JP2018521999A5 - - Google Patents
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- Publication number
- JP2018521999A5 JP2018521999A5 JP2017568205A JP2017568205A JP2018521999A5 JP 2018521999 A5 JP2018521999 A5 JP 2018521999A5 JP 2017568205 A JP2017568205 A JP 2017568205A JP 2017568205 A JP2017568205 A JP 2017568205A JP 2018521999 A5 JP2018521999 A5 JP 2018521999A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- fusion protein
- hvem
- mutation
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021083133A JP2021113240A (ja) | 2015-06-30 | 2021-05-17 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2022115473A JP7559013B2 (ja) | 2015-06-30 | 2022-07-20 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2023210069A JP2024019529A (ja) | 2015-06-30 | 2023-12-13 | Btla融合タンパク質アゴニストおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187105P | 2015-06-30 | 2015-06-30 | |
| US62/187,105 | 2015-06-30 | ||
| PCT/US2016/040108 WO2017004213A1 (en) | 2015-06-30 | 2016-06-29 | Btla fusion protein agonists and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083133A Division JP2021113240A (ja) | 2015-06-30 | 2021-05-17 | Btla融合タンパク質アゴニストおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521999A JP2018521999A (ja) | 2018-08-09 |
| JP2018521999A5 true JP2018521999A5 (https=) | 2019-06-06 |
| JP7116285B2 JP7116285B2 (ja) | 2022-08-10 |
Family
ID=57609132
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017568205A Active JP7116285B2 (ja) | 2015-06-30 | 2016-06-29 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2021083133A Pending JP2021113240A (ja) | 2015-06-30 | 2021-05-17 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2022115473A Active JP7559013B2 (ja) | 2015-06-30 | 2022-07-20 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2023210069A Pending JP2024019529A (ja) | 2015-06-30 | 2023-12-13 | Btla融合タンパク質アゴニストおよびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021083133A Pending JP2021113240A (ja) | 2015-06-30 | 2021-05-17 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2022115473A Active JP7559013B2 (ja) | 2015-06-30 | 2022-07-20 | Btla融合タンパク質アゴニストおよびその使用 |
| JP2023210069A Pending JP2024019529A (ja) | 2015-06-30 | 2023-12-13 | Btla融合タンパク質アゴニストおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10961297B2 (https=) |
| EP (1) | EP3317297A4 (https=) |
| JP (4) | JP7116285B2 (https=) |
| KR (2) | KR102669985B1 (https=) |
| CN (2) | CN108026159B9 (https=) |
| AU (3) | AU2016286108B2 (https=) |
| BR (1) | BR112017028316A2 (https=) |
| CA (1) | CA2990885A1 (https=) |
| EA (1) | EA201890171A1 (https=) |
| IL (2) | IL256383B2 (https=) |
| MX (1) | MX2018000073A (https=) |
| SG (1) | SG10201913567QA (https=) |
| WO (1) | WO2017004213A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| KR102669985B1 (ko) | 2015-06-30 | 2024-05-29 | 샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 | Btla 융합 단백질 작용제 및 이의 용도 |
| GB201820554D0 (en) | 2018-12-17 | 2019-01-30 | Univ Oxford Innovation Ltd | BTLA antibodies |
| GB202008860D0 (en) | 2020-06-11 | 2020-07-29 | Univ Oxford Innovation Ltd | BTLA antibodies |
