JP2018512401A5 - - Google Patents
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- Publication number
- JP2018512401A5 JP2018512401A5 JP2017548089A JP2017548089A JP2018512401A5 JP 2018512401 A5 JP2018512401 A5 JP 2018512401A5 JP 2017548089 A JP2017548089 A JP 2017548089A JP 2017548089 A JP2017548089 A JP 2017548089A JP 2018512401 A5 JP2018512401 A5 JP 2018512401A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- seq
- tumor
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 108091000080 Phosphotransferase Proteins 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 102000020233 phosphotransferase Human genes 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 230000035572 chemosensitivity Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562132374P | 2015-03-12 | 2015-03-12 | |
| US62/132,374 | 2015-03-12 | ||
| PCT/US2016/021843 WO2016145234A2 (en) | 2015-03-12 | 2016-03-10 | Use of mk2 inhibitor peptide-containing compositions for treating non-small cell lung cancer with same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018512401A JP2018512401A (ja) | 2018-05-17 |
| JP2018512401A5 true JP2018512401A5 (enExample) | 2019-04-25 |
Family
ID=56880599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548089A Pending JP2018512401A (ja) | 2015-03-12 | 2016-03-10 | Mk2阻害剤ペプチド含有組成物を用いた非小細胞肺癌の治療を目的とするその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9999655B2 (enExample) |
| EP (1) | EP3268022A4 (enExample) |
| JP (1) | JP2018512401A (enExample) |
| KR (1) | KR20170125090A (enExample) |
| CN (1) | CN107921082A (enExample) |
| AU (1) | AU2016229017A1 (enExample) |
| BR (1) | BR112017019343A2 (enExample) |
| CA (1) | CA2978941A1 (enExample) |
| HK (1) | HK1249433A1 (enExample) |
| MX (1) | MX2017011633A (enExample) |
| RU (1) | RU2017135072A (enExample) |
| SG (1) | SG11201707281QA (enExample) |
| WO (1) | WO2016145234A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10617717B2 (en) | 2016-12-04 | 2020-04-14 | Expression Pathology, Inc. | Methods of treating lung cancer by predicting responders to cisplatin-pemetrexed combination therapy |
| WO2018216009A1 (en) * | 2017-05-22 | 2018-11-29 | The National Institute For Biotechnology In The Negev Ltd. Ben-Gurion University Of The Negev | Biomarkers for diagnosis of lung cancer |
| US10952799B2 (en) * | 2017-05-31 | 2021-03-23 | Covidien Lp | Systems and methods for navigational bronchoscopy and selective drug delivery |
| WO2018231722A1 (en) * | 2017-06-12 | 2018-12-20 | Moerae Matrix, Inc. | Immunomodulatory effect of inhaled kinase inhibitor peptides in lung |
| US20210253635A1 (en) * | 2018-06-12 | 2021-08-19 | Universite De Geneve | Peptidic protein kinase c inhibitors and uses thereof |
| WO2020102670A1 (en) * | 2018-11-15 | 2020-05-22 | Nantomics, Llc | Classification based on characterization analysis methods and systems |
| EP4004548A1 (en) | 2019-07-29 | 2022-06-01 | Yeda Research and Development Co. Ltd | Methods of treating and diagnosing lung cancer |
| CN113261532A (zh) * | 2020-02-17 | 2021-08-17 | 中山大学 | 一种肺癌动物模型的构建方法 |
| EP4114411A4 (en) * | 2020-03-02 | 2024-04-24 | Washington University | Compositions and methods for the treatment of pancreatic cancer |
| CN116437962A (zh) * | 2020-11-18 | 2023-07-14 | 隆萨本德公司 | 包括血管生成抑制剂的可吸入干粉调配物 |
| AU2023207395A1 (en) | 2022-01-14 | 2024-07-11 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Pyridine-containing polycyclic derivative, and preparation method therefor and use thereof |
| EP4608401A2 (en) * | 2022-10-27 | 2025-09-03 | Bristol-Myers Squibb Company | Mk2 inhibitors and uses thereof |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1521000A (en) | 1975-06-13 | 1978-08-09 | Syntex Puerto Rico Inc | Inhalation device |
| US4227522A (en) | 1978-09-05 | 1980-10-14 | Syntex Puerto Rico, Inc. | Inhalation device |
| US4192309A (en) | 1978-09-05 | 1980-03-11 | Syntex Puerto Rico, Inc. | Inhalation device with capsule opener |
| ES286422Y (es) | 1982-10-08 | 1986-09-16 | Glaxo Group Limited | Dispositivo para administrar medicamentos a pacientes |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| AT396872B (de) | 1985-07-30 | 1993-12-27 | Glaxo Group Ltd | Gerät zur verabreichung von medikamenten in pulverform |
