JP2018521651A5 - - Google Patents
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- JP2018521651A5 JP2018521651A5 JP2018500943A JP2018500943A JP2018521651A5 JP 2018521651 A5 JP2018521651 A5 JP 2018521651A5 JP 2018500943 A JP2018500943 A JP 2018500943A JP 2018500943 A JP2018500943 A JP 2018500943A JP 2018521651 A5 JP2018521651 A5 JP 2018521651A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- sequence
- nucleic acid
- expression cassette
- promoter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical group 0.000 claims description 57
- 108020004707 nucleic acids Proteins 0.000 claims description 38
- 102000039446 nucleic acids Human genes 0.000 claims description 38
- 108091026890 Coding region Proteins 0.000 claims description 32
- 239000013598 vector Substances 0.000 claims description 27
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 13
- 239000000427 antigen Substances 0.000 claims description 13
- 108091007433 antigens Proteins 0.000 claims description 13
- 102000036639 antigens Human genes 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 230000037430 deletion Effects 0.000 claims description 7
- 238000012217 deletion Methods 0.000 claims description 7
- 230000037431 insertion Effects 0.000 claims description 6
- 238000003780 insertion Methods 0.000 claims description 6
- 241000700663 Avipoxvirus Species 0.000 claims description 4
- 241000700629 Orthopoxvirus Species 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 108020005544 Antisense RNA Proteins 0.000 claims description 2
- 102100024003 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 Human genes 0.000 claims description 2
- 108090000994 Catalytic RNA Proteins 0.000 claims description 2
- 102000053642 Catalytic RNA Human genes 0.000 claims description 2
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 claims description 2
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 claims description 2
- 101000796203 Homo sapiens L-dopachrome tautomerase Proteins 0.000 claims description 2
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 claims description 2
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 2
- 102100031413 L-dopachrome tautomerase Human genes 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- 102100034256 Mucin-1 Human genes 0.000 claims description 2
- 108010008707 Mucin-1 Proteins 0.000 claims description 2
- 101100262328 Mus musculus Dct gene Proteins 0.000 claims description 2
- 101100154912 Mus musculus Tyrp1 gene Proteins 0.000 claims description 2
- 102100021768 Phosphoserine aminotransferase Human genes 0.000 claims description 2
- 102100022019 Pregnancy-specific beta-1-glycoprotein 2 Human genes 0.000 claims description 2
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims description 2
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 2
- 102000000763 Survivin Human genes 0.000 claims description 2
- 108010002687 Survivin Proteins 0.000 claims description 2
- 241000700647 Variola virus Species 0.000 claims description 2
- 230000000890 antigenic effect Effects 0.000 claims description 2
- 239000003184 complementary RNA Substances 0.000 claims description 2
- 108040000983 polyphosphate:AMP phosphotransferase activity proteins Proteins 0.000 claims description 2
- 108091092562 ribozyme Proteins 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 238000007792 addition Methods 0.000 claims 4
- 108020001507 fusion proteins Proteins 0.000 claims 4
- 102000037865 fusion proteins Human genes 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 3
- 102100033130 T-box transcription factor T Human genes 0.000 claims 3
- 101710086566 T-box transcription factor T Proteins 0.000 claims 3
- 102100035359 Cerebellar degeneration-related protein 2-like Human genes 0.000 claims 1
- 241000700662 Fowlpox virus Species 0.000 claims 1
- 101000737792 Homo sapiens Cerebellar degeneration-related protein 2-like Proteins 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000006698 induction Effects 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 108091029795 Intergenic region Proteins 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- -1 antigenic epitope Proteins 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562199681P | 2015-07-31 | 2015-07-31 | |
| US62/199,681 | 2015-07-31 | ||
| PCT/IB2016/001183 WO2017021776A1 (en) | 2015-07-31 | 2016-07-28 | Promoters for enhancing expression in poxviruses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521651A JP2018521651A (ja) | 2018-08-09 |
| JP2018521651A5 true JP2018521651A5 (enExample) | 2019-07-11 |
| JP6851364B2 JP6851364B2 (ja) | 2021-03-31 |
Family
