JP2018516854A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516854A5 JP2018516854A5 JP2017552058A JP2017552058A JP2018516854A5 JP 2018516854 A5 JP2018516854 A5 JP 2018516854A5 JP 2017552058 A JP2017552058 A JP 2017552058A JP 2017552058 A JP2017552058 A JP 2017552058A JP 2018516854 A5 JP2018516854 A5 JP 2018516854A5
- Authority
- JP
- Japan
- Prior art keywords
- immunoconjugate
- nanoparticles
- composition
- antibody fragment
- peg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562144278P | 2015-04-07 | 2015-04-07 | |
| US62/144,278 | 2015-04-07 | ||
| US201562151943P | 2015-04-23 | 2015-04-23 | |
| US62/151,943 | 2015-04-23 | ||
| PCT/US2016/026434 WO2016164578A1 (en) | 2015-04-07 | 2016-04-07 | Nanoparticle immunoconjugates |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021014331A Division JP7016975B2 (ja) | 2015-04-07 | 2021-02-01 | ナノ粒子イムノコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516854A JP2018516854A (ja) | 2018-06-28 |
| JP2018516854A5 true JP2018516854A5 (OSRAM) | 2019-05-09 |
| JP6869187B2 JP6869187B2 (ja) | 2021-05-12 |
Family
ID=55806803
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017552058A Active JP6869187B2 (ja) | 2015-04-07 | 2016-04-07 | ナノ粒子イムノコンジュゲート |
| JP2021014331A Active JP7016975B2 (ja) | 2015-04-07 | 2021-02-01 | ナノ粒子イムノコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021014331A Active JP7016975B2 (ja) | 2015-04-07 | 2021-02-01 | ナノ粒子イムノコンジュゲート |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US10548989B2 (OSRAM) |
| EP (1) | EP3280454A1 (OSRAM) |
| JP (2) | JP6869187B2 (OSRAM) |
| KR (1) | KR102701678B1 (OSRAM) |
| CN (2) | CN113876962A (OSRAM) |
| AU (2) | AU2016246737B2 (OSRAM) |
| CA (1) | CA2980462C (OSRAM) |
| HK (1) | HK1250646A1 (OSRAM) |
| WO (1) | WO2016164578A1 (OSRAM) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12161734B2 (en) | 2009-07-02 | 2024-12-10 | Sloan-Kettering Institute For Cancer Research | Multimodal silica-based nanoparticles |
| CN105307687A (zh) | 2013-03-15 | 2016-02-03 | 索隆-基特林癌症研究协会 | 多模态的基于二氧化硅的纳米粒子 |
| CN113876962A (zh) * | 2015-04-07 | 2022-01-04 | 纪念斯隆-凯特琳癌症中心 | 纳米粒子免疫偶联物 |
| JP6974178B2 (ja) | 2015-05-29 | 2021-12-01 | メモリアル スローン ケタリング キャンサー センター | フェロトーシスを介して栄養欠乏がん細胞の細胞死を誘導するための極小ナノ粒子を使用する処置方法 |
| KR20190003630A (ko) | 2016-04-29 | 2019-01-09 | 메모리얼 슬로안 케터링 캔서 센터 | 악성 뇌 종양에서의 표적화된 입자 침투, 분포, 및 반응을 위한 조성물 및 방법 |
| AU2017291702B2 (en) | 2016-07-07 | 2022-04-28 | Cornell University | Imaging systems and methods for particle-driven, knowledge-based, and predictive cancer radiogenomics |
| BR112019010947A2 (pt) | 2016-11-30 | 2019-10-01 | Memorial Sloan Kettering Cancer Center | nanopartículas ultrapequenas funcionalizadas por inibidores e métodos das mesmas |
| CN110291089B (zh) | 2017-01-17 | 2022-05-27 | 海帕瑞吉尼克斯股份有限公司 | 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂 |
| KR102228571B1 (ko) | 2017-02-09 | 2021-03-16 | 주식회사 메디폴리머 | 정신질환 또는 중추신경계 질환 치료용 약물전달 제형 |
