JP2018520124A5 - - Google Patents
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- Publication number
- JP2018520124A5 JP2018520124A5 JP2017563973A JP2017563973A JP2018520124A5 JP 2018520124 A5 JP2018520124 A5 JP 2018520124A5 JP 2017563973 A JP2017563973 A JP 2017563973A JP 2017563973 A JP2017563973 A JP 2017563973A JP 2018520124 A5 JP2018520124 A5 JP 2018520124A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- heterocycloalkyl
- alkylene
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 36
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 26
- 125000001072 heteroaryl group Chemical group 0.000 claims 22
- 125000000217 alkyl group Chemical group 0.000 claims 20
- 229940125763 bromodomain inhibitor Drugs 0.000 claims 20
- 125000001424 substituent group Chemical group 0.000 claims 20
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 12
- 125000002947 alkylene group Chemical group 0.000 claims 10
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 9
- 102100022338 Integrin alpha-M Human genes 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000003112 inhibitor Substances 0.000 claims 5
- 102000007999 Nuclear Proteins Human genes 0.000 claims 4
- 108010089610 Nuclear Proteins Proteins 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000005275 alkylenearyl group Chemical group 0.000 claims 4
- 125000005218 alkyleneheteroaryl group Chemical group 0.000 claims 4
- 125000001246 bromo group Chemical group Br* 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- -1 R B is H Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
- 102000001805 Bromodomains Human genes 0.000 claims 2
- 108050009021 Bromodomains Proteins 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 230000002381 testicular Effects 0.000 claims 2
- 238000011282 treatment Methods 0.000 claims 2
- 238000011269 treatment regimen Methods 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 230000004797 therapeutic response Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562185203P | 2015-06-26 | 2015-06-26 | |
| US62/185,203 | 2015-06-26 | ||
| PCT/US2016/039270 WO2016210275A1 (en) | 2015-06-26 | 2016-06-24 | Treatment of nut midline carcinoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018520124A JP2018520124A (ja) | 2018-07-26 |
| JP2018520124A5 true JP2018520124A5 (enExample) | 2019-07-25 |
Family
ID=56409188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017563973A Pending JP2018520124A (ja) | 2015-06-26 | 2016-06-24 | Ｎｕｔ正中線癌の治療 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20180193350A1 (enExample) |
| EP (1) | EP3314005A1 (enExample) |
| JP (1) | JP2018520124A (enExample) |
| KR (1) | KR20180035785A (enExample) |
| CN (1) | CN107787227A (enExample) |
| AR (1) | AR105124A1 (enExample) |
| AU (1) | AU2016283020A1 (enExample) |
| BR (1) | BR112017028178A2 (enExample) |
| CA (1) | CA2989313A1 (enExample) |
| HK (1) | HK1252062A1 (enExample) |
| IL (1) | IL256186A (enExample) |
| MA (1) | MA42249A (enExample) |
| MX (1) | MX2017016337A (enExample) |
| WO (1) | WO2016210275A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2799403C (en) | 2010-05-14 | 2020-01-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating leukemia |
| HUE031073T2 (en) | 2010-05-14 | 2017-06-28 | Dana Farber Cancer Inst Inc | Thieno triazolo-diazepine compounds for the treatment of neoplasia |
| RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
| CA2940472A1 (en) | 2014-02-28 | 2015-09-03 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
| EA033325B1 (ru) | 2014-10-27 | 2019-09-30 | Тэнша Терапеутикс, Инк. | Ингибиторы бромодомена |
| WO2024123929A1 (en) * | 2022-12-06 | 2024-06-13 | Bioventures, Llc | Development of potent dual hdac/brd4 inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| CN101910182B (zh) | 2007-12-28 | 2013-07-17 | 田边三菱制药株式会社 | 抗癌剂 |
| GB0919431D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| EP3050885B1 (en) | 2009-11-05 | 2017-10-18 | GlaxoSmithKline LLC | Benzodiazepine bromodomain inhibitor |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919426D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| ES2652304T3 (es) | 2009-11-05 | 2018-02-01 | Glaxosmithkline Llc | Compuesto de benzodiacepina novedoso |
| HUE031073T2 (en) | 2010-05-14 | 2017-06-28 | Dana Farber Cancer Inst Inc | Thieno triazolo-diazepine compounds for the treatment of neoplasia |
| JP5715241B2 (ja) * | 2010-05-14 | 2015-05-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 新生物、炎症性疾患、およびその他の障害を治療するための組成物および方法 |
| WO2011161031A1 (en) | 2010-06-22 | 2011-12-29 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
| WO2012075456A1 (en) | 2010-12-02 | 2012-06-07 | Constellation Pharmaceuticals | Bromodomain inhibitors and uses thereof |
| AR084070A1 (es) | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| EP2705039B1 (en) | 2011-05-04 | 2017-07-26 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| EP2721031B1 (en) | 2011-06-17 | 2016-01-20 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| CA2940472A1 (en) | 2014-02-28 | 2015-09-03 | Tensha Therapeutics, Inc. | Treatment of conditions associated with hyperinsulinaemia |
-
2016
- 2016-06-24 AU AU2016283020A patent/AU2016283020A1/en not_active Abandoned
- 2016-06-24 MA MA042249A patent/MA42249A/fr unknown
- 2016-06-24 CA CA2989313A patent/CA2989313A1/en not_active Abandoned
- 2016-06-24 HK HK18111394.9A patent/HK1252062A1/zh unknown
- 2016-06-24 JP JP2017563973A patent/JP2018520124A/ja active Pending
- 2016-06-24 EP EP16738292.8A patent/EP3314005A1/en not_active Withdrawn
- 2016-06-24 US US15/739,905 patent/US20180193350A1/en not_active Abandoned
- 2016-06-24 KR KR1020187000569A patent/KR20180035785A/ko not_active Withdrawn
- 2016-06-24 WO PCT/US2016/039270 patent/WO2016210275A1/en not_active Ceased
- 2016-06-24 AR ARP160101908A patent/AR105124A1/es unknown
- 2016-06-24 MX MX2017016337A patent/MX2017016337A/es unknown
- 2016-06-24 CN CN201680036201.4A patent/CN107787227A/zh active Pending
- 2016-06-24 BR BR112017028178A patent/BR112017028178A2/pt not_active Application Discontinuation
-
2017
- 2017-12-07 IL IL256186A patent/IL256186A/en unknown
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