| JPH05963A (ja) | 1990-04-13 | 1993-01-08 | Toray Ind Inc | ポリペプチド類組成物 |
| US6331318B1 (en) | 1994-09-30 | 2001-12-18 | Emisphere Technologies Inc. | Carbon-substituted diketopiperazine delivery systems |
| US5352461A (en) | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| WO1993022443A1 (en) | 1992-04-24 | 1993-11-11 | Sri International | In vivo homologous sequence targeting in eukaryotic cells |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| KR100386337B1 (ko) | 1993-12-09 | 2004-03-24 | 토마스 제퍼슨 대학교 | 진핵세포에서부위-특이적돌연변이를위한화합물과그방법 |
| US6428771B1 (en) | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| CA2367131C (en) | 1999-04-05 | 2007-07-03 | Solomon S. Steiner | Methods for fine powder formation |
| DK1808438T3 (da) | 1999-06-29 | 2014-10-27 | Mannkind Corp | Rensning og stabilisering af peptid og proteiner i lægemidler |
| US8853266B2 (en) | 2001-12-06 | 2014-10-07 | University Of Tennessee Research Foundation | Selective androgen receptor modulators for treating diabetes |
| US20060039985A1 (en) * | 2004-04-27 | 2006-02-23 | Bennett David B | Methotrexate compositions |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR20070057829A (ko) | 2004-08-23 | 2007-06-07 | 맨카인드 코포레이션 | 포스포디에스테라아제 5형의 억제제의 폐 전달 |
| EP2314298B1 (en) | 2004-08-23 | 2015-05-27 | MannKind Corporation | Microparticles comprising diketopiperazine salts for drug delivery |
| AU2006290870B2 (en) | 2005-09-14 | 2013-02-28 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces |
| DK1986679T3 (da) | 2006-02-22 | 2017-11-20 | Mannkind Corp | Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof |
| EP2617431B1 (en) | 2007-01-10 | 2017-04-12 | Purdue Research Foundation | Polypeptide inhibitors of HSP27 kinase and uses therefor |
| JP5703466B2 (ja) * | 2007-08-07 | 2015-04-22 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | キナーゼ阻害薬およびその使用 |
| DK2349310T3 (da) | 2008-10-20 | 2014-08-11 | Moerae Matrix Inc | Polypeptid til behandling eller forebyggelse af adhæsioner |
| BRPI0922448A2 (pt) | 2008-12-10 | 2021-02-17 | Purdue Research Foundation | inibidor com base em peptídeo penetrante celular de quinases |
| WO2011017132A2 (en) | 2009-07-27 | 2011-02-10 | Purdue Research, Foundation | Mk2 inhibitor compositions and methods to enhance neurite outgrowth, neuroprotection, and nerve regeneration |
| US20110288036A1 (en) | 2010-05-24 | 2011-11-24 | Cynthia Lander | Methods for Treating or Preventing Vascular Graft Failure |
| US10105356B2 (en) * | 2011-01-31 | 2018-10-23 | Avalyn Pharma Inc. | Aerosol pirfenidone and pyridone analog compounds and uses thereof |
| ES2711670T3 (es) | 2011-04-12 | 2019-05-06 | Moerae Matrix Inc | Composiciones y métodos para la prevención o tratamiento de la fibrosis pulmonar |
| US9890200B2 (en) * | 2011-04-12 | 2018-02-13 | Moerae Matrix, Inc. | Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition |
| ES2705237T3 (es) * | 2012-06-06 | 2019-03-22 | Fundacio Inst De Recerca Biomedica Irb Barcelona | Método para el diagnóstico y el pronóstico de metástasis del cáncer de pulmón |
| US20140072613A1 (en) | 2012-09-10 | 2014-03-13 | Cynthia Lander | Compositions and Methods for Treating Cutaneous Scarring |
-
2016
- 2016-03-10 BR BR112017019343A patent/BR112017019343A2/pt not_active Application Discontinuation
- 2016-03-10 MX MX2017011633A patent/MX2017011633A/es unknown
- 2016-03-10 US US15/066,976 patent/US9999655B2/en not_active Expired - Fee Related
- 2016-03-10 AU AU2016229017A patent/AU2016229017A1/en not_active Abandoned
- 2016-03-10 SG SG11201707281QA patent/SG11201707281QA/en unknown
- 2016-03-10 HK HK18109079.5A patent/HK1249433A1/zh unknown
- 2016-03-10 WO PCT/US2016/021843 patent/WO2016145234A2/en not_active Ceased
- 2016-03-10 EP EP16762545.8A patent/EP3268022A4/en not_active Withdrawn
- 2016-03-10 JP JP2017548089A patent/JP2018512401A/ja active Pending
- 2016-03-10 RU RU2017135072A patent/RU2017135072A/ru not_active Application Discontinuation
- 2016-03-10 CN CN201680022723.9A patent/CN107921082A/zh active Pending
- 2016-03-10 CA CA2978941A patent/CA2978941A1/en not_active Abandoned
- 2016-03-10 KR KR1020177028070A patent/KR20170125090A/ko not_active Withdrawn
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