JP2018520647A5 - - Google Patents
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- JP2018520647A5 JP2018520647A5 JP2017558986A JP2017558986A JP2018520647A5 JP 2018520647 A5 JP2018520647 A5 JP 2018520647A5 JP 2017558986 A JP2017558986 A JP 2017558986A JP 2017558986 A JP2017558986 A JP 2017558986A JP 2018520647 A5 JP2018520647 A5 JP 2018520647A5
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- JP
- Japan
- Prior art keywords
- composition
- enzyme
- biological sample
- inactivating
- amount
- Prior art date
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- 102000004190 Enzymes Human genes 0.000 claims 40
- 108090000790 Enzymes Proteins 0.000 claims 40
- 230000000415 inactivating effect Effects 0.000 claims 16
- 230000002779 inactivation Effects 0.000 claims 16
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical group [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 14
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical group OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 12
- 238000000034 method Methods 0.000 claims 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 7
- 150000002978 peroxides Chemical class 0.000 claims 5
- 239000003755 preservative agent Substances 0.000 claims 5
- 230000002335 preservative effect Effects 0.000 claims 5
- 239000003638 chemical reducing agent Substances 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 4
- 239000011780 sodium chloride Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- 102000003992 Peroxidases Human genes 0.000 claims 2
- 238000004090 dissolution Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 108040007629 peroxidase activity proteins Proteins 0.000 claims 2
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims 1
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 150000001860 citric acid derivatives Chemical class 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562159297P | 2015-05-10 | 2015-05-10 | |
| US62/159,297 | 2015-05-10 | ||
| PCT/EP2016/060263 WO2016180747A1 (en) | 2015-05-10 | 2016-05-09 | Compositions and methods for simultaneous inactivation of alkaline phosphatase and peroxidase enzymes during automated multiplex tissue staining assays |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205107A Division JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018520647A JP2018520647A (ja) | 2018-08-02 |
| JP2018520647A5 true JP2018520647A5 (enExample) | 2019-05-30 |
| JP7044554B2 JP7044554B2 (ja) | 2022-03-30 |
Family
ID=55953158
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017558986A Active JP7044554B2 (ja) | 2015-05-10 | 2016-05-09 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
| JP2020205107A Pending JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020205107A Pending JP2021058193A (ja) | 2015-05-10 | 2020-12-10 | 自動多重組織染色アッセイの間のアルカリホスファターゼ及びペルオキシダーゼ酵素の同時不活化のための組成物と方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US11162877B2 (enExample) |
| EP (1) | EP3295173B1 (enExample) |
| JP (2) | JP7044554B2 (enExample) |
| CN (1) | CN107980095A (enExample) |
| AU (1) | AU2016261279B2 (enExample) |
| CA (1) | CA2984701C (enExample) |
| WO (1) | WO2016180747A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7455816B2 (ja) | 2018-09-20 | 2024-03-26 | ヴェンタナ メディカル システムズ， インク． | クマリン系架橋試薬 |
| EP3904383A4 (en) | 2018-12-25 | 2022-08-17 | Hanx Biopharmaceutics, Inc | ANTI-OX40 MONOCLONAL ANTIBODY AND USE THEREOF |
| CN116783485A (zh) | 2021-01-15 | 2023-09-19 | 文塔纳医疗系统公司 | 储存稳定的笼状半抗原 |
| JP2024507677A (ja) | 2021-01-25 | 2024-02-21 | ベンタナ メディカル システムズ， インコーポレイテッド | １つ又は複数の検出可能部分で標識された１つ又は複数のバイオマーカーを含む染色された生物学的検体 |
