JP2018513715A - 異なる大きさの薬剤溶出性微小球ビーズによる肝動脈化学塞栓術後の薬剤濃度決定 - Google Patents

異なる大きさの薬剤溶出性微小球ビーズによる肝動脈化学塞栓術後の薬剤濃度決定 Download PDF

Info

Publication number
JP2018513715A
JP2018513715A JP2017547143A JP2017547143A JP2018513715A JP 2018513715 A JP2018513715 A JP 2018513715A JP 2017547143 A JP2017547143 A JP 2017547143A JP 2017547143 A JP2017547143 A JP 2017547143A JP 2018513715 A JP2018513715 A JP 2018513715A
Authority
JP
Japan
Prior art keywords
drug
region
interest
contrast agent
image data
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2017547143A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018513715A5 (cg-RX-API-DMAC7.html
Inventor
クリスティアン ハーセ
クリスティアン ハーセ
ディルク スハーフェル
ディルク スハーフェル
エベルハルト セバスティアン ハンシス
エベルハルト セバスティアン ハンシス
トビアス クリンデル
トビアス クリンデル
ミシェル グラス
ミシェル グラス
ミン ダー リン
ミン ダー リン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of JP2018513715A publication Critical patent/JP2018513715A/ja
Publication of JP2018513715A5 publication Critical patent/JP2018513715A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0419Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/032Transmission computed tomography [CT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/42Arrangements for detecting radiation specially adapted for radiation diagnosis
    • A61B6/4208Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector
    • A61B6/4241Arrangements for detecting radiation specially adapted for radiation diagnosis characterised by using a particular type of detector using energy resolving detectors, e.g. photon counting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48Diagnostic techniques
    • A61B6/481Diagnostic techniques involving the use of contrast agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/48Diagnostic techniques
    • A61B6/482Diagnostic techniques involving multiple energy imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/504Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for diagnosis of blood vessels, e.g. by angiography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/40Arrangements for generating radiation specially adapted for radiation diagnosis
    • A61B6/405Source units specially adapted to modify characteristics of the beam during the data acquisition process
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Theoretical Computer Science (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Dentistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Surgical Instruments (AREA)
  • Medicinal Preparation (AREA)
JP2017547143A 2015-03-18 2015-12-04 異なる大きさの薬剤溶出性微小球ビーズによる肝動脈化学塞栓術後の薬剤濃度決定 Pending JP2018513715A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562134639P 2015-03-18 2015-03-18
US62/134,639 2015-03-18
EP15166519.7 2015-05-06
EP15166519 2015-05-06
PCT/EP2015/078737 WO2016146214A1 (en) 2015-03-18 2015-12-04 Drug concentration determination after transarterial chemoembolization with different sized drug-eluting microsphere beads

Publications (2)

Publication Number Publication Date
JP2018513715A true JP2018513715A (ja) 2018-05-31
JP2018513715A5 JP2018513715A5 (cg-RX-API-DMAC7.html) 2019-01-17

Family

ID=53181069

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017547143A Pending JP2018513715A (ja) 2015-03-18 2015-12-04 異なる大きさの薬剤溶出性微小球ビーズによる肝動脈化学塞栓術後の薬剤濃度決定

Country Status (5)

Country Link
US (1) US11172896B2 (cg-RX-API-DMAC7.html)
EP (1) EP3270785B1 (cg-RX-API-DMAC7.html)
JP (1) JP2018513715A (cg-RX-API-DMAC7.html)
CN (1) CN107666861B (cg-RX-API-DMAC7.html)
WO (1) WO2016146214A1 (cg-RX-API-DMAC7.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3400877A1 (de) 2017-05-10 2018-11-14 Siemens Healthcare GmbH Verfahren zur bildgebung eines untersuchungsbereichs mit erstem kontrastmittel und zweitem kontrastmittel
DE102019218589A1 (de) * 2019-11-29 2021-06-02 Bayer Aktiengesellschaft Simultane Bilddarstellung von zwei unterschiedlichen funktionellen Bereichen
CN113546234B (zh) * 2020-04-24 2022-09-20 苏州医本生命科技有限公司 一种血管介入具有示踪功能的药物制剂及其输送系统
DE102021210860A1 (de) 2021-09-28 2023-03-30 Siemens Healthcare Gmbh Computerimplementiertes Verfahren zur Auswertung von Bilddaten eines Patienten, Eingriffsanordnung, Computerprogramm und elektronisch lesbarer Datenträger
US12484865B2 (en) * 2024-02-02 2025-12-02 Varian Medical Systems, Inc. Selective internal radiation therapy mapping via microbeads with different contrast materials

