | 用于在微纳米环境中感测、检测和实现的系统、设备和方法 |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN118203401A (zh) | 2019-04-18 | 2024-06-18 | 盖能适治疗股份有限公司 | 用于治疗异常组织的装置、系统和方法 |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| IL297761A (en) | 2020-05-08 | 2022-12-01 | Broad Inst Inc | Methods and compositions for simultaneously editing two helices of a designated double-helix nucleotide sequence |
| CN115666529B (zh) * | 2020-05-29 | 2025-06-06 | 佐治亚科技研究公司 | 用于促进药物的组织递送的装置、系统及方法 |
| EP4192572A4 (en) * | 2020-08-04 | 2024-08-21 | Galvanize Therapeutics, Inc. | TRANSFER OF MOLECULES BY PULSED ELECTRIC FIELD TO CELLS IN THE ORGANISM |
| CN116829691A (zh) * | 2020-08-04 | 2023-09-29 | 盖能适治疗股份有限公司 | 分子到体内细胞的脉冲电场转移 |
| CN112807273B (zh) * | 2021-02-23 | 2022-06-17 | 浙江大学 | 一种治疗炎症性皮肤病的基因编辑微针及其应用 |
| JP2023094496A (ja) * | 2021-12-23 | 2023-07-05 | 委子 陌間 | 抗菌・ウイルス治療薬の製造方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713291B2 (en) * | 1999-01-28 | 2004-03-30 | Alan D. King | Electrodes coated with treating agent and uses thereof |
| JP2004535813A (ja) * | 2001-07-17 | 2004-12-02 | ミルナー，アン，ジョセフィーヌ | 遺伝子発現のサイレンシング |
| ES2751916T3 (es) * | 2010-02-08 | 2020-04-02 | Sangamo Therapeutics Inc | Semidominios de escisión genomanipulados |
| US10537725B2 (en) * | 2010-03-05 | 2020-01-21 | Cornell University | Ultrasound-assisted convection enhanced delivery of compounds in vivo with a transducer cannula assembly |
| SG10201804975PA (en) * | 2013-12-12 | 2018-07-30 | Broad Inst Inc | Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders |
| US10286084B2 (en) * | 2014-02-18 | 2019-05-14 | Duke University | Compositions for the inactivation of virus replication and methods of making and using the same |
| WO2015184259A1 (en) * | 2014-05-30 | 2015-12-03 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods to treat latent viral infections |
| WO2016196282A1 (en) * | 2015-05-29 | 2016-12-08 | Agenovir Corporation | Compositions and methods for cell targeted hpv treatment |
| EP3420077A4 (en) * | 2016-02-25 | 2019-12-25 | Agenovir Corporation | VIRAL AND ONCOVIRAL NUCLEASE TREATMENT |
-
2016
- 2016-09-27 JP JP2018516030A patent/JP2018532403A/ja active Pending
- 2016-09-27 CA CA2999922A patent/CA2999922A1/en not_active Abandoned
- 2016-09-27 US US15/277,595 patent/US20170087224A1/en not_active Abandoned
- 2016-09-27 AU AU2016332704A patent/AU2016332704A1/en not_active Abandoned
- 2016-09-27 HK HK19101376.1A patent/HK1258900A1/zh unknown
- 2016-09-27 CN CN201680068693.5A patent/CN108601883A/zh active Pending
- 2016-09-27 EP EP16852411.4A patent/EP3355954A4/en not_active Withdrawn
- 2016-09-27 WO PCT/US2016/053960 patent/WO2017058793A1/en not_active Ceased
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