JP2018504915A5 - - Google Patents
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- JP2018504915A5 JP2018504915A5 JP2017541256A JP2017541256A JP2018504915A5 JP 2018504915 A5 JP2018504915 A5 JP 2018504915A5 JP 2017541256 A JP2017541256 A JP 2017541256A JP 2017541256 A JP2017541256 A JP 2017541256A JP 2018504915 A5 JP2018504915 A5 JP 2018504915A5
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- JP
- Japan
- Prior art keywords
- hsa
- mir
- expression level
- mirs
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 25
- 108091070501 miRNA Proteins 0.000 claims 21
- 108091067573 Homo sapiens miR-222 stem-loop Proteins 0.000 claims 10
- 108091070373 Homo sapiens miR-24-1 stem-loop Proteins 0.000 claims 10
- 108091070374 Homo sapiens miR-24-2 stem-loop Proteins 0.000 claims 10
- 206010060862 Prostate cancer Diseases 0.000 claims 8
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 8
- 108091065163 Homo sapiens miR-30c-1 stem-loop Proteins 0.000 claims 7
- 108091067641 Homo sapiens miR-30c-2 stem-loop Proteins 0.000 claims 7
- 108091070365 Homo sapiens miR-30a stem-loop Proteins 0.000 claims 6
- -1 hsa-miR-203a Proteins 0.000 claims 6
- 210000002700 urine Anatomy 0.000 claims 6
- 108091069457 Homo sapiens miR-200b stem-loop Proteins 0.000 claims 5
- 108091070395 Homo sapiens miR-31 stem-loop Proteins 0.000 claims 5
- 108091067014 Homo sapiens miR-151a stem-loop Proteins 0.000 claims 4
- 108091069018 Homo sapiens miR-27b stem-loop Proteins 0.000 claims 4
- 108091069021 Homo sapiens miR-30b stem-loop Proteins 0.000 claims 4
- 108091067259 Homo sapiens miR-362 stem-loop Proteins 0.000 claims 4
- 108091032103 Homo sapiens miR-425 stem-loop Proteins 0.000 claims 4
- 108091007424 MIR27B Proteins 0.000 claims 4
- 238000011529 RT qPCR Methods 0.000 claims 4
- 108091070521 Homo sapiens let-7a-1 stem-loop Proteins 0.000 claims 3
- 108091070522 Homo sapiens let-7a-2 stem-loop Proteins 0.000 claims 3
- 108091070513 Homo sapiens let-7a-3 stem-loop Proteins 0.000 claims 3
- 108091070496 Homo sapiens miR-20a stem-loop Proteins 0.000 claims 3
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims 3
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims 3
- 239000003153 chemical reaction reagent Substances 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 108091070514 Homo sapiens let-7b stem-loop Proteins 0.000 claims 2
- 108091070511 Homo sapiens let-7c stem-loop Proteins 0.000 claims 2
- 108091070508 Homo sapiens let-7e stem-loop Proteins 0.000 claims 2
- 108091070510 Homo sapiens let-7f-1 stem-loop Proteins 0.000 claims 2
- 108091070526 Homo sapiens let-7f-2 stem-loop Proteins 0.000 claims 2
- 108091069046 Homo sapiens let-7g stem-loop Proteins 0.000 claims 2
- 108091068853 Homo sapiens miR-100 stem-loop Proteins 0.000 claims 2
- 108091068941 Homo sapiens miR-106a stem-loop Proteins 0.000 claims 2
- 108091067628 Homo sapiens miR-10a stem-loop Proteins 0.000 claims 2
- 108091067631 Homo sapiens miR-10b stem-loop Proteins 0.000 claims 2
- 108091044938 Homo sapiens miR-1238 stem-loop Proteins 0.000 claims 2
- 108091069006 Homo sapiens miR-125b-1 stem-loop Proteins 0.000 claims 2
- 108091069087 Homo sapiens miR-125b-2 stem-loop Proteins 0.000 claims 2
- 108091044862 Homo sapiens miR-1260a stem-loop Proteins 0.000 claims 2
- 108091069022 Homo sapiens miR-130a stem-loop Proteins 0.000 claims 2