| EP3634500B1 (en) | 2017-05-25 | 2023-10-25 | Memorial Sloan-Kettering Cancer Center | Ultrasmall nanoparticles labeled with zirconium-89 and methods thereof |
| EP3737383A4 (en) * | 2018-01-12 | 2021-12-15 | Prolynx LLC | SYNERGISTIC CANCER TREATMENT |
| EP3773742A4 (en) * | 2018-04-06 | 2022-03-16 | North Carolina State University | CELL SET-MEDIATED CHECKPOINT INHIBITOR DELIVERY FOR CANCER IMMUNOTHERAPY |
| US12066382B2 (en) * | 2018-06-21 | 2024-08-20 | Lonza Sales Ag | Methods of measuring extracellular vesicles and nanoparticles in complex matrices by light scattering |
| JP7486505B2 (ja) | 2018-10-16 | 2024-05-17 | ファーマ イン シリカ ラボラトリーズ インコーポレイティド | シリカカプセル／スフェアの調製のためのチューニング可能な方法及びそれらの使用 |
| CN109490523A (zh) * | 2018-10-22 | 2019-03-19 | 北京纳晶生物科技有限公司 | 用于标记的纳米材料、核酸探针及核酸与纳米材料偶联的方法 |
| KR102336120B1 (ko) * | 2019-06-05 | 2021-12-08 | 주식회사 엔이에스바이오테크놀러지 | 금 나노입자-앱타머 결합체를 기반으로 하는 항체 전달체 및 이의 제조 방법 |
| EP4031195A4 (en) | 2019-09-16 | 2023-11-29 | ABK Biomedical Incorporated | Composition of radioactive and non-radioactive microparticles |
| WO2021054490A1 (ko) * | 2019-09-18 | 2021-03-25 | 연세대학교 산학협력단 | 양친매성 고분자, 이를 포함하는 수분산성 금속나노입자 및 이의 제조방법 |
| AU2020377966A1 (en) * | 2019-11-04 | 2022-05-19 | Cornell University | Ultrasmall nanoparticles and methods of making, using and analyzing same |
| WO2021222759A1 (en) * | 2020-04-30 | 2021-11-04 | Board Of Regents, The University Of Texas System | Albumin drug conjugates and use thereof for the treatment of cancer |
| CN111906328B (zh) * | 2020-08-11 | 2022-10-25 | 苏州大学 | 一种177Lu标记的金纳米团簇及其制备方法和应用 |
| ES2963150T3 (es) | 2020-10-27 | 2024-03-25 | Elucida Oncology Inc | Procedimientos para funcionalizar nanopartículas |
| WO2025178318A1 (ko) * | 2024-02-20 | 2025-08-28 | 주식회사 심비스타 | Nmda 수용체 항체 및 형광물질을 포함하는 신규 테라그노스틱 나노복합체 및 이것의 용도 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| US5141648A (en) | 1987-12-02 | 1992-08-25 | Neorx Corporation | Methods for isolating compounds using cleavable linker bound matrices |
| US5563250A (en) | 1987-12-02 | 1996-10-08 | Neorx Corporation | Cleavable conjugates for the delivery and release of agents in native form |
| FI102355B1 (fi) | 1988-02-11 | 1998-11-30 | Bristol Myers Squibb Co | Menetelmä yhdistävän välikappaleen omaavien antrasykliini-immunokonjugaattien valmistamiseksi |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5543390A (en) | 1990-11-01 | 1996-08-06 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University | Covalent microparticle-drug conjugates for biological targeting |
| CA2076465C (en) | 1992-03-25 | 2002-11-26 | Ravi V. J. Chari | Cell binding agent conjugates of analogues and derivatives of cc-1065 |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| WO1996040662A2 (en) | 1995-06-07 | 1996-12-19 | Cellpro, Incorporated | Aminooxy-containing linker compounds and their application in conjugates |
| ES2276708T3 (es) | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
| US7087600B2 (en) | 2001-05-31 | 2006-08-08 | Medarex, Inc. | Peptidyl prodrugs and linkers and stabilizers useful therefor |
