JP2018511625A5 - - Google Patents

Info

Publication number

JP2018511625A5

JP2018511625A5 JP2017553410A JP2017553410A JP2018511625A5 JP 2018511625 A5 JP2018511625 A5 JP 2018511625A5 JP 2017553410 A JP2017553410 A JP 2017553410A JP 2017553410 A JP2017553410 A JP 2017553410A JP 2018511625 A5 JP2018511625 A5 JP 2018511625A5

Authority

JP

Japan

Prior art keywords

kit

hyperglycemia

chemotherapy

cancer

subject

Prior art date

2016-04-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 201000001421 hyperglycemia Diseases 0.000 claims 14
• 238000002512 chemotherapy Methods 0.000 claims 13
• 239000003795 chemical substances by application Substances 0.000 claims 9
• 230000001939 inductive effect Effects 0.000 claims 9
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 8
• 102000004877 Insulin Human genes 0.000 claims 4
• 108090001061 Insulin Proteins 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 4
• 229960003957 dexamethasone Drugs 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940125396 insulin Drugs 0.000 claims 4
• XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims 4
• 229960003105 metformin Drugs 0.000 claims 4
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 4
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 4
• 229960002930 sirolimus Drugs 0.000 claims 4
• 230000003637 steroidlike Effects 0.000 claims 4
• 206010070834 Sensitisation Diseases 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 3
• 210000004369 blood Anatomy 0.000 claims 3
• 235000013305 food Nutrition 0.000 claims 3
• 235000003642 hunger Nutrition 0.000 claims 3
• 230000008313 sensitization Effects 0.000 claims 3
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 239000008103 glucose Substances 0.000 claims 2
• 238000011275 oncology therapy Methods 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 206010029260 Neuroblastoma Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 206010060862 Prostate cancer Diseases 0.000 claims 1
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 235000005911 diet Nutrition 0.000 claims 1
• 230000037213 diet Effects 0.000 claims 1
• 235000012054 meals Nutrition 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 230000003278 mimic effect Effects 0.000 claims 1
• 230000037351 starvation Effects 0.000 claims 1