JP2018505899A5 - - Google Patents

Info

Publication number

JP2018505899A5

JP2018505899A5 JP2017543785A JP2017543785A JP2018505899A5 JP 2018505899 A5 JP2018505899 A5 JP 2018505899A5 JP 2017543785 A JP2017543785 A JP 2017543785A JP 2017543785 A JP2017543785 A JP 2017543785A JP 2018505899 A5 JP2018505899 A5 JP 2018505899A5

Authority

JP

Japan

Prior art keywords

alzheimer

disease

mammal

condition

cognitive dysfunction

Prior art date

2016-02-17

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 241000124008 Mammalia Species 0.000 claims 11
• 208000024827 Alzheimer disease Diseases 0.000 claims 10
• 208000010877 cognitive disease Diseases 0.000 claims 10
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims 4
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims 4
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims 4
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• 239000012453 solvate Substances 0.000 claims 4
• 208000024891 symptom Diseases 0.000 claims 4
• 208000031124 Dementia Alzheimer type Diseases 0.000 claims 2
• 230000007450 amyloidogenic pathway Effects 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000000825 pharmaceutical preparation Substances 0.000 claims 1