CA3033909A1 - Connexin 45 inhibition for therapy - Google Patents

Connexin 45 inhibition for therapy Download PDF

Info

Publication number
CA3033909A1
CA3033909A1 CA3033909A CA3033909A CA3033909A1 CA 3033909 A1 CA3033909 A1 CA 3033909A1 CA 3033909 A CA3033909 A CA 3033909A CA 3033909 A CA3033909 A CA 3033909A CA 3033909 A1 CA3033909 A1 CA 3033909A1
Authority
CA
Canada
Prior art keywords
sequence
vector
ventricular
inhibitor
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3033909A
Other languages
English (en)
French (fr)
Inventor
Eddy KIZANA
Peter FAHMY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sydney
Western Sydney Local Health District
Original Assignee
University of Sydney
Western Sydney Local Health District
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2015903282A external-priority patent/AU2015903282A0/en
Application filed by University of Sydney, Western Sydney Local Health District filed Critical University of Sydney
Publication of CA3033909A1 publication Critical patent/CA3033909A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3033909A 2015-08-14 2016-08-12 Connexin 45 inhibition for therapy Pending CA3033909A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903282A AU2015903282A0 (en) 2015-08-14 Connexin 45 Inhibition for Therapy
AU2015903282 2015-08-14
PCT/AU2016/050740 WO2017027910A1 (en) 2015-08-14 2016-08-12 Connexin 45 inhibition for therapy

Publications (1)

Publication Number Publication Date
CA3033909A1 true CA3033909A1 (en) 2017-02-23

Family

ID=58050389

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3033909A Pending CA3033909A1 (en) 2015-08-14 2016-08-12 Connexin 45 inhibition for therapy

Country Status (6)

Country Link
US (1) US10709726B2 (cg-RX-API-DMAC7.html)
EP (2) EP3334746B1 (cg-RX-API-DMAC7.html)
JP (2) JP2018529759A (cg-RX-API-DMAC7.html)
AU (2) AU2016309948B2 (cg-RX-API-DMAC7.html)
CA (1) CA3033909A1 (cg-RX-API-DMAC7.html)
WO (1) WO2017027910A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200061210A1 (en) * 2018-08-27 2020-02-27 BioViva USA, Inc. Novel method for gene therapy using intranasal administration of genetically modified viral vectors

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA962806A (en) 1970-06-04 1975-02-18 Ontario Research Foundation Surgical prosthetic device
US4101984A (en) 1975-05-09 1978-07-25 Macgregor David C Cardiovascular prosthetic devices and implants with porous systems
US4281669A (en) 1975-05-09 1981-08-04 Macgregor David C Pacemaker electrode with porous system
IT1196836B (it) 1986-12-12 1988-11-25 Sorin Biomedica Spa Protesi in materiale polimerico con rivestimento di carbonio biocompatibile
US5672344A (en) 1987-12-30 1997-09-30 The Regents Of The University Of Michigan Viral-mediated gene transfer system
US5163958A (en) 1989-02-02 1992-11-17 Cordis Corporation Carbon coated tubular endoprosthesis
US5302523A (en) 1989-06-21 1994-04-12 Zeneca Limited Transformation of plant cells
US5236457A (en) 1992-02-27 1993-08-17 Zimmer, Inc. Method of making an implant having a metallic porous surface
US6613749B1 (en) 1994-07-26 2003-09-02 Imperial College Innovations Limited Papovavirus pseudocapsids and use thereof for exogenous material transfer
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
JP2000500744A (ja) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ
US20020001574A1 (en) 1995-12-13 2002-01-03 Jon A. Woiff Process of delivering a polynucleotide to a muscle cell via the vascular system
US5843172A (en) 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
DE19855421C2 (de) 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
AU2002239436B2 (en) 2000-10-31 2007-04-26 Cook Medical Technologies Llc Coated implantable medical device
DK1521603T3 (da) 2002-07-12 2011-04-18 Cook Inc Coated medicinsk anordning
JP2006514848A (ja) 2002-11-13 2006-05-18 セタゴン インコーポレーティッド 多孔質層を有する医療装置およびその作製方法
US8090542B2 (en) * 2002-11-14 2012-01-03 Dharmacon Inc. Functional and hyperfunctional siRNA
CA3059497A1 (en) * 2003-12-03 2005-06-16 Ocunexus Therapeutics, Inc. Antisense compounds targeted to connexins and methods of use thereof
CN101052717A (zh) * 2004-05-11 2007-10-10 α基因株式会社 诱发rna干扰的多核苷酸以及使用该多核苷酸的基因表达抑制方法
JP5964538B2 (ja) * 2005-02-03 2016-08-03 コーダ セラピューティクス， インコーポレイテッド 抗コネキシン化合物およびそれらの使用
US20180099029A9 (en) 2010-04-15 2018-04-12 Mount Sinai School Of Medicine Serca2 therapeutic compositions and methods of use
CA2817256A1 (en) * 2010-11-12 2012-05-18 The General Hospital Corporation Polycomb-associated non-coding rnas
CA2822462A1 (en) * 2010-12-20 2012-06-28 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013176772A1 (en) 2012-05-25 2013-11-28 The Regents Of The University Of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
EP3808844A1 (en) 2012-07-25 2021-04-21 The Broad Institute, Inc. Inducible dna binding proteins and genome perturbation tools and applications thereof
EP2880171B1 (en) 2012-08-03 2018-10-03 The Regents of The University of California Methods and compositions for controlling gene expression by rna processing
CN110643600A (zh) 2012-10-23 2020-01-03 基因工具股份有限公司 用于切割靶dna的系统及其用途
LT3138910T (lt) 2012-12-06 2017-11-10 Sigma-Aldrich Co. Llc Crispr pagrįstas genomo modifikavimas ir reguliavimas
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
ES2786193T3 (es) 2012-12-12 2020-10-09 Broad Inst Inc Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
WO2014093655A2 (en) 2012-12-12 2014-06-19 The Broad Institute, Inc. Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
EP2840140B2 (en) 2012-12-12 2023-02-22 The Broad Institute, Inc. Crispr-Cas based method for mutation of prokaryotic cells
US20140310830A1 (en) 2012-12-12 2014-10-16 Feng Zhang CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
SG10201707569YA (en) 2012-12-12 2017-10-30 Broad Inst Inc Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
US20170106047A1 (en) * 2014-06-12 2017-04-20 The Research Foundation For The State University Of New York Methods of using gap junctions as therapeutic targets for the treatment of degenerative disorders of the retina

