JP2018518459A5 - - Google Patents
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- JP2018518459A5 JP2018518459A5 JP2017556587A JP2017556587A JP2018518459A5 JP 2018518459 A5 JP2018518459 A5 JP 2018518459A5 JP 2017556587 A JP2017556587 A JP 2017556587A JP 2017556587 A JP2017556587 A JP 2017556587A JP 2018518459 A5 JP2018518459 A5 JP 2018518459A5
- Authority
- JP
- Japan
- Prior art keywords
- molecule comprises
- immunomodulatory molecule
- ccl19
- optionally
- ccl21
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 230000002519 immonomodulatory effect Effects 0.000 claims description 118
- 210000004027 cell Anatomy 0.000 claims description 67
- 102100036842 C-C motif chemokine 19 Human genes 0.000 claims description 60
- 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 claims description 60
- 102100036846 C-C motif chemokine 21 Human genes 0.000 claims description 59
- 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 claims description 59
- 102000013462 Interleukin-12 Human genes 0.000 claims description 58
- 108010065805 Interleukin-12 Proteins 0.000 claims description 58
- 102100023700 C-C motif chemokine 16 Human genes 0.000 claims description 57
- 101000978375 Homo sapiens C-C motif chemokine 16 Proteins 0.000 claims description 57
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 37
- 108010002350 Interleukin-2 Proteins 0.000 claims description 35
- 239000000203 mixture Substances 0.000 claims description 33
- 150000007523 nucleic acids Chemical group 0.000 claims description 26
- 108091033319 polynucleotide Proteins 0.000 claims description 22
- 102000040430 polynucleotide Human genes 0.000 claims description 22
- 239000002157 polynucleotide Substances 0.000 claims description 22
- 102000000588 Interleukin-2 Human genes 0.000 claims description 21
- 239000000427 antigen Substances 0.000 claims description 20
- 102000036639 antigens Human genes 0.000 claims description 20
- 108091007433 antigens Proteins 0.000 claims description 20
- 108010029697 CD40 Ligand Proteins 0.000 claims description 18
- 102100032937 CD40 ligand Human genes 0.000 claims description 18
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 18
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 18
- 102000003812 Interleukin-15 Human genes 0.000 claims description 18
- 108090000172 Interleukin-15 Proteins 0.000 claims description 18
- 108010042215 OX40 Ligand Proteins 0.000 claims description 18
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims description 18
- 101000597780 Mus musculus Tumor necrosis factor ligand superfamily member 18 Proteins 0.000 claims description 17
- 102100035283 Tumor necrosis factor ligand superfamily member 18 Human genes 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 239000013598 vector Substances 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 231100000053 low toxicity Toxicity 0.000 claims description 13
- 101000638251 Homo sapiens Tumor necrosis factor ligand superfamily member 9 Proteins 0.000 claims description 12
- 102000003810 Interleukin-18 Human genes 0.000 claims description 12
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims description 12
- 230000000295 complement effect Effects 0.000 claims description 10
- 229920001184 polypeptide Polymers 0.000 claims description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 10
- 238000002560 therapeutic procedure Methods 0.000 claims description 10
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
- 201000011510 cancer Diseases 0.000 claims description 8
- 230000002435 cytoreductive effect Effects 0.000 claims description 8
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims description 6
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims description 6
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 claims description 6
- 150000001413 amino acids Chemical group 0.000 claims description 6
- 238000002512 chemotherapy Methods 0.000 claims description 6
- 210000003527 eukaryotic cell Anatomy 0.000 claims description 6
- 238000001959 radiotherapy Methods 0.000 claims description 6
- 230000011664 signaling Effects 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 5
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 4
