JP2018518498A5 - - Google Patents
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- Publication number
- JP2018518498A5 JP2018518498A5 JP2017566151A JP2017566151A JP2018518498A5 JP 2018518498 A5 JP2018518498 A5 JP 2018518498A5 JP 2017566151 A JP2017566151 A JP 2017566151A JP 2017566151 A JP2017566151 A JP 2017566151A JP 2018518498 A5 JP2018518498 A5 JP 2018518498A5
- Authority
- JP
- Japan
- Prior art keywords
- delivery device
- transdermal delivery
- ketamine
- plasma concentration
- immediate release
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037317 transdermal delivery Effects 0.000 claims 21
- YQEZLKZALYSWHR-UHFFFAOYSA-N Ketamine Chemical compound C=1C=CC=C(Cl)C=1C1(NC)CCCCC1=O YQEZLKZALYSWHR-UHFFFAOYSA-N 0.000 claims 13
- 229960003299 ketamine Drugs 0.000 claims 13
- 230000036470 plasma concentration Effects 0.000 claims 8
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 238000009472 formulation Methods 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 230000001070 adhesive effect Effects 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical group COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 claims 2
- 238000002425 crystallisation Methods 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims 1
- VMWNQDUVQKEIOC-CYBMUJFWSA-N apomorphine Chemical compound C([C@H]1N(C)CC2)C3=CC=C(O)C(O)=C3C3=C1C2=CC=C3 VMWNQDUVQKEIOC-CYBMUJFWSA-N 0.000 claims 1
- 229960004046 apomorphine Drugs 0.000 claims 1
- 229960002504 capsaicin Drugs 0.000 claims 1
- 235000017663 capsaicin Nutrition 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- VWTINHYPRWEBQY-UHFFFAOYSA-N denatonium Chemical compound [O-]C(=O)C1=CC=CC=C1.C=1C=CC=CC=1C[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C VWTINHYPRWEBQY-UHFFFAOYSA-N 0.000 claims 1
- 229940006275 denatonium Drugs 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 229940100640 transdermal system Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562185573P | 2015-06-27 | 2015-06-27 | |
| US62/185,573 | 2015-06-27 | ||
| PCT/US2016/039601 WO2017003935A1 (en) | 2015-06-27 | 2016-06-27 | Ketamine transdermal delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018518498A JP2018518498A (ja) | 2018-07-12 |
| JP2018518498A5 true JP2018518498A5 (https=) | 2019-08-08 |
| JP6845162B2 JP6845162B2 (ja) | 2021-03-17 |
Family
ID=57609546
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566151A Active JP6845162B2 (ja) | 2015-06-27 | 2016-06-27 | ケタミン経皮送達システム |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11191734B2 (https=) |
| EP (1) | EP3297620A4 (https=) |
| JP (1) | JP6845162B2 (https=) |
| KR (1) | KR102299359B1 (https=) |
| CN (1) | CN107847469A (https=) |
| AU (1) | AU2016288188B2 (https=) |
| CA (1) | CA2987909C (https=) |
| HK (1) | HK1248578A1 (https=) |
| WO (1) | WO2017003935A1 (https=) |
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| PE20200404A1 (es) | 2013-03-15 | 2020-02-26 | Janssen Pharmaceutica Nv | Composicion farmaceutica de clorhidrato de s-ketamina |
| SI3043785T1 (sl) | 2013-09-13 | 2022-02-28 | National University Corporation Chiba University | Uporaba R-ketamina in njegove soli kot farmacevtska sredstva |
| CN107208133A (zh) | 2014-09-15 | 2017-09-26 | 詹森药业有限公司 | 用于治疗抑郁症的Val66Met (SNPrs6265)基因型特异性给药方案和方法 |
| MX389336B (es) | 2016-11-15 | 2025-03-20 | Klaria Pharma Holding Ab | Formulacion farmaceutica. |
| CN110913844A (zh) * | 2017-04-20 | 2020-03-24 | 广州大洲生物医药科技有限公司 | 用于氯胺酮的透皮药物递送系统 |
