|
DE1445742A1
(de)
|
1963-11-06 |
1968-12-19 |
Bayer Ag |
Verfahren zur Herstellung von 2-Stellung substituierten Benzoxazinonen
|
|
US4017500A
(en)
|
1973-07-16 |
1977-04-12 |
Schering Corporation |
Certain 8-amino-1,7-naphthyridines
|
|
BE786081A
(fr)
*
|
1971-07-13 |
1973-01-10 |
Uniroyal Sa |
Appareil et procede pour maintenir les tringles des bourrelets de pneu
|
|
US5703075A
(en)
|
1988-12-21 |
1997-12-30 |
Pharmacia & Upjohn Company |
Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
|
|
CN1250294A
(zh)
*
|
1999-07-27 |
2000-04-12 |
邮电部武汉邮电科学研究院 |
以太网与同步数字体系或同步光网络融合的适配方法
|
|
HK1044277B
(en)
|
1999-08-03 |
2014-02-28 |
Icos Corporation |
Pharmaceutical formulation comprising a beta-carboline and its use for treating sexual dysfunction
|
|
CN1186324C
(zh)
|
2000-04-27 |
2005-01-26 |
山之内制药株式会社 |
稠合杂芳基衍生物
|
|
US6608053B2
(en)
|
2000-04-27 |
2003-08-19 |
Yamanouchi Pharmaceutical Co., Ltd. |
Fused heteroaryl derivatives
|
|
EP1296975A1
(en)
|
2000-06-30 |
2003-04-02 |
Sugen, Inc. |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
|
|
US6905669B2
(en)
|
2001-04-24 |
2005-06-14 |
Supergen, Inc. |
Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
|
|
EP2277867B1
(en)
|
2002-07-15 |
2012-12-05 |
Symphony Evolution, Inc. |
Compounds, pharmaceutical compositions thereof and their use in treating cancer
|
|
FR2846657B1
(fr)
|
2002-11-05 |
2004-12-24 |
Servier Lab |
Nouveaux composes pyridopyrimidinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
JP4912145B2
(ja)
|
2004-02-26 |
2012-04-11 |
あすか製薬株式会社 |
ピリミジン誘導体
|
|
EP1755609A1
(en)
|
2004-05-25 |
2007-02-28 |
Icos Corporation |
Methods for treating and/or preventing aberrant proliferation of hematopoietic cells
|
|
GB0423653D0
(en)
|
2004-10-25 |
2004-11-24 |
Piramed Ltd |
Pharmaceutical compounds
|
|
CA2609126A1
(en)
|
2005-05-20 |
2006-11-30 |
Vertex Pharmaceuticals Incorporated |
Pyrrolopyridines useful as inhibitors of protein kinase
|
|
TW200738709A
(en)
|
2006-01-19 |
2007-10-16 |
Osi Pharm Inc |
Fused heterobicyclic kinase inhibitors
|
|
JP5302186B2
(ja)
|
2006-04-26 |
2013-10-02 |
エフ.ホフマン−ラ ロシュ アーゲー |
Pi3k阻害剤としてのピリミジン誘導体
|
|
WO2007127183A1
(en)
|
2006-04-26 |
2007-11-08 |
Genentech, Inc. |
Phosphoinositide 3-kinase inhibitor compounds and pharmaceutical compositions containing them
|
|
ATE510840T1
(de)
|
2006-06-26 |
2011-06-15 |
Ucb Pharma Sa |
Kondensierte thiazol-derivate als kinasehemmer
|
|
CN101501035B
(zh)
*
|
2006-08-08 |
2013-01-23 |
中外制药株式会社 |
作为pi3k抑制剂的嘧啶衍生物及其用途
|
|
NZ576997A
(en)
|
2006-11-13 |
2012-02-24 |
Icos Corp |
Thienopyrimidinones for treatment of inflammatory disorders and cancers
|
|
AU2007334343A1
(en)
|
2006-12-15 |
2008-06-26 |
Ordway Research Institute, Inc. |
Treatments of therapy-resistant diseases comprising drug combinations
|
|
NZ578744A
(en)
|
2007-01-31 |
2012-02-24 |
Vertex Pharma |
2-aminopyridine derivatives useful as kinase inhibitors
|
|
US20100063032A1
(en)
|
2007-03-28 |
2010-03-11 |
Debenham John S |
Substituted pyrido[2,3-d]pyrimidine derivatives as cannabinoid-1 receptor modulators
|
|
WO2008150827A1
(en)
|
2007-05-29 |
2008-12-11 |
Smithkline Beecham Corporation |
Naphthyridine, derivatives as p13 kinase inhibitors
|
|
GB0710528D0
(en)
|
2007-06-01 |
2007-07-11 |
Glaxo Group Ltd |
Novel compounds
|
|
JP5658565B2
(ja)
*
|
2007-09-12 |
2015-01-28 |
ジェネンテック, インコーポレイテッド |
ホスホイノシチド3−キナーゼ阻害剤化合物と化学療法剤との組合せ、および使用方法
|
|
EP2324022A1
(de)
|
2008-08-05 |
2011-05-25 |
Boehringer Ingelheim International GmbH |
Substituierte naphthyridine und ihre verwendung als arzneimittel
|
|
AU2009299894A1
(en)
|
2008-10-03 |
2010-04-08 |
Merck Serono S.A. |
4 -morpholino-pyrido [3, 2 -d] pyrimidines active on Pi3k
|
|
GB2465405A
(en)
|
2008-11-10 |
2010-05-19 |
Univ Basel |
Triazine, pyrimidine and pyridine analogues and their use in therapy
|
|
EP2459543B1
(en)
|
2009-07-29 |
2017-08-30 |
Karus Therapeutics Limited |
Benzo[e][1,3]oxazin-4-one derivatives as phosphoinositide 3-kinase inhibitors
|
|
EP2467387B1
(en)
*
|
2009-08-20 |
2015-01-07 |
Karus Therapeutics Limited |
Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors.
