JP2018521643A5 - - Google Patents
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- JP2018521643A5 JP2018521643A5 JP2017564550A JP2017564550A JP2018521643A5 JP 2018521643 A5 JP2018521643 A5 JP 2018521643A5 JP 2017564550 A JP2017564550 A JP 2017564550A JP 2017564550 A JP2017564550 A JP 2017564550A JP 2018521643 A5 JP2018521643 A5 JP 2018521643A5
- Authority
- JP
- Japan
- Prior art keywords
- viral
- delivery system
- replication
- virus
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000003612 virological effect Effects 0.000 claims description 76
- 108090000623 proteins and genes Proteins 0.000 claims description 42
- 230000010076 replication Effects 0.000 claims description 36
- 239000002924 silencing RNA Substances 0.000 claims description 32
- 239000003999 initiator Substances 0.000 claims description 26
- 102000004169 proteins and genes Human genes 0.000 claims description 26
- 241000700605 Viruses Species 0.000 claims description 21
- 108091027967 Small hairpin RNA Proteins 0.000 claims description 16
- 108020004459 Small interfering RNA Proteins 0.000 claims description 16
- 230000030279 gene silencing Effects 0.000 claims description 16
- 238000012226 gene silencing method Methods 0.000 claims description 16
- 108091070501 miRNA Proteins 0.000 claims description 16
- 239000002679 microRNA Substances 0.000 claims description 16
- 239000004055 small Interfering RNA Substances 0.000 claims description 16
- 208000027418 Wounds and injury Diseases 0.000 claims description 13
- 206010052428 Wound Diseases 0.000 claims description 11
- 108010061833 Integrases Proteins 0.000 claims description 8
- 230000002950 deficient Effects 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 6
- 208000016361 genetic disease Diseases 0.000 claims description 6
- 230000001939 inductive effect Effects 0.000 claims description 6
- 208000035473 Communicable disease Diseases 0.000 claims description 4
- 241001115402 Ebolavirus Species 0.000 claims description 4
- 206010023927 Lassa fever Diseases 0.000 claims description 4
- 208000015181 infectious disease Diseases 0.000 claims description 4
- 208000028389 Nerve injury Diseases 0.000 claims description 3
- 230000008764 nerve damage Effects 0.000 claims description 3
- 208000007848 Alcoholism Diseases 0.000 claims description 2
- 241000701822 Bovine papillomavirus Species 0.000 claims description 2
- 108010031111 EBV-encoded nuclear antigen 1 Proteins 0.000 claims description 2
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 2
- 241000701806 Human papillomavirus Species 0.000 claims description 2
- 241000713666 Lentivirus Species 0.000 claims description 2
- 108010025020 Nerve Growth Factor Proteins 0.000 claims description 2
- 102000015336 Nerve Growth Factor Human genes 0.000 claims description 2
- 241001631646 Papillomaviridae Species 0.000 claims description 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims description 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims description 2
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims description 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 2
- 206010001584 alcohol abuse Diseases 0.000 claims description 2
- 208000025746 alcohol use disease Diseases 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims description 2
- 230000035876 healing Effects 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 229940053128 nerve growth factor Drugs 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 230000001568 sexual effect Effects 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- 108010046910 brain-derived growth factor Proteins 0.000 claims 1
- 231100000878 neurological injury Toxicity 0.000 claims 1
- 238000000034 method Methods 0.000 description 18
- 210000004556 brain Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562173784P | 2015-06-10 | 2015-06-10 | |
| US62/173,784 | 2015-06-10 | ||
| PCT/US2016/036519 WO2016200997A1 (en) | 2015-06-10 | 2016-06-08 | Non-integrating viral delivery system and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021021627A Division JP2021072865A (ja) | 2015-06-10 | 2021-02-15 | 非組み込みウイルス送達システムおよびその使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521643A JP2018521643A (ja) | 2018-08-09 |
| JP2018521643A5 true JP2018521643A5 (https=) | 2019-07-11 |
| JP6924487B2 JP6924487B2 (ja) | 2021-08-25 |
Family
ID=57503988
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564550A Active JP6924487B2 (ja) | 2015-06-10 | 2016-06-08 | 非組み込みウイルス送達システムおよびその使用の方法 |
| JP2021021627A Pending JP2021072865A (ja) | 2015-06-10 | 2021-02-15 | 非組み込みウイルス送達システムおよびその使用の方法 |
| JP2023099918A Withdrawn JP2023113963A (ja) | 2015-06-10 | 2023-06-19 | 非組み込みウイルス送達システムおよびその使用の方法 |
| JP2025063242A Pending JP2025114562A (ja) | 2015-06-10 | 2025-04-07 | 非組み込みウイルス送達システムおよびその使用の方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021021627A Pending JP2021072865A (ja) | 2015-06-10 | 2021-02-15 | 非組み込みウイルス送達システムおよびその使用の方法 |
