JP2018509890A5 - - Google Patents
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- Publication number
- JP2018509890A5 JP2018509890A5 JP2017540262A JP2017540262A JP2018509890A5 JP 2018509890 A5 JP2018509890 A5 JP 2018509890A5 JP 2017540262 A JP2017540262 A JP 2017540262A JP 2017540262 A JP2017540262 A JP 2017540262A JP 2018509890 A5 JP2018509890 A5 JP 2018509890A5
- Authority
- JP
- Japan
- Prior art keywords
- δ133p53β
- isoform
- δ133p53γ
- pluripotent stem
- induced pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000001708 Protein Isoforms Human genes 0.000 claims 22
- 108010029485 Protein Isoforms Proteins 0.000 claims 22
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 19
- 238000000034 method Methods 0.000 claims 11
- 210000001082 somatic cell Anatomy 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 230000032683 aging Effects 0.000 claims 2
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 210000002950 fibroblast Anatomy 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000008672 reprogramming Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000002463 transducing effect Effects 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 206010010099 Combined immunodeficiency Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 206010013801 Duchenne Muscular Dystrophy Diseases 0.000 claims 1
- 208000011345 Duchenne and Becker muscular dystrophy Diseases 0.000 claims 1
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 1
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 1
- 208000015872 Gaucher disease Diseases 0.000 claims 1
- 208000028735 Gaucher disease type III Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 241001529936 Murinae Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 201000009628 adenosine deaminase deficiency Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000036556 autosomal recessive T cell-negative B cell-negative NK cell-negative due to adenosine deaminase deficiency severe combined immunodeficiency Diseases 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 229910003460 diamond Inorganic materials 0.000 claims 1
- 239000010432 diamond Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002242 embryoid body Anatomy 0.000 claims 1
- 230000007717 exclusion Effects 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 238000003306 harvesting Methods 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 230000001177 retroviral effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims 1
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15305145 | 2015-01-30 | ||
| EP15305145.3 | 2015-01-30 | ||
| PCT/EP2016/052085 WO2016120493A1 (en) | 2015-01-30 | 2016-02-01 | Reprogramming method for producing induced pluripotent stem cells (ipsc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018509890A JP2018509890A (ja) | 2018-04-12 |
| JP2018509890A5 true JP2018509890A5 (cg-RX-API-DMAC7.html) | 2019-03-14 |
Family
ID=52589314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017540262A Pending JP2018509890A (ja) | 2015-01-30 | 2016-02-01 | 人工多能性幹細胞（ｉＰＳＣ）の生産を再プログラムする方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10767165B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3250679B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2018509890A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016120493A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109689860A (zh) | 2016-09-12 | 2019-04-26 | 哈佛学院院长及董事 | 转录因子控制干细胞的分化 |
| EP4056189A1 (en) * | 2016-09-30 | 2022-09-14 | Mayo Foundation for Medical Education and Research | Viral vectors for nuclear reprogramming |
| US20200063105A1 (en) * | 2017-05-01 | 2020-02-27 | President And Fellows Of Harvard College | Transcription factors controlling differentiation of stem cells |
| GB2564437B (en) | 2017-07-10 | 2020-11-04 | Univ Brunel | Method of testing a gene therapy vector using induced pluripotent stem cells |
| EP3717654A4 (en) | 2017-12-01 | 2021-11-10 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR PRODUCING OLIGODENDROCYTE PRECURSOR CELLS |
| WO2019195675A1 (en) | 2018-04-06 | 2019-10-10 | President And Fellows Of Harvard College | Methods of identifying combinations of transcription factors |
| JP2022534295A (ja) * | 2019-05-30 | 2022-07-28 | イミュノルクス インターナショナル コーポレーション | ワクチン接種及び疾患治療法のための自己人工多能性幹細胞とのポックスウイルスの使用 |
| GB201909975D0 (en) * | 2019-07-11 | 2019-08-28 | Babraham Inst | Novel reprogramming method |
| US20220273591A1 (en) * | 2019-07-26 | 2022-09-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for determining risk of developing insulin resistance |
| CN114736872A (zh) * | 2022-05-06 | 2022-07-12 | 中国科学院动物研究所 | 提高多能干细胞性能的组合物、方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009117439A2 (en) * | 2008-03-17 | 2009-09-24 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| CA2695590C (en) * | 2008-06-27 | 2018-01-09 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| US8703413B2 (en) * | 2008-09-22 | 2014-04-22 | Children's Medical Center Corporation | Detection of human somatic cell reprogramming |
| EP2272979A1 (en) | 2009-06-30 | 2011-01-12 | Centre National de la Recherche Scientifique (CNRS) | Method for testing a subject thought to be predisposed to having cancer |
| KR101774206B1 (ko) * | 2009-08-07 | 2017-09-04 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 유도된 다능성 줄기 세포의 효율적인 확립 방법 |
| WO2012044979A2 (en) * | 2010-10-01 | 2012-04-05 | The Goverment Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Manipulation of stem cell function by p53 isoforms |
| US10920198B2 (en) * | 2015-01-30 | 2021-02-16 | Centre National De La Recherche Scientifique (Cnrs) | Delta133p53beta and delta133p53gamma isoforms are biomarkers of cancer stem cells |
-
2016
- 2016-02-01 WO PCT/EP2016/052085 patent/WO2016120493A1/en not_active Ceased
- 2016-02-01 US US15/547,212 patent/US10767165B2/en active Active
- 2016-02-01 JP JP2017540262A patent/JP2018509890A/ja active Pending
- 2016-02-01 EP EP16702146.8A patent/EP3250679B1/en active Active
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