| SG187991A1 (en) | 2002-05-02 | 2013-03-28 | Wyeth Corp | Calicheamicin derivative-carrier conjugates |
| CA2484640C (en) | 2002-05-15 | 2012-01-17 | Endocyte, Inc. | Vitamin-mitomycin conjugates |
| US20040101822A1 (en) | 2002-11-26 | 2004-05-27 | Ulrich Wiesner | Fluorescent silica-based nanoparticles |
| EP3434275A1 (en) | 2003-11-06 | 2019-01-30 | Seattle Genetics, Inc. | Assay for cancer cells based on the use of auristatin conjugates with antibodies |
| EP1718667B1 (en) | 2004-02-23 | 2013-01-09 | Genentech, Inc. | Heterocyclic self-immolative linkers and conjugates |
| US7691962B2 (en) | 2004-05-19 | 2010-04-06 | Medarex, Inc. | Chemical linkers and conjugates thereof |
| US20060222595A1 (en) * | 2005-03-31 | 2006-10-05 | Priyabrata Mukherjee | Nanoparticles for therapeutic and diagnostic applications |
| CA2627190A1 (en) | 2005-11-10 | 2007-05-24 | Medarex, Inc. | Duocarmycin derivatives as novel cytotoxic compounds and conjugates |
| WO2009045579A2 (en) * | 2007-06-14 | 2009-04-09 | The Regents Of The University Of California | Multimodal imaging probes for in vivo targeted and non-targeted imaging and therapeutics |
| US20080317768A1 (en) * | 2007-06-21 | 2008-12-25 | Boeing Company | Bioconjugated nanoparticles |
| WO2009046407A2 (en) * | 2007-10-04 | 2009-04-09 | Zymogenetics, Inc. | B7 FAMILY MEMBER zB7H6 AND RELATED COMPOSITIONS AND METHODS |
| EP2281006B1 (en) | 2008-04-30 | 2017-08-02 | Immunogen, Inc. | Cross-linkers and their uses |
| CA2744344A1 (en) * | 2008-11-26 | 2010-06-03 | National Research Council Of Canada | Antibody-targeted carrier for contrast agents |
| EP3243527B1 (en) | 2009-02-13 | 2019-06-05 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| DK3223013T3 (en) * | 2009-07-02 | 2019-04-15 | Sloan Kettering Inst Cancer Res | FLUORESCING SILICA-BASED NANOPARTICLES |
| NO331080B1 (no) * | 2010-01-29 | 2011-09-26 | Nordic Nanovector As | Radioimmunkonjugater, farmasøytiske sammensetninger og kit omfattende det samme og anvendelse derav |
| ES2742216T3 (es) * | 2010-04-15 | 2020-02-13 | Kodiak Sciences Inc | Polímeros que contienen zwitteriones de alto peso molecular |
| CN105307687A (zh) | 2013-03-15 | 2016-02-03 | 索隆-基特林癌症研究协会 | 多模态的基于二氧化硅的纳米粒子 |
| CN113876962A (zh) | 2015-04-07 | 2022-01-04 | 纪念斯隆-凯特琳癌症中心 | 纳米粒子免疫偶联物 |
| EP3634500B1 (en) * | 2017-05-25 | 2023-10-25 | Memorial Sloan-Kettering Cancer Center | Ultrasmall nanoparticles labeled with zirconium-89 and methods thereof |
-
2016
- 2016-04-07 CN CN202111317319.3A patent/CN113876962A/zh active Pending
- 2016-04-07 JP JP2017552058A patent/JP6869187B2/ja active Active
- 2016-04-07 KR KR1020177031663A patent/KR102701678B1/ko active Active
- 2016-04-07 CN CN201680024624.4A patent/CN107735110B/zh active Active
- 2016-04-07 WO PCT/US2016/026434 patent/WO2016164578A1/en not_active Ceased
- 2016-04-07 CA CA2980462A patent/CA2980462C/en active Active
- 2016-04-07 AU AU2016246737A patent/AU2016246737B2/en active Active
