JP2018525034A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018525034A5 JP2018525034A5 JP2018527008A JP2018527008A JP2018525034A5 JP 2018525034 A5 JP2018525034 A5 JP 2018525034A5 JP 2018527008 A JP2018527008 A JP 2018527008A JP 2018527008 A JP2018527008 A JP 2018527008A JP 2018525034 A5 JP2018525034 A5 JP 2018525034A5
- Authority
- JP
- Japan
- Prior art keywords
- tumor
- cell receptor
- clone
- nucleic acid
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 206010028980 Neoplasm Diseases 0.000 claims 132
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 111
- 108091008874 T cell receptors Proteins 0.000 claims 110
- 150000007523 nucleic acids Chemical class 0.000 claims 77
- 239000000523 sample Substances 0.000 claims 69
- 125000003275 alpha amino acid group Chemical group 0.000 claims 62
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 30
- 210000001744 T-lymphocyte Anatomy 0.000 claims 22
- 238000002360 preparation method Methods 0.000 claims 17
- 238000000034 method Methods 0.000 claims 16
- 108020004707 nucleic acids Proteins 0.000 claims 15
- 102000039446 nucleic acids Human genes 0.000 claims 15
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- 238000002955 isolation Methods 0.000 claims 9
- 210000004698 lymphocyte Anatomy 0.000 claims 7
- 108020003175 receptors Proteins 0.000 claims 7
- 102000005962 receptors Human genes 0.000 claims 7
- 150000001413 amino acids Chemical class 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims 4
- 239000002853 nucleic acid probe Substances 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 210000000078 claw Anatomy 0.000 claims 1
- 238000010494 dissociation reaction Methods 0.000 claims 1
- 230000005593 dissociations Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180383 | 2015-08-10 | ||
| EP15180383.0 | 2015-08-10 | ||
| EP15202419.6 | 2015-12-23 | ||
| EP15202419 | 2015-12-23 | ||
| PCT/EP2016/069041 WO2017025564A1 (en) | 2015-08-10 | 2016-08-10 | Method for providing tumour-specific t cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018525034A JP2018525034A (ja) | 2018-09-06 |
| JP2018525034A5 true JP2018525034A5 (enExample) | 2019-09-19 |
| JP6815400B2 JP6815400B2 (ja) | 2021-01-20 |
Family
ID=56738102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018527008A Active JP6815400B2 (ja) | 2015-08-10 | 2016-08-10 | 腫瘍特異的ｔ細胞を提供するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20190255162A1 (enExample) |
| EP (2) | EP3372683B1 (enExample) |
| JP (1) | JP6815400B2 (enExample) |
| CA (1) | CA3030959A1 (enExample) |
| DK (2) | DK3180433T3 (enExample) |
| ES (2) | ES2807026T3 (enExample) |
| WO (1) | WO2017025564A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220112557A1 (en) * | 2019-01-10 | 2022-04-14 | Iovance Biotherapeutics, Inc. | System and methods for monitoring adoptive cell therapy clonality and persistence |
| CA3225111A1 (en) | 2021-07-15 | 2023-02-02 | Rudolf Hammer | Identification of common tumor-specific t cell receptors and antigens |
| EP4426320A4 (en) * | 2021-11-03 | 2025-11-05 | Univ Delaware | SYSTEM FOR ADMINISTRATING CELL-DERIVED MICROPARTICLES AND ITS USES |
| CN114530202A (zh) * | 2021-12-20 | 2022-05-24 | 深圳泛因医学有限公司 | 鉴定抗原特异性tcr或bcr的方法及应用 |
| US20250368717A1 (en) | 2022-05-30 | 2025-12-04 | Hs Diagnomics Gmbh | Common tumor-specific t cell receptors |