| TWI741168B (zh) * | 2017-04-28 | 2021-10-01 | 日商日東電工股份有限公司 | 經皮吸收製劑 |
| GB201709141D0 (en) | 2017-06-08 | 2017-07-26 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
| US11622948B2 (en) | 2017-11-09 | 2023-04-11 | The Trustees Of Columbia University In The City Of New York | Biomarkers for efficacy of prophylactic treatments against stress-induced affective disorders |
| US11491120B2 (en) | 2017-11-09 | 2022-11-08 | The Trustees Of Columbia University In The City Of New York | Pharmacological prophylactics against stress-induced affective disorders in females |
| CN107823195A (zh) * | 2017-11-24 | 2018-03-23 | 无锡市精神卫生中心 | R‑氯胺酮在抑郁症急性期治疗中的应用 |
| MX2020006650A (es) | 2017-12-22 | 2020-11-06 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| PL3505157T3 (pl) | 2017-12-29 | 2022-04-11 | Celon Pharma S.A. | Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie |
| JP7548669B2 (ja) | 2018-02-15 | 2024-09-10 | 国立大学法人千葉大学 | 炎症性疾患若しくは骨疾患の予防又は治療剤及び医薬組成物 |
| EP3784237B1 (en) * | 2018-04-25 | 2023-11-01 | Shinkei Therapeutics, Inc. | Tetrabenazine transdermal delivery device |
| AU2019262197B2 (en) | 2018-05-04 | 2024-12-19 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
| GB201808462D0 (en) | 2018-05-23 | 2018-07-11 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| WO2020086673A1 (en) * | 2018-10-26 | 2020-04-30 | Guangzhou Dazhou Biomedicine Ltd. | Ketamine oral transmucosal delivery system |
| CN111346073B (zh) * | 2018-12-21 | 2022-06-10 | 宜昌人福药业有限责任公司 | 一种透皮给药的药物组合物及其制备方法和应用 |
| MX2021010683A (es) | 2019-03-05 | 2021-12-10 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
| EP3725306A1 (en) | 2019-04-17 | 2020-10-21 | LTS Lohmann Therapie-Systeme AG | Transdermal therapeutic system |
| US20220241218A1 (en) * | 2019-04-17 | 2022-08-04 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system |
| US11752114B2 (en) | 2019-04-17 | 2023-09-12 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system |
| CN109966272A (zh) * | 2019-04-30 | 2019-07-05 | 深圳市泛谷药业股份有限公司 | 一种氯胺酮透皮贴剂及其制备方法 |
| GB201912505D0 (en) * | 2019-08-30 | 2019-10-16 | Klaria Pharma Holding Ab | Pharmaceutical formulation |
| EP4076410B1 (en) | 2019-12-20 | 2025-09-10 | Alar Pharmaceuticals Inc. | Long-acting injectable formulations of ketamine pamoate salts |
| TW202214218A (zh) * | 2020-06-19 | 2022-04-16 | 大陸商廣州大洲生物醫藥科技有限公司 | 氯胺酮的透皮給藥系統 |
| EP3949956A1 (en) * | 2020-08-06 | 2022-02-09 | LTS Lohmann Therapie-Systeme AG | Esketamine-suspension-tts |
| CN117797130A (zh) * | 2022-09-30 | 2024-04-02 | 宜昌人福药业有限责任公司 | S-氯胺酮经皮组合物及其制备方法和应用 |
| WO2024067729A1 (zh) * | 2022-09-30 | 2024-04-04 | 宜昌人福药业有限责任公司 | S-氯胺酮经皮组合物及其制备方法和应用 |
| US12005035B1 (en) * | 2023-08-14 | 2024-06-11 | Daniel C. Javitt | Compositions and methods for treatment of chronic pain and depression |
| WO2025037252A1 (en) * | 2023-08-14 | 2025-02-20 | Javitt Daniel C | Compositions and methods for treatment of chronic pain and depression |
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| WO1997007750A1 (en) * | 1995-08-30 | 1997-03-06 | Weg Stuart L | Administration of ketamine to manage pain and to reduce drug dependency |
| US6248789B1 (en) | 1996-08-29 | 2001-06-19 | Stuart L. Weg | Administration of ketamine to manage pain and to reduce drug dependency |
| US6017961A (en) | 1999-07-08 | 2000-01-25 | Flores; John Anthony | Ketamine and n-butyl-p-aminobezoate in PLO |
