JP2018513121A - 経皮薬物投与デバイス - Google Patents

経皮薬物投与デバイス Download PDF

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Publication number
JP2018513121A
JP2018513121A JP2017547510A JP2017547510A JP2018513121A JP 2018513121 A JP2018513121 A JP 2018513121A JP 2017547510 A JP2017547510 A JP 2017547510A JP 2017547510 A JP2017547510 A JP 2017547510A JP 2018513121 A JP2018513121 A JP 2018513121A
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JP
Japan
Prior art keywords
drug delivery
transdermal drug
delivery element
solvent
skin
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Pending
Application number
JP2017547510A
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English (en)
Japanese (ja)
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JP2018513121A5 (enExample
Inventor
スザンヌ・ブレデンベルグ
ビン・カイ
ホーカン・エンクヴィスト
ウェイ・シア
Original Assignee
エンプリキュア・アクチエボラゲット
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Publication of JP2018513121A publication Critical patent/JP2018513121A/ja
Publication of JP2018513121A5 publication Critical patent/JP2018513121A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017547510A 2015-03-09 2016-03-09 経皮薬物投与デバイス Pending JP2018513121A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201503961A GB201503961D0 (en) 2015-03-09 2015-03-09 A transdermal drug administration device
GB1503961.3 2015-03-09
PCT/GB2016/050640 WO2016142705A1 (en) 2015-03-09 2016-03-09 A transdermal drug administration device

Publications (2)

Publication Number Publication Date
JP2018513121A true JP2018513121A (ja) 2018-05-24
JP2018513121A5 JP2018513121A5 (enExample) 2019-04-18

Family

ID=52998626

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017547510A Pending JP2018513121A (ja) 2015-03-09 2016-03-09 経皮薬物投与デバイス

Country Status (9)

Country Link
US (1) US20180049976A1 (enExample)
EP (1) EP3267974B1 (enExample)
JP (1) JP2018513121A (enExample)
CN (1) CN107405300A (enExample)
CA (1) CA2978167A1 (enExample)
ES (1) ES2716737T3 (enExample)
GB (1) GB201503961D0 (enExample)
HK (1) HK1249450B (enExample)
WO (1) WO2016142705A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017149287A1 (en) 2016-02-29 2017-09-08 Emplicure Ab Devices for evaporation and inhalation of active agents
GB201714412D0 (en) * 2017-09-07 2017-10-25 Emplicure Ab Evaporation devices containing plant material
KR20220124281A (ko) * 2017-10-16 2022-09-13 트러스티즈 오브 터프츠 칼리지 마이크로니들 제조 시스템 및 방법
CN107942018A (zh) * 2017-10-20 2018-04-20 上海交通大学 一种评价或质检微针透皮给药的体外评价模型
US10022233B1 (en) * 2017-12-04 2018-07-17 Duke University Orthopedic implant for sustained drug release
JP2021506790A (ja) * 2017-12-14 2021-02-22 エルテーエス ローマン テラピー−ジステーメ アーゲー 塩形態の有効成分を含むマイクロニードルアレイ
ES3034959T3 (en) * 2018-03-13 2025-08-27 Medrx Co Ltd Adhesion member and microneedle patch
US11690799B2 (en) 2018-04-19 2023-07-04 Lts Lohmann Therapie-Systeme Ag Microneedle system for applying interferon
CN108720990A (zh) * 2018-06-04 2018-11-02 界首市龙鑫生物科技有限公司 一种能够加快伤口愈合的医用冷敷贴
CN109045460B (zh) * 2018-08-28 2021-08-03 江苏熙美生物科技有限公司 一种微针贴片及其制备方法
CN109044907A (zh) * 2018-08-30 2018-12-21 杜玉堂 一种无痛透皮美容微针贴及其制备方法
CN110947085A (zh) * 2018-09-27 2020-04-03 中科微针（北京）科技有限公司 一种加速聚乙烯醇可溶性微针成型和速溶给药的方法及制备的微针
CA3155522A1 (en) * 2019-10-22 2021-04-29 Georgia Tech Research Corporation Methods for making microneedles using adjustment of component solubility in casting formulations
EP4376933A4 (en) * 2021-07-30 2025-06-25 Nusmetics Pte. Ltd. Microneedling device
TWI803052B (zh) * 2021-11-12 2023-05-21 佛教慈濟醫療財團法人 經皮遞送裝置及其使用及製造方法
CN116999383A (zh) * 2023-09-20 2023-11-07 四川大学 一种负载纳米羟基磷灰石粒子的抗肿瘤复合微针及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009094394A1 (en) * 2008-01-23 2009-07-30 Georgia Tech Research Corporation Microneedle devices and methods of drug delivery or fluid withdrawal
JP2013536875A (ja) * 2010-09-07 2013-09-26 オレクソ・アクチエボラゲット 経皮薬物投与デバイス
EP2823850A1 (en) * 2012-03-06 2015-01-14 Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences Polymer micro-needle array chip, preparation process and use thereof

Family Cites Families (4)

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US8062573B2 (en) * 2002-09-16 2011-11-22 Theraject, Inc. Solid micro-perforators and methods of use
US7699819B2 (en) * 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
US20090182306A1 (en) * 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
EP2100850A1 (en) * 2008-03-11 2009-09-16 Stichting Voor De Technische Wetenschappen Microneedle array and a method for manufacturing microneedles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009094394A1 (en) * 2008-01-23 2009-07-30 Georgia Tech Research Corporation Microneedle devices and methods of drug delivery or fluid withdrawal
JP2013536875A (ja) * 2010-09-07 2013-09-26 オレクソ・アクチエボラゲット 経皮薬物投与デバイス
EP2823850A1 (en) * 2012-03-06 2015-01-14 Technical Institute of Physics and Chemistry of the Chinese Academy of Sciences Polymer micro-needle array chip, preparation process and use thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MATERIALS CHEMISTRY B, vol. 2, no. 36, JPN6019051270, 2014, pages 5992 - 5998, ISSN: 0004343381 *
MICROELECTRONIC ENGINEERING, vol. 88, JPN6019051269, 2011, pages 1681 - 1684, ISSN: 0004343380 *

Also Published As

Publication number Publication date
GB201503961D0 (en) 2015-04-22
EP3267974A1 (en) 2018-01-17
US20180049976A1 (en) 2018-02-22
EP3267974B1 (en) 2018-12-26
CN107405300A (zh) 2017-11-28
WO2016142705A1 (en) 2016-09-15
CA2978167A1 (en) 2016-09-15
ES2716737T3 (es) 2019-06-14
HK1249450B (en) 2020-02-21

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