ID=57068152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500943A Active JP6851364B2 (ja) | 2015-07-31 | 2016-07-28 | ポックスウイルスにおける発現を増強するためのプロモーター |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11753652B2 (enExample) |
| EP (1) | EP3329016B1 (enExample) |
| JP (1) | JP6851364B2 (enExample) |
| KR (1) | KR102565284B1 (enExample) |
| CN (1) | CN107922981B (enExample) |
| AU (1) | AU2016303378B2 (enExample) |
| CA (1) | CA2990549A1 (enExample) |
| DK (1) | DK3329016T3 (enExample) |
| ES (1) | ES2901468T3 (enExample) |
| IL (1) | IL256869B (enExample) |
| MX (1) | MX389312B (enExample) |
| RU (1) | RU2753884C2 (enExample) |
| SG (1) | SG10202000447YA (enExample) |
| WO (1) | WO2017021776A1 (enExample) |
| ZA (1) | ZA201800104B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7202362B2 (ja) | 2017-08-24 | 2023-01-11 | バヴァリアン・ノルディック・アクティーゼルスカブ | 組み換えｍｖａ及び抗体の静脈内投与を用いた、がん治療のための併用療法 |
| MX2020006471A (es) | 2017-12-19 | 2020-09-22 | Janssen Sciences Ireland Unlimited Co | Metodos y composiciones para inducir una respuesta inmune contra el virus de hepatitis b (hbv). |
| EP3860641A1 (en) | 2018-10-05 | 2021-08-11 | Bavarian Nordic A/S | Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist |
| BR112021009856A8 (pt) | 2018-11-20 | 2021-09-08 | Bavarian Nordic As | Terapia para tratamento do câncer com uma administração intratumoral e / ou intravenosa de um mva recombinante que codifica 4-1bbl (cd137l) e / ou cd40l |
| BR112022009798A2 (pt) | 2019-11-20 | 2022-10-18 | Bavarian Nordic As | Vírus mva recombinante para administração intratumoral e/ou intravenosa para tratamento de câncer |
| WO2023118508A1 (en) | 2021-12-23 | 2023-06-29 | Bavarian Nordic A/S | Recombinant mva viruses for intraperitoneal administration for treating cancer |
| CA3240596A1 (en) | 2021-12-23 | 2023-06-29 | Cigdem ATAY LANGBEIN | Therapy for modulating immune response with recombinant mva encoding il-12 |
| AU2024208643A1 (en) | 2023-01-12 | 2025-06-26 | Bavarian Nordic A/S | RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5766598A (en) | 1991-03-07 | 1998-06-16 | Virogenetics Corporation | Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products |
| DE69133333T2 (de) * | 1991-08-26 | 2004-07-29 | Baxter Healthcare S.A. | Ein intaktes FPV-tk-Gen enthaltender rekombinanter Virus der Vogelpocken |
| WO1998004727A1 (en) | 1996-07-25 | 1998-02-05 | Therion Biologics Corporation | Recombinant pox virus for immunization against tumor-associated antigens |
| RU2180352C2 (ru) | 1999-11-24 | 2002-03-10 | Государственный научный центр вирусологии и биотехнологии "Вектор" | ФРАГМЕНТ ГЕНОМА ВИРУСА ОСПЫ КУР ШТАММА "К", СОДЕРЖАЩИЙ ГЕН ТИМИДИНКИНАЗЫ, РЕКОМБИНАНТНЫЕ ПЛАЗМИДНЫЕ ДНК pTK1FPV И pTK2FPV, СОДЕРЖАЩИЕ ЭТУ ПОСЛЕДОВАТЕЛЬНОСТЬ, И РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pINTFPV1, ОБЛАДАЮЩАЯ СПОСОБНОСТЬЮ ИНТЕГРИРОВАТЬСЯ В ГЕНОМ ВИРУСА ОСПЫ КУР |
| WO2005048957A2 (en) | 2003-02-20 | 2005-06-02 | Therion Biologics Corporation | Novel insertion sites in pox vectors |
| EP1673458A4 (en) | 2003-10-15 | 2007-12-12 | Virax Dev Pty Ltd | FOR RETROVIRUS (e.g., HIV) AND CYTOKIN-CODING POXVIRUS VECTOR |
| DK2918598T3 (en) * | 2007-02-28 | 2019-04-29 | The Govt Of U S A As Represented By The Secretary Of The Dept Of Health And Human Services | Brachyury polypeptides and methods of use |
| CN101775410B (zh) * | 2009-01-09 | 2011-11-16 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种鸡痘病毒载体穿梭质粒及其应用 |
| EP2419126B1 (en) * | 2009-04-17 | 2018-01-10 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
| CN102321637A (zh) * | 2011-09-09 | 2012-01-18 | 中国人民解放军军事医学科学院军事兽医研究所 | 中国鸡痘病毒282e4弱毒株全基因组序列及其应用 |
| WO2014043535A1 (en) * | 2012-09-14 | 2014-03-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions for the treatment of cancer |
-
2016
- 2016-07-28 KR KR1020187000086A patent/KR102565284B1/ko active Active
- 2016-07-28 MX MX2018001055A patent/MX389312B/es unknown
- 2016-07-28 ES ES16775852T patent/ES2901468T3/es active Active
- 2016-07-28 RU RU2018106643A patent/RU2753884C2/ru active
- 2016-07-28 JP JP2018500943A patent/JP6851364B2/ja active Active
- 2016-07-28 WO PCT/IB2016/001183 patent/WO2017021776A1/en not_active Ceased
- 2016-07-28 US US15/747,844 patent/US11753652B2/en active Active
- 2016-07-28 SG SG10202000447YA patent/SG10202000447YA/en unknown
- 2016-07-28 DK DK16775852.3T patent/DK3329016T3/da active
- 2016-07-28 IL IL256869A patent/IL256869B/en unknown
- 2016-07-28 CN CN201680042251.3A patent/CN107922981B/zh active Active
- 2016-07-28 AU AU2016303378A patent/AU2016303378B2/en active Active
- 2016-07-28 EP EP16775852.3A patent/EP3329016B1/en active Active
- 2016-07-28 CA CA2990549A patent/CA2990549A1/en active Pending
-
2018
- 2018-01-05 ZA ZA2018/00104A patent/ZA201800104B/en unknown
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