| DE60143671D1 (de) | 2001-06-07 | 2011-01-27 | Sang Christine | Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists |
| US20030082225A1 (en) * | 2001-10-19 | 2003-05-01 | Mason Paul Arthur | Sterile, breathable patch for treating wound pain |
| US6855735B2 (en) | 2002-03-20 | 2005-02-15 | Temple University Of The Commonwealth System Of Higher Education | Ketamine treatment of restless legs syndrome |
| US20050148673A1 (en) | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
| AU2003268026A1 (en) | 2002-07-30 | 2004-02-16 | Peter Migaly | Combination therapy for depression, prevention of suicide, and varous medical and psychiatric conditions |
| US7273889B2 (en) | 2002-09-25 | 2007-09-25 | Innovative Drug Delivery Systems, Inc. | NMDA receptor antagonist formulation with reduced neurotoxicity |
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| WO2007111880A2 (en) | 2006-03-22 | 2007-10-04 | Mount Sinai School Of Medicine | Intranasal administration of ketamine to treat depression |
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| EA201590697A1 (ru) | 2012-10-08 | 2015-09-30 | Окленд Юнисервисиз Лимитед | Производные кетамина |
| PE20200404A1 (es) | 2013-03-15 | 2020-02-26 | Janssen Pharmaceutica Nv | Composicion farmaceutica de clorhidrato de s-ketamina |
| JP6462663B2 (ja) | 2013-04-12 | 2019-01-30 | アイカーン スクール オブ メディシン アット マウント シナイ | 心的外傷後ストレス障害を処置するための方法 |
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| JP7603368B2 (ja) | 2016-03-25 | 2024-12-20 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | （２ｒ，６ｒ）－ヒドロキシノルケタミン塩酸塩の結晶形態 |
| CA3019012A1 (en) | 2016-03-25 | 2017-09-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of using (2r, 6r)-hydroxynorketamine and (2s, 6s)-hydroxynorketamine in the treatment of depression, anxiety, anhedonia, fatigue, suicidal ideation, and post traumatic stress disorders |
| US20200297621A1 (en) | 2016-04-01 | 2020-09-24 | Good Pharmaceutical Development Company, Llc | Topical Compositions for Neuropathic Pain |
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| US20170348252A1 (en) | 2016-04-21 | 2017-12-07 | Robert Kent | Preparation and Use of Ketamine Derivatives and Ketamine Modifiers in the Treatment of Pain |
| US11213495B2 (en) | 2016-05-25 | 2022-01-04 | National Health Research Institutes | Method and composition for decreasing the psychotomimetic side effect and addictive disorder of ketamine |
| US20190380978A1 (en) | 2016-06-03 | 2019-12-19 | Small Pharma Ltd | Solid oral dosage forms of 2r,6r-hydroxynorketamine or derivatives thereof |
| CN110913844A (zh) | 2017-04-20 | 2020-03-24 | 广州大洲生物医药科技有限公司 | 用于氯胺酮的透皮药物递送系统 |
-
2016
- 2016-06-27 US US15/736,182 patent/US11191734B2/en active Active
- 2016-06-27 AU AU2016288188A patent/AU2016288188B2/en not_active Ceased
- 2016-06-27 CN CN201680037543.8A patent/CN107847469A/zh active Pending
- 2016-06-27 CA CA2987909A patent/CA2987909C/en active Active
- 2016-06-27 JP JP2017566151A patent/JP6845162B2/ja active Active
- 2016-06-27 KR KR1020187002315A patent/KR102299359B1/ko not_active Expired - Fee Related
- 2016-06-27 HK HK18108421.2A patent/HK1248578A1/zh unknown
- 2016-06-27 EP EP16818548.6A patent/EP3297620A4/en not_active Withdrawn
- 2016-06-27 WO PCT/US2016/039601 patent/WO2017003935A1/en not_active Ceased
-
2021
- 2021-12-02 US US17/540,695 patent/US20220193000A1/en not_active Abandoned
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