- 2016-04-07 US US15/564,315 patent/US10548989B2/en active Active
- 2016-04-07 EP EP16718099.1A patent/EP3280454A1/en active Pending
- 2016-04-07 HK HK18110131.9A patent/HK1250646A1/zh unknown
-
2019
- 2019-11-26 AU AU2019271919A patent/AU2019271919B2/en active Active
- 2019-12-19 US US16/720,176 patent/US20200353096A1/en not_active Abandoned
-
2021
- 2021-02-01 JP JP2021014331A patent/JP7016975B2/ja active Active
-
2022
- 2022-10-07 US US17/961,761 patent/US20230037294A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7016975B2 (ja) | ナノ粒子イムノコンジュゲート | |
| Wu et al. | Radioactive polymeric nanoparticles for biomedical application | |
| Majkowska-Pilip et al. | Nanoparticles in targeted alpha therapy | |
| Dekempeneer et al. | Therapeutic efficacy of 213Bi-labeled sdAbs in a preclinical model of ovarian cancer | |
| Boswell et al. | Effects of charge on antibody tissue distribution and pharmacokinetics | |
| Wängler et al. | Antibody− dendrimer conjugates: The number, not the size of the dendrimers, determines the immunoreactivity | |
| JP2025013502A (ja) | 悪性脳腫瘍における標的化粒子の浸透、分布および応答のための組成物及び方法 | |
| Cohen et al. | Development of novel ADCs: conjugation of tubulysin analogues to trastuzumab monitored by dual radiolabeling | |
| Pant et al. | Radiolabelled polymeric materials for imaging and treatment of cancer: quo vadis? | |
| Etrych et al. | Targeted drug delivery and theranostic strategies in malignant lymphomas | |
| Azadbakht et al. | Preparation and evaluation of APTES-PEG coated iron oxide nanoparticles conjugated to rhenium-188 labeled rituximab | |
| CA2986699A1 (en) | Systems and methods for determining optimum patient-specific antibody dose for tumor targeting | |
| Aranda‐Lara et al. | Drug Delivery Systems‐Based Dendrimers and Polymer Micelles for Nuclear Diagnosis and Therapy | |
| DE60320398T2 (de) | Methoden und medizinische zusammensetzungen zur intravesikalen behandlung von blasenkrebs | |
| Trencsényi et al. | Targeted radium alpha therapy in the era of nanomedicine: in vivo results | |
| Warnders et al. | Influence of protein properties and protein modification on biodistribution and tumor uptake of anticancer antibodies, antibody derivatives, and non‐Ig scaffolds | |
| Polyak et al. | Preparation and 68Ga-radiolabeling of porous zirconia nanoparticle platform for PET/CT-imaging guided drug delivery | |
| Jimenez-Mancilla et al. | Multifunctional targeted radiotherapy system for induced tumours expressing gastrin-releasing peptide receptors | |
| TWI908815B (zh) | 用於人類疾病之治療的ｃｄ３８抗體 | |
| Wang et al. | Ultrasmall gold nanoparticles radiolabeled with iodine-125 as potential new radiopharmaceutical | |
| Misri et al. | Evaluation of 111In labeled antibodies for SPECT imaging of mesothelin expressing tumors | |
| CN107690334A (zh) | 使用针对haah的抗体对癌症的放射成像和放射治疗 | |
| CN102065906B (zh) | 放射性标记大分子的方法 | |
| CN120129537A (zh) | 用于医学成像的放射性药物mof | |
| US20100179303A1 (en) | Site-specific conjugation of ligands to nanoparticles |