JP2018521651A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018521651A5 JP2018521651A5 JP2018500943A JP2018500943A JP2018521651A5 JP 2018521651 A5 JP2018521651 A5 JP 2018521651A5 JP 2018500943 A JP2018500943 A JP 2018500943A JP 2018500943 A JP2018500943 A JP 2018500943A JP 2018521651 A5 JP2018521651 A5 JP 2018521651A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- nucleic acid
- expression cassette
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims description 57
- 108020004707 nucleic acids Proteins 0.000 claims description 38
- 102000039446 nucleic acids Human genes 0.000 claims description 38
- 108091026890 Coding region Proteins 0.000 claims description 32
- 239000013598 vector Substances 0.000 claims description 27
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 230000037430 deletion Effects 0.000 claims description 7
- 238000012217 deletion Methods 0.000 claims description 7
- 230000037431 insertion Effects 0.000 claims description 6
- 238000003780 insertion Methods 0.000 claims description 6
- 241000700663 Avipoxvirus Species 0.000 claims description 4
- 241000700629 Orthopoxvirus Species 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 108020005544 Antisense RNA Proteins 0.000 claims description 2
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 2
- 101000796203 Homo sapiens L-dopachrome tautomerase Proteins 0.000 claims description 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 102100034256 Mucin-1 Human genes 0.000 claims description 2
- 108010008707 Mucin-1 Proteins 0.000 claims description 2
- 101100262328 Mus musculus Dct gene Proteins 0.000 claims description 2
- 101100154912 Mus musculus Tyrp1 gene Proteins 0.000 claims description 2
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims description 2
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 2
- 102000000763 Survivin Human genes 0.000 claims description 2
- 108010002687 Survivin Proteins 0.000 claims description 2
- 241000700647 Variola virus Species 0.000 claims description 2
- 230000000890 antigenic effect Effects 0.000 claims description 2
- 239000003184 complementary RNA Substances 0.000 claims description 2
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 238000007792 addition Methods 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 3
- 102100033130 T-box transcription factor T Human genes 0.000 claims 3
- 101710086566 T-box transcription factor T Proteins 0.000 claims 3
- 102100035359 Cerebellar degeneration-related protein 2-like Human genes 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 101000737792 Homo sapiens Cerebellar degeneration-related protein 2-like Proteins 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 108091029795 Intergenic region Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- -1 antigenic epitope Proteins 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199681P | 2015-07-31 | 2015-07-31 | |
| US62/199,681 | 2015-07-31 | ||
| PCT/IB2016/001183 WO2017021776A1 (en) | 2015-07-31 | 2016-07-28 | Promoters for enhancing expression in poxviruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521651A JP2018521651A (ja) | 2018-08-09 |
| JP2018521651A5 true JP2018521651A5 (enExample) | 2019-07-11 |
| JP6851364B2 JP6851364B2 (ja) | 2021-03-31 |
Family
ID=57068152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500943A Active JP6851364B2 (ja) | 2015-07-31 | 2016-07-28 | ポックスウイルスにおける発現を増強するためのプロモーター |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11753652B2 (enExample) |
| EP (1) | EP3329016B1 (enExample) |
| JP (1) | JP6851364B2 (enExample) |
| KR (1) | KR102565284B1 (enExample) |
| CN (1) | CN107922981B (enExample) |
| AU (1) | AU2016303378B2 (enExample) |
| CA (1) | CA2990549A1 (enExample) |
| DK (1) | DK3329016T3 (enExample) |
| ES (1) | ES2901468T3 (enExample) |
| IL (1) | IL256869B (enExample) |
| MX (1) | MX389312B (enExample) |
| RU (1) | RU2753884C2 (enExample) |
| SG (1) | SG10202000447YA (enExample) |
| WO (1) | WO2017021776A1 (enExample) |
| ZA (1) | ZA201800104B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272546B2 (en) | 2017-08-24 | 2024-01-01 | Bavarian Nordic As | Combined therapy for the treatment of cancer with intravenous administration of recombinant MVA and antibody |
| JP2021506300A (ja) | 2017-12-19 | 2021-02-22 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Ｂ型肝炎ウイルス（ｈｂｖ）に対する免疫応答を誘導するための方法および組成物 |
| IL281988B2 (en) | 2018-10-05 | 2025-03-01 | Bavarian Nordic As | Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist |
| JP7625518B2 (ja) | 2018-11-20 | 2025-02-03 | バヴァリアン・ノルディック・アクティーゼルスカブ | ４－１ｂｂｌ（ｃｄ１３７ｌ）及び／またはｃｄ４０ｌをコードする組み換えｍｖａの腫瘍内及び／または静脈内投与によって、がんを治療する療法 |
| BR112022009798A2 (pt) | 2019-11-20 | 2022-10-18 | Bavarian Nordic As | Vírus mva recombinante para administração intratumoral e/ou intravenosa para tratamento de câncer |
