JP2018529666A5 - - Google Patents
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- Publication number
- JP2018529666A5 JP2018529666A5 JP2018511381A JP2018511381A JP2018529666A5 JP 2018529666 A5 JP2018529666 A5 JP 2018529666A5 JP 2018511381 A JP2018511381 A JP 2018511381A JP 2018511381 A JP2018511381 A JP 2018511381A JP 2018529666 A5 JP2018529666 A5 JP 2018529666A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- hydroxyacetoxy
- cyclopentyl
- carboxymethyl
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 53
- KTCKPDPJTAUEPP-UHFFFAOYSA-N 2-[3-(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy-1-methylpyrrolidin-1-ium-1-yl]acetate Chemical compound C1[N+](C)(CC([O-])=O)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 KTCKPDPJTAUEPP-UHFFFAOYSA-N 0.000 claims description 50
- 150000003839 salts Chemical class 0.000 claims description 50
- 150000001875 compounds Chemical class 0.000 claims description 42
- 230000004379 myopia Effects 0.000 claims description 18
- 208000001491 myopia Diseases 0.000 claims description 18
- 239000008194 pharmaceutical composition Substances 0.000 claims description 8
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 230000004515 progressive myopia Effects 0.000 claims description 4
- 238000011200 topical administration Methods 0.000 claims description 2
- 230000003442 weekly effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 description 12
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020134413A JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461952342P | 2014-03-13 | 2014-03-13 | |
| US14/845,645 | 2015-09-04 | ||
| US14/845,645 US10632067B2 (en) | 2014-03-13 | 2015-09-04 | Use of selected anticholinergic zwitterions |
| PCT/US2016/049047 WO2017040307A1 (en) | 2014-03-13 | 2016-08-26 | Use of selected anticholinergic zwitterions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020134413A Division JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529666A JP2018529666A (ja) | 2018-10-11 |
| JP2018529666A5 true JP2018529666A5 (OSRAM) | 2019-10-03 |
| JP6750900B2 JP6750900B2 (ja) | 2020-09-02 |
Family
ID=54072392
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556253A Withdrawn JP2017507959A (ja) | 2014-03-13 | 2015-03-12 | 選択された抗コリン作動性両性イオンの使用 |
| JP2018511381A Active JP6750900B2 (ja) | 2014-03-13 | 2016-08-26 | 選択された抗コリン作用性双性イオンの使用 |
| JP2020050858A Active JP6732356B2 (ja) | 2014-03-13 | 2020-03-23 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020115416A Active JP6968457B2 (ja) | 2014-03-13 | 2020-07-03 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020134413A Active JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016556253A Withdrawn JP2017507959A (ja) | 2014-03-13 | 2015-03-12 | 選択された抗コリン作動性両性イオンの使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020050858A Active JP6732356B2 (ja) | 2014-03-13 | 2020-03-23 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020115416A Active JP6968457B2 (ja) | 2014-03-13 | 2020-07-03 | 選択された抗コリン作動性両性イオンの使用 |
| JP2020134413A Active JP6981694B2 (ja) | 2014-03-13 | 2020-08-07 | 選択された抗コリン作用性双性イオンの使用 |
Country Status (3)
| Country | Link |
|---|---|
| US (2) | US10632067B2 (OSRAM) |
| JP (5) | JP2017507959A (OSRAM) |
| WO (2) | WO2015138700A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150259283A1 (en) | 2014-03-13 | 2015-09-17 | Brickell Biotech, Inc. | Formulation for soft anticholinergic analogs |
| WO2015138700A1 (en) * | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
| KR20180030893A (ko) | 2015-07-21 | 2018-03-26 | 보도르 라보래토리즈, 인크. | 연성 항콜린제 유사체를 위한 제제 |
| CA3029621A1 (en) * | 2016-07-01 | 2018-01-04 | Bodor Laboratories, Inc. | Compositions and methods for treatment of copd |
| TWI719046B (zh) * | 2016-07-21 | 2021-02-21 | 美商波德實驗股份有限公司 | 軟性抗膽鹼類似物之製劑 |
| IL298974A (en) * | 2020-06-11 | 2023-02-01 | Univ Columbia | METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING MYOPIA WITH FENOTEROL HYDROBROMIDE, A β2- ADRENERGIC RECEPTOR AGONIST, AND DERIVATIVES THEREOF |
| CN116133665A (zh) * | 2020-06-11 | 2023-05-16 | 纽约市哥伦比亚大学理事会 | 用于用鞘氨醇-1-磷酸受体调节剂芬戈莫德及其衍生物预防和治疗近视的方法和组合物 |
| KR20230051153A (ko) * | 2020-06-11 | 2023-04-17 | 더 트러스티스 오브 콜롬비아 유니버시티 인 더 시티 오브 뉴욕 | 히스톤 데아세틸레이스(hdac) 저해제인 트라이코스타틴 a 및 이의 유도체를 이용한 근시의 예방 및 치료를 위한 방법 및 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002515008A (ja) * | 1994-10-27 | 2002-05-21 | メルク エンド カンパニー インコーポレーテッド | ムスカリン・アンタゴニスト |
| US6433003B1 (en) | 1999-04-23 | 2002-08-13 | Arthur M. Bobrove | Method for treating hyperhidrosis in mammals |
| EP1438001A4 (en) | 2001-09-26 | 2006-03-15 | Alison B Lukacsko | COMPOSITIONS AND METHODS FOR INHIBITING ECCRINS PERSPIRATION IN HUMANS |
| EP1948596B1 (en) * | 2005-11-10 | 2011-10-19 | Nicholas S. Bodor | Soft anticholinergic esters |
| US7417147B2 (en) * | 2005-11-10 | 2008-08-26 | Bodor Nicholas S | Soft anticholinergic zwitterions |
| JP2007308398A (ja) * | 2006-05-17 | 2007-11-29 | Chang Gung Memorial Hospital | 目薬、及びその製造方法 |
| CN101616640B (zh) * | 2006-12-26 | 2013-02-27 | Qlt插入传输公司 | 用于抑制视觉缺陷的给药植入体 |
| EP2200550B1 (en) | 2007-10-18 | 2018-04-18 | Rose U, LLC | Topical glycopyrrolate formulations |
| DK2968267T3 (en) | 2013-03-15 | 2018-06-25 | Bodor Laboratories Inc | SOFT ANTICHOLINERGE ESTERS FOR TREATMENT OF HYPERHIDROSE |
| WO2015138700A1 (en) | 2014-03-13 | 2015-09-17 | Bodor Laboratories, Inc. | Use of selected anticholinergic zwitterions |
-
2015
- 2015-03-12 WO PCT/US2015/020137 patent/WO2015138700A1/en not_active Ceased
- 2015-03-12 JP JP2016556253A patent/JP2017507959A/ja not_active Withdrawn
- 2015-09-04 US US14/845,645 patent/US10632067B2/en active Active
-
2016
- 2016-08-26 WO PCT/US2016/049047 patent/WO2017040307A1/en not_active Ceased
- 2016-08-26 US US15/757,534 patent/US10335367B2/en active Active
- 2016-08-26 JP JP2018511381A patent/JP6750900B2/ja active Active
-
2020
- 2020-03-23 JP JP2020050858A patent/JP6732356B2/ja active Active
- 2020-07-03 JP JP2020115416A patent/JP6968457B2/ja active Active
- 2020-08-07 JP JP2020134413A patent/JP6981694B2/ja active Active
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