JP2018530593A - 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ - Google Patents

統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ Download PDF

Info

Publication number
JP2018530593A
JP2018530593A JP2018519482A JP2018519482A JP2018530593A JP 2018530593 A JP2018530593 A JP 2018530593A JP 2018519482 A JP2018519482 A JP 2018519482A JP 2018519482 A JP2018519482 A JP 2018519482A JP 2018530593 A JP2018530593 A JP 2018530593A
Authority
JP
Japan
Prior art keywords
pyrrolidine
amino
hydroxy
carbonyl
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018519482A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018530593A5 (enExample
Inventor
ジョセフ アール モスカル
ジョセフ アール モスカル
ヘバート メルツァー
ヘバート メルツァー
Original Assignee
ノースウェスタン ユニバーシティ
ノースウェスタン ユニバーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノースウェスタン ユニバーシティ, ノースウェスタン ユニバーシティ filed Critical ノースウェスタン ユニバーシティ
Publication of JP2018530593A publication Critical patent/JP2018530593A/ja
Publication of JP2018530593A5 publication Critical patent/JP2018530593A5/ja
Priority to JP2022107539A priority Critical patent/JP2022140441A/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2018519482A 2015-10-16 2016-10-14 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ Pending JP2018530593A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2022107539A JP2022140441A (ja) 2015-10-16 2022-07-04 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562242633P 2015-10-16 2015-10-16
US62/242,633 2015-10-16
PCT/US2016/057071 WO2017066590A1 (en) 2015-10-16 2016-10-14 Pharmaceutical combination of an atypical antipsychotic and an nmda modulator for the treatment of schizophrenia,bipolar disorder, cognitive impairment and major depressive disorder

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2022107539A Division JP2022140441A (ja) 2015-10-16 2022-07-04 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ

Publications (2)

Publication Number Publication Date
JP2018530593A true JP2018530593A (ja) 2018-10-18
JP2018530593A5 JP2018530593A5 (enExample) 2019-11-28

Family

ID=57178579

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2018519482A Pending JP2018530593A (ja) 2015-10-16 2016-10-14 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ
JP2022107539A Pending JP2022140441A (ja) 2015-10-16 2022-07-04 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2022107539A Pending JP2022140441A (ja) 2015-10-16 2022-07-04 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ

Country Status (10)

Country Link
US (1) US20180325893A1 (enExample)
EP (1) EP3362080A1 (enExample)
JP (2) JP2018530593A (enExample)
KR (1) KR20180102052A (enExample)
CN (1) CN108601814A (enExample)
AU (2) AU2016340080A1 (enExample)
BR (1) BR112018007681A2 (enExample)
CA (1) CA3002070A1 (enExample)
MX (1) MX2018004553A (enExample)
WO (1) WO2017066590A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017100599A1 (en) 2015-12-09 2017-06-15 Luc Therapeutics Thienopyrimidinone nmda receptor modulators and uses thereof
ES2821010T3 (es) 2015-12-09 2021-04-23 Cadent Therapeutics Inc Moduladores heteroaromáticos del receptor NMDA y usos de los mismos
AU2017382339B2 (en) 2016-12-22 2024-02-15 Novartis Ag NMDA receptor modulators and uses thereof
US20200199173A1 (en) * 2017-07-28 2020-06-25 Naurex, Inc. Process and intermediates for synthesis of peptide compounds
BR112020009310A2 (pt) 2017-11-14 2020-10-13 Sk Biopharmaceuticals Co., Ltd. combinação e composição farmacêutica para a prevenção, alívio ou tratamento da esquizofrenia.
DK3505157T3 (da) 2017-12-29 2022-02-28 Celon Pharma Sa Tørpulver-ketaminsammensætning til pulmonal indgivelse ved behandlingsresistent depression
PT3830092T (pt) 2018-08-03 2023-07-25 Novartis Ag Moduladores do recetor nmda heteroaromáticos e suas utilizações
US20220024976A1 (en) * 2019-01-11 2022-01-27 Naurex Inc. Salt and crystalline forms of rapastinel
KR20210060843A (ko) 2019-11-19 2021-05-27 뉴트라팜주식회사 기억력 및 인지기능 개선, 조현병 예방, 치료 또는 개선용 조성물

