JP2018513171A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018513171A5 JP2018513171A5 JP2017554815A JP2017554815A JP2018513171A5 JP 2018513171 A5 JP2018513171 A5 JP 2018513171A5 JP 2017554815 A JP2017554815 A JP 2017554815A JP 2017554815 A JP2017554815 A JP 2017554815A JP 2018513171 A5 JP2018513171 A5 JP 2018513171A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical formulation
- oral pharmaceutical
- formulation according
- oral
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 23
- LRSYFEZBIMVWRY-VWMHFEHESA-N (2s)-2,5-diaminopentanoic acid;2-phenylacetic acid Chemical compound NCCC[C@H](N)C(O)=O.OC(=O)CC1=CC=CC=C1 LRSYFEZBIMVWRY-VWMHFEHESA-N 0.000 claims 7
- 239000002552 dosage form Substances 0.000 claims 5
- WLJVXDMOQOGPHL-UHFFFAOYSA-N phenylacetic acid Chemical compound OC(=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-UHFFFAOYSA-N 0.000 claims 4
- JFLIEFSWGNOPJJ-JTQLQIEISA-N N(2)-phenylacetyl-L-glutamine Chemical compound NC(=O)CC[C@@H](C(O)=O)NC(=O)CC1=CC=CC=C1 JFLIEFSWGNOPJJ-JTQLQIEISA-N 0.000 claims 3
- 239000008183 oral pharmaceutical preparation Substances 0.000 claims 3
- IPBVNPXQWQGGJP-UHFFFAOYSA-N acetic acid phenyl ester Natural products CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229940049953 phenylacetate Drugs 0.000 claims 2
- 208000007788 Acute Liver Failure Diseases 0.000 claims 1
- 206010000804 Acute hepatic failure Diseases 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010020575 Hyperammonaemia Diseases 0.000 claims 1
- 208000028547 Inborn Urea Cycle disease Diseases 0.000 claims 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims 1
- 231100000836 acute liver failure Toxicity 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 230000007882 cirrhosis Effects 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 238000013270 controlled release Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009969 flowable effect Effects 0.000 claims 1
- 208000007386 hepatic encephalopathy Diseases 0.000 claims 1
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 208000019423 liver disease Diseases 0.000 claims 1
- 239000008188 pellet Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960003424 phenylacetic acid Drugs 0.000 claims 1
- 239000003279 phenylacetic acid Substances 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 208000007232 portal hypertension Diseases 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 208000030954 urea cycle disease Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022046762A JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562150238P | 2015-04-20 | 2015-04-20 | |
| US62/150,238 | 2015-04-20 | ||
| US201562150676P | 2015-04-21 | 2015-04-21 | |
| US62/150,676 | 2015-04-21 | ||
| US201562211619P | 2015-08-28 | 2015-08-28 | |
| US62/211,619 | 2015-08-28 | ||
| US201562255300P | 2015-11-13 | 2015-11-13 | |
| US62/255,300 | 2015-11-13 | ||
| US201662276754P | 2016-01-08 | 2016-01-08 | |
| US62/276,754 | 2016-01-08 | ||
| PCT/US2016/028298 WO2016172112A1 (en) | 2015-04-20 | 2016-04-19 | Formulations of l-ornithine phenylacetate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022046762A Division JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018513171A JP2018513171A (ja) | 2018-05-24 |
| JP2018513171A5 true JP2018513171A5 (enExample) | 2019-05-30 |
Family
ID=57144228