| WO2023215560A1 (en) | 2022-05-05 | 2023-11-09 | Atoosa Corporation | Tumor cell/immune cell multivalent receptor engager – bio-nanoparticle (timre-bnp) |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291207B1 (en) * | 1995-07-28 | 2001-09-18 | Northwestern University | Herpes virus entry receptor protein |
| TR200504220T2 (tr) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
| US8546541B2 (en) | 2002-06-20 | 2013-10-01 | Washington University | Compositions and methods for modulating lymphocyte activity |
| US20030235580A1 (en) | 2002-06-24 | 2003-12-25 | Fen Zhang | Amniotic membrane mediated delivery of bioactive molecules |
| EP1560593B1 (en) | 2002-10-25 | 2016-04-20 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| WO2006054961A2 (en) * | 2004-11-12 | 2006-05-26 | Genentech, Inc. | Novel composition and methods for the treatment of immune related diseases |
| US8188232B1 (en) | 2004-11-15 | 2012-05-29 | Washington University In St. Louis | Compositions and methods for modulating lymphocyte activity |
| EP1833848A2 (en) * | 2004-12-09 | 2007-09-19 | Lajolla Institute for Allergy and Immunology | Novel tnf receptor regulatory domain |
| WO2010006071A1 (en) * | 2008-07-08 | 2010-01-14 | La Jolla Institute For Allergy And Immunology | Hvem/btla, hvem/cd160 and hvem/gd cis complexes and methods of use |
| US8349320B2 (en) * | 2004-12-09 | 2013-01-08 | La Jolla Institute For Allergy And Immunology | Compositions and methods for modulating responses mediated or associated with BTLA activity |
| WO2007010692A1 (ja) | 2005-07-19 | 2007-01-25 | Japan Science And Technology Agency | Hvem及びbtlaを標的とした炎症性腸疾患治療用医薬組成物及び治療方法 |
| EP2097447A4 (en) | 2006-11-15 | 2010-12-29 | Medarex Inc | HUMAN MONOCLONAL ANTIBODIES AGAINST BTLA AND METHODS OF USE |
| US8318662B2 (en) | 2009-03-16 | 2012-11-27 | Korea Institute Of Radiological & Medical Sciences | Protein increasing cell infectivity of herpes simplex virus and use thereof |
| US8303952B2 (en) | 2009-06-08 | 2012-11-06 | Washington University | Methods for inducing in vivo tolerance |
| BR112012007875A2 (pt) | 2009-07-31 | 2016-11-22 | Medarex Inc | anticorpos totalmente humanos para btla |
| US9982023B2 (en) * | 2011-11-15 | 2018-05-29 | Sanford-Burnham Medical Research Institute | Compositions and methods for treating autoimmune and inflammatory disorders |
| EP3041494A4 (en) | 2013-09-05 | 2017-10-18 | Sanford-Burnham Medical Research Institute | Modulation of gamma delta t cells |
| CA2981304C (en) | 2015-04-02 | 2024-01-02 | Memorial Sloan Kettering Cancer Center | Tnfrsf14/hvem proteins and methods of use thereof |
| EP3288587A4 (en) | 2015-04-29 | 2018-09-12 | Sanford-Burnham Medical Research Institute | Modulation of immune response using btla agonist antibodies |
| KR102669985B1 (ko) | 2015-06-30 | 2024-05-29 | 샌포드 번햄 프레비즈 메디컬 디스커버리 인스티튜트 | Btla 융합 단백질 작용제 및 이의 용도 |
| MX2018010295A (es) | 2016-02-26 | 2019-06-06 | Inst Nat Sante Rech Med | Anticuerpos que tienen especificidad para atenuador de linfocitos b y t (btla) y usos de los mismos. |
| EP3470424B1 (en) * | 2016-06-08 | 2025-04-23 | Shanghai Jiao Tong University School of Medicine | Sequence of antibody heavy chain constant region for enhancing agonist antibody activity |
| CN119950689A (zh) | 2016-07-05 | 2025-05-09 | 北极星药业集团股份有限公司 | 使用精氨酸耗竭剂的组合癌症免疫疗法 |
