JP2018502579A5 - - Google Patents
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- Publication number
- JP2018502579A5 JP2018502579A5 JP2017536359A JP2017536359A JP2018502579A5 JP 2018502579 A5 JP2018502579 A5 JP 2018502579A5 JP 2017536359 A JP2017536359 A JP 2017536359A JP 2017536359 A JP2017536359 A JP 2017536359A JP 2018502579 A5 JP2018502579 A5 JP 2018502579A5
- Authority
- JP
- Japan
- Prior art keywords
- genetically modified
- promoter
- medical
- cells
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15150454.5 | 2015-01-08 | ||
| EP15150454 | 2015-01-08 | ||
| EP15191934.7 | 2015-10-28 | ||
| EP15191934 | 2015-10-28 | ||
| PCT/EP2016/050271 WO2016110565A1 (en) | 2015-01-08 | 2016-01-08 | Genetically modified mesenchymal stem cells expressing alpha-1 antitrypsin (aat) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199368A Division JP2021046416A (ja) | 2015-01-08 | 2020-12-01 | α１−アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018502579A JP2018502579A (ja) | 2018-02-01 |
| JP2018502579A5 true JP2018502579A5 (https=) | 2019-02-14 |
Family
ID=55129837
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017536359A Pending JP2018502579A (ja) | 2015-01-08 | 2016-01-08 | α１−アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
| JP2020199368A Pending JP2021046416A (ja) | 2015-01-08 | 2020-12-01 | α１−アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
| JP2022166094A Active JP7374527B2 (ja) | 2015-01-08 | 2022-10-17 | α１－アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
| JP2023179480A Pending JP2024010006A (ja) | 2015-01-08 | 2023-10-18 | α１－アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020199368A Pending JP2021046416A (ja) | 2015-01-08 | 2020-12-01 | α１−アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
| JP2022166094A Active JP7374527B2 (ja) | 2015-01-08 | 2022-10-17 | α１－アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
| JP2023179480A Pending JP2024010006A (ja) | 2015-01-08 | 2023-10-18 | α１－アンチトリプシン（ＡＡＴ）を発現する遺伝子改変された間葉系幹細胞 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US20180000969A1 (https=) |
| EP (1) | EP3242933B1 (https=) |
| JP (4) | JP2018502579A (https=) |
| CN (1) | CN107208063A (https=) |
| AU (1) | AU2016206033B2 (https=) |
| CA (1) | CA2970993C (https=) |
| CY (1) | CY1122004T1 (https=) |
| DK (1) | DK3242933T3 (https=) |
| ES (1) | ES2727820T3 (https=) |
| HU (1) | HUE043478T2 (https=) |
| IL (1) | IL253063B (https=) |
| LT (1) | LT3242933T (https=) |
| PL (1) | PL3242933T3 (https=) |
| PT (1) | PT3242933T (https=) |
| RS (1) | RS58977B1 (https=) |
| SI (1) | SI3242933T1 (https=) |
| SM (1) | SMT201900381T1 (https=) |
| WO (1) | WO2016110565A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20210086662A (ko) * | 2018-10-29 | 2021-07-08 | 오타와 하스피털 리서치 인스티튜트 | Aoah를 과발현하는 유전자조작된 중간엽 줄기 세포 및 이의 용도 |
| CN109512893A (zh) * | 2018-11-05 | 2019-03-26 | 北京世纪劲得生物技术有限公司 | 间充质干细胞及其注射液和组合物在高尿酸血症中的应用 |
| WO2021020509A1 (ja) * | 2019-07-31 | 2021-02-04 | 株式会社ステムリム | 間葉系幹細胞の増殖促進または減少抑制のための組成物 |
| EP4585223A3 (en) * | 2020-01-15 | 2025-07-30 | The Regents of the University of California | Transplanted cell protection via inhibition of polymorphonuclear cells |
| EP3964265A1 (en) * | 2020-09-07 | 2022-03-09 | Fundacion Instituto De Investigacion Sanitaria Fundacion Jimenez Diaz | Mesenchymal stem cells co-expressing cxcr4 and il-10 and uses thereof |
| EP4240323A1 (en) * | 2020-11-06 | 2023-09-13 | AATEC Medical GmbH | A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections |
