AU2016309948B2 - Connexin 45 inhibition for therapy - Google Patents

Connexin 45 inhibition for therapy Download PDF

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Publication number
AU2016309948B2
AU2016309948B2 AU2016309948A AU2016309948A AU2016309948B2 AU 2016309948 B2 AU2016309948 B2 AU 2016309948B2 AU 2016309948 A AU2016309948 A AU 2016309948A AU 2016309948 A AU2016309948 A AU 2016309948A AU 2016309948 B2 AU2016309948 B2 AU 2016309948B2
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AU
Australia
Prior art keywords
sequence
inhibitor
vector
ventricular
nucleic acid
Prior art date
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AU2016309948A
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English (en)
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AU2016309948A1 (en
Inventor
Peter FAHMY
Eddy KIZANA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Sydney
Western Sydney Local Health District
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University of Sydney
Western Sydney Local Health District
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Filing date
Publication date
Priority claimed from AU2015903282A external-priority patent/AU2015903282A0/en
Application filed by University of Sydney, Western Sydney Local Health District filed Critical University of Sydney
Publication of AU2016309948A1 publication Critical patent/AU2016309948A1/en
Application granted granted Critical
Publication of AU2016309948B2 publication Critical patent/AU2016309948B2/en
Priority to AU2021215254A priority Critical patent/AU2021215254A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2016309948A 2015-08-14 2016-08-12 Connexin 45 inhibition for therapy Active AU2016309948B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2021215254A AU2021215254A1 (en) 2015-08-14 2021-08-13 Connexin 45 Inhibition for Therapy

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2015903282A AU2015903282A0 (en) 2015-08-14 Connexin 45 Inhibition for Therapy
AU2015903282 2015-08-14
PCT/AU2016/050740 WO2017027910A1 (en) 2015-08-14 2016-08-12 Connexin 45 inhibition for therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2021215254A Division AU2021215254A1 (en) 2015-08-14 2021-08-13 Connexin 45 Inhibition for Therapy

Publications (2)

Publication Number Publication Date
AU2016309948A1 AU2016309948A1 (en) 2018-03-08
AU2016309948B2 true AU2016309948B2 (en) 2021-05-20

Family

ID=58050389

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2016309948A Active AU2016309948B2 (en) 2015-08-14 2016-08-12 Connexin 45 inhibition for therapy
AU2021215254A Abandoned AU2021215254A1 (en) 2015-08-14 2021-08-13 Connexin 45 Inhibition for Therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2021215254A Abandoned AU2021215254A1 (en) 2015-08-14 2021-08-13 Connexin 45 Inhibition for Therapy

Country Status (6)

Country Link
US (1) US10709726B2 (cg-RX-API-DMAC7.html)
EP (2) EP3334746B1 (cg-RX-API-DMAC7.html)
JP (2) JP2018529759A (cg-RX-API-DMAC7.html)
AU (2) AU2016309948B2 (cg-RX-API-DMAC7.html)
CA (1) CA3033909A1 (cg-RX-API-DMAC7.html)
WO (1) WO2017027910A1 (cg-RX-API-DMAC7.html)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20200061210A1 (en) * 2018-08-27 2020-02-27 BioViva USA, Inc. Novel method for gene therapy using intranasal administration of genetically modified viral vectors

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2005053600A2 (en) * 2003-12-03 2005-06-16 Coda Therapeutics (Nz) Ltd Antisense compounds targeted to connexins and methods of use thereof
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof
WO2012065143A1 (en) * 2010-11-12 2012-05-18 The General Hospital Corporation Polycomb-associated non-coding rnas

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IT1196836B (it) 1986-12-12 1988-11-25 Sorin Biomedica Spa Protesi in materiale polimerico con rivestimento di carbonio biocompatibile
US5672344A (en) 1987-12-30 1997-09-30 The Regents Of The University Of Michigan Viral-mediated gene transfer system
US5163958A (en) 1989-02-02 1992-11-17 Cordis Corporation Carbon coated tubular endoprosthesis
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US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
JP2000500744A (ja) 1995-11-09 2000-01-25 マイクロバイオロジカル リサーチ オーソリティー ワクチン接種および遺伝子治療のためのマイクロカプセル化ｄｎａ
US20020001574A1 (en) 1995-12-13 2002-01-03 Jon A. Woiff Process of delivering a polynucleotide to a muscle cell via the vascular system
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US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
DE19855421C2 (de) 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
AU2002239436B2 (en) 2000-10-31 2007-04-26 Cook Medical Technologies Llc Coated implantable medical device
DK1521603T3 (da) 2002-07-12 2011-04-18 Cook Inc Coated medicinsk anordning
JP2006514848A (ja) 2002-11-13 2006-05-18 セタゴン インコーポレーティッド 多孔質層を有する医療装置およびその作製方法
US8090542B2 (en) * 2002-11-14 2012-01-03 Dharmacon Inc. Functional and hyperfunctional siRNA
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US20180099029A9 (en) 2010-04-15 2018-04-12 Mount Sinai School Of Medicine Serca2 therapeutic compositions and methods of use
CA2822462A1 (en) * 2010-12-20 2012-06-28 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013176772A1 (en) 2012-05-25 2013-11-28 The Regents Of The University Of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
EP3808844A1 (en) 2012-07-25 2021-04-21 The Broad Institute, Inc. Inducible dna binding proteins and genome perturbation tools and applications thereof
EP2880171B1 (en) 2012-08-03 2018-10-03 The Regents of The University of California Methods and compositions for controlling gene expression by rna processing
CN110643600A (zh) 2012-10-23 2020-01-03 基因工具股份有限公司 用于切割靶dna的系统及其用途
LT3138910T (lt) 2012-12-06 2017-11-10 Sigma-Aldrich Co. Llc Crispr pagrįstas genomo modifikavimas ir reguliavimas
US8697359B1 (en) 2012-12-12 2014-04-15 The Broad Institute, Inc. CRISPR-Cas systems and methods for altering expression of gene products
ES2786193T3 (es) 2012-12-12 2020-10-09 Broad Inst Inc Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005053600A2 (en) * 2003-12-03 2005-06-16 Coda Therapeutics (Nz) Ltd Antisense compounds targeted to connexins and methods of use thereof
WO2006134494A2 (en) * 2005-02-03 2006-12-21 Coda Therapeutics Limited Anti-connexin compounds and therapeutic uses thereof
WO2012065143A1 (en) * 2010-11-12 2012-05-18 The General Hospital Corporation Polycomb-associated non-coding rnas

Also Published As

Publication number Publication date
JP2018529759A (ja) 2018-10-11
EP3334746B1 (en) 2021-11-24
JP7668686B2 (ja) 2025-04-25
EP3334746A1 (en) 2018-06-20
EP3334746A4 (en) 2019-04-24
AU2021215254A1 (en) 2021-09-02
US20190030063A1 (en) 2019-01-31
CA3033909A1 (en) 2017-02-23
JP2021176848A (ja) 2021-11-11
EP4043074A1 (en) 2022-08-17
US10709726B2 (en) 2020-07-14
WO2017027910A1 (en) 2017-02-23
AU2016309948A1 (en) 2018-03-08

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