CN107922981B - 用于增强在痘病毒中的表达的启动子 - Google Patents

用于增强在痘病毒中的表达的启动子 Download PDF

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CN107922981B
CN107922981B CN201680042251.3A CN201680042251A CN107922981B CN 107922981 B CN107922981 B CN 107922981B CN 201680042251 A CN201680042251 A CN 201680042251A CN 107922981 B CN107922981 B CN 107922981B
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CN107922981A (zh
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阿兰·德尔凯尔
李曽基
瑞安·朗特里
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Bavarian Nordic AS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/863—Poxviral vectors, e.g. entomopoxvirus
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24041—Use of virus, viral particle or viral elements as a vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201680042251.3A 2015-07-31 2016-07-28 用于增强在痘病毒中的表达的启动子 Active CN107922981B (zh)

Applications Claiming Priority (3)

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US201562199681P 2015-07-31 2015-07-31
US62/199,681 2015-07-31
PCT/IB2016/001183 WO2017021776A1 (en) 2015-07-31 2016-07-28 Promoters for enhancing expression in poxviruses

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CN107922981A CN107922981A (zh) 2018-04-17
CN107922981B true CN107922981B (zh) 2022-02-25

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US (1) US11753652B2 (enExample)
EP (1) EP3329016B1 (enExample)
JP (1) JP6851364B2 (enExample)
KR (1) KR102565284B1 (enExample)
CN (1) CN107922981B (enExample)
AU (1) AU2016303378B2 (enExample)
CA (1) CA2990549A1 (enExample)
DK (1) DK3329016T3 (enExample)
ES (1) ES2901468T3 (enExample)
IL (1) IL256869B (enExample)
MX (1) MX389312B (enExample)
RU (1) RU2753884C2 (enExample)
SG (1) SG10202000447YA (enExample)
WO (1) WO2017021776A1 (enExample)
ZA (1) ZA201800104B (enExample)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
IL272546B2 (en) 2017-08-24 2024-01-01 Bavarian Nordic As Combined therapy for the treatment of cancer with intravenous administration of recombinant MVA and antibody
JP2021506300A (ja) 2017-12-19 2021-02-22 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Ｂ型肝炎ウイルス（ｈｂｖ）に対する免疫応答を誘導するための方法および組成物
IL281988B2 (en) 2018-10-05 2025-03-01 Bavarian Nordic As Combination therapy for treating cancer with an intravenous administration of a recombinant mva and an immune checkpoint antagonist or agonist
JP7625518B2 (ja) 2018-11-20 2025-02-03 バヴァリアン・ノルディック・アクティーゼルスカブ ４－１ｂｂｌ（ｃｄ１３７ｌ）及び／またはｃｄ４０ｌをコードする組み換えｍｖａの腫瘍内及び／または静脈内投与によって、がんを治療する療法
BR112022009798A2 (pt) 2019-11-20 2022-10-18 Bavarian Nordic As Vírus mva recombinante para administração intratumoral e/ou intravenosa para tratamento de câncer
WO2023118563A1 (en) 2021-12-23 2023-06-29 Bavarian Nordic A/S Therapy for modulating immune response with recombinant mva encoding il-12
WO2023118508A1 (en) 2021-12-23 2023-06-29 Bavarian Nordic A/S Recombinant mva viruses for intraperitoneal administration for treating cancer
AU2024208643A1 (en) 2023-01-12 2025-06-26 Bavarian Nordic A/S RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670367A (en) * 1991-08-26 1997-09-23 Immuno Aktiengesellschaft Recombinant fowlpox virus
RU2180352C2 (ru) * 1999-11-24 2002-03-10 Государственный научный центр вирусологии и биотехнологии "Вектор" ФРАГМЕНТ ГЕНОМА ВИРУСА ОСПЫ КУР ШТАММА "К", СОДЕРЖАЩИЙ ГЕН ТИМИДИНКИНАЗЫ, РЕКОМБИНАНТНЫЕ ПЛАЗМИДНЫЕ ДНК pTK1FPV И pTK2FPV, СОДЕРЖАЩИЕ ЭТУ ПОСЛЕДОВАТЕЛЬНОСТЬ, И РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pINTFPV1, ОБЛАДАЮЩАЯ СПОСОБНОСТЬЮ ИНТЕГРИРОВАТЬСЯ В ГЕНОМ ВИРУСА ОСПЫ КУР
WO2005038028A1 (en) * 2003-10-15 2005-04-28 Virax Development Pty Ltd Poxvirus vector encoding retrovirus (eg hiv) and cytokine
WO2008106551A2 (en) * 2007-02-28 2008-09-04 The Govt. Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Serv. Brachyury polypeptides and methods for use
CN101775410A (zh) * 2009-01-09 2010-07-14 中国人民解放军军事医学科学院军事兽医研究所 一种鸡痘病毒载体穿梭质粒及其应用
CN102321637A (zh) * 2011-09-09 2012-01-18 中国人民解放军军事医学科学院军事兽医研究所 中国鸡痘病毒282e4弱毒株全基因组序列及其应用
CN102458458A (zh) * 2009-04-17 2012-05-16 全球免疫股份有限公司 组合免疫疗法组合物和方法
WO2014043535A1 (en) * 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions for the treatment of cancer

