JP2018527295A5 - - Google Patents
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- JP2018527295A5 JP2018527295A5 JP2017566161A JP2017566161A JP2018527295A5 JP 2018527295 A5 JP2018527295 A5 JP 2018527295A5 JP 2017566161 A JP2017566161 A JP 2017566161A JP 2017566161 A JP2017566161 A JP 2017566161A JP 2018527295 A5 JP2018527295 A5 JP 2018527295A5
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- JP
- Japan
- Prior art keywords
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- substituted
- salt
- Prior art date
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- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 101710011551 PTGER4 Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 150000001924 cycloalkanes Chemical class 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- 206010002556 Ankylosing spondylitis Diseases 0.000 claims 2
- 208000007474 Aortic Aneurysm Diseases 0.000 claims 2
- 239000005977 Ethylene Substances 0.000 claims 2
- 208000005726 Inflammatory Breast Neoplasms Diseases 0.000 claims 2
- 206010021980 Inflammatory carcinoma of the breast Diseases 0.000 claims 2
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 201000009273 endometriosis Diseases 0.000 claims 2
- VGGSQFUCUMXWEO-UHFFFAOYSA-N ethene Chemical group C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 125000004043 oxo group Chemical group O=* 0.000 claims 2
- 125000004430 oxygen atoms Chemical group O* 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004434 sulfur atoms Chemical group 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N 289-95-2 Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- -1 5-tetrazolyl Chemical group 0.000 claims 1
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 1
- WBGYLVWDBOGTNU-INIZCTEOSA-N COc1ccc(CN2CCOc3ccnc(N[C@@H](C)c4ccc(cc4)C(O)=O)c23)cc1 Chemical compound COc1ccc(CN2CCOc3ccnc(N[C@@H](C)c4ccc(cc4)C(O)=O)c23)cc1 WBGYLVWDBOGTNU-INIZCTEOSA-N 0.000 claims 1
- ABPSJACXBSUUTJ-HNNXBMFYSA-N C[C@H](Nc1nccc2OCCN(Cc3cccc(Cl)c3)c12)c1ccc(cc1)C(O)=O Chemical compound C[C@H](Nc1nccc2OCCN(Cc3cccc(Cl)c3)c12)c1ccc(cc1)C(O)=O ABPSJACXBSUUTJ-HNNXBMFYSA-N 0.000 claims 1
- AMGKUSVGMAGQLE-UHFFFAOYSA-N FC=1C=C(C=CC=1F)CN1C2=C(OCC1)C=CN=C2NC1(CC1)C1=CC=C(C(=O)O)C=C1 Chemical compound FC=1C=C(C=CC=1F)CN1C2=C(OCC1)C=CN=C2NC1(CC1)C1=CC=C(C(=O)O)C=C1 AMGKUSVGMAGQLE-UHFFFAOYSA-N 0.000 claims 1
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 230000003449 preventive Effects 0.000 claims 1
- 230000000069 prophylaxis Effects 0.000 claims 1
- 239000002464 receptor antagonist Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2244DE2015 | 2015-07-23 | ||
| IN2244/DEL/2015 | 2015-07-23 | ||
| PCT/JP2016/072244 WO2017014323A1 (en) | 2015-07-23 | 2016-07-22 | 1-substituted 1,2,3,4-tetrahydro-1,7-naphthyridin-8-amine derivatives and their use as ep4 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527295A JP2018527295A (ja) | 2018-09-20 |
| JP2018527295A5 true JP2018527295A5 (US07794700-20100914-C00152.png) | 2019-06-13 |
| JP6689297B2 JP6689297B2 (ja) | 2020-04-28 |
Family
ID=56740432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566161A Expired - Fee Related JP6689297B2 (ja) | 2015-07-23 | 2016-07-22 | 複素環化合物 |
Country Status (7)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| SI3625224T1 (sl) | 2017-05-18 | 2021-11-30 | Idorsia Pharmaceuticals Ltd | N-substituirani indolni derivati |
| HUE056080T2 (hu) | 2017-05-18 | 2022-01-28 | Idorsia Pharmaceuticals Ltd | Fenilszármazékok mint PGE2 receptor modulátorok |
| ES2896476T3 (es) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
| TW201900178A (zh) | 2017-05-18 | 2019-01-01 | 瑞士商愛杜西亞製藥有限公司 | 作為pge2受體調節劑之嘧啶衍生物 |
| CN110621671A (zh) | 2017-05-18 | 2019-12-27 | 爱杜西亚药品有限公司 | 作为pge2受体调节剂的苯并呋喃及苯并噻吩衍生物 |
| WO2019147987A1 (en) * | 2018-01-26 | 2019-08-01 | The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Antimicrobial compositions and methods of using the same |
