JP2018527007A - ヒト多能性幹細胞からネフロンを生成する方法 - Google Patents

ヒト多能性幹細胞からネフロンを生成する方法 Download PDF

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JP2018527007A
JP2018527007A JP2018514450A JP2018514450A JP2018527007A JP 2018527007 A JP2018527007 A JP 2018527007A JP 2018514450 A JP2018514450 A JP 2018514450A JP 2018514450 A JP2018514450 A JP 2018514450A JP 2018527007 A JP2018527007 A JP 2018527007A
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differentiation
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nephron
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ジョセフ ブイ． ボンベンター
ジョセフ ブイ． ボンベンター
リュウジ モリザネ
リュウジ モリザネ
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The Brigham and Women's Hospital Inc
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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JP2018514450A 2015-09-17 2016-09-16 ヒト多能性幹細胞からネフロンを生成する方法 Pending JP2018527007A (ja)

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US201562219704P 2015-09-17 2015-09-17
US62/219,704 2015-09-17
PCT/US2016/052350 WO2017049243A1 (en) 2015-09-17 2016-09-16 Methods of generating nephrons from human pluripotent stem cells

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JP2018527007A5 JP2018527007A5 (enExample) 2019-10-17

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Cited By (4)

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WO2020095423A1 (ja) * 2018-11-08 2020-05-14 国立大学法人熊本大学 多能性幹細胞から樹状分岐した集合管を伴う腎臓構造を作製する方法
JPWO2021015245A1 (enExample) * 2019-07-23 2021-01-28
JP2023070667A (ja) * 2021-11-09 2023-05-19 ポステック・リサーチ・アンド・ビジネス・ディベロップメント・ファウンデーション 腎臓オルガノイド及びその製造方法
WO2025192746A1 (ja) * 2024-03-15 2025-09-18 株式会社Racthera 腎臓オルガノイド及びその製造方法

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WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
ES2860423T3 (es) 2014-05-28 2021-10-05 Childrens Hospital Med Ct Métodos y sistemas para convertir células precursoras en tejidos gástricos mediante diferenciación dirigida
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
AU2017335841A1 (en) * 2016-09-28 2019-04-04 Organovo, Inc. Use of engineered renal tissues in assays
SG10202104575WA (en) 2016-11-04 2021-06-29 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
CA3045145A1 (en) 2016-12-05 2018-06-14 Children's Hospital Medical Center Colonic organoids and methods of making and using same
US12281334B2 (en) 2017-04-14 2025-04-22 Children's Hospital Medical Center Multi donor stem cell compositions and methods of making same
WO2018216743A1 (ja) 2017-05-25 2018-11-29 国立大学法人京都大学 中間中胚葉細胞から腎前駆細胞への分化誘導方法、および多能性幹細胞から腎前駆細胞への分化誘導方法
CN110997024A (zh) 2017-06-09 2020-04-10 哈佛大学的校长及成员们 增强肾脏类器官发育的方法及其使用方法
WO2019048689A1 (en) 2017-09-11 2019-03-14 Imba - Institut Für Molekulare Biotechnologie Gmbh TUMOR ORGANOID MODEL
WO2019074793A1 (en) 2017-10-10 2019-04-18 Children's Hospital Medical Center OESOPHAGIAN TISSUE COMPOSITIONS AND / OR ORGANOIDS AND METHODS OF MAKING SAME
KR102946635B1 (ko) * 2017-10-31 2026-04-01 머독 칠드런스 리서치 인스티튜트 조성물 및 방법
CN111417716A (zh) * 2017-11-30 2020-07-14 公立大学法人横滨市立大学 由多潜能干细胞进行的立体器官的构建
US12379372B2 (en) 2017-12-21 2025-08-05 Children's Hospital Medical Center Digitalized human organoids and methods of using same
CA3106634A1 (en) 2018-07-26 2020-01-30 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CN112823012A (zh) 2018-09-12 2021-05-18 儿童医院医学中心 用于产生造血干细胞及其衍生物的类器官组合物
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
EP3927378A1 (en) * 2019-02-21 2021-12-29 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Method for reduction drug-induced nephrotoxicity
US12534709B2 (en) 2019-05-31 2026-01-27 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CA3141807A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CN110468095A (zh) * 2019-09-05 2019-11-19 安徽中盛溯源生物科技有限公司 一种肾上皮细胞及其制备方法和应用
EP4288591A4 (en) * 2021-02-02 2025-02-12 Rosebud Biosciences, Inc. METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF RARE GENETIC DISEASES
US20250333708A1 (en) * 2022-06-03 2025-10-30 The Trustees Of The University Of Pennsylvania Manipulating nephron differentiation rate in induced human pluripotent stem cell organoids and tissues by engineering mechanics of the microenvironment
GB202308793D0 (en) * 2023-06-13 2023-07-26 Astrazeneca Ab Tissue regeneration
WO2025114599A1 (en) * 2023-12-01 2025-06-05 Academisch Ziekenhuis Maastricht Improved kidney organoid culture method by modulating pka
CN117904029A (zh) * 2024-01-22 2024-04-19 上海赛傲生物技术有限公司 人羊膜上皮细胞在制备肾脏类器官中的应用
CN120988975A (zh) * 2025-08-26 2025-11-21 复旦大学附属中山医院 一种多能干细胞衍生肾脏类器官的诱导分化方法

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020095423A1 (ja) * 2018-11-08 2020-05-14 国立大学法人熊本大学 多能性幹細胞から樹状分岐した集合管を伴う腎臓構造を作製する方法
JPWO2021015245A1 (enExample) * 2019-07-23 2021-01-28
WO2021015245A1 (ja) * 2019-07-23 2021-01-28 国立大学法人京都大学 繊毛関連疾患モデルおよびその利用
JP7671987B2 (ja) 2019-07-23 2025-05-07 国立大学法人京都大学 繊毛関連疾患モデルおよびその利用
JP2023070667A (ja) * 2021-11-09 2023-05-19 ポステック・リサーチ・アンド・ビジネス・ディベロップメント・ファウンデーション 腎臓オルガノイド及びその製造方法
US12371669B2 (en) 2021-11-09 2025-07-29 POSTECH Research and Business Development Foundation Kidney organoids and method for producing the same
WO2025192746A1 (ja) * 2024-03-15 2025-09-18 株式会社Racthera 腎臓オルガノイド及びその製造方法

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