| JPWO2024005157A1 (https=) * | 2022-06-30 | 2024-01-04 | ||
| CN116173218B (zh) * | 2023-04-28 | 2023-08-04 | 北京大学口腔医学院 | 蛋白转运抑制剂在制备用于治疗或缓解牙周炎的药物中的用途 |
| CN121909290A (zh) * | 2023-07-10 | 2026-04-21 | 普瑞赛格恩公司 | α-1抗胰蛋白酶缺乏症的治疗 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266491A (en) * | 1989-03-14 | 1993-11-30 | Mochida Pharmaceutical Co., Ltd. | DNA fragment and expression plasmid containing the DNA fragment |
| US20070003518A1 (en) | 2002-04-19 | 2007-01-04 | Atkinson Mark A | Raav vector-based compositions and methods for the prevention and treatment of mammalian diseases |
| US20080095749A1 (en) * | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| US9457070B2 (en) * | 2005-06-07 | 2016-10-04 | The Regents Of The University Of Colorado, A Body Corporate | Compositions, methods and uses of alpha 1-antitrypsin for early intervention in bone marrow transplantation and treatment of graft versus host disease |
| EP2578677A1 (en) | 2007-08-09 | 2013-04-10 | Genzyme Corporation | Method of treating autoimmune disease with mesenchymal stem cells |
| US8758761B2 (en) | 2007-09-30 | 2014-06-24 | University Of Florida Research Foundation, Inc. | Combination therapies for treating type 1 diabetes |
| EP2626369A1 (en) * | 2011-11-24 | 2013-08-14 | Fundació Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Engineered mesenchymal stem cells and their therapeutic use |
| BR112014014751A8 (pt) * | 2011-12-19 | 2017-07-04 | Lfb Usa Inc | composição compreendendo alfa-1-antitripsina, células epiteliais de glândula mamária, mamífero não humano transgênico, e, método para reduzir a atividade de elastase no pulmão |
| CN102920735A (zh) | 2012-11-14 | 2013-02-13 | 青岛奥克生物开发有限公司 | 一种间充质干细胞注射液及其制备方法和在制备治疗糖尿病药物中的应用 |
| CN105456293A (zh) | 2014-09-05 | 2016-04-06 | 深圳市北科生物科技有限公司 | 一种用于治疗糖尿病的干细胞制剂及其制备方法 |
-
2016
- 2016-01-08 DK DK16700404.3T patent/DK3242933T3/da active
- 2016-01-08 AU AU2016206033A patent/AU2016206033B2/en active Active
- 2016-01-08 HU HUE16700404A patent/HUE043478T2/hu unknown
- 2016-01-08 PT PT16700404T patent/PT3242933T/pt unknown
- 2016-01-08 SM SM20190381T patent/SMT201900381T1/it unknown
- 2016-01-08 EP EP16700404.3A patent/EP3242933B1/en active Active
- 2016-01-08 PL PL16700404T patent/PL3242933T3/pl unknown
- 2016-01-08 CN CN201680005202.2A patent/CN107208063A/zh active Pending
- 2016-01-08 JP JP2017536359A patent/JP2018502579A/ja active Pending
- 2016-01-08 RS RS20190634A patent/RS58977B1/sr unknown
- 2016-01-08 LT LTEP16700404.3T patent/LT3242933T/lt unknown
- 2016-01-08 US US15/542,031 patent/US20180000969A1/en not_active Abandoned
- 2016-01-08 CA CA2970993A patent/CA2970993C/en active Active
- 2016-01-08 SI SI201630262T patent/SI3242933T1/sl unknown
- 2016-01-08 WO PCT/EP2016/050271 patent/WO2016110565A1/en not_active Ceased
- 2016-01-08 ES ES16700404T patent/ES2727820T3/es active Active
-
2017
- 2017-06-21 IL IL253063A patent/IL253063B/en active IP Right Grant
-
2019
- 2019-05-24 CY CY20191100553T patent/CY1122004T1/el unknown
-
2020
- 2020-02-25 US US16/800,840 patent/US20200282078A1/en not_active Abandoned
- 2020-12-01 JP JP2020199368A patent/JP2021046416A/ja active Pending
-
2022
- 2022-10-17 JP JP2022166094A patent/JP7374527B2/ja active Active
-
2023
- 2023-03-31 US US18/194,383 patent/US20230226222A1/en active Pending
- 2023-10-18 JP JP2023179480A patent/JP2024010006A/ja active Pending
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