JP2018528424A5 - - Google Patents
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- Publication number
- JP2018528424A5 JP2018528424A5 JP2018510376A JP2018510376A JP2018528424A5 JP 2018528424 A5 JP2018528424 A5 JP 2018528424A5 JP 2018510376 A JP2018510376 A JP 2018510376A JP 2018510376 A JP2018510376 A JP 2018510376A JP 2018528424 A5 JP2018528424 A5 JP 2018528424A5
- Authority
- JP
- Japan
- Prior art keywords
- probe tip
- analyte
- immersing
- antibody
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 60
- 239000012491 analyte Substances 0.000 claims 27
- 238000000034 method Methods 0.000 claims 18
- 239000003153 chemical reaction reagent Substances 0.000 claims 12
- 238000004020 luminiscence type Methods 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 12
- 238000010828 elution Methods 0.000 claims 11
- 238000004140 cleaning Methods 0.000 claims 8
- 230000003321 amplification Effects 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 238000003199 nucleic acid amplification method Methods 0.000 claims 4
- 239000012488 sample solution Substances 0.000 claims 4
- 238000005406 washing Methods 0.000 claims 4
- 150000004676 glycans Chemical class 0.000 claims 3
- 229920001282 polysaccharide Polymers 0.000 claims 3
- 239000005017 polysaccharide Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 239000007850 fluorescent dye Substances 0.000 claims 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
- 108010090804 Streptavidin Proteins 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 125000005228 aryl sulfonate group Chemical group 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- HWYHZTIRURJOHG-UHFFFAOYSA-N luminol Chemical compound O=C1NNC(=O)C2=C1C(N)=CC=C2 HWYHZTIRURJOHG-UHFFFAOYSA-N 0.000 claims 1
- RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical compound C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 claims 1
- -1 ruthenium (II) tris-bipyridine Chemical compound 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- ANRHNWWPFJCPAZ-UHFFFAOYSA-M thionine Chemical compound [Cl-].C1=CC(N)=CC2=[S+]C3=CC(N)=CC=C3N=C21 ANRHNWWPFJCPAZ-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562210372P | 2015-08-26 | 2015-08-26 | |
| US62/210,372 | 2015-08-26 | ||
| PCT/US2016/048672 WO2017035343A1 (en) | 2015-08-26 | 2016-08-25 | Immunoassay with enhanced sensitivity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018528424A JP2018528424A (ja) | 2018-09-27 |
| JP2018528424A5 true JP2018528424A5 (https=) | 2019-08-29 |
| JP6820319B2 JP6820319B2 (ja) | 2021-01-27 |
Family
ID=58101001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510376A Active JP6820319B2 (ja) | 2015-08-26 | 2016-08-25 | 増強された感度を有するイムノアッセイ |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10809251B2 (https=) |
| EP (1) | EP3341726B1 (https=) |
| JP (1) | JP6820319B2 (https=) |
| CN (1) | CN107923908B (https=) |
| WO (1) | WO2017035343A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3946737B1 (en) * | 2019-04-03 | 2025-06-04 | Access Medical Systems, Ltd. | Method for re-using hapten-coated probe in an immunoassay |
| US12399173B2 (en) * | 2019-10-09 | 2025-08-26 | Access Medical Systems, Ltd. | Method for re-using test probe and reagents in biochemical assay based on interferometry |
| CN115698055A (zh) * | 2020-06-05 | 2023-02-03 | 万迈医疗仪器有限公司 | 用于确定抗体解离速率的方法 |
| US12590976B2 (en) * | 2020-12-23 | 2026-03-31 | Access Medical Systems, Ltd. | Detection method using both fluorescence and chemiluminescence labels |
| CN114994302B (zh) * | 2022-06-09 | 2024-11-22 | 星童医疗技术(苏州)有限公司 | 免疫类体外诊断试剂检测结果有效性确定方法及系统 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US4891321A (en) * | 1987-10-21 | 1990-01-02 | Hubscher Thomas T | Apparatus for performing determinations of immune reactants in biological fluids |
| US5650334A (en) | 1995-08-31 | 1997-07-22 | First Medical, Inc. | Fluorescent labelling compositions and methods for their use |
| EP1347301A1 (en) * | 2000-12-01 | 2003-09-24 | International Reagents Corporation | Method for ultra-rapid and ultra-sensitive measurement |
| ATE476494T1 (de) * | 2003-02-24 | 2010-08-15 | Pritest Inc | Lichtdurchlässige festmatrix-prüfvorrichtung zur mikroarray-analyse |
| CN100420947C (zh) * | 2005-05-30 | 2008-09-24 | 孙东旭 | 用单一捕获剂定量检测特异性分析物的方法及其试剂盒 |
| EP2404162B1 (en) * | 2009-03-03 | 2017-12-27 | Access Medical System Co., Ltd. | Detection system and method for high sensitivity fluorescent assays |
| CN103608675B (zh) * | 2011-04-20 | 2015-07-22 | 万迈医疗仪器有限公司 | 发光聚合物循环扩增 |
| US8293487B1 (en) * | 2012-01-06 | 2012-10-23 | Jiandi Zhang | Zestern, a simple, fast, specific and quantifiable improvement of immunodetection process |
| US9568431B2 (en) * | 2012-04-16 | 2017-02-14 | Access Medical Systems, Ltd. | Luminescent immunoassays for quantitating analytes having a wide concentration range |
| CN103115934B (zh) * | 2013-01-29 | 2015-08-12 | 南昌大学 | 一种基于Fe3O4@Au复合纳米粒子的NMR食源性致病菌快速检测方法 |
-
2016
- 2016-08-25 EP EP16840112.3A patent/EP3341726B1/en active Active
- 2016-08-25 CN CN201680047534.7A patent/CN107923908B/zh active Active
- 2016-08-25 JP JP2018510376A patent/JP6820319B2/ja active Active
- 2016-08-25 WO PCT/US2016/048672 patent/WO2017035343A1/en not_active Ceased
-
2018
- 2018-02-23 US US15/903,838 patent/US10809251B2/en active Active
-
2020
- 2020-10-13 US US17/069,591 patent/US12416627B2/en active Active
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