JP2018529759A5 - - Google Patents
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- Publication number
- JP2018529759A5 JP2018529759A5 JP2018526974A JP2018526974A JP2018529759A5 JP 2018529759 A5 JP2018529759 A5 JP 2018529759A5 JP 2018526974 A JP2018526974 A JP 2018526974A JP 2018526974 A JP2018526974 A JP 2018526974A JP 2018529759 A5 JP2018529759 A5 JP 2018529759A5
- Authority
- JP
- Japan
- Prior art keywords
- sequence
- rna molecule
- target region
- inhibitor
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 25
- 239000003112 inhibitor Substances 0.000 claims description 20
- 102100039290 Gap junction gamma-1 protein Human genes 0.000 claims description 16
- 101710178004 Gap junction gamma-1 protein Proteins 0.000 claims description 16
- 108020004707 nucleic acids Proteins 0.000 claims description 13
- 102000039446 nucleic acids Human genes 0.000 claims description 13
- 150000007523 nucleic acids Chemical group 0.000 claims description 13
- 206010003119 arrhythmia Diseases 0.000 claims description 12
- 230000006793 arrhythmia Effects 0.000 claims description 12
- 239000013598 vector Substances 0.000 claims description 12
- 230000002159 abnormal effect Effects 0.000 claims description 11
- 230000000295 complement effect Effects 0.000 claims description 10
- 208000010125 myocardial infarction Diseases 0.000 claims description 10
- 230000000747 cardiac effect Effects 0.000 claims description 8
- 230000004064 dysfunction Effects 0.000 claims description 8
- 206010006578 Bundle-Branch Block Diseases 0.000 claims description 6
- 206010047281 Ventricular arrhythmia Diseases 0.000 claims description 6
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims description 5
- 206010071186 Ventricular dyssynchrony Diseases 0.000 claims description 5
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 108020004999 messenger RNA Proteins 0.000 claims description 5
- 239000002773 nucleotide Substances 0.000 claims description 5
- 125000003729 nucleotide group Chemical group 0.000 claims description 5
- 206010049418 Sudden Cardiac Death Diseases 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 206010003671 Atrioventricular Block Diseases 0.000 claims description 3
- 206010006580 Bundle branch block left Diseases 0.000 claims description 3
- 206010006582 Bundle branch block right Diseases 0.000 claims description 3
- 238000007914 intraventricular administration Methods 0.000 claims description 3
- 201000001715 left bundle branch hemiblock Diseases 0.000 claims description 3
- 201000007916 right bundle branch block Diseases 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 238000000306 qrs interval Methods 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 15
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 19
- 241000702421 Dependoparvovirus Species 0.000 description 3
- 208000003663 ventricular fibrillation Diseases 0.000 description 2
- 206010047302 ventricular tachycardia Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021104925A JP7668686B2 (ja) | 2015-08-14 | 2021-06-24 | 治療用コネキシン４５阻害剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015903282A AU2015903282A0 (en) | 2015-08-14 | Connexin 45 Inhibition for Therapy | |
| AU2015903282 | 2015-08-14 | ||
| PCT/AU2016/050740 WO2017027910A1 (en) | 2015-08-14 | 2016-08-12 | Connexin 45 inhibition for therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021104925A Division JP7668686B2 (ja) | 2015-08-14 | 2021-06-24 | 治療用コネキシン４５阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529759A JP2018529759A (ja) | 2018-10-11 |
| JP2018529759A5 true JP2018529759A5 (cg-RX-API-DMAC7.html) | 2020-12-24 |
Family
ID=58050389
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018526974A Pending JP2018529759A (ja) | 2015-08-14 | 2016-08-12 | 治療用コネキシン４５阻害剤 |
| JP2021104925A Active JP7668686B2 (ja) | 2015-08-14 | 2021-06-24 | 治療用コネキシン４５阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021104925A Active JP7668686B2 (ja) | 2015-08-14 | 2021-06-24 | 治療用コネキシン４５阻害剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10709726B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3334746B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2018529759A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016309948B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3033909A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017027910A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200061210A1 (en) * | 2018-08-27 | 2020-02-27 | BioViva USA, Inc. | Novel method for gene therapy using intranasal administration of genetically modified viral vectors |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA962806A (en) | 1970-06-04 | 1975-02-18 | Ontario Research Foundation | Surgical prosthetic device |