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080102029A1 (en) * 2004-10-25 2008-05-01 Celonova Biosciences, Inc. Loadable Polymeric Particles For Enhanced Imaging In Clinical Applications And Methods Of Preparing And Using The Same
US20080113029A1 (en) * 2004-10-25 2008-05-15 Celonova Biosciences, Inc. Color-Coded and Sized Loadable Polymeric Particles for Therapeutic and/or Diagnostic Applications and Methods of Preparing and Using the Same
JP2011528248A (ja) * 2008-07-18 2011-11-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ スペクトルイメージング
JP2012506281A (ja) * 2008-10-23 2012-03-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 分子イメージング
WO2013164725A1 (en) * 2012-05-02 2013-11-07 Koninklijke Philips N.V. Spectral ct visualization of imageable drug eluting beads
WO2013186661A1 (en) * 2012-06-14 2013-12-19 Koninklijke Philips N.V. Spectral imaging based decision support, treatment planning and/or intervention guidance
WO2014024061A1 (en) * 2012-08-06 2014-02-13 Koninklijke Philips N.V. Dynamic contrast-enhanced imaging based permeability metric

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2360542T3 (es) * 2004-10-25 2011-06-06 Celonova Biosciences Germany Gmbh Partículas poliméricas cargables para aplicaciones terapéuticas y/o diagnósticos y procedimientos para preparar y utilizar las mismas.
AU2007356895B2 (en) 2007-07-25 2012-11-15 Varian Medical Systems, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
WO2011014562A1 (en) 2009-07-28 2011-02-03 North Carolina State University Methods and devices for targeted injection of microspheres

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080102029A1 (en) * 2004-10-25 2008-05-01 Celonova Biosciences, Inc. Loadable Polymeric Particles For Enhanced Imaging In Clinical Applications And Methods Of Preparing And Using The Same
US20080113029A1 (en) * 2004-10-25 2008-05-15 Celonova Biosciences, Inc. Color-Coded and Sized Loadable Polymeric Particles for Therapeutic and/or Diagnostic Applications and Methods of Preparing and Using the Same
JP2011528248A (ja) * 2008-07-18 2011-11-17 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ スペクトルイメージング
JP2012506281A (ja) * 2008-10-23 2012-03-15 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 分子イメージング
WO2013164725A1 (en) * 2012-05-02 2013-11-07 Koninklijke Philips N.V. Spectral ct visualization of imageable drug eluting beads
WO2013186661A1 (en) * 2012-06-14 2013-12-19 Koninklijke Philips N.V. Spectral imaging based decision support, treatment planning and/or intervention guidance
WO2014024061A1 (en) * 2012-08-06 2014-02-13 Koninklijke Philips N.V. Dynamic contrast-enhanced imaging based permeability metric

Also Published As

Publication number Publication date
EP3270785B1 (en) 2020-07-08
EP3270785A1 (en) 2018-01-24
CN107666861B (zh) 2022-03-01
WO2016146214A1 (en) 2016-09-22
US11172896B2 (en) 2021-11-16
US20180035960A1 (en) 2018-02-08
CN107666861A (zh) 2018-02-06