- 230000000139 costimulatory effect Effects 0.000 claims description 4
- 238000000315 cryotherapy Methods 0.000 claims description 4
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 238000001727 in vivo Methods 0.000 claims description 4
- 238000011534 incubation Methods 0.000 claims description 4
- 210000000822 natural killer cell Anatomy 0.000 claims description 4
- 231100000331 toxic Toxicity 0.000 claims description 4
- 230000002588 toxic effect Effects 0.000 claims description 4
- 230000002463 transducing effect Effects 0.000 claims description 4
- 239000013603 viral vector Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 3
- 239000003550 marker Substances 0.000 claims description 3
- 241000283690 Bos taurus Species 0.000 claims description 2
- 241000282465 Canis Species 0.000 claims description 2
- 108091035707 Consensus sequence Proteins 0.000 claims description 2
- 241000283073 Equus caballus Species 0.000 claims description 2
- 241000282324 Felis Species 0.000 claims description 2
- BCCRXDTUTZHDEU-VKHMYHEASA-N Gly-Ser Chemical compound NCC(=O)N[C@@H](CO)C(O)=O BCCRXDTUTZHDEU-VKHMYHEASA-N 0.000 claims description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
- 210000004102 animal cell Anatomy 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000001185 bone marrow Anatomy 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 210000005260 human cell Anatomy 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000013612 plasmid Substances 0.000 claims description 2
- 210000001236 prokaryotic cell Anatomy 0.000 claims description 2
- 230000001177 retroviral effect Effects 0.000 claims description 2
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000004246 ligand exchange chromatography Methods 0.000 claims 30
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 230000008102 immune modulation Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000001568 sexual effect Effects 0.000 claims 1
- 230000001018 virulence Effects 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 102100030703 Interleukin-22 Human genes 0.000 description 6
- 239000003242 anti bacterial agent Substances 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562155296P | 2015-04-30 | 2015-04-30 | |
| US62/155,296 | 2015-04-30 | ||
| PCT/US2016/030248 WO2016176639A1 (en) | 2015-04-30 | 2016-04-29 | Secretory tnt car cell immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018518459A JP2018518459A (ja) | 2018-07-12 |
| JP2018518459A5 true JP2018518459A5 (enExample) | 2019-04-18 |
Family
ID=57199395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017556587A Pending JP2018518459A (ja) | 2015-04-30 | 2016-04-29 | 分泌性ｔｎｔ ｃａｒ細胞免疫療法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180291089A1 (enExample) |
| EP (1) | EP3288568A4 (enExample) |
| JP (1) | JP2018518459A (enExample) |
| CN (1) | CN107635569A (enExample) |
| AU (1) | AU2016255535A1 (enExample) |
| CA (1) | CA2984180A1 (enExample) |
| IL (1) | IL255280A0 (enExample) |
| WO (1) | WO2016176639A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016251687C1 (en) * | 2015-04-22 | 2023-07-27 | CureVac SE | RNA containing composition for treatment of tumor diseases |
| US20220348633A1 (en) * | 2015-06-25 | 2022-11-03 | Icell Gene Therapeutics Llc | COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHOD OF USE THEREOF |
| WO2018064076A1 (en) | 2016-09-27 | 2018-04-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| CA3039797A1 (en) * | 2016-10-11 | 2018-04-19 | Minerva Biotechnologies Corporation | Humanized anti-muc1* antibodies and use of cleavage enzyme |
| CN110352068A (zh) | 2016-12-02 | 2019-10-18 | 南加利福尼亚大学 | 合成的免疫受体及其使用方法 |
| WO2018124766A2 (ko) * | 2016-12-28 | 2018-07-05 | 주식회사 녹십자랩셀 | 키메라 항원 수용체 및 이를 발현하는 자연 살해 세포 |
| CA3063695A1 (en) * | 2017-05-17 | 2018-11-22 | Seattle Children's Hospital (Dba Seattle Children's Research Institute | Generating mammalian t cell activation inducible synthetic promoters (syn+pro) to improve t cell therapy |
| AU2018287317B2 (en) * | 2017-06-19 | 2024-06-20 | Medicenna Therapeutics Inc. | Uses and methods for IL-2 superagonists, agonists, and fusions thereof |
