JP2018513171A5 - - Google Patents
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- Publication number
- JP2018513171A5 JP2018513171A5 JP2017554815A JP2017554815A JP2018513171A5 JP 2018513171 A5 JP2018513171 A5 JP 2018513171A5 JP 2017554815 A JP2017554815 A JP 2017554815A JP 2017554815 A JP2017554815 A JP 2017554815A JP 2018513171 A5 JP2018513171 A5 JP 2018513171A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- oral pharmaceutical
- formulation according
- oral
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 23
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 5
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 4
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims 3
- 239000008183 oral pharmaceutical preparation Substances 0.000 claims 3
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940049953 phenylacetate Drugs 0.000 claims 2
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010020575 Hyperammonaemia Diseases 0.000 claims 1
- 208000028547 Inborn Urea Cycle disease Diseases 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009969 flowable effect Effects 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 208000007232 portal hypertension Diseases 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 208000030954 urea cycle disease Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022046762A JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150238P | 2015-04-20 | 2015-04-20 | |
| US62/150,238 | 2015-04-20 | ||
| US201562150676P | 2015-04-21 | 2015-04-21 | |
| US62/150,676 | 2015-04-21 | ||
| US201562211619P | 2015-08-28 | 2015-08-28 | |
| US62/211,619 | 2015-08-28 | ||
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| PCT/US2016/028298 WO2016172112A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022046762A Division JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018513171A JP2018513171A (ja) | 2018-05-24 |
| JP2018513171A5 true JP2018513171A5 (https=) | 2019-05-30 |
Family
ID=57144228
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554815A Pending JP2018513171A (ja) | 2015-04-20 | 2016-04-19 | Ｌ−オルニチンフェニルアセテート製剤 |
| JP2022046762A Pending JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022046762A Pending JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20160338982A1 (https=) |
| EP (2) | EP3285756B1 (https=) |
| JP (2) | JP2018513171A (https=) |
| KR (1) | KR20180006904A (https=) |
| CN (2) | CN107708684A (https=) |
| AU (2) | AU2016252382A1 (https=) |
| CA (1) | CA2983146C (https=) |
| DK (1) | DK3285756T3 (https=) |
| ES (1) | ES2944311T3 (https=) |
| HK (1) | HK1251149A1 (https=) |
| MX (2) | MX391167B (https=) |
| RU (1) | RU2755904C2 (https=) |
| WO (1) | WO2016172112A1 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2153870T1 (sl) | 2004-11-26 | 2014-05-30 | Ucl Business Plc | Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije |
| HUE035921T2 (en) | 2009-04-03 | 2018-05-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| CN104434894A (zh) | 2009-06-08 | 2015-03-25 | Ucl商业有限公司 | 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能 |
| ES2769000T3 (es) | 2014-11-24 | 2020-06-24 | Ucl Business Ltd | Tratamiento de enfermedades asociadas con la activación de células estrelladas hepáticas utilizando terapias reductoras de amoníaco |
| WO2017031131A1 (en) | 2015-08-18 | 2017-02-23 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using l-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| CN108366983A (zh) * | 2015-11-13 | 2018-08-03 | 欧塞拉治疗有限公司 | L-鸟氨酸苯乙酸盐制剂 |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| MX389665B (es) | 2017-05-11 | 2025-03-20 | Ocera Therapeutics Inc | Procesos para producir fenilacetato de l-ornitina |
| MX2020001765A (es) | 2017-08-14 | 2020-07-29 | Axcella Health Inc | Composiciones de aminoacidos para el tratamiento de enfermedad hepatica. |
| CN112839643A (zh) | 2018-06-20 | 2021-05-25 | 胺细拉健康公司 | 用于治疗肌肉中脂肪浸润的组合物及方法 |
| SG11202111509PA (en) | 2019-05-09 | 2021-11-29 | Ocera Therapeutics Inc | Methods of assessing and treating hepatic encephalopathy |
| PH12022550738A1 (en) * | 2019-10-16 | 2023-05-08 | Mallinckrodt Entpr Llc | Dosages and uses of ornithine phenylacetate for treating hyperammonemia |
| EP4096647A1 (en) | 2020-01-30 | 2022-12-07 | Yeda Research and Development Co. Ltd | Treating acute liver disease with tlr-mik inhibitors |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
| SI2153870T1 (sl) * | 2004-11-26 | 2014-05-30 | Ucl Business Plc | Sestavki, ki obsegajo ornitin in fenilacetat ali fenilbutirat, za zdravljenje hepatitične encefalopatije |
| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| HUE035921T2 (en) | 2009-04-03 | 2018-05-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| CN104434894A (zh) * | 2009-06-08 | 2015-03-25 | Ucl商业有限公司 | 使用l-鸟氨酸苯乙酸盐治疗门静脉高压和恢复肝功能 |
| AU2014250643B2 (en) * | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| US8946473B2 (en) * | 2010-10-06 | 2015-02-03 | Ocera Therapeutics, Inc. | Methods of making L-ornithine phenyl acetate |
-
2016
- 2016-04-19 CN CN201680036045.1A patent/CN107708684A/zh active Pending
- 2016-04-19 DK DK16783692.3T patent/DK3285756T3/da active
- 2016-04-19 CN CN202110931620.7A patent/CN113599350A/zh active Pending
- 2016-04-19 EP EP16783692.3A patent/EP3285756B1/en active Active
- 2016-04-19 CA CA2983146A patent/CA2983146C/en active Active
- 2016-04-19 JP JP2017554815A patent/JP2018513171A/ja active Pending
- 2016-04-19 US US15/133,087 patent/US20160338982A1/en not_active Abandoned
- 2016-04-19 MX MX2017013170A patent/MX391167B/es unknown
- 2016-04-19 EP EP23157390.8A patent/EP4205735A1/en not_active Withdrawn
- 2016-04-19 ES ES16783692T patent/ES2944311T3/es active Active
- 2016-04-19 KR KR1020177032260A patent/KR20180006904A/ko not_active Ceased
- 2016-04-19 HK HK18110518.2A patent/HK1251149A1/zh unknown
- 2016-04-19 AU AU2016252382A patent/AU2016252382A1/en not_active Abandoned
- 2016-04-19 RU RU2017137643A patent/RU2755904C2/ru active
- 2016-04-19 WO PCT/US2016/028298 patent/WO2016172112A1/en not_active Ceased
-
2017
- 2017-10-12 MX MX2022003855A patent/MX2022003855A/es unknown
-
2021
- 2021-02-05 AU AU2021200740A patent/AU2021200740A1/en not_active Abandoned
- 2021-12-22 US US17/559,453 patent/US20220184014A1/en not_active Abandoned
-
2022
- 2022-03-23 JP JP2022046762A patent/JP2022101549A/ja active Pending
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