AU2016252382A1 - Formulations of L-ornithine phenylacetate - Google Patents
Formulations of L-ornithine phenylacetate Download PDFInfo
- Publication number
- AU2016252382A1 AU2016252382A1 AU2016252382A AU2016252382A AU2016252382A1 AU 2016252382 A1 AU2016252382 A1 AU 2016252382A1 AU 2016252382 A AU2016252382 A AU 2016252382A AU 2016252382 A AU2016252382 A AU 2016252382A AU 2016252382 A1 AU2016252382 A1 AU 2016252382A1
- Authority
- AU
- Australia
- Prior art keywords
- pharmaceutical formulation
- phenylacetate
- omithine
- oral pharmaceutical
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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| AU2021200740A AU2021200740A1 (en) | 2015-04-20 | 2021-02-05 | Formulations of L-ornithine phenylacetate |
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| US62/150,676 | 2015-04-21 | ||
| US201562211619P | 2015-08-28 | 2015-08-28 | |
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| PCT/US2016/028298 WO2016172112A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
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| SG158073A1 (en) | 2004-11-26 | 2010-01-29 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| CA2757373C (en) | 2009-04-03 | 2018-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| EA201691430A1 (ru) | 2009-06-08 | 2017-02-28 | ЮСиЭл БИЗНЕС ПиЭлСи | Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата |
| US10039735B2 (en) | 2014-11-24 | 2018-08-07 | Ucl Business Plc | Treatment of diseases associated with hepatic stellate cell activation using ammonia-lowering therapies |
| EP3337473A4 (en) | 2015-08-18 | 2019-04-17 | Ocera Therapeutics, Inc. | TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| AU2016353350B2 (en) * | 2015-11-13 | 2021-09-23 | Ocera Therapeutics, Inc. | Formulation of L-ornithine phenylacetate |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| WO2018208677A1 (en) | 2017-05-11 | 2018-11-15 | Ocera Therapeutics, Inc. | Processes of making l-ornithine phenylacetate |
| IL296055A (en) | 2017-08-14 | 2022-10-01 | Axcella Health Inc | Amino acid compositions for the treatment of liver disease |
| MA52971A (fr) | 2018-06-20 | 2021-04-28 | Axcella Health Inc | Compositions et procédés pour le traitement de l'infiltration de graisse dans le muscle |
| KR102852068B1 (ko) | 2019-05-09 | 2025-08-28 | 오세라 테라퓨틱스, 아이엔씨. | 간성 뇌증의 평가 및 치료 방법 |
| WO2021076709A1 (en) * | 2019-10-16 | 2021-04-22 | Ocera Therapeutics, Inc. | Dosages and uses of ornithine phenylacetate for treating hyperammonemia |
| WO2021152587A1 (en) | 2020-01-30 | 2021-08-05 | Yeda Research And Development Co. Ltd. | Treating acute liver disease with tlr-mik inhibitors |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
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| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
| SG158073A1 (en) | 2004-11-26 | 2010-01-29 | Ucl Business Plc | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
| CA2757373C (en) | 2009-04-03 | 2018-05-08 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| AU2014250643B2 (en) * | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| EA201691430A1 (ru) * | 2009-06-08 | 2017-02-28 | ЮСиЭл БИЗНЕС ПиЭлСи | Лечение портальной гипертензии и восстановление функции печени с помощью l-орнитинфенилацетата |
| MX360062B (es) | 2010-10-06 | 2018-10-22 | Ocera Therapeutics Inc | Metodos de elaboracion de fenilacetato de l-ornitina. |
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| RU2017137643A3 (https=) | 2019-09-17 |
| JP2018513171A (ja) | 2018-05-24 |
| US20220184014A1 (en) | 2022-06-16 |
| US20160338982A1 (en) | 2016-11-24 |
| CN107708684A (zh) | 2018-02-16 |
| EP3285756A1 (en) | 2018-02-28 |
| ES2944311T3 (es) | 2023-06-20 |
| EP3285756B1 (en) | 2023-02-22 |
| HK1251149A1 (zh) | 2019-01-25 |
| RU2017137643A (ru) | 2019-05-20 |
| JP2022101549A (ja) | 2022-07-06 |
| CA2983146A1 (en) | 2016-10-27 |
| MX391167B (es) | 2025-03-11 |
| RU2755904C2 (ru) | 2021-09-22 |
| DK3285756T3 (da) | 2023-05-08 |
| CA2983146C (en) | 2023-09-12 |
| KR20180006904A (ko) | 2018-01-19 |
| AU2021200740A1 (en) | 2021-03-04 |
| CN113599350A (zh) | 2021-11-05 |
| EP4205735A1 (en) | 2023-07-05 |
| EP3285756A4 (en) | 2019-01-23 |
| MX2017013170A (es) | 2018-04-11 |
| MX2022003855A (es) | 2023-03-02 |
| WO2016172112A1 (en) | 2016-10-27 |
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