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554815A Pending JP2018513171A (ja) | 2015-04-20 | 2016-04-19 | Ｌ−オルニチンフェニルアセテート製剤 |
| JP2022046762A Pending JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022046762A Pending JP2022101549A (ja) | 2015-04-20 | 2022-03-23 | Ｌ－オルニチンフェニルアセテート製剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20160338982A1 (enExample) |
| EP (2) | EP3285756B1 (enExample) |
| JP (2) | JP2018513171A (enExample) |
| KR (1) | KR20180006904A (enExample) |
| CN (2) | CN113599350A (enExample) |
| AU (2) | AU2016252382A1 (enExample) |
| CA (1) | CA2983146C (enExample) |
| DK (1) | DK3285756T3 (enExample) |
| ES (1) | ES2944311T3 (enExample) |
| HK (1) | HK1251149A1 (enExample) |
| MX (2) | MX391167B (enExample) |
| RU (1) | RU2755904C2 (enExample) |
| WO (1) | WO2016172112A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1824563T3 (pl) | 2004-11-26 | 2010-07-30 | Ucl Business Plc | Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej |
| SG174982A1 (en) | 2009-04-03 | 2011-11-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| JP5749255B2 (ja) | 2009-06-08 | 2015-07-15 | ユーシーエル ビジネス ピーエルシー | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| IL281349B (en) | 2014-11-24 | 2022-09-01 | Ucl Business Ltd | Treatment of diseases related to hepatic stellate cell activity using ammonia-lowering treatments |
| US10835506B2 (en) | 2015-08-18 | 2020-11-17 | Ocera Therapeutics, Inc. | Treatment and prevention of muscle loss using L-ornithine in combination with at least one of phenylacetate and phenylbutyrate |
| US11219611B2 (en) | 2015-11-13 | 2022-01-11 | Ocera Therapeutics, Inc. | Formulations of L-ornithine phenylacetate |
| SG11201802987UA (en) * | 2015-11-13 | 2018-05-30 | Ocera Therapeutics Inc | Formulation of l-ornithine phenylacetate |
| JOP20190146A1 (ar) | 2016-12-19 | 2019-06-18 | Axcella Health Inc | تركيبات حمض أميني وطرق لمعالجة أمراض الكبد |
| CA3063134A1 (en) | 2017-05-11 | 2018-11-15 | Ocera Therapeutics, Inc. | Processes of making l-ornithine phenylacetate |
| US10682325B2 (en) | 2017-08-14 | 2020-06-16 | Axcella Health Inc. | Compositions and methods for the treatment of liver diseases and disorders associated with one or both of hyperammonemia or muscle wasting |
| JP2021527670A (ja) | 2018-06-20 | 2021-10-14 | アクセラ・ヘルス・インコーポレイテッドＡｘｃｅｌｌａ Ｈｅａｌｔｈ Ｉｎｃ． | 筋肉中の脂肪浸潤の治療のための組成物及び方法 |
| JP2022533569A (ja) | 2019-05-09 | 2022-07-25 | オセラ セラピューティクス， インコーポレイテッド | 肝性脳症を評価および処置する方法 |
| US20220362192A1 (en) * | 2019-10-16 | 2022-11-17 | Ocera Therapeutics, Inc. | Dosages and uses of ornithine phenylacetate for treating hyperammonemia |
| EP4096647A1 (en) | 2020-01-30 | 2022-12-07 | Yeda Research and Development Co. Ltd | Treating acute liver disease with tlr-mik inhibitors |
| WO2024261477A1 (en) | 2023-06-20 | 2024-12-26 | Yaqrit Limited | Combination of tlr4 antagonist, ornithine and phenylacetate or phenylbutyrate |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4783443A (en) | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
| IL116674A (en) * | 1995-01-09 | 2003-05-29 | Mendell Co Inc Edward | Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof |
| PL1824563T3 (pl) * | 2004-11-26 | 2010-07-30 | Ucl Business Plc | Kompozycje zawierające ornitynę i fenylooctan lub fenylomaślan do leczenia encefalopatii wątrobowej |