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009169A1 (en) * 2002-02-25 2004-01-15 Julie Taylor Administration of agents for the treatment of inflammation
JP2012193180A (ja) * 2005-04-15 2012-10-11 Macrogenics Inc 共有結合型ダイアボディとその使用
WO2014059326A2 (en) * 2012-10-12 2014-04-17 Northwestern University Methods of identifying compounds for treating depression and other related diseases
JP2014520072A (ja) * 2011-04-27 2014-08-21 ノースウエスタン ユニバーシティ アルツハイマー病、ハンチントン病、自閉症及びその他の疾患を治療する方法
JP2015502941A (ja) * 2011-12-02 2015-01-29 大日本住友製薬株式会社 少なくとも１つのｃｎｓ障害の治療、予防、および／または管理のためのルラシドン新規投与レジメンおよびその使用
WO2015089503A2 (en) * 2013-12-13 2015-06-18 Northwestern University Methods of treating brain disorders or identifying biomarkers related thereto
JP2015522075A (ja) * 2012-07-12 2015-08-03 ダニエル・シー・ジャヴィット ヒトにおけるうつ病及び精神病の治療のための組成物及び方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5902815A (en) * 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
WO2006066121A2 (en) * 2004-12-16 2006-06-22 Janssen Pharmaceutica N.V. Combination of a glycine transporter (glyt1) inhibitor and an antipsychotic for the treatment of symptoms of schizophrenia as well as its preparation and use thereof
EP2485751B1 (en) * 2009-10-05 2014-05-21 Northwestern University GLYX-13 for use in a method of treating refractory depression
KR101692275B1 (ko) * 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
SG10201501050RA (en) * 2010-02-11 2015-04-29 Univ Northwestern Secondary Structure Stabilized NMDA Receptor Modulators And Uses Thereof
BR112016025910A8 (pt) * 2014-05-06 2021-07-13 Univ Northwestern uso de uma quantidade eficaz de glyx-13, uso de glyx-13 e um antagonista de nmdar e composição farmaceuticamente aceitável compreendendo os mesmos
KR20170040351A (ko) * 2014-08-14 2017-04-12 노렉스, 인크. Nmda 조절인자를 사용하여 우울증을 치료하는 방법

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040009169A1 (en) * 2002-02-25 2004-01-15 Julie Taylor Administration of agents for the treatment of inflammation
JP2005526045A (ja) * 2002-02-25 2005-09-02 エラン ファーマシューティカルズ，インコーポレイテッド 炎症の治療用薬剤の投与
JP2012193180A (ja) * 2005-04-15 2012-10-11 Macrogenics Inc 共有結合型ダイアボディとその使用
JP2014520072A (ja) * 2011-04-27 2014-08-21 ノースウエスタン ユニバーシティ アルツハイマー病、ハンチントン病、自閉症及びその他の疾患を治療する方法
JP2015502941A (ja) * 2011-12-02 2015-01-29 大日本住友製薬株式会社 少なくとも１つのｃｎｓ障害の治療、予防、および／または管理のためのルラシドン新規投与レジメンおよびその使用
JP2015522075A (ja) * 2012-07-12 2015-08-03 ダニエル・シー・ジャヴィット ヒトにおけるうつ病及び精神病の治療のための組成物及び方法
WO2014059326A2 (en) * 2012-10-12 2014-04-17 Northwestern University Methods of identifying compounds for treating depression and other related diseases
WO2015089503A2 (en) * 2013-12-13 2015-06-18 Northwestern University Methods of treating brain disorders or identifying biomarkers related thereto

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BEHAVIOURAL BRAIN RESEARCH, vol. 244, JPN6020042348, 2013, pages 66 - 69, ISSN: 0004717926 *
BRAIN MEDICAL, vol. 24(3), JPN6020042346, 2012, pages 74 - 79, ISSN: 0004717924 *
J.CLIN.PSYCHIATRY, vol. 74(5), JPN6020042347, 2013, pages 507 - 515, ISSN: 0004717925 *
THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 293(1), JPN6020042352, 2000, pages 8 - 14, ISSN: 0004717927 *

Also Published As

Publication number Publication date
RU2018116882A3 (enExample) 2020-02-18
US20180325893A1 (en) 2018-11-15
EP3362080A1 (en) 2018-08-22
CA3002070A1 (en) 2017-04-20
JP2022140441A (ja) 2022-09-26
BR112018007681A2 (en) 2018-11-06
KR20180102052A (ko) 2018-09-14
CN108601814A (zh) 2018-09-28
AU2016340080A1 (en) 2018-05-10
AU2023216827A1 (en) 2023-09-07
MX2018004553A (es) 2019-04-15
WO2017066590A1 (en) 2017-04-20
RU2018116882A (ru) 2019-11-18

Similar Documents

Publication Publication Date Title
AU2019204073B2 (en) NMDA receptor modulators and uses thereof
JP2022140441A (ja) 統合失調症、双極性障害、認知障害及び大うつ病性障害の治療のための非定型的抗精神病薬ならびにｎｍｄａ調節剤の医薬品の組み合わせ
US10195179B2 (en) Spiro-lactam NMDA receptor modulators and uses thereof
US20230192693A1 (en) Spiro-lactam nmda modulators and methods of using same
US9932347B2 (en) Spiro-lactam NMDA receptor modulators and uses thereof
JP2016506962A (ja) スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
CN108026049B (zh) 用于治疗和预防神经退化性病症的组合物和方法
BR112019001926A2 (pt) moduladores do receptor nmda espiro-lactama e bis-espiro-lactama e usos destes
CN105229011A (zh) 螺-内酰胺nmda受体调节剂及其用途
RU2802972C2 (ru) Фармацевтическая комбинация атипичного антипсихотика и модулятора nmda для лечения шизофрении, биполярного расстройства, когнитивного нарушения и клинической депрессии
EA042012B1 (ru) Спиролактамовые модуляторы nmda-рецептора и их применение

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191015

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20191015

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20201105

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210204

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210405

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210506

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210624

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210924

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20211124

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20220302