|
|
WO2011079231A1
(en)
|
2009-12-23 |
2011-06-30 |
Gatekeeper Pharmaceutical, Inc. |
Compounds that modulate egfr activity and methods for treating or preventing conditions therewith
|
|
GB201007347D0
(en)
|
2010-04-30 |
2010-06-16 |
Karus Therapeutics Ltd |
Compounds
|
|
CN101849934B
(zh)
*
|
2010-05-25 |
2011-11-09 |
苏州大学 |
一种磷脂酰肌醇-3-激酶抑制剂及其应用
|
|
EP2518070A1
(en)
|
2011-04-29 |
2012-10-31 |
Almirall, S.A. |
Pyrrolotriazinone derivatives as PI3K inhibitors
|
|
CN105198862B
(zh)
|
2011-07-27 |
2018-01-23 |
阿斯利康(瑞典)有限公司 |
取代的n‑(4‑氟‑2‑甲氧基‑5‑硝基苯基)嘧啶‑2‑胺化合物及其盐
|
|
WO2013017480A1
(en)
|
2011-07-29 |
2013-02-07 |
Cellzome Limited |
Pyrazolo[4,3-c]pyridine derivatives as jak inhibitors
|
|
GB201204125D0
(en)
|
2012-03-08 |
2012-04-25 |
Karus Therapeutics Ltd |
Compounds
|
|
EP3181564B1
(en)
|
2012-11-20 |
2019-09-18 |
H. Hoffnabb-La Roche Ag |
Aminopyrimidine compounds as inhibitors of t790m containing egfr mutants
|
|
PT2994465T
(pt)
|
2013-05-10 |
2018-10-25 |
Karus Therapeutics Ltd |
Novos inibidores de histona desacetilase
|
|
DK3003309T3
(da)
*
|
2013-05-30 |
2020-12-14 |
Infinity Pharmaceuticals Inc |
Behandling af cancer med PI3-kinase-isoform modulatorer
|
|
WO2014210354A1
(en)
|
2013-06-28 |
2014-12-31 |
Genentech, Inc. |
Azaindazole compounds as inhibitors of t790m containing egfr mutants
|
|
JP6626437B2
(ja)
|
2013-10-08 |
2019-12-25 |
アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. |
ヒストンデアセチラーゼ阻害剤とHer2阻害剤またはPI3K阻害剤のいずれかの組み合わせ
|
|
JP6584391B2
(ja)
|
2013-10-10 |
2019-10-02 |
アセチロン ファーマシューティカルズ インコーポレイテッドAcetylon Pharmaceuticals,Inc. |
非ホジキンリンパ腫を治療するための、hdac阻害剤単独またはpi3k阻害剤との組み合わせ
|
|
GB201321728D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321738D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
GB201321730D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201321729D0
(en)
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic agents
|
|
GB201402431D0
(en)
*
|
2014-02-12 |
2014-03-26 |
Karus Therapeutics Ltd |
Compounds
|
|
MA40933A
(fr)
|
2014-11-11 |
2017-09-19 |
Piqur Therapeutics Ag |
Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
|
|
GB201514758D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Formulation
|
|
GB201514756D0
(en)
*
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compound and method of use
|
|
GB201514760D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds and method of use
|
|
GB201514754D0
(en)
*
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201514751D0
(en)
|
2015-08-19 |
2015-09-30 |
Karus Therapeutics Ltd |
Compounds
|
|
GB201909468D0
(en)
|
2019-07-01 |
2019-08-14 |
Karus Therapeutics Ltd |
Compounds for treating cancer
|