- 108091069024 Homo sapiens miR-132 stem-loop Proteins 0.000 claims 2
- 108091068987 Homo sapiens miR-135a-1 stem-loop Proteins 0.000 claims 2
- 108091068986 Homo sapiens miR-135a-2 stem-loop Proteins 0.000 claims 2
- 108091066895 Homo sapiens miR-135b stem-loop Proteins 0.000 claims 2
- 108091069102 Homo sapiens miR-136 stem-loop Proteins 0.000 claims 2
- 108091069017 Homo sapiens miR-140 stem-loop Proteins 0.000 claims 2
- 108091068991 Homo sapiens miR-141 stem-loop Proteins 0.000 claims 2
- 108091068993 Homo sapiens miR-142 stem-loop Proteins 0.000 claims 2
- 108091069089 Homo sapiens miR-146a stem-loop Proteins 0.000 claims 2
- 108091067654 Homo sapiens miR-148a stem-loop Proteins 0.000 claims 2
- 108091069045 Homo sapiens miR-15b stem-loop Proteins 0.000 claims 2
- 108091070491 Homo sapiens miR-16-1 stem-loop Proteins 0.000 claims 2
- 108091068927 Homo sapiens miR-16-2 stem-loop Proteins 0.000 claims 2
- 108091068998 Homo sapiens miR-191 stem-loop Proteins 0.000 claims 2
- 108091039001 Homo sapiens miR-1972-1 stem-loop Proteins 0.000 claims 2
- 108091033921 Homo sapiens miR-1972-2 stem-loop Proteins 0.000 claims 2
- 108091070517 Homo sapiens miR-19a stem-loop Proteins 0.000 claims 2
- 108091070519 Homo sapiens miR-19b-1 stem-loop Proteins 0.000 claims 2
- 108091070495 Homo sapiens miR-19b-2 stem-loop Proteins 0.000 claims 2
- 108091065166 Homo sapiens miR-200a stem-loop Proteins 0.000 claims 2
- 108091066023 Homo sapiens miR-200c stem-loop Proteins 0.000 claims 2
- 108091067470 Homo sapiens miR-204 stem-loop Proteins 0.000 claims 2
- 108091067482 Homo sapiens miR-205 stem-loop Proteins 0.000 claims 2
- 108091067468 Homo sapiens miR-210 stem-loop Proteins 0.000 claims 2
- 108091070494 Homo sapiens miR-22 stem-loop Proteins 0.000 claims 2
- 108091069527 Homo sapiens miR-223 stem-loop Proteins 0.000 claims 2
- 108091070492 Homo sapiens miR-23a stem-loop Proteins 0.000 claims 2
- 108091069063 Homo sapiens miR-23b stem-loop Proteins 0.000 claims 2
- 108091070371 Homo sapiens miR-25 stem-loop Proteins 0.000 claims 2
- 108091070372 Homo sapiens miR-26a-1 stem-loop Proteins 0.000 claims 2
- 108091065428 Homo sapiens miR-26a-2 stem-loop Proteins 0.000 claims 2
- 108091070398 Homo sapiens miR-29a stem-loop Proteins 0.000 claims 2
- 108091068837 Homo sapiens miR-29b-1 stem-loop Proteins 0.000 claims 2
- 108091068845 Homo sapiens miR-29b-2 stem-loop Proteins 0.000 claims 2
- 108091065168 Homo sapiens miR-29c stem-loop Proteins 0.000 claims 2
- 108091065436 Homo sapiens miR-30e stem-loop Proteins 0.000 claims 2
- 108091060457 Homo sapiens miR-320b-1 stem-loop Proteins 0.000 claims 2
- 108091062096 Homo sapiens miR-320b-2 stem-loop Proteins 0.000 claims 2
- 108091060471 Homo sapiens miR-320c-1 stem-loop Proteins 0.000 claims 2
- 108091078079 Homo sapiens miR-320c-2 stem-loop Proteins 0.000 claims 2
- 108091066896 Homo sapiens miR-331 stem-loop Proteins 0.000 claims 2
- 108091067286 Homo sapiens miR-363 stem-loop Proteins 0.000 claims 2
- 108091067535 Homo sapiens miR-375 stem-loop Proteins 0.000 claims 2
- 108091063813 Homo sapiens miR-455 stem-loop Proteins 0.000 claims 2
- 108091092228 Homo sapiens miR-490 stem-loop Proteins 0.000 claims 2
- 108091061672 Homo sapiens miR-660 stem-loop Proteins 0.000 claims 2
- 108091068854 Homo sapiens miR-99a stem-loop Proteins 0.000 claims 2