| US4101984A (en) | 1975-05-09 | 1978-07-25 | Macgregor David C | Cardiovascular prosthetic devices and implants with porous systems |
| US4281669A (en) | 1975-05-09 | 1981-08-04 | Macgregor David C | Pacemaker electrode with porous system |
| IT1196836B (it) | 1986-12-12 | 1988-11-25 | Sorin Biomedica Spa | Protesi in materiale polimerico con rivestimento di carbonio biocompatibile |
| US5672344A (en) | 1987-12-30 | 1997-09-30 | The Regents Of The University Of Michigan | Viral-mediated gene transfer system |
| US5163958A (en) | 1989-02-02 | 1992-11-17 | Cordis Corporation | Carbon coated tubular endoprosthesis |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US5236457A (en) | 1992-02-27 | 1993-08-17 | Zimmer, Inc. | Method of making an implant having a metallic porous surface |
| US6613749B1 (en) | 1994-07-26 | 2003-09-02 | Imperial College Innovations Limited | Papovavirus pseudocapsids and use thereof for exogenous material transfer |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| JP2000500744A (ja) | 1995-11-09 | 2000-01-25 | マイクロバイオロジカル リサーチ オーソリティー | ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ |
| US20020001574A1 (en) | 1995-12-13 | 2002-01-03 | Jon A. Woiff | Process of delivering a polynucleotide to a muscle cell via the vascular system |
| US5843172A (en) | 1997-04-15 | 1998-12-01 | Advanced Cardiovascular Systems, Inc. | Porous medicated stent |
| US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| DE19855421C2 (de) | 1998-11-02 | 2001-09-20 | Alcove Surfaces Gmbh | Implantat |
| AU2002239436B2 (en) | 2000-10-31 | 2007-04-26 | Cook Medical Technologies Llc | Coated implantable medical device |
| DK1521603T3 (da) | 2002-07-12 | 2011-04-18 | Cook Inc | Coated medicinsk anordning |
| JP2006514848A (ja) | 2002-11-13 | 2006-05-18 | セタゴン インコーポレーティッド | 多孔質層を有する医療装置およびその作製方法 |
| US8090542B2 (en) * | 2002-11-14 | 2012-01-03 | Dharmacon Inc. | Functional and hyperfunctional siRNA |
| CA3059497A1 (en) * | 2003-12-03 | 2005-06-16 | Ocunexus Therapeutics, Inc. | Antisense compounds targeted to connexins and methods of use thereof |
| CN101052717A (zh) * | 2004-05-11 | 2007-10-10 | α基因株式会社 | 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法 |
| JP5964538B2 (ja) * | 2005-02-03 | 2016-08-03 | コーダ セラピューティクス， インコーポレイテッド | 抗コネキシン化合物およびそれらの使用 |
| US20180099029A9 (en) | 2010-04-15 | 2018-04-12 | Mount Sinai School Of Medicine | Serca2 therapeutic compositions and methods of use |
| CA2817256A1 (en) * | 2010-11-12 | 2012-05-18 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| CA2822462A1 (en) * | 2010-12-20 | 2012-06-28 | The General Hospital Corporation | Polycomb-associated non-coding rnas |
| WO2013176772A1 (en) | 2012-05-25 | 2013-11-28 | The Regents Of The University Of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| EP3808844A1 (en) | 2012-07-25 | 2021-04-21 | The Broad Institute, Inc. | Inducible dna binding proteins and genome perturbation tools and applications thereof |
| EP2880171B1 (en) | 2012-08-03 | 2018-10-03 | The Regents of The University of California | Methods and compositions for controlling gene expression by rna processing |
| CN110643600A (zh) | 2012-10-23 | 2020-01-03 | 基因工具股份有限公司 | 用于切割靶dna的系统及其用途 |
| LT3138910T (lt) | 2012-12-06 | 2017-11-10 | Sigma-Aldrich Co. Llc | Crispr pagrįstas genomo modifikavimas ir reguliavimas |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| ES2786193T3 (es) | 2012-12-12 | 2020-10-09 | Broad Inst Inc | Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| EP2840140B2 (en) | 2012-12-12 | 2023-02-22 | The Broad Institute, Inc. | Crispr-Cas based method for mutation of prokaryotic cells |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| SG10201707569YA (en) | 2012-12-12 | 2017-10-30 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
| US20170106047A1 (en) * | 2014-06-12 | 2017-04-20 | The Research Foundation For The State University Of New York | Methods of using gap junctions as therapeutic targets for the treatment of degenerative disorders of the retina |
-
2016
- 2016-08-12 CA CA3033909A patent/CA3033909A1/en active Pending
- 2016-08-12 EP EP16836267.1A patent/EP3334746B1/en active Active
- 2016-08-12 US US15/751,802 patent/US10709726B2/en active Active
- 2016-08-12 JP JP2018526974A patent/JP2018529759A/ja active Pending
- 2016-08-12 WO PCT/AU2016/050740 patent/WO2017027910A1/en not_active Ceased
- 2016-08-12 AU AU2016309948A patent/AU2016309948B2/en active Active
- 2016-08-12 EP EP21209350.4A patent/EP4043074A1/en not_active Withdrawn
-
2021
- 2021-06-24 JP JP2021104925A patent/JP7668686B2/ja active Active
- 2021-08-13 AU AU2021215254A patent/AU2021215254A1/en not_active Abandoned