ZA201707710B - Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone - Google Patents
Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasoneInfo
- Publication number
- ZA201707710B ZA201707710B ZA2017/07710A ZA201707710A ZA201707710B ZA 201707710 B ZA201707710 B ZA 201707710B ZA 2017/07710 A ZA2017/07710 A ZA 2017/07710A ZA 201707710 A ZA201707710 A ZA 201707710A ZA 201707710 B ZA201707710 B ZA 201707710B
- Authority
- ZA
- South Africa
- Prior art keywords
- conditions
- fmd
- rapamycin
- dexamethasone
- standard
- Prior art date
Links
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 title 1
- 229960003957 dexamethasone Drugs 0.000 title 1
- 235000021439 fasting mimicking diet Nutrition 0.000 title 1
- 239000008103 glucose Substances 0.000 title 1
- 229940127208 glucose-lowering drug Drugs 0.000 title 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- 230000001235 sensitizing effect Effects 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562148451P | 2015-04-16 | 2015-04-16 | |
| PCT/US2016/028055 WO2016168802A2 (en) | 2015-04-16 | 2016-04-18 | Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201707710B true ZA201707710B (en) | 2019-04-24 |
Family
ID=57126369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2017/07710A ZA201707710B (en) | 2015-04-16 | 2017-11-14 | Fasting mimicking diet (fmd) and glucose lowering drugs protect normal cells and generate cancer sensitizing conditions in response to standard and high glucose conditions induced by rapamycin and dexamethasone |
Country Status (14)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3291693A4 (en) * | 2015-05-06 | 2019-04-03 | University of Southern California | FASTENIMITIER AND IMPROVING DIET FOR THE TREATMENT OF HYPERTENSION AND LIPID DISORDER |
| JP2019505592A (ja) | 2016-02-15 | 2019-02-28 | ユニバーシティ オブ サザン カリフォルニア | 糖尿病及び他の疾患を治療するための胚様再生を刺激するための薬剤の組み合わせ及び方法 |
| KR20180136551A (ko) | 2016-05-11 | 2018-12-24 | 유니버시티 오브 써던 캘리포니아 | 위장 자가면역/염증 질환을 위한 면역조절 치료로서의 단식 모방 식이(fmd) |
| WO2018102393A1 (en) * | 2016-11-30 | 2018-06-07 | Cure Cancer Worldwide Llc | System for chemotherapy delivery and method of the same |
| US11284640B2 (en) * | 2017-02-14 | 2022-03-29 | University Of Southern California | Fasting mimicking diet |
| MX2020009613A (es) | 2018-03-15 | 2021-02-26 | Univ Southern California | Dieta que imita el ayuno (fmd) pero no ayuno solo con agua, promueve la reversion de la inflamacion y patologia de la enfermedad de intestino irritable (ibd). |
| EP3801069A4 (en) | 2018-06-01 | 2022-03-16 | Cornell University | COMBINATION THERAPY FOR A PI3K-ASSOCIATED DISEASE OR DISORDER |
| US12628858B2 (en) | 2019-03-21 | 2026-05-19 | Cornell University | Therapy for colorectal and small intestine cancers |
| EP3963599B1 (en) | 2019-04-30 | 2026-06-03 | University of Southern California | Fasting-mimicking diet (fmd) as an intervention for alzheimer's disease (ad) |
| IT201900009954A1 (it) * | 2019-06-24 | 2020-12-24 | Fondazione Irccs Istituto Naz Dei Tumori | Preparazione alimentare a basso contenuto calorico per l’alimentazione di pazienti affetti da neoplasie |
| JP2023529504A (ja) * | 2020-06-14 | 2023-07-10 | エル－ニュートラ・インコーポレイテッド | ファスティング状態を維持及び延長する断続的なファスティングバー／ドリンク |
| WO2022008943A1 (ru) * | 2020-07-10 | 2022-01-13 | Елена Анатольевна МАРТЫНОВА | Способ проведения курса голодания для тяжелобольных пациентов |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011050302A2 (en) * | 2009-10-22 | 2011-04-28 | University Of Southern California | Methods and nutritional formulations to increase the efficacy and reduce the side effects of cancer treatment |
| AU2011339929B2 (en) * | 2010-12-06 | 2017-05-11 | Tom C. Tsang | Methods of metabolic targeting cancer cells using chemo- and immunotherapy for treating cancer |
| CA2900782C (en) * | 2013-02-12 | 2022-09-27 | University Of Southern California | Methods and diets to protect against chemotoxicity and age related illnesses |
| RU2727960C2 (ru) * | 2013-07-01 | 2020-07-28 | Юниверсити Оф Саутерн Калифорния | Состояние воздержания от пищи в качестве диетического лечения диабета |
| CN106456631A (zh) * | 2014-03-06 | 2017-02-22 | 南加利福尼亚大学 | 利用短期饥饿方案结合激酶抑制剂来增强传统化学药物功效和可行性并逆转激酶在正常细胞和组织中的副作用 |
-
2016
- 2016-04-18 BR BR112017022244A patent/BR112017022244A2/pt not_active IP Right Cessation
- 2016-04-18 AU AU2016248443A patent/AU2016248443B2/en active Active