| US20240177633A1 (en) | 2021-03-30 | 2024-05-30 | Sato Holdings Kabushiki Kaisha | Label structure and label |
| WO2022223137A1 (en) | 2021-04-18 | 2022-10-27 | Ventana Medical Systems, Inc. | Morphological marker staining |
| CN113552362B (zh) * | 2021-07-23 | 2024-08-09 | 湖北百奥斯生物科技有限公司 | 一种新型信号放大的免疫荧光试剂盒 |
| CN120359417A (zh) | 2022-12-23 | 2025-07-22 | 文塔纳医疗系统公司 | 用于评估抗原呈递机制组分的材料和方法及其用途 |
| WO2025014787A1 (en) | 2023-07-07 | 2025-01-16 | Ventana Medical Systems, Inc. | Brightfield triplex immunohistochemistry assay for evaluating the colocalization of the er, pr, and ki-67 biomarkers in cells |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3410400C2 (de) * | 1984-03-21 | 1987-04-02 | Titmus Eurocon Kontaktlinsen GmbH, 8750 Aschaffenburg | Kontaktlinsenpflegesatz und Verfahren zur Pflege von Kontaktlinsen |
| US5225325A (en) * | 1990-03-02 | 1993-07-06 | Ventana Medical Systems, Inc. | Immunohistochemical staining method and reagents therefor |
| US5595707A (en) | 1990-03-02 | 1997-01-21 | Ventana Medical Systems, Inc. | Automated biological reaction apparatus |
| CN1282422A (zh) * | 1997-10-21 | 2001-01-31 | 癌症研究行动技术有限公司 | 对细胞生长异常的测定 |
| AU763354B2 (en) | 1998-02-27 | 2003-07-17 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US20030211630A1 (en) | 1998-02-27 | 2003-11-13 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6582962B1 (en) | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| SE9804064D0 (sv) | 1998-11-25 | 1998-11-25 | A & Science Invest Ab | Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells |
| US20050176072A1 (en) * | 2002-06-21 | 2005-08-11 | Martin Michelle D. | MTA1 is a predictive and prognostic factor in human breast cancer |
| US20040248223A1 (en) * | 2003-06-05 | 2004-12-09 | Idexx Laboratories, Inc. | Reduction of interfering peroxidase activity in peroxidase based detection methods |
| WO2005033333A2 (en) * | 2003-10-07 | 2005-04-14 | Dako Denmark A/S | Methods and compositions for the diagnosis of cancer |
| JP5733734B2 (ja) * | 2009-02-19 | 2015-06-10 | 国立大学法人 千葉大学 | 成長因子に誘発されるユークロマチン化（ｅｕｃｈｒｏｍａｔｉｎｉｚａｔｉｏｎ）に必要な、ＳＲＣ−ファミリーチロシンキナーゼの核局在 |
| EP3061463A1 (en) * | 2009-04-08 | 2016-08-31 | LipUm AB | New methods for treatment of inflammatory diseases |
| EP2993478B1 (en) | 2009-10-19 | 2022-08-24 | Ventana Medical Systems, Inc. | Device and method for slide caching |
| US9920324B2 (en) * | 2011-06-01 | 2018-03-20 | Intrexon Actobiotics Nv | Polycistronic expression system for bacteria |
| SG2014011084A (en) | 2011-09-09 | 2014-04-28 | Ventana Med Syst Inc | Imaging systems, cassettes, and methods of using the same |
| WO2013148498A1 (en) | 2012-03-27 | 2013-10-03 | Ventana Medical Systems, Inc. | Signaling conjugates and methods of use |
-
2016
- 2016-05-09 CA CA2984701A patent/CA2984701C/en active Active
- 2016-05-09 EP EP16721425.3A patent/EP3295173B1/en active Active
- 2016-05-09 CN CN201680027053.XA patent/CN107980095A/zh active Pending
- 2016-05-09 JP JP2017558986A patent/JP7044554B2/ja active Active
- 2016-05-09 WO PCT/EP2016/060263 patent/WO2016180747A1/en not_active Ceased
- 2016-05-09 AU AU2016261279A patent/AU2016261279B2/en active Active
-
2017
- 2017-11-09 US US15/807,612 patent/US11162877B2/en active Active
-
2020
- 2020-12-10 JP JP2020205107A patent/JP2021058193A/ja active Pending
-
2021
- 2021-10-04 US US17/493,477 patent/US11971337B2/en active Active
-
2024
- 2024-03-30 US US18/622,914 patent/US20240328910A1/en active Pending
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