- 108091065457 Homo sapiens miR-99b stem-loop Proteins 0.000 claims 2
- 108091008060 MIR10A Proteins 0.000 claims 2
- 210000001808 exosome Anatomy 0.000 claims 2
- 238000010606 normalization Methods 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000007476 Maximum Likelihood Methods 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 238000012417 linear regression Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 108091092722 miR-23b stem-loop Proteins 0.000 claims 1
- 238000003253 miRNA assay Methods 0.000 claims 1
- 239000002679 microRNA Substances 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 238000012360 testing method Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA201500079 | 2015-02-11 | ||
| DKPA201500079 | 2015-02-11 | ||
| DKPA201500825 | 2015-12-21 | ||
| DKPA201500825 | 2015-12-21 | ||
| PCT/DK2016/050032 WO2016127998A1 (en) | 2015-02-11 | 2016-02-05 | A microrna-based method for early detection of prostate cancer in urine samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018504915A JP2018504915A (ja) | 2018-02-22 |
| JP2018504915A5 true JP2018504915A5 (enExample) | 2019-02-28 |
Family
ID=55435920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017541256A Pending JP2018504915A (ja) | 2015-02-11 | 2016-02-05 | 尿中の前立腺癌の早期発見のためのｍｉｃｒｏＲＮＡに基づく方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10400288B2 (enExample) |
| EP (1) | EP3256602B1 (enExample) |
| JP (1) | JP2018504915A (enExample) |
| CA (1) | CA2976577C (enExample) |
| ES (1) | ES2749651T3 (enExample) |
| WO (1) | WO2016127998A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016134727A1 (en) | 2015-02-27 | 2016-09-01 | Exiqon A/S | A microrna-based method for assessing the prognosis of a prostate cancer patient |
| WO2018049506A1 (en) * | 2016-09-14 | 2018-03-22 | Ontario Institute For Cancer Research (Oicr) | Mirna prostate cancer marker |
| CN106834470A (zh) * | 2017-02-17 | 2017-06-13 | 张灏 | miRNA在制备癌症诊断试剂盒中的用途 |
| WO2018159750A1 (ja) * | 2017-03-02 | 2018-09-07 | 第一三共株式会社 | オピオイド薬の治療有効性を予測するためのｍｉｃｒｏＲＮＡバイオマーカー |
| CN107488734B (zh) * | 2017-10-10 | 2019-11-05 | 广州医科大学附属第二医院 | miR-19a-3p在制备前列腺癌骨转移诊断试剂和治疗药物中的应用 |
| CN107663541A (zh) * | 2017-10-31 | 2018-02-06 | 温州医科大学 | 一种用于诊断原发性肝癌的特异性生物标志物及其筛选方法与应用 |
| US20210147944A1 (en) * | 2018-04-10 | 2021-05-20 | Unity Health Toronto | Methods for monitoring and treating prostate cancer |
| WO2019220759A1 (ja) * | 2018-05-17 | 2019-11-21 | Ｓｔｅｍｃｅｌｌ株式会社 | がんの分析方法、がんの分析システム、プログラムおよびコンピュータ読み取り可能な記録媒体 |
| CN108424962B (zh) * | 2018-05-25 | 2021-08-03 | 中国人民解放军陆军军医大学 | 系膜增生性肾小球肾炎的miRNA检测标志物及其诊断试剂盒 |
| CN109112109A (zh) * | 2018-07-27 | 2019-01-01 | 浙江大学 | 一种骨髓间充质干细胞外泌体的改造方法 |
| EP3699300A1 (en) * | 2019-02-22 | 2020-08-26 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Seminal mirnas as non-invasive biomarkers for the diagnosis and/or prognosis of prostate cancer |
| JP2022524382A (ja) | 2019-03-15 | 2022-05-02 | エムアイアール サイエンティフィック，エルエルシー | 前立腺がんを予測するための方法およびその使用 |
| EP3719144A1 (en) * | 2019-04-05 | 2020-10-07 | Fundación para la Investigación Biomédica del Hospital Universitario de la Paz (FIBHULP) | Mir-151a-3p as an universal endogenous control for exosome cargo normalization |
| JP2020195314A (ja) * | 2019-05-31 | 2020-12-10 | 医薬資源研究所株式会社 | 疾患・体質の分析方法、疾患・体質の分析システム、プログラムおよびコンピュータ読み取り可能な記録媒体 |