| EP4649952A1 (en) | 2024-05-14 | 2025-11-19 | HS Diagnomics GmbH | Kras q16h specific t cell receptors and uses thereof |
| WO2025238079A1 (en) | 2024-05-14 | 2025-11-20 | Hs Diagnomics Gmbh | Kras q16h specific t cell receptors and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128153D0 (en) * | 2001-11-23 | 2002-01-16 | Bayer Ag | Profiling of the immune gene repertoire |
| DE102004063339A1 (de) | 2004-12-23 | 2006-07-06 | Bayer Technology Services Gmbh | Sonde zum Nachweis von Nukleinsäuren |
| EP2980225B1 (en) * | 2012-04-20 | 2017-11-08 | Alacris Theranostics GmbH | Cdr sequence-specific enrichment of live immune cells |
| EP2746405B1 (en) | 2012-12-23 | 2015-11-04 | HS Diagnomics GmbH | Methods and primer sets for high throughput PCR sequencing |
| JP6164759B2 (ja) * | 2013-11-21 | 2017-07-19 | Ｒｅｐｅｒｔｏｉｒｅ Ｇｅｎｅｓｉｓ株式会社 | Ｔ細胞受容体およびｂ細胞受容体レパトアの解析システムならびにその治療および診断への利用 |
-
2016
- 2016-08-10 EP EP18167345.0A patent/EP3372683B1/en active Active
- 2016-08-10 EP EP16753630.9A patent/EP3180433B1/en active Active
- 2016-08-10 CA CA3030959A patent/CA3030959A1/en active Pending
- 2016-08-10 DK DK16753630.9T patent/DK3180433T3/en active
- 2016-08-10 DK DK18167345.0T patent/DK3372683T3/da active
- 2016-08-10 JP JP2018527008A patent/JP6815400B2/ja active Active
- 2016-08-10 WO PCT/EP2016/069041 patent/WO2017025564A1/en not_active Ceased
- 2016-08-10 US US15/751,883 patent/US20190255162A1/en not_active Abandoned
- 2016-08-10 ES ES18167345T patent/ES2807026T3/es active Active
- 2016-08-10 ES ES16753630.9T patent/ES2679798T3/es active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018525034A5 (enExample) | ||
| US12351872B2 (en) | Determining antigen-specific T-cells | |
| JP6383789B2 (ja) | 配列タグによる大規模生体分子解析 | |
| Francica et al. | Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization | |
| Warren et al. | Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes | |
| CA2999888C (en) | Affinity-oligonucleotide conjugates and uses thereof | |
| JP2021166532A (ja) | 腫瘍試料の多重遺伝子分析 | |
| US20210087610A9 (en) | Methods for analyzing t cell receptors and b cell receptors | |
| JP6085249B2 (ja) | 複雑なアンプリコンの配列解析 | |
| JP6929354B2 (ja) | 親和性−オリゴヌクレオチドコンジュゲートおよびその使用 | |
| Liu et al. | Characterization of human αβTCR repertoire and discovery of DD fusion in TCRβ chains | |
| JP2013539970A5 (enExample) | ||
| EP4234576A3 (en) | Methods of isolating neoantigen-specific t cell receptor sequences | |
| JP2016000057A5 (enExample) | ||
| JP2015501658A (ja) | 組織浸潤リンパ球の検出および測定方法 | |
| EP2702146A2 (en) | Identification of polynucleotides associated with a sample | |
| US11319590B2 (en) | Enhanced immune cell receptor sequencing methods | |
| WO2008026927A2 (en) | Process for displaying t- and b-cell receptor repertoires | |
| US20210317522A1 (en) | Phenotypic and molecular characterisation of single cells | |
| JP2020527036A5 (enExample) | ||
| JP2019517774A (ja) | 核酸を濃縮及びキャプチャーするためのプローブと設計方法 | |
| WO2015200701A3 (en) | Software haplotying of hla loci | |
| RU2014102617A (ru) | Выявление аффинно-зрелых человеческих антител | |
| JP2014521316A5 (enExample) | ||
| Dambrot et al. | Strategies for rapidly mapping proviral integration sites and assessing cardiogenic potential of nascent human induced pluripotent stem cell clones |