Similar Documents

Publication Publication Date Title
Hainfeld et al. Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions
Seyal et al. CT of the abdomen with reduced tube voltage in adults: a practical approach
Damascelli et al. A novel intraarterial chemotherapy using paclitaxel in albumin nanoparticles to treat advanced squamous cell carcinoma of the tongue: preliminary findings
US6251059B1 (en) Medical radiation treatment delivery apparatus
CN107666861B (zh) 在利用尺寸不同的药物洗脱微球珠粒进行经动脉化疗栓塞之后的药物浓度确定
US6162165A (en) Medical radiation treatment device
Weber et al. Assessment of Diffusion-Weighted MRI and 18 F-Fluoro-Deoxyglucose PET/CT in Monitoring Early Response to Neoadjuvant Chemotherapy in Adenocarcinoma of the Esophagogastric Junction.
Riederer et al. Liquid embolic agents in spectral X-ray photon-counting computed tomography using tantalum K-edge imaging
Wang et al. Three-dimensional evaluation of lipiodol retention in HCC after chemoembolization: a quantitative comparison between CBCT and MDCT
Xiong et al. Current techniques for lymphatic imaging: State of the art and future perspectives
Kurian et al. The role of CT angiography in the evaluation of pediatric renovascular hypertension
Tacher et al. Multimodality imaging of ethiodized oil–loaded radiopaque microspheres during transarterial embolization of rabbits with VX2 liver tumors
Carling et al. Transarterial chemoembolization of liver metastases from uveal melanoma using irinotecan-loaded beads: treatment response and complications
Yao et al. Dual-phase cone-beam CT-based navigation imaging significantly enhances tumor detectability and aids superselective transarterial chemoembolization of liver cancer
Kim et al. Yttrium-90 radioembolization of the right inferior phrenic artery in 20 patients with hepatocellular carcinoma
Schmitt et al. Imaging artifacts of liquid embolic agents on conventional CT in an experimental in vitro model
Gholamrezanezhad et al. Evaluation of 70–150-μm doxorubicin-eluting beads for transcatheter arterial chemoembolization in the rabbit liver VX2 tumour model
Peynircioğlu et al. Quantitative liver tumor blood volume measurements by a C-arm CT post-processing software before and after hepatic arterial embolization therapy: comparison with MDCT perfusion
Aliberti et al. Chemoembolization adopting polyethylene glycol drug-eluting embolics loaded with doxorubicin for the treatment of hepatocellular carcinoma
Rose et al. The beauty and bane of pressure-directed embolotherapy: hemodynamic principles and preliminary clinical evidence
EP2844147B1 (en) Spectral ct visualization of imageable drug eluting beads
Kennoki et al. Transcatheter arterial chemoembolization with spherical embolic material for locally advanced breast cancer: first report of HepaSphere™ treatment for primary breast cancer
Subramaniam Science to Practice: Molecular Targeting with SPECT/CT and MR Imaging in Oncology—Integration of Functional and Structural Imaging
Oprea-Lager et al. [18F] fluoromethylcholine as a chemotherapy response read-out in prostate cancer cells
Chung et al. Transarterial chemoembolization as an alternative to radioembolization is associated with earlier tumor recurrence than in radioembolization-eligible patients

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181130

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181130

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20191119

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20191205

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200605

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20200811

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201211

C60 Trial request (containing other claim documents, opposition documents)

Free format text: JAPANESE INTERMEDIATE CODE: C60

Effective date: 20201211

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20201222

C21 Notice of transfer of a case for reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C21

Effective date: 20201224

A912 Re-examination (zenchi) completed and case transferred to appeal board

Free format text: JAPANESE INTERMEDIATE CODE: A912

Effective date: 20210129

C211 Notice of termination of reconsideration by examiners before appeal proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C211

Effective date: 20210202

C22 Notice of designation (change) of administrative judge

Free format text: JAPANESE INTERMEDIATE CODE: C22

Effective date: 20210304

C23 Notice of termination of proceedings

Free format text: JAPANESE INTERMEDIATE CODE: C23

Effective date: 20210803

C03 Trial/appeal decision taken

Free format text: JAPANESE INTERMEDIATE CODE: C03

Effective date: 20210831

C30A Notification sent

Free format text: JAPANESE INTERMEDIATE CODE: C3012

Effective date: 20210831