JP2018521139A - 急速な作用発現を得るための発作の治療における口腔投与のためのミダゾラム組成物 - Google Patents

急速な作用発現を得るための発作の治療における口腔投与のためのミダゾラム組成物 Download PDF

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Publication number
JP2018521139A
JP2018521139A JP2018521707A JP2018521707A JP2018521139A JP 2018521139 A JP2018521139 A JP 2018521139A JP 2018521707 A JP2018521707 A JP 2018521707A JP 2018521707 A JP2018521707 A JP 2018521707A JP 2018521139 A JP2018521139 A JP 2018521139A
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JP
Japan
Prior art keywords
film
midazolam
unit dosage
forming substance
composition according
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Pending
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JP2018521707A
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English (en)
Japanese (ja)
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JP2018521139A5 (cg-RX-API-DMAC10.html
Inventor
シェーグレン，クリステル
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Swipp AB
Original Assignee
Swipp AB
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Application filed by Swipp AB filed Critical Swipp AB
Publication of JP2018521139A publication Critical patent/JP2018521139A/ja
Publication of JP2018521139A5 publication Critical patent/JP2018521139A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018521707A 2015-07-16 2016-07-15 急速な作用発現を得るための発作の治療における口腔投与のためのミダゾラム組成物 Pending JP2018521139A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201570475 2015-07-16
DKPA201570475 2015-07-16
PCT/EP2016/066860 WO2017009446A1 (en) 2015-07-16 2016-07-15 Compositions of midazolam for buccal administration in the treatment of seizures to obtain rapid onset of action

Publications (2)

Publication Number Publication Date
JP2018521139A true JP2018521139A (ja) 2018-08-02
JP2018521139A5 JP2018521139A5 (cg-RX-API-DMAC10.html) 2019-07-18

Family

ID=53785375

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018521707A Pending JP2018521139A (ja) 2015-07-16 2016-07-15 急速な作用発現を得るための発作の治療における口腔投与のためのミダゾラム組成物

Country Status (6)

Country Link
US (2) US20180221384A1 (cg-RX-API-DMAC10.html)
EP (1) EP3322402B1 (cg-RX-API-DMAC10.html)
JP (1) JP2018521139A (cg-RX-API-DMAC10.html)
CN (1) CN108024952A (cg-RX-API-DMAC10.html)
ES (1) ES2738652T3 (cg-RX-API-DMAC10.html)
WO (1) WO2017009446A1 (cg-RX-API-DMAC10.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024513303A (ja) * 2021-03-04 2024-03-25 エルテーエス ローマン テラピー－ジステーメ アーゲー 経口薄フィルム

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12629380B2 (en) 2021-08-25 2026-05-19 Swipp Ab Oral film unit dosage form
EP4673122A1 (en) 2023-03-01 2026-01-07 Swipp Ab Oral film unit dosage form
EP4673121A1 (en) 2023-03-01 2026-01-07 Swipp Ab Crystalline form of midazolam hydrochloride

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512402A (ja) * 1999-10-27 2003-04-02 アネスタ・コーポレーション 固溶体を用いる経口経粘膜薬剤投与形態
JP2007502823A (ja) * 2003-08-15 2007-02-15 キューエルティー・ユーエスエイ・インコーポレーテッド 接着性および生体侵食性の経粘膜薬物送達システム

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9717770D0 (en) * 1997-08-21 1997-10-29 Scherer Ltd R P Pharmaceutical composition
WO2004087089A2 (en) * 2003-03-26 2004-10-14 The Procter & Gamble Company Rapidly dissolving edible film compositions with improved film strength and stability
CN1830447B (zh) * 2006-04-02 2011-03-16 岳振江 马来酸咪达唑仑口服膜剂及其制备方法
WO2011053251A1 (en) * 2009-10-30 2011-05-05 Ix Biopharma Pte Ltd Fast dissolving solid dosage form
CN102892815B (zh) * 2010-03-26 2016-05-18 陶氏环球技术有限责任公司 熔体挤出的膜

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003512402A (ja) * 1999-10-27 2003-04-02 アネスタ・コーポレーション 固溶体を用いる経口経粘膜薬剤投与形態
JP2007502823A (ja) * 2003-08-15 2007-02-15 キューエルティー・ユーエスエイ・インコーポレーテッド 接着性および生体侵食性の経粘膜薬物送達システム

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BR J CLIN PHARMACOL, vol. 46, JPN6020019907, 1998, pages 203 - 206, ISSN: 0004283883 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024513303A (ja) * 2021-03-04 2024-03-25 エルテーエス ローマン テラピー－ジステーメ アーゲー 経口薄フィルム
JP7738665B2 (ja) 2021-03-04 2025-09-12 エルテーエス ローマン テラピー－ジステーメ アーゲー 経口薄フィルム

Also Published As

Publication number Publication date
CN108024952A (zh) 2018-05-11
WO2017009446A1 (en) 2017-01-19
ES2738652T3 (es) 2020-01-24
EP3322402A1 (en) 2018-05-23
EP3322402B1 (en) 2019-05-29
US20180221384A1 (en) 2018-08-09
US20200306260A1 (en) 2020-10-01

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