| WO2023118563A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Therapy for modulating immune response with recombinant mva encoding il-12 |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| AU2024208643A1 (en) | 2023-01-12 | 2025-06-26 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766598A (en) | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
| EP1380651A2 (en) | 1991-08-26 | 2004-01-14 | Baxter Healthcare S.A. | Recombinant fowlpox virus with intact FPV-tk-gene |
| EP0954593A1 (en) | 1996-07-25 | 1999-11-10 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| RU2180352C2 (ru) * | 1999-11-24 | 2002-03-10 | Государственный научный центр вирусологии и биотехнологии "Вектор" | ФРАГМЕНТ ГЕНОМА ВИРУСА ОСПЫ КУР ШТАММА "К", СОДЕРЖАЩИЙ ГЕН ТИМИДИНКИНАЗЫ, РЕКОМБИНАНТНЫЕ ПЛАЗМИДНЫЕ ДНК pTK1FPV И pTK2FPV, СОДЕРЖАЩИЕ ЭТУ ПОСЛЕДОВАТЕЛЬНОСТЬ, И РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pINTFPV1, ОБЛАДАЮЩАЯ СПОСОБНОСТЬЮ ИНТЕГРИРОВАТЬСЯ В ГЕНОМ ВИРУСА ОСПЫ КУР |
| JP5052893B2 (ja) * | 2003-02-20 | 2012-10-17 | アメリカ合衆国 | ポックスベクターにおける新規の挿入部位 |
| EP1673458A4 (en) * | 2003-10-15 | 2007-12-12 | Virax Dev Pty Ltd | FOR RETROVIRUS (e.g., HIV) AND CYTOKIN-CODING POXVIRUS VECTOR |
| CA2678404C (en) * | 2007-02-28 | 2019-03-19 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Brachyury polypeptides and methods for use |
| CN101775410B (zh) * | 2009-01-09 | 2011-11-16 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种鸡痘病毒载体穿梭质粒及其应用 |
| ES2660597T3 (es) * | 2009-04-17 | 2018-03-23 | Globeimmune, Inc. | Composiciones inmunoterápicas de combinación contra el cáncer y métodos |
| CN102321637A (zh) * | 2011-09-09 | 2012-01-18 | 中国人民解放军军事医学科学院军事兽医研究所 | 中国鸡痘病毒282e4弱毒株全基因组序列及其应用 |
| WO2014043535A1 (en) | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
-
2016
- 2016-07-28 DK DK16775852.3T patent/DK3329016T3/da active
- 2016-07-28 EP EP16775852.3A patent/EP3329016B1/en active Active
- 2016-07-28 SG SG10202000447YA patent/SG10202000447YA/en unknown
- 2016-07-28 JP JP2018500943A patent/JP6851364B2/ja active Active
- 2016-07-28 CN CN201680042251.3A patent/CN107922981B/zh active Active
- 2016-07-28 IL IL256869A patent/IL256869B/en unknown
- 2016-07-28 WO PCT/IB2016/001183 patent/WO2017021776A1/en not_active Ceased
- 2016-07-28 US US15/747,844 patent/US11753652B2/en active Active
- 2016-07-28 ES ES16775852T patent/ES2901468T3/es active Active
- 2016-07-28 RU RU2018106643A patent/RU2753884C2/ru active
- 2016-07-28 MX MX2018001055A patent/MX389312B/es unknown
- 2016-07-28 CA CA2990549A patent/CA2990549A1/en active Pending
- 2016-07-28 AU AU2016303378A patent/AU2016303378B2/en active Active
- 2016-07-28 KR KR1020187000086A patent/KR102565284B1/ko active Active
-
2018
- 2018-01-05 ZA ZA2018/00104A patent/ZA201800104B/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2741724C (en) | Promoters for recombinant viral expression | |
| JP4282095B2 (ja) | Ｃｄ８ ｔ細胞免疫応答を発生するワクチン接種のための方法および試薬 | |
| JP6851364B2 (ja) | ポックスウイルスにおける発現を増強するためのプロモーター | |
| Baur et al. | Immediate-early expression of a recombinant antigen by modified vaccinia virus ankara breaks the immunodominance of strong vector-specific B8R antigen in acute and memory CD8 T-cell responses | |
| JP2016510989A5 (enExample) | ||
| CN1154069A (zh) | 多表位疫苗 | |
| RU2013152648A (ru) | Аденовирус обезьян и гибридные аденовирусные векторы | |
| EP2238255A1 (en) | Replication-defective arenavirus vectors | |
| RU2019112725A (ru) | Композиции и способы для повышения стабильности трансгенов в поксвирусах | |
| IL199128A (en) | Promoters for expression in modified vaccinia virus ankara (mva) and vectors comprising said promoters | |
| JP2019500907A5 (enExample) | ||
| Staib et al. | Improved host range selection for recombinant modified vaccinia virus Ankara | |
| JP2024535145A5 (enExample) | ||
| JP2012513208A (ja) | 単一組換え系及びその使用方法 | |
| JP5639736B2 (ja) | ポックスウイルスゲノムへの異種遺伝子の組込みのためのベクター | |
| US20050287162A1 (en) | Recombinant fowlpox virus | |
| JP2004529646A (ja) | 病原性を低下させたウイルスベクター | |
| CN102732543B (zh) | 以粘蛋白1和生存素为靶点的肿瘤基因工程疫苗 | |
| JP2007511534A5 (enExample) | ||
| JP7034818B2 (ja) | 増殖性ヘルパーワクシニアウイルスを使用するポックスウイルスの製造方法 | |
| DK2864487T3 (en) | COPPER VIRUS VECTORS TO GET LOW ANTIBODY RESPONSE AFTER A FIRST PRIMING IMMUNIZATION | |
| Spencer | Matthew G. Cottingham, Rikke F. Andersen, Alexandra J. Spencer, Saroj Saurya, Julie Furze, Adrian VS Hill and Sarah C. Gilbert | |
| BRPI0705874B1 (pt) | seqüência geneticamente modificada do antígeno cs de plasmodium vivax, proteína recombinante cs e vírus geneticamente modificados que expressam o antígeno cs recombinante | |
| WO2008076157A2 (en) | Modified vaccinia ankara virus vaccine | |
| JPH02303482A (ja) | 日本悩炎ウイルスｎｓ１遺伝子組み換えワクチニアウイルス |