JP2018531929A5 - - Google Patents
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- Publication number
- JP2018531929A5 JP2018531929A5 JP2018515468A JP2018515468A JP2018531929A5 JP 2018531929 A5 JP2018531929 A5 JP 2018531929A5 JP 2018515468 A JP2018515468 A JP 2018515468A JP 2018515468 A JP2018515468 A JP 2018515468A JP 2018531929 A5 JP2018531929 A5 JP 2018531929A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- subject
- liver disease
- neuronal loss
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562233002P | 2015-09-25 | 2015-09-25 | |
| US62/233,002 | 2015-09-25 | ||
| PCT/US2016/053176 WO2017053613A1 (en) | 2015-09-25 | 2016-09-22 | Treatment and prevention of neuronal cell loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018531929A JP2018531929A (ja) | 2018-11-01 |
| JP2018531929A5 true JP2018531929A5 (cg-RX-API-DMAC7.html) | 2019-11-07 |
| JP6989495B2 JP6989495B2 (ja) | 2022-01-05 |
Family
ID=58387333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515468A Active JP6989495B2 (ja) | 2015-09-25 | 2016-09-22 | Ｌ−オルニチンをフェニルアセテートおよびフェニルブチレートのうちの少なくとも１つと組み合わせて用いる神経細胞喪失の治療および予防 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200206174A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3352748A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6989495B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016325556B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2998490A1 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1257679A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017053613A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA025735B1 (ru) | 2009-06-08 | 2017-01-30 | ЮСиЭл БИЗНЕС ПиЭлСи | Способ лечения портальной гипертензии с использованием l-орнитина в сочетании по меньшей мере с одним из соединений, выбранных из фенилацетата и фенилбутирата |
| NZ732632A (en) | 2014-11-24 | 2021-07-30 | Ucl Business Ltd | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| CA3004331A1 (en) * | 2015-11-13 | 2017-05-18 | Ocera Therapeutics, Inc. | Formulations of l-ornithine phenylacetate |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| CN111295187A (zh) | 2017-08-14 | 2020-06-16 | 胺细拉健康公司 | 用于治疗肝脏疾病的氨基酸组合物 |
| CA3100944A1 (en) * | 2018-05-22 | 2019-11-28 | Duke University | Compositions and methods for treating neurodegenerative disorders with rifaximin |
| AR115585A1 (es) | 2018-06-20 | 2021-02-03 | Axcella Health Inc | Composiciones y métodos para el tratamiento de la infiltración de grasa en músculo |
| JP2022533569A (ja) * | 2019-05-09 | 2022-07-25 | オセラ セラピューティクス， インコーポレイテッド | 肝性脳症を評価および処置する方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| CN1304723A (zh) * | 2001-01-16 | 2001-07-25 | 中山大学 | 含二氢呋喃环结构的丹参酮类化合物用于治疗肝性脑病的药物 |
| PT2153870E (pt) * | 2004-11-26 | 2014-03-12 | Ucl Business Plc | Composições compreendendo ornitina e fenilacetato ou fenilbutirato para tratamento de encefalopatia hepática |
| NZ708458A (en) | 2009-04-03 | 2017-02-24 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| EA025735B1 (ru) * | 2009-06-08 | 2017-01-30 | ЮСиЭл БИЗНЕС ПиЭлСи | Способ лечения портальной гипертензии с использованием l-орнитина в сочетании по меньшей мере с одним из соединений, выбранных из фенилацетата и фенилбутирата |
-
2016
- 2016-09-22 JP JP2018515468A patent/JP6989495B2/ja active Active
- 2016-09-22 AU AU2016325556A patent/AU2016325556B2/en active Active
- 2016-09-22 WO PCT/US2016/053176 patent/WO2017053613A1/en not_active Ceased
- 2016-09-22 US US15/751,442 patent/US20200206174A1/en not_active Abandoned
- 2016-09-22 CA CA2998490A patent/CA2998490A1/en not_active Abandoned
- 2016-09-22 EP EP16849626.3A patent/EP3352748A4/en not_active Withdrawn
- 2016-09-22 HK HK19100043.6A patent/HK1257679A1/zh unknown
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