SMT202300063T1 - Composizioni comprendenti inibitori della fosfoinositide 3-chinasi e un secondo agente antiproliferativo - Google Patents

Composizioni comprendenti inibitori della fosfoinositide 3-chinasi e un secondo agente antiproliferativo

Info

Publication number
SMT202300063T1
SMT202300063T1 SM20230063T SMT202300063T SMT202300063T1 SM T202300063 T1 SMT202300063 T1 SM T202300063T1 SM 20230063 T SM20230063 T SM 20230063T SM T202300063 T SMT202300063 T SM T202300063T SM T202300063 T1 SMT202300063 T1 SM T202300063T1
Authority
SM
San Marino
Prior art keywords
phosphoinositide
compositions
kinase inhibitors
antiproliferative agent
antiproliferative
Prior art date
Application number
SM20230063T
Other languages
English (en)
Italian (it)
Inventor
Stephen Joseph Shuttleworth
Andrew David Whale
Original Assignee
Convalife Shanghai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Convalife Shanghai Co Ltd filed Critical Convalife Shanghai Co Ltd
Publication of SMT202300063T1 publication Critical patent/SMT202300063T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SM20230063T 2015-08-19 2016-08-19 Composizioni comprendenti inibitori della fosfoinositide 3-chinasi e un secondo agente antiproliferativo SMT202300063T1 (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1514760.6A GB201514760D0 (en) 2015-08-19 2015-08-19 Compounds and method of use
PCT/GB2016/052575 WO2017029517A1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent
EP16756763.5A EP3337477B1 (en) 2015-08-19 2016-08-19 Compositions comprising phosphoinositide 3-kinase inhibitors and a second antiproliferative agent

Publications (1)

Publication Number Publication Date
SMT202300063T1 true SMT202300063T1 (it) 2023-03-17

Family

ID=54258859

Family Applications (1)

Application Number Title Priority Date Filing Date
SM20230063T SMT202300063T1 (it) 2015-08-19 2016-08-19 Composizioni comprendenti inibitori della fosfoinositide 3-chinasi e un secondo agente antiproliferativo

Country Status (22)

Country Link
US (3) US10668077B2 (cg-RX-API-DMAC7.html)
EP (1) EP3337477B1 (cg-RX-API-DMAC7.html)
JP (1) JP2018523689A (cg-RX-API-DMAC7.html)
KR (1) KR20180064387A (cg-RX-API-DMAC7.html)
CN (2) CN108348505B (cg-RX-API-DMAC7.html)
AU (1) AU2016307885B2 (cg-RX-API-DMAC7.html)
CA (1) CA2995898A1 (cg-RX-API-DMAC7.html)
DK (1) DK3337477T3 (cg-RX-API-DMAC7.html)
ES (1) ES2939815T3 (cg-RX-API-DMAC7.html)
FI (1) FI3337477T3 (cg-RX-API-DMAC7.html)
GB (1) GB201514760D0 (cg-RX-API-DMAC7.html)
HR (1) HRP20230376T1 (cg-RX-API-DMAC7.html)
HU (1) HUE061615T2 (cg-RX-API-DMAC7.html)
IL (1) IL257499A (cg-RX-API-DMAC7.html)
LT (1) LT3337477T (cg-RX-API-DMAC7.html)
MX (1) MX2018001926A (cg-RX-API-DMAC7.html)
PL (1) PL3337477T3 (cg-RX-API-DMAC7.html)
PT (1) PT3337477T (cg-RX-API-DMAC7.html)
RS (1) RS64095B1 (cg-RX-API-DMAC7.html)
SI (1) SI3337477T1 (cg-RX-API-DMAC7.html)
SM (1) SMT202300063T1 (cg-RX-API-DMAC7.html)
WO (1) WO2017029517A1 (cg-RX-API-DMAC7.html)

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GB201402431D0 (en) 2014-02-12 2014-03-26 Karus Therapeutics Ltd Compounds
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GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514758D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Formulation
GB201514760D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds and method of use
GB201514754D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
SG11202102343QA (en) * 2018-09-11 2021-04-29 Curis Inc Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety
US20220008409A1 (en) * 2018-09-18 2022-01-13 Kabushiki Kaisha Yakult Honsha Cancer combination therapy using quinoline carboxamide derivative
HUE067967T2 (hu) * 2019-02-27 2024-12-28 Astrazeneca Ab Szarakatinib idiopátiás tüdõfibrózis kezelésében történõ alkalmazásra
CN111904958B (zh) * 2019-05-09 2022-09-13 浙江大学 Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用
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GB201514754D0 (en) * 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201514751D0 (en) 2015-08-19 2015-09-30 Karus Therapeutics Ltd Compounds
GB201909468D0 (en) 2019-07-01 2019-08-14 Karus Therapeutics Ltd Compounds for treating cancer

Also Published As

Publication number Publication date
PL3337477T3 (pl) 2023-07-03
PT3337477T (pt) 2023-03-20
LT3337477T (lt) 2023-03-10
AU2016307885A1 (en) 2018-03-08
SI3337477T1 (sl) 2023-04-28
ES2939815T3 (es) 2023-04-27
US20230066999A1 (en) 2023-03-02
CN108348505B (zh) 2021-10-12
US20180243313A1 (en) 2018-08-30
CN113786409B (zh) 2024-04-02
CA2995898A1 (en) 2017-02-23
RS64095B1 (sr) 2023-04-28
EP3337477A1 (en) 2018-06-27
WO2017029517A1 (en) 2017-02-23
GB201514760D0 (en) 2015-09-30
CN113786409A (zh) 2021-12-14
KR20180064387A (ko) 2018-06-14
CN108348505A (zh) 2018-07-31
MX2018001926A (es) 2018-06-19
HK1251467A1 (en) 2019-02-01
JP2018523689A (ja) 2018-08-23
US10668077B2 (en) 2020-06-02
HRP20230376T1 (hr) 2023-06-23
AU2016307885B2 (en) 2019-07-25
US11291669B2 (en) 2022-04-05
EP3337477B1 (en) 2023-02-01
US20210069200A1 (en) 2021-03-11
HUE061615T2 (hu) 2023-07-28
DK3337477T3 (en) 2023-02-20
US12257254B2 (en) 2025-03-25
FI3337477T3 (fi) 2023-04-27
IL257499A (en) 2018-07-31

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