| JP2023099918A Withdrawn JP2023113963A (ja) | 2015-06-10 | 2023-06-19 | 非組み込みウイルス送達システムおよびその使用の方法 |
| JP2025063242A Pending JP2025114562A (ja) | 2015-06-10 | 2025-04-07 | 非組み込みウイルス送達システムおよびその使用の方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20180161455A1 (https=) |
| EP (1) | EP3307894B1 (https=) |
| JP (4) | JP6924487B2 (https=) |
| WO (1) | WO2016200997A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010045659A1 (en) | 2008-10-17 | 2010-04-22 | American Gene Technologies International Inc. | Safe lentiviral vectors for targeted delivery of multiple therapeutic molecules |
| JP6890831B2 (ja) | 2015-07-08 | 2021-06-18 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | Ｈｉｖ予備免疫化および免疫療法 |
| US10137144B2 (en) | 2016-01-15 | 2018-11-27 | American Gene Technologies International Inc. | Methods and compositions for the activation of gamma-delta T-cells |
| DK3402483T3 (da) | 2016-01-15 | 2024-01-02 | American Gene Tech Int Inc | Fremgangsmåder og sammensætninger til aktivering af gamma-delta-T-celler |
| US10888613B2 (en) | 2016-02-08 | 2021-01-12 | American Gene Technologies International Inc. | Method of producing cells resistant to HIV infection |
| DK3426777T3 (da) | 2016-03-09 | 2022-04-25 | American Gene Tech Int Inc | Kombinationsvektorer og fremgangsmåder til behandling af cancer |
| US11976292B2 (en) | 2016-06-08 | 2024-05-07 | American Gene Technologies International Inc. | Non-integrating viral delivery system and methods related thereto |
| IL284348B2 (en) | 2016-07-08 | 2025-06-01 | American Gene Tech Int Inc | Hiv pre-immunization and immunotherapy |
| JP7176756B2 (ja) | 2016-07-21 | 2022-11-22 | アメリカン ジーン テクノロジーズ インターナショナル インコーポレイテッド | パーキンソン病を処置するためのウイルスベクター |
| CA3057142A1 (en) | 2017-04-03 | 2018-10-11 | American Gene Technologies International Inc. | Compositions and methods for treating phenylketonuria |
| CA3064442A1 (en) | 2017-06-16 | 2018-12-20 | American Gene Technologies International Inc. | Methods and compositions for the activation of tumor cytotoxicity via human gamma-delta t-cells |
| WO2025255019A1 (en) * | 2024-06-03 | 2025-12-11 | Mayo Foundation For Medical Education And Research | Transcription and replication particles and their use as antiviral therapies |
| US12480129B1 (en) * | 2024-09-17 | 2025-11-25 | Wyvern Pharmaceuticals Inc. | Composition for regulating production of interfering ribonucleic acid |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994012629A1 (en) * | 1992-12-02 | 1994-06-09 | Baylor College Of Medicine | Episomal vectors for gene therapy |
| BR9405507A (pt) * | 1993-07-13 | 1999-05-25 | Rhone Poulenc Rorer Sa | Adenovirus recombinante defeituoso linhagem celular e composição farmaceutica |
| US6635472B1 (en) * | 1997-08-15 | 2003-10-21 | Rubicon Laboratory, Inc. | Retrovirus and viral vectors |
| AU1124499A (en) * | 1997-10-28 | 1999-05-17 | Maxygen, Inc. | Human papillomavirus vectors |
| AU3097399A (en) * | 1998-03-20 | 1999-10-11 | Trustees Of The University Of Pennsylvania, The | Compositions and methods for helper-free production of recombinant adeno-associated viruses |
| AU2003283174A1 (en) | 2002-12-11 | 2004-06-30 | Cytos Biotechnology Ag | Method for protein production |
| WO2005005644A1 (en) * | 2003-07-11 | 2005-01-20 | Cytos Biotechnology Ag | Gene expression system |
| US20070298498A1 (en) * | 2004-11-02 | 2007-12-27 | Stefano Colloca | Adenoviral Amplicon and Producer Cells for the Production of Replication-Defective Adenoviral Vectors, Methods of Preparation and Use Thereof |
| WO2007133674A2 (en) * | 2006-05-12 | 2007-11-22 | Lentigen Corporation | Lentiviral vector compositions, methods and applications |
| EP2342321B1 (en) * | 2008-09-17 | 2018-04-11 | Isogenis, Inc. | Construction of fully-deleted adenovirus-based gene delivery vectors and uses thereof |
| CN102369288A (zh) * | 2008-11-14 | 2012-03-07 | 生命技术公司 | 用于工程化细胞的组合物和方法 |
| WO2011119942A1 (en) * | 2010-03-25 | 2011-09-29 | Vistagen Therapeutics, Inc. | Induction of ips cells using transient episomal vectors |
| EP2878674A1 (en) * | 2013-11-28 | 2015-06-03 | Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) | Stable episomes based on non-integrative lentiviral vectors |
-
2016
- 2016-06-08 EP EP16808223.8A patent/EP3307894B1/en active Active
- 2016-06-08 US US15/580,661 patent/US20180161455A1/en active Pending
- 2016-06-08 WO PCT/US2016/036519 patent/WO2016200997A1/en not_active Ceased
- 2016-06-08 JP JP2017564550A patent/JP6924487B2/ja active Active
-
2021
- 2021-02-15 JP JP2021021627A patent/JP2021072865A/ja active Pending
-
2023
- 2023-06-19 JP JP2023099918A patent/JP2023113963A/ja not_active Withdrawn
-
2025
- 2025-04-07 JP JP2025063242A patent/JP2025114562A/ja active Pending
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