| DK3688032T3 (da) | 2017-09-26 | 2025-12-15 | Cero Therapeutics Holdings Inc | Kimære engulfment-receptormolekyler og anvendelsesfremgangsmåder |
| KR102774451B1 (ko) | 2017-11-14 | 2025-02-28 | 앱클론(주) | 항-her2 항체 또는 그의 항원 결합 단편, 및 이를 포함하는 키메라 항원 수용체 |
| US11649294B2 (en) | 2017-11-14 | 2023-05-16 | GC Cell Corporation | Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same |
| CN111601882A (zh) * | 2017-11-22 | 2020-08-28 | 拉霍拉敏感及免疫学研究所 | 工程化的免疫细胞的应用和生产 |
| US20210032351A1 (en) * | 2017-12-13 | 2021-02-04 | Xdcexplorer (Shanghai) Co., Ltd. | Egfrviii antibody and conjugate, and preparation method and use thereof |
| US12291557B2 (en) | 2018-03-28 | 2025-05-06 | Cero Therapeutics Holdings, Inc. | Chimeric TIM4 receptors and uses thereof |
| RU2020135107A (ru) | 2018-03-28 | 2022-04-29 | Серо Терапьютикс, Инк. | Клеточные иммунотерапевтические композиции и их применения |
| CN108641001A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 结肠癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108641000A (zh) * | 2018-04-26 | 2018-10-12 | 上海怡豪生物科技有限公司 | 肝癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108659133A (zh) * | 2018-04-26 | 2018-10-16 | 上海怡豪生物科技有限公司 | 肺癌的双靶点car-t治疗载体及其构建方法和应用 |
| CN108864289A (zh) * | 2018-04-26 | 2018-11-23 | 上海怡豪生物科技有限公司 | 胃癌的双靶点car-t治疗载体及其构建方法和应用 |
| JP2021523743A (ja) * | 2018-05-15 | 2021-09-09 | カースゲン セラピューティクス カンパニー リミテッドＣａｒｓｇｅｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｃｏ．， Ｌｔｄ． | 遺伝子操作された細胞及びその応用 |
| KR102907902B1 (ko) | 2018-08-01 | 2026-01-02 | 난트퀘스트, 인크. | 면역 요법의 안정한 유전적 변형을 위한 귀소 수용체 또는 사이토카인, 및 키메라 항원 수용체를 포함하는 4 시스트론 시스템 |
| EP3848387A4 (en) * | 2018-09-05 | 2022-06-22 | Kong, Seogkyoung | CHIMERIC ANTIGEN RECEPTOR FOR SOLID TUMOR AND T-CELLS EXPRESSING A CHIMERIC ANTIGEN RECEPTOR |
| CN112771167B (zh) * | 2018-09-20 | 2025-09-26 | 克莱格医学有限公司 | 表达有趋化因子的细胞及用途 |
| US20210338729A1 (en) * | 2018-10-12 | 2021-11-04 | Icell Gene Therapeutics Llc | CHIMERIC ANTIGEN RECEPTORS (CARs) COMPOSITIONS AND METHODS OF USE THEREOF |
| CN110818803B (zh) * | 2019-07-24 | 2023-01-03 | 浙江启新生物技术有限公司 | 分泌表达il15ra-il15融合蛋白、ccl21趋化因子的嵌合抗原受体-t细胞及应用 |
| WO2021057906A1 (zh) * | 2019-09-25 | 2021-04-01 | 科济生物医药（上海）有限公司 | 表达il-15的免疫效应细胞 |
| CN110684739B (zh) * | 2019-11-11 | 2022-05-27 | 深圳市体内生物医药科技有限公司 | 一种嵌合抗原受体t细胞及其应用 |
| US11230699B2 (en) | 2020-01-28 | 2022-01-25 | Immunitybio, Inc. | Chimeric antigen receptor-modified NK-92 cells targeting EGFR super-family receptors |
| JP2023531506A (ja) * | 2020-06-23 | 2023-07-24 | ザ ジェネラル ホスピタル コーポレイション | トンネルナノチューブ細胞および生体分子の送達のためのその使用方法 |
| JP7868033B2 (ja) | 2020-08-14 | 2026-06-01 | セロ・セラピューティクス・ホールディングス・インコーポレイテッド | キメラｔｉｍ受容体およびその使用 |
| CN112608902B (zh) * | 2020-12-21 | 2024-07-02 | 广东昭泰细胞生物科技有限公司 | 一种第四代car-t细胞及其应用 |
| KR20220144327A (ko) * | 2021-04-15 | 2022-10-26 | 주식회사 유틸렉스 | Hla-dr 특이적 키메라 항원 수용체 및 이의 용도 |
| KR20240022465A (ko) * | 2021-04-28 | 2024-02-20 | 산퀸 아이피 비.브이. | 키메라 Fc-알파 수용체 및 그것의 용도 |
| CN115725504A (zh) * | 2021-08-26 | 2023-03-03 | 南京北恒生物科技有限公司 | 工程化免疫细胞及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9814383D0 (en) * | 1998-07-02 | 1998-09-02 | Cambridge Antibody Tech | Improvements relating to antibodies |
| CN1883454A (zh) * | 2006-06-01 | 2006-12-27 | 复旦大学 | 一种肿瘤坏死靶向单抗预定位脂质体给药系统及其应用 |
| CN101028525B (zh) * | 2006-09-01 | 2010-12-08 | 上海美恩生物技术有限公司 | 肿瘤细胞核单抗在物理治疗实体瘤中作为增效剂的用途 |
| PH12013501201A1 (en) * | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| CN103304669A (zh) * | 2012-03-12 | 2013-09-18 | 复旦大学 | 人源化肿瘤免疫细胞因子tntil2及其制备方法和用途 |
| IL298125A (en) * | 2013-02-26 | 2023-01-01 | Memorial Sloan Kettering Cancer Center | Preparations and methods for immunotherapy |
-
2016
- 2016-04-29 WO PCT/US2016/030248 patent/WO2016176639A1/en not_active Ceased
- 2016-04-29 US US15/570,747 patent/US20180291089A1/en not_active Abandoned
- 2016-04-29 EP EP16787271.2A patent/EP3288568A4/en not_active Withdrawn
- 2016-04-29 JP JP2017556587A patent/JP2018518459A/ja active Pending
- 2016-04-29 CN CN201680031760.6A patent/CN107635569A/zh active Pending
- 2016-04-29 AU AU2016255535A patent/AU2016255535A1/en not_active Abandoned
- 2016-04-29 CA CA2984180A patent/CA2984180A1/en not_active Abandoned
-
2017
- 2017-10-26 IL IL255280A patent/IL255280A0/en unknown
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