- 2016-04-18 CA CA3108664A patent/CA3108664A1/en not_active Abandoned
- 2016-04-18 CA CA2982875A patent/CA2982875C/en active Active
- 2016-04-18 MX MX2017013133A patent/MX2017013133A/es unknown
- 2016-04-18 KR KR1020177032463A patent/KR20180002677A/ko not_active Ceased
- 2016-04-18 HK HK18109338.2A patent/HK1249858A1/zh unknown
- 2016-04-18 EP EP23209796.4A patent/EP4299061A3/en active Pending
- 2016-04-18 CN CN201680022154.8A patent/CN107613979A/zh active Pending
- 2016-04-18 JP JP2017553410A patent/JP2018511625A/ja active Pending
- 2016-04-18 US US15/131,586 patent/US20160303056A1/en not_active Abandoned
- 2016-04-18 WO PCT/US2016/028055 patent/WO2016168802A2/en not_active Ceased
- 2016-04-18 EP EP16780985.4A patent/EP3283073A4/en not_active Ceased
- 2016-04-18 RU RU2017136423A patent/RU2734774C2/ru active
-
2017
- 2017-10-15 IL IL255026A patent/IL255026A0/en unknown
- 2017-11-14 ZA ZA2017/07710A patent/ZA201707710B/en unknown
-
2020
- 2020-10-02 JP JP2020168000A patent/JP2021008491A/ja active Pending
-
2021
- 2021-01-12 US US17/147,280 patent/US20210137856A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2017136423A3 (cg-RX-API-DMAC10.html) | 2019-09-04 |
| CN107613979A (zh) | 2018-01-19 |
| EP4299061A2 (en) | 2024-01-03 |
| US20210137856A1 (en) | 2021-05-13 |
| RU2734774C2 (ru) | 2020-10-23 |
| EP4299061A3 (en) | 2024-02-28 |
| AU2016248443B2 (en) | 2021-03-18 |
| JP2021008491A (ja) | 2021-01-28 |
| IL255026A0 (en) | 2017-12-31 |
| EP3283073A2 (en) | 2018-02-21 |
| BR112017022244A2 (pt) | 2018-07-10 |
| JP2018511625A (ja) | 2018-04-26 |
| HK1249858A1 (zh) | 2018-11-16 |
| KR20180002677A (ko) | 2018-01-08 |
| CA2982875A1 (en) | 2016-10-20 |
| AU2016248443A1 (en) | 2017-11-02 |
| EP3283073A4 (en) | 2019-02-13 |
| WO2016168802A2 (en) | 2016-10-20 |
| CA3108664A1 (en) | 2016-10-20 |
| CA2982875C (en) | 2021-10-19 |
| RU2017136423A (ru) | 2019-05-16 |
| US20160303056A1 (en) | 2016-10-20 |
| MX2017013133A (es) | 2018-09-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL255026A0 (en) | A fasting-mimicking diet and glucose-lowering drugs that protect normal cells and produce cancer-susceptible states in response to rapamycin- and dexamethasone-induced standard and high-glucose conditions | |
| SG11201709321RA (en) | Preparation method for solar cell piece unit and solar cell module | |
| LT2968290T (lt) | Laikina normalių ląstelių apsauga chemoterapijos metu | |
| EP3238070A4 (en) | Memory protection with non-readable pages | |
| EP2923248A4 (en) | Reversible folio for tablet computer with reversible connection for keyboard and reading configuration | |
| EP3019936A4 (en) | Fast multi-touch post processing | |
| EP3084830A4 (en) | Liner for phase change memory (pcm) array and associated techniques and configurations | |
| GB2521562B (en) | Anti-tumor T cell immunity induced by high dose radiation | |
| EP3069171A4 (en) | Seismic data processing | |
| EP3259868A4 (en) | Protecting sensitive data security | |
| EP3066496B8 (en) | Device and method for detecting neutrons and gamma rays | |
| EP3088951A4 (en) | Array substrate, preparation method thereof, motherboard comprising array substrate and display apparatus | |
| EP3135678A4 (en) | Heterocyclic compound and organic solar cell comprising same | |
| EP3298918A4 (en) | Improvements to skull protection cell | |
| EP3198466A4 (en) | Multicore memory data recorder for kernel module | |
| EP2989491A4 (en) | CORE RADIATION DETECTOR CALIBRATION IN A BOREOILL | |
| EP3260456A4 (en) | Heterocyclic compound and organic solar cell comprising same | |
| EP3241116A4 (en) | Memory access protection using processor transactional memory support | |
| EP3140673A4 (en) | Gamma detector protection for downhole operations | |
| GB201802711D0 (en) | Design structure for reducing pre-charge voltage for static random-access memory arrays | |
| LT3024833T (lt) | Nauji indolizino dariniai, jų gamybos būdas ir juos turinčios farmacinės kompozicijos | |
| EP3271828A4 (en) | Cache and data organization for memory protection | |
| EP3287452A4 (en) | Heterocyclic compound and organic solar cell comprising same | |
| EP3031449A4 (en) | Entecavir microspheres and pharmaceutical composition for parenteral administration containing same | |
| ZA201505391B (en) | Framed implementation for payment widgets |