Also Published As

Publication number Publication date
JP2018529759A (ja) 2018-10-11
EP3334746B1 (en) 2021-11-24
JP7668686B2 (ja) 2025-04-25
EP3334746A1 (en) 2018-06-20
EP3334746A4 (en) 2019-04-24
AU2021215254A1 (en) 2021-09-02
US20190030063A1 (en) 2019-01-31
AU2016309948B2 (en) 2021-05-20
JP2021176848A (ja) 2021-11-11
EP4043074A1 (en) 2022-08-17
US10709726B2 (en) 2020-07-14
WO2017027910A1 (en) 2017-02-23
AU2016309948A1 (en) 2018-03-08

Similar Documents

Publication Publication Date Title
AU2018311504B2 (en) Cellular models of and therapies for ocular diseases
Galbiati et al. Caveolin-1 expression negatively regulates cell cycle progression by inducing G0/G1 arrest via a p53/p21WAF1/Cip1-dependent mechanism
Mearini et al. Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice
US11806367B2 (en) Methods of treating lysosomal disorders
JP2022543589A (ja) Ｋｌｆ誘導心筋再生
US20200308582A1 (en) Kcnk3-based gene therapy of cardiac arrhythmia
CN116887868A (zh) 达农病的治疗
US20220023384A1 (en) Mybpc3 polypeptides and uses thereof
Sultan et al. Exploring small nucleolar RNA host gene 3 as a therapeutic target in breast cancer through metabolic reprogramming
CN116171325A (zh) 用于eEF1A2的基因疗法载体及其用途
JP2007516230A (ja) 心臓組織の変性を治療及び予防するための組成物及び方法並びにその用途
JP7668686B2 (ja) 治療用コネキシン４５阻害剤
EP3285813B1 (en) Smad7 gene delivery as a therapeutic
Pratt et al. Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency
US20230313182A1 (en) Preparation method for diabetes early warning and/or diagnostic reagent kit based on hsa-mir-320a, medicament for preventing diabetes, screening method for medicament, and preparation method therefor
CN118697878B (zh) Cd36作为抑制肺癌脑膜转移的分子标志物和治疗靶点的应用
RU2773358C2 (ru) Композиции и способы усиления экспрессии гена pklr
Hanns et al. Screening for pro-adhesive compounds and their relevance as therapeutic approach in Arrhythmogenic Cardiomyopathy
US20220349876A1 (en) Use of dkk1 inhibitor in prevention and/or treatment of tumor cachexia and diseases associated with diabetes
Sacal Inherited Arrhythmogenic Cardiac Diseases and the Kir2. 1-NaV1. 5 Channelosome
WO2025030125A1 (en) Applications of cmya5 minigenes
WO2025060840A1 (zh) Bcor和Zc3h12a在预防和治疗慢性感染中的用途
CN120860261A (zh) Angulin-1基因和/或Angulin-1蛋白在制备抗衰老及治疗衰老相关疾病的产品中的应用
HK40016634A (en) Methods of treating lysosomal disorders
KR20110039527A (ko) 마이크로 ｒｎａ분자를 포함하는 항암 조성물

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803

EEER Examination request

Effective date: 20210803