JP2018520647A5 - - Google Patents
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- JP2018520647A5 JP2018520647A5 JP2017558986A JP2017558986A JP2018520647A5 JP 2018520647 A5 JP2018520647 A5 JP 2018520647A5 JP 2017558986 A JP2017558986 A JP 2017558986A JP 2017558986 A JP2017558986 A JP 2017558986A JP 2018520647 A5 JP2018520647 A5 JP 2018520647A5
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- JP
- Japan
- Prior art keywords
- composition
- enzyme
- biological sample
- inactivating
- amount
- Prior art date
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- 102000004190 Enzymes Human genes 0.000 claims 40
- 108090000790 Enzymes Proteins 0.000 claims 40
- 230000000415 inactivating effect Effects 0.000 claims 16
- 230000002779 inactivation Effects 0.000 claims 16
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical group [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 150000002978 peroxides Chemical class 0.000 claims 5
- 239000003755 preservative agent Substances 0.000 claims 5
- 230000002335 preservative effect Effects 0.000 claims 5
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 102000003992 Peroxidases Human genes 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159297P | 2015-05-10 | 2015-05-10 | |
| US62/159,297 | 2015-05-10 | ||
| PCT/EP2016/060263 WO2016180747A1 (en) | 2015-05-10 | 2016-05-09 | Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205107A Division JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520647A JP2018520647A (ja) | 2018-08-02 |
| JP2018520647A5 true JP2018520647A5 (enExample) | 2019-05-30 |
| JP7044554B2 JP7044554B2 (ja) | 2022-03-30 |
Family
ID=55953158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558986A Active JP7044554B2 (ja) | 2015-05-10 | 2016-05-09 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
| JP2020205107A Pending JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205107A Pending JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11162877B2 (enExample) |
| EP (1) | EP3295173B1 (enExample) |
| JP (2) | JP7044554B2 (enExample) |
| CN (1) | CN107980095A (enExample) |
| AU (1) | AU2016261279B2 (enExample) |
| CA (1) | CA2984701C (enExample) |
| WO (1) | WO2016180747A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7455816B2 (ja) | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
| US12195545B2 (en) | 2018-12-25 | 2025-01-14 | Hanx Biopharmaceutics, Inc | Anti-OX40 monoclonal antibody and application thereof |
| EP4278181A1 (en) | 2021-01-15 | 2023-11-22 | Ventana Medical Systems, Inc. | Storage stable caged haptens |
| WO2022156920A1 (en) | 2021-01-25 | 2022-07-28 | Ventana Medical Systems, Inc. | Stained biological specimens including one or more biomarkers labeled with one or more detectable moieties |
| US12555497B2 (en) | 2021-03-30 | 2026-02-17 | Sato Corporation | Label structure and label |
| WO2022223137A1 (en) | 2021-04-18 | 2022-10-27 | Ventana Medical Systems, Inc. | Morphological marker staining |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| JP2026502116A (ja) | 2022-12-23 | 2026-01-21 | ヴェンタナ メディカル システムズ， インク． | 抗原提示機構の構成要素を評価するための材料および方法ならびにそれらの使用 |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3410400C2 (de) * | 1984-03-21 | 1987-04-02 | Titmus Eurocon Kontaktlinsen GmbH, 8750 Aschaffenburg | Kontaktlinsenpflegesatz und Verfahren zur Pflege von Kontaktlinsen |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| US5225325A (en) * | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
| EP1025444B1 (en) * | 1997-10-21 | 2005-03-02 | Cancer Research Technology Limited | Determination of cellular growth abnormality |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| EP2284543A3 (en) | 1998-02-27 | 2015-05-27 | Ventana Medical Systems, Inc. | System and method of aspirating and dispensing reagent |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| SE9804064D0 (sv) * | 1998-11-25 | 1998-11-25 | A & Science Invest Ab | Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells |
| US20050176072A1 (en) * | 2002-06-21 | 2005-08-11 | Martin Michelle D. | MTA1 is a predictive and prognostic factor in human breast cancer |
| US20040248223A1 (en) * | 2003-06-05 | 2004-12-09 | Idexx Laboratories, Inc. | Reduction of interfering peroxidase activity in peroxidase based detection methods |
| WO2005033333A2 (en) * | 2003-10-07 | 2005-04-14 | Dako Denmark A/S | Methods and compositions for the diagnosis of cancer |
| JP5733734B2 (ja) * | 2009-02-19 | 2015-06-10 | 国立大学法人 千葉大学 | 成長因子に誘発されるユークロマチン化（ｅｕｃｈｒｏｍａｔｉｎｉｚａｔｉｏｎ）に必要な、ＳＲＣ−ファミリーチロシンキナーゼの核局在 |
| WO2010117325A1 (en) | 2009-04-08 | 2010-10-14 | Olle Hernell | New methods for treatment of inflammatory diseases |
| JP5627698B2 (ja) | 2009-10-19 | 2014-11-19 | ベンタナ メディカル システムズ， インコーポレイテッド | 撮像システムおよび技法 |
| BR112013030824A8 (pt) * | 2011-06-01 | 2018-04-03 | Actogenix Nv | Bactéria gram-positiva, ácido necleico recombinante, composição farmacêutica e vetor |
| CA2928374C (en) | 2011-09-09 | 2018-09-25 | Ventana Medical Systems, Inc. | Imaging systems, cassettes, and methods of using the same |
| CA2867144C (en) | 2012-03-27 | 2019-07-02 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
-
2016
- 2016-05-09 JP JP2017558986A patent/JP7044554B2/ja active Active
- 2016-05-09 AU AU2016261279A patent/AU2016261279B2/en active Active
- 2016-05-09 EP EP16721425.3A patent/EP3295173B1/en active Active
- 2016-05-09 CN CN201680027053.XA patent/CN107980095A/zh active Pending
- 2016-05-09 CA CA2984701A patent/CA2984701C/en active Active
- 2016-05-09 WO PCT/EP2016/060263 patent/WO2016180747A1/en not_active Ceased
-
2017
- 2017-11-09 US US15/807,612 patent/US11162877B2/en active Active
-
2020
- 2020-12-10 JP JP2020205107A patent/JP2021058193A/ja active Pending
-
2021
- 2021-10-04 US US17/493,477 patent/US11971337B2/en active Active
-
2024
- 2024-03-30 US US18/622,914 patent/US20240328910A1/en active Pending
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