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5766598A (en) 1991-03-07 1998-06-16 Virogenetics Corporation Recombinant attenuated ALVAC canarypoxvirus expression vectors containing heterologous DNA segments encoding lentiviral gene products
EP0954593A1 (en) 1996-07-25 1999-11-10 Therion Biologics Corporation Recombinant pox virus for immunization against tumor-associated antigens
JP5052893B2 (ja) * 2003-02-20 2012-10-17 アメリカ合衆国 ポックスベクターにおける新規の挿入部位

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670367A (en) * 1991-08-26 1997-09-23 Immuno Aktiengesellschaft Recombinant fowlpox virus
RU2180352C2 (ru) * 1999-11-24 2002-03-10 Государственный научный центр вирусологии и биотехнологии "Вектор" ФРАГМЕНТ ГЕНОМА ВИРУСА ОСПЫ КУР ШТАММА "К", СОДЕРЖАЩИЙ ГЕН ТИМИДИНКИНАЗЫ, РЕКОМБИНАНТНЫЕ ПЛАЗМИДНЫЕ ДНК pTK1FPV И pTK2FPV, СОДЕРЖАЩИЕ ЭТУ ПОСЛЕДОВАТЕЛЬНОСТЬ, И РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pINTFPV1, ОБЛАДАЮЩАЯ СПОСОБНОСТЬЮ ИНТЕГРИРОВАТЬСЯ В ГЕНОМ ВИРУСА ОСПЫ КУР
WO2005038028A1 (en) * 2003-10-15 2005-04-28 Virax Development Pty Ltd Poxvirus vector encoding retrovirus (eg hiv) and cytokine
WO2008106551A2 (en) * 2007-02-28 2008-09-04 The Govt. Of The U.S.A. As Represented By The Secretary Of The Dept. Of Health & Human Serv. Brachyury polypeptides and methods for use
CN101775410A (zh) * 2009-01-09 2010-07-14 中国人民解放军军事医学科学院军事兽医研究所 一种鸡痘病毒载体穿梭质粒及其应用
CN102458458A (zh) * 2009-04-17 2012-05-16 全球免疫股份有限公司 组合免疫疗法组合物和方法
CN102321637A (zh) * 2011-09-09 2012-01-18 中国人民解放军军事医学科学院军事兽医研究所 中国鸡痘病毒282e4弱毒株全基因组序列及其应用
WO2014043535A1 (en) * 2012-09-14 2014-03-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Compositions for the treatment of cancer

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BR112018002172A8 (pt) 2024-02-15
AU2016303378A1 (en) 2018-01-25
DK3329016T3 (da) 2022-01-10
MX2018001055A (es) 2018-05-17
KR102565284B1 (ko) 2023-08-08
RU2018106643A (ru) 2019-08-28
KR20180033498A (ko) 2018-04-03
JP2018521651A (ja) 2018-08-09
EP3329016B1 (en) 2021-10-20
WO2017021776A1 (en) 2017-02-09
US11753652B2 (en) 2023-09-12
AU2016303378B2 (en) 2021-12-23
IL256869B (en) 2022-07-01
CN107922981A (zh) 2018-04-17
JP6851364B2 (ja) 2021-03-31
HK1254405A1 (en) 2019-07-19
IL256869A (en) 2018-03-29
US20180216134A1 (en) 2018-08-02
RU2018106643A3 (enExample) 2020-01-30
NZ738713A (en) 2024-11-29
RU2753884C2 (ru) 2021-08-24
MX389312B (es) 2025-03-20
ZA201800104B (en) 2022-04-28
EP3329016A1 (en) 2018-06-06
BR112018002172A2 (pt) 2018-09-18
SG10202000447YA (en) 2020-03-30
ES2901468T3 (es) 2022-03-22
CA2990549A1 (en) 2017-02-09

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