| KR20200118037A (ko) * | 2018-02-05 | 2020-10-14 | 셴젠 이오노바 라이프 사이언스 시오., 엘티디. | 암 또는 염증성 질환들을 치료하기 위한 헤테로비시클릭 카르복시산들 |
| EP3870581B1 (en) | 2018-10-23 | 2023-06-14 | Basf Se | Tricyclic pesticidal compounds |
| CN113727758A (zh) * | 2019-03-01 | 2021-11-30 | 锐新医药公司 | 双环杂环基化合物及其用途 |
| CN112094249B (zh) * | 2019-06-17 | 2022-03-08 | 中国科学院苏州纳米技术与纳米仿生研究所 | 磺胺甲噻二唑-糖精共晶及其制备方法与应用 |
| KR20220100903A (ko) | 2019-11-08 | 2022-07-18 | 레볼루션 메디슨즈, 인크. | 이환식 헤테로아릴 화합물 및 이의 용도 |
| BR112022020641A2 (pt) | 2020-04-14 | 2022-11-29 | Basf Se | Compostos, uso de compostos, mistura pesticida, composições agroquímicas ou veterinárias, métodos para controlar pragas invertebradas, proteger plantas em crescimento e tratar ou proteger animais contra infestação ou infecção por parasitas e semente |
| EP3907214A1 (en) * | 2020-05-04 | 2021-11-10 | Dompe' Farmaceutici S.P.A. | Co-crystal of ketoprofen, lysine and gabapentin, pharmaceutical compositions and their medical use |
| TW202228674A (zh) | 2020-11-13 | 2022-08-01 | 日商小野藥品工業股份有限公司 | 藉由併用ｅｐ４拮抗藥與免疫檢查點抑制物質而進行之癌症治療 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0752421B1 (en) * | 1995-07-07 | 2005-10-12 | AstraZeneca AB | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists |
| ZA973884B (en) | 1996-05-23 | 1998-11-06 | Du Pont Merck Pharma | Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders |
| DE19944767A1 (de) * | 1999-09-17 | 2001-03-29 | Vasopharm Biotech Gmbh & Co Kg | N-substituierte 4-Aminopteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU1071301A (en) | 1999-11-01 | 2001-05-14 | Eli Lilly And Company | Pharmaceutical compounds |
| US20070293532A1 (en) | 2004-07-28 | 2007-12-20 | Takeda Pharmaceutical Compan6Y Limited | Pyrrolo [2,3-C] Pyridine Compound, Process for Producing the Same, and Use |
| CA2590294A1 (en) | 2004-12-13 | 2006-06-22 | Sunesis Pharmaceuticals, Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors |
| TW200838526A (en) * | 2006-12-01 | 2008-10-01 | Astellas Pharma Inc | Carboxylic acid derivatives |
| JP5396379B2 (ja) * | 2007-04-02 | 2014-01-22 | エボテック・アーゲー | ピリド−２−イル縮合複素環式化合物ならびにその組成物および使用 |
| WO2009005076A1 (ja) * | 2007-07-03 | 2009-01-08 | Astellas Pharma Inc. | アミド化合物 |
| EP2565191B1 (en) * | 2008-05-14 | 2014-10-08 | Astellas Pharma Inc. | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexanecarboxylic acid derivatives as EP4 receptor antagonists useful for the treatment of chronic renal failure or diabetic nephropathy |
| JP5536773B2 (ja) * | 2008-08-14 | 2014-07-02 | ベータ・ファーマ・カナダ・インコーポレイテッド | Ｅｐ４受容体アンタゴニストとしてのヘテロ環式アミド誘導体 |
| EP2341052A4 (en) * | 2008-09-05 | 2011-10-12 | Shionogi & Co | RING-CONDENSED MORPHOLINE DERIVATIVITY WITH PI3K-INHIBITING EFFECT |
| EP2375899B1 (en) | 2009-01-12 | 2015-02-25 | Array Biopharma Inc. | Piperidine-containing compounds and use thereof in the treatment of diabetes |
| TW201103904A (en) | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
| RS55566B1 (sr) | 2010-09-21 | 2017-05-31 | Eisai R&D Man Co Ltd | Farmaceutska kompozicija |
| WO2016021742A1 (en) | 2014-08-07 | 2016-02-11 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds as ep4 receptor antagonists |
| WO2016088903A1 (en) | 2014-12-05 | 2016-06-09 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds |
-
2016
- 2016-07-22 EP EP16753995.6A patent/EP3325490B1/en active Active
- 2016-07-22 WO PCT/JP2016/072244 patent/WO2017014323A1/en active Application Filing
- 2016-07-22 DK DK16753995.6T patent/DK3325490T3/da active
- 2016-07-22 CN CN201680042838.4A patent/CN108368127B/zh not_active Expired - Fee Related
- 2016-07-22 JP JP2017566161A patent/JP6689297B2/ja not_active Expired - Fee Related
- 2016-07-22 CA CA2993312A patent/CA2993312A1/en not_active Abandoned
- 2016-07-26 US US15/746,828 patent/US10745397B2/en active Active
-
2020
- 2020-07-06 US US16/921,338 patent/US20200339577A1/en not_active Abandoned