| SG174982A1 (en) * | 2009-04-03 | 2011-11-28 | Ocera Therapeutics Inc | L-ornithine phenyl acetate and methods of making thereof |
| AU2015221466B2 (en) * | 2009-04-03 | 2017-02-02 | Ocera Therapeutics, Inc. | L-ornithine phenyl acetate and methods of making thereof |
| JP5749255B2 (ja) * | 2009-06-08 | 2015-07-15 | ユーシーエル ビジネス ピーエルシー | Ｌ−オルニチンフェニル酢酸塩を用いる門脈圧亢進の治療及び肝機能の修復 |
| AU2014250643B2 (en) * | 2009-06-08 | 2016-07-14 | Ocera Therapeutics, Inc. | Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate |
| JP6087284B2 (ja) * | 2010-10-06 | 2017-03-01 | オセラ セラピューティクス， インコーポレイテッド | Ｌ−オルニチンフェニルアセテートを製造するための方法 |
-
2016
- 2016-04-19 CA CA2983146A patent/CA2983146C/en active Active
- 2016-04-19 ES ES16783692T patent/ES2944311T3/es active Active
- 2016-04-19 US US15/133,087 patent/US20160338982A1/en not_active Abandoned
- 2016-04-19 CN CN202110931620.7A patent/CN113599350A/zh active Pending
- 2016-04-19 MX MX2017013170A patent/MX391167B/es unknown
- 2016-04-19 RU RU2017137643A patent/RU2755904C2/ru active
- 2016-04-19 HK HK18110518.2A patent/HK1251149A1/zh unknown
- 2016-04-19 CN CN201680036045.1A patent/CN107708684A/zh active Pending
- 2016-04-19 EP EP16783692.3A patent/EP3285756B1/en active Active
- 2016-04-19 WO PCT/US2016/028298 patent/WO2016172112A1/en not_active Ceased
- 2016-04-19 JP JP2017554815A patent/JP2018513171A/ja active Pending
- 2016-04-19 AU AU2016252382A patent/AU2016252382A1/en not_active Abandoned
- 2016-04-19 KR KR1020177032260A patent/KR20180006904A/ko not_active Ceased
- 2016-04-19 EP EP23157390.8A patent/EP4205735A1/en not_active Withdrawn
- 2016-04-19 DK DK16783692.3T patent/DK3285756T3/da active
-
2017
- 2017-10-12 MX MX2022003855A patent/MX2022003855A/es unknown
-
2021
- 2021-02-05 AU AU2021200740A patent/AU2021200740A1/en not_active Abandoned
- 2021-12-22 US US17/559,453 patent/US20220184014A1/en not_active Abandoned
-
2022
- 2022-03-23 JP JP2022046762A patent/JP2022101549A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018513171A5 (enExample) | ||
| RU2017137643A (ru) | Составы l-орнитин фенилацетата | |
| JP2015503593A5 (enExample) | ||
| JP2018533601A5 (enExample) | ||
| HRP20211644T1 (hr) | Liječenje ili prevencija kardiovaskularnih događaja administracijom kolhicina | |
| FI3936130T3 (fi) | Valbenatsiinin annostusohjelma hyperkineettisten liikehäiriöiden hoitoon | |
| RU2018114447A (ru) | Введение дейтерированных усилителей cftr | |
| CA2709997A1 (en) | Pirfenidone treatment for patients with atypical liver function | |
| HRP20192133T1 (hr) | Kemijski spoj koristan kao posrednik za pripremu inhibitora katekol-o-metiltransferaze | |
| JP2011173928A5 (enExample) | ||
| JP2014515373A5 (enExample) | ||
| JP2012193216A5 (enExample) | ||
| HRP20171570T1 (hr) | Tapentadol za sprječavanje i liječenje depresije i tjeskobe | |
| ME02474B (me) | Terapijski režimi | |
| JP2013541583A5 (enExample) | ||
| JP2016534081A5 (ja) | ゾレドロン酸の増強された経口バイオアベイラビリティーを有する経口剤形を調製する方法 | |
| JP2017512194A5 (enExample) | ||
| RU2018113801A (ru) | Составы l-орнитин фенилацетата | |
| JP2019218379A5 (enExample) | ||
| JP2007238598A5 (enExample) | ||
| JP2015531749A5 (enExample) | ||
| RU2018146504A (ru) | Лечение внутрипеченочных холестатических заболеваний | |
| JP2019518022A5 (enExample) | ||
| IL272834B2 (en) | Amantadine compositions, preparations thereof, and methods of use | |
| JP2018513204A5 (enExample) |