| US12447213B2 (en) | 2016-10-07 | 2025-10-21 | The Broad Institute, Inc. | Modulation of novel immune checkpoint targets |
| SG11201909160WA (en) | 2017-04-11 | 2019-10-30 | Inhibrx Inc | Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same |
| US20200140547A1 (en) | 2017-05-26 | 2020-05-07 | The Johns Hopkins University | Multifunctional antibody-ligand traps to modulate immune tolerance |
| EP3700536A4 (en) | 2017-10-27 | 2021-11-17 | Shanghai Yao Yuan Biotechnology Co., Ltd. | COMPOSITIONS AND PROCEDURES FOR MODULATING IMMUNE REACTION BY ACTIVATING ALPHA-PROTEIN KINASE 1 |
| EP3707163A4 (en) | 2017-11-09 | 2021-08-18 | The General Hospital Corporation | POLYPEPTIDES ANTAGONISTS OF THE TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY |
| JP7337099B2 (ja) | 2018-05-25 | 2023-09-01 | アレクトル エルエルシー | 抗sirpa抗体およびその使用法 |
| WO2019245817A1 (en) | 2018-06-19 | 2019-12-26 | Armo Biosciences, Inc. | Compositions and methods of use of il-10 agents in conjunction with chimeric antigen receptor cell therapy |
| BR112020026819A2 (pt) | 2018-06-29 | 2021-04-20 | Alector Llc | anticorpos isolados, ácido nucleico, vetor, células hospedeiras, método de produção de um anticorpo, composição farmacêutica, métodos para tratar o câncer e para tratar uma doença e usos de um anticorpo |
| CN112955179A (zh) | 2018-08-20 | 2021-06-11 | 综合医院公司 | 拮抗性抗肿瘤坏死因子受体超家族多肽 |
| EP3849666B1 (en) | 2018-09-14 | 2026-04-15 | Université de Lausanne | Methods for modulating regulatory t cells and inhibiting tumor growth |
| CN113302205B (zh) | 2018-11-15 | 2024-12-06 | 综合医院公司 | 激动性肿瘤坏死因子受体超家族多肽 |
-
2016
- 2016-06-29 KR KR1020187002960A patent/KR102669985B1/ko active Active
- 2016-06-29 EP EP16818691.4A patent/EP3317297A4/en active Pending
- 2016-06-29 CN CN201680049768.5A patent/CN108026159B9/zh active Active
- 2016-06-29 CA CA2990885A patent/CA2990885A1/en active Pending
- 2016-06-29 BR BR112017028316-6A patent/BR112017028316A2/en active Search and Examination
- 2016-06-29 US US15/737,259 patent/US10961297B2/en active Active
- 2016-06-29 SG SG10201913567QA patent/SG10201913567QA/en unknown
- 2016-06-29 EA EA201890171A patent/EA201890171A1/ru unknown
- 2016-06-29 AU AU2016286108A patent/AU2016286108B2/en active Active
- 2016-06-29 WO PCT/US2016/040108 patent/WO2017004213A1/en not_active Ceased
- 2016-06-29 IL IL256383A patent/IL256383B2/en unknown
- 2016-06-29 MX MX2018000073A patent/MX2018000073A/es unknown
- 2016-06-29 JP JP2017568205A patent/JP7116285B2/ja active Active
- 2016-06-29 IL IL297395A patent/IL297395B2/en unknown
- 2016-06-29 KR KR1020247017225A patent/KR20240110000A/ko active Pending
- 2016-06-29 CN CN202210348320.0A patent/CN114853903A/zh active Pending
-
2021
- 2021-03-01 US US17/188,912 patent/US11939367B2/en active Active
- 2021-05-17 JP JP2021083133A patent/JP2021113240A/ja active Pending
- 2021-06-08 AU AU2021203768A patent/AU2021203768B2/en active Active
-
2022
- 2022-07-20 JP JP2022115473A patent/JP7559013B2/ja active Active
-
2023
- 2023-04-14 AU AU2023202302A patent/AU2023202302A1/en not_active Abandoned
- 2023-12-13 JP JP2023210069A patent/JP2024019529A/ja active Pending
-
2024
- 2024-02-15 US US18/442,988 patent/US20240247047A1/en active Pending
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