| JP7660898B2 (ja) * | 2019-09-09 | 2025-04-14 | Ｃｒａｉｆ株式会社 | マイクロｒｎａを含む体液抽出物 |
| CN111118165B (zh) * | 2020-03-04 | 2023-04-07 | 朱伟 | 一种与前列腺癌辅助诊断相关的血清miRNA标志物及其应用 |
| CN112094910B (zh) * | 2020-09-25 | 2023-03-24 | 无锡市中医医院 | 一种用于前列腺癌患病风险评估的miRNA标志物 |
| CN112795657A (zh) * | 2021-03-22 | 2021-05-14 | 中国农业大学 | miRNA在制备诊断或辅助诊断哺乳动物前列腺癌症产品中的应用 |
| EP4317454A4 (en) * | 2021-03-29 | 2025-02-19 | Toray Industries, Inc. | Method for detecting microrna in biological sample, composition of hydrochloride of neutral amino acid, and container |
| KR102550113B1 (ko) * | 2021-05-28 | 2023-07-03 | 주식회사 시스바이오젠 | 전립선암 진단용 바이오마커 및 이의 용도 |
| CN114045344B (zh) * | 2021-12-09 | 2024-12-17 | 觅瑞（杭州）生物科技有限公司 | 前列腺癌诊断用尿液miRNA标志物、诊断试剂及试剂盒 |
| ES2995178A1 (es) * | 2023-07-31 | 2025-02-07 | Servicio Andaluz De Salud | Biomarcadores y método de diagnóstico de la diabetes monogénica en adultos jóvenes portadores de alelos HNF1A deletéreos |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8455199B2 (en) | 2007-09-14 | 2013-06-04 | The Ohio State University Research Foundation | MicroRNA expression in human peripheral blood microvesicles and uses thereof |
| CA2762986C (en) | 2009-05-22 | 2018-03-06 | Asuragen, Inc. | Mirna biomarkers of prostate disease |
| EP3118334A1 (en) | 2009-11-04 | 2017-01-18 | DiamiR, LLC | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
| EP2341145A1 (en) * | 2009-12-30 | 2011-07-06 | febit holding GmbH | miRNA fingerprint in the diagnosis of diseases |
| CA2795776A1 (en) | 2010-04-06 | 2011-10-13 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers for disease |
| MX338883B (es) | 2010-07-27 | 2016-05-04 | Genomic Health Inc | Metodo para usar expresion de gen para determinar el pronostico de cancer de prostata. |
| EP2771487A1 (en) * | 2011-10-27 | 2014-09-03 | Asuragen, INC. | Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors |
| US9944991B2 (en) | 2012-11-02 | 2018-04-17 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies |
| WO2014085906A1 (en) | 2012-12-03 | 2014-06-12 | St. Michael's Hospital | Microrna biomarkers for prostate cancer |
| CA2834187A1 (en) * | 2013-04-15 | 2014-10-15 | Norgen Biotek Corporation | Use of micrornas for screening and diagnosis of prostate cancer and benign prostatic hyperplasia |
| CN103882118A (zh) * | 2014-02-13 | 2014-06-25 | 绍兴市人民医院 | 用于检测前列腺癌的miRNAs |
| KR102761162B1 (ko) * | 2014-06-12 | 2025-02-03 | 국립연구개발법인 고쿠리츠간켄큐센터 | 전립선암 검출 키트 또는 디바이스 및 검출 방법 |
| EP3000895A1 (en) | 2014-09-26 | 2016-03-30 | Integragen | A method for predicting responsiveness to a treatment with an EGFR inhibitor |
| WO2016115312A1 (en) * | 2015-01-14 | 2016-07-21 | Ohio State Innovation Foundation | Mirna-based predictive models for diagnosis and prognosis of prostate cancer |
| WO2016134727A1 (en) | 2015-02-27 | 2016-09-01 | Exiqon A/S | A microrna-based method for assessing the prognosis of a prostate cancer patient |
-
2016
- 2016-02-05 CA CA2976577A patent/CA2976577C/en active Active
- 2016-02-05 JP JP2017541256A patent/JP2018504915A/ja active Pending
- 2016-02-05 WO PCT/DK2016/050032 patent/WO2016127998A1/en not_active Ceased
- 2016-02-05 US US15/550,416 patent/US10400288B2/en active Active
- 2016-02-05 EP EP16706303.1A patent/EP3256602B1/en active Active
- 2016-02-05 ES ES16